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AR082101A1 - Acidos de hidroxifenilhexinoico ariloxialquileno-sustituido, procedimiento para su preparacion y su uso como medicamento - Google Patents

Acidos de hidroxifenilhexinoico ariloxialquileno-sustituido, procedimiento para su preparacion y su uso como medicamento

Info

Publication number
AR082101A1
AR082101A1 ARP110102384A ARP110102384A AR082101A1 AR 082101 A1 AR082101 A1 AR 082101A1 AR P110102384 A ARP110102384 A AR P110102384A AR P110102384 A ARP110102384 A AR P110102384A AR 082101 A1 AR082101 A1 AR 082101A1
Authority
AR
Argentina
Prior art keywords
alkyl
radical
cycloalkyl
alkylene
aryl
Prior art date
Application number
ARP110102384A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR082101A1 publication Critical patent/AR082101A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Los compuestos son adecuados, por ejemplo, para el tratamiento de la diabetes. Composiciones farmacéuticas y usos.Reivindicación 1: Un compuesto de la fórmula (1) en la que: R1 es alquilo C1-6, cicloalquilo C3-6, alquilen C1-3-cicloalquilo C3-6 donde el radical alquilo C1-6, el radical cicloalquilo C3-6 y el radical alquilen C1-3-cicloalquilo C3-6 puede estar cada uno mono- o polisustituido por F; R2, R3 son cada uno independientemente H, F, Cl, Br, CN, CO-alquilo C1-6, alquilo C1-6 o O-alquilo C1-6, donde el radical CO-alquilo C1-6, el radical alquilo C1-6 y el radical O-alquilo C1-6 puede estar cada uno mono- o polisustituido por F; R4, R5, R6, R7, R8, R9, R10, R11 son cada uno independientemente H, alquilo C1-6, alquilen C1-3-cicloalquilo C3-6, cicloalquilo C3-6, arilo C6-10, OH, O-alquilo C1-6, O-alquilen C1-3-arilo C6-10, O-alquilen C1-3-cicloalquilo C3-6, O-cicloalquilo C3-6, alquilen C1-3-OH, alquilen C1-3-O-alquilo C1-6, alquilen C1-3-O-alquilen C1-3-cicloalquilo C3-6, alquilen C1-3-O-cicloalquilo C3-6, donde el radical alquilo C1-6, el radical alquilen C1-3-cicloalquilo C3-6, el radical cicloalquilo C3-6, el radical O-alquilo C1-6, el radical O-alquilen C1-3-arilo C6-10, el radical O-alquilen C1-3-cicloalquilo C3-6, el radical O-cicloalquilo C3-6, el radical alquilen C1-3-OH, el radical alquilen C1-3-O-alquilo C1-6, el radical alquilen C1-3-O-alquilen C1-3-cicloalquilo C3-6 y el radical alquilen C1-3-O-cicloalquilo C3-6 puede estar cada uno mono- o polisustituido por F; q, r son cada uno independientemente 0, 1; R12, R13, R14 son cada uno independientemente H, F, Cl, Br, I, NO2, CN, O-alquilo C1-6, alquilo C1-6, alquilen C1-3-cicloalquilo C3-6, SO2-CH3, SO2-NH2, SO2-NH-alquilo C1-6, SO2-N(alquil C1-6)2, CONH2, CONH-alquilo C1-6, CON(alquil C1-6)2, SF5, arilo C6-10, cicloalquilo C3-10 o un heterociclo de 4 a 12 miembros, donde el radical O-alquilo C1-6, el radical alquilo C1-6, el radical alquilen C1-3-cicloalquilo C3-6, el radical SO2-NH-alquilo C1-6, el radical SO2-N(alquil C1-6)2, el radical CONH-alquilo C1-6 y el radical CON(alquil C1-6)2 puede estar cada uno mono- o polisustituido por F y donde el radical arilo C6-10, el radical cicloalquilo C3-10 y el heterociclo de 4 a 12 miembros puede estar cada uno mono- o trisustituido por F, Cl, Br, I, OH, CF3, CHF2, CH2F, NO2, CN, OCF3, OCHF2, O-alquilo C1-6, alquilo C1-6, NH2, NH-alquilo C1-6, N(alquil C1-6)2, SO2-CH3, SO2-NH2, SO2-NH-alquilo C1-6, SO2-N(alquil C1-6)2, COOH, COO-alquilo C1-6, CONH2, CONH-alquilo C1-6, CON(alquil C1-6)2 o SF5; A es arilo C6-10, cicloalquilo C3-10 o un heterociclo de 4 a 12 miembros; y sales fisiológicamente compatibles de los mismos.
ARP110102384A 2010-07-05 2011-07-04 Acidos de hidroxifenilhexinoico ariloxialquileno-sustituido, procedimiento para su preparacion y su uso como medicamento AR082101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10305732 2010-07-05

Publications (1)

Publication Number Publication Date
AR082101A1 true AR082101A1 (es) 2012-11-14

Family

ID=43100553

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110102384A AR082101A1 (es) 2010-07-05 2011-07-04 Acidos de hidroxifenilhexinoico ariloxialquileno-sustituido, procedimiento para su preparacion y su uso como medicamento

Country Status (14)

Country Link
US (1) US20120004166A1 (es)
EP (1) EP2590929A1 (es)
JP (1) JP2013535410A (es)
KR (1) KR20130095255A (es)
CN (1) CN103080063A (es)
AR (1) AR082101A1 (es)
AU (1) AU2011281835A1 (es)
BR (1) BR112013000255A2 (es)
CA (1) CA2804110A1 (es)
MX (1) MX2013000073A (es)
SG (1) SG186771A1 (es)
TW (1) TW201221505A (es)
UY (1) UY33483A (es)
WO (1) WO2012010413A1 (es)

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WO2012010413A1 (de) 2012-01-26
BR112013000255A2 (pt) 2016-05-24
CA2804110A1 (en) 2012-01-26
CN103080063A (zh) 2013-05-01
EP2590929A1 (de) 2013-05-15
AU2011281835A1 (en) 2013-01-24
JP2013535410A (ja) 2013-09-12
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US20120004166A1 (en) 2012-01-05

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