NO312939B1 - Anvendelse av hyaluronsyre og/eller salter eller homologer derav - Google Patents

Anvendelse av hyaluronsyre og/eller salter eller homologer derav Download PDF

Info

Publication number: NO312939B1
Authority: NO; Norway
Prior art keywords: hyaluronic acid; skin; composition; drug; nsaid
Prior art date: 1992-02-20

Application number

NO19943044A

Other languages

English (en)

Norwegian (no)

Other versions

NO943044D0 (no

NO943044L (no

Inventor

Rudolf Edgar Falk

Samuel Simon Asculai

Ehud Shmuel Klein

David William Harper

David Hochman

Don Purschke

Original Assignee

Jagotec Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-20

Filing date

1994-08-17

Publication date

2002-07-22

1994-08-17 Application filed by Jagotec Ag filed Critical Jagotec Ag

1994-08-17 Publication of NO943044D0 publication Critical patent/NO943044D0/no

1994-10-19 Publication of NO943044L publication Critical patent/NO943044L/no

2002-07-22 Publication of NO312939B1 publication Critical patent/NO312939B1/no

Links

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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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NO19943044A 1992-02-20 1994-08-17 Anvendelse av hyaluronsyre og/eller salter eller homologer derav NO312939B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA002061703A CA2061703C (en)	1992-02-20	1992-02-20	Formulations containing hyaluronic acid
PCT/CA1993/000061 WO1993016732A1 (en)	1992-02-20	1993-02-16	Formulations containing hyaluronic acid

Publications (3)

Publication Number	Publication Date
NO943044D0 NO943044D0 (no)	1994-08-17
NO943044L NO943044L (no)	1994-10-19
NO312939B1 true NO312939B1 (no)	2002-07-22

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JP (1)	JPH07506812A (el)
KR (1)	KR100315371B1 (el)
CN (1)	CN1103219C (el)
AP (1)	AP475A (el)
AT (1)	ATE200736T1 (el)
AU (1)	AU3488893A (el)
CA (1)	CA2061703C (el)
CZ (1)	CZ290637B6 (el)
DE (1)	DE69330180T2 (el)
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ES (1)	ES2156124T3 (el)
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IN (5)	IN175918B (el)
MD (1)	MD960307A (el)
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Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2122519C (en) *	1994-04-29	2001-02-20	Rudolf Edgar Dr. Falk	Cancer treatment and metastasis prevention
CA2130762C (en) *	1994-08-24	1999-07-06	Eva Anne Turley	Treatment of disease and conditions associated with macrophage infiltration
WO1996004922A1 (en) *	1994-08-10	1996-02-22	Davis, Joanne, T.	Method of using hyaluronic acid for the detection, location and diagnosis of tumors
JPH10504828A (ja) *	1994-08-30	1998-05-12	ハイアルファーマスティカルコーポレイション	細胞活性調整のためのヒアルロン酸およびその誘導体
JP4010574B2 (ja) *	1994-12-05	2007-11-21	電気化学工業株式会社	皮膚外用剤
US5626838A (en) *	1995-03-13	1997-05-06	The Procter & Gamble Company	Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx
CA2154103C (en) *	1995-07-18	1998-02-24	Samuel Simon Asculai	Treatment of mucous membrane disease, trauma or condition and for the relief of pain
US6875753B1 (en)	1996-03-14	2005-04-05	The Governors Of The University Of Alberta	Methods for cell mobilization using in vivo treatment with hyaluronan (HA)
US5939047A (en) *	1996-04-16	1999-08-17	Jernberg; Gary R.	Local delivery of chemotherapeutic agents for treatment of periodontal disease
CA2266622C (en)	1996-09-27	2006-08-15	Hyal Pharmaceutical Corporation	Hyaluronic drug delivery system
KR20010031682A (ko) *	1997-10-31	2001-04-16	존 팔머	히알우로난 합성효소 유전자 및 그의 용도
EP1073460A4 (en) *	1998-04-02	2001-05-23	Univ Oklahoma	NUCLEIC ACID CODING FOR HYALURONAN SYNTHASE AND METHODS FOR USE
EP1140006B1 (de) *	1998-12-23	2003-07-23	Esparma GmbH	Mittel zum schutz der haut enthaltend hydrolysierte hyaluronsäure
DK1140198T3 (da)	1999-01-13	2008-03-10	Alchemia Oncology Pty Ltd	Anvendelse af hyaluronan til fremstilling af et lægemiddel til forögelse af cytotoksiske lægemidlers virkningsgrad
AUPQ879500A0 (en)	2000-07-14	2000-08-10	Meditech Research Limited	Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en)	2000-07-14	2015-06-30	Alchemia Oncology Pty Limited	Hyaluronan as a chemo-sensitizer in the treatment of cancer
US6828308B2 (en) *	2000-07-28	2004-12-07	Sinclair Pharmaceuticals, Ltd.	Compositions and methods for the treatment or prevention of inflammation
US6726898B2 (en)	2000-11-17	2004-04-27	Gary R. Jernberg	Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6576226B1 (en)	2000-11-17	2003-06-10	Gary R. Jernberg	Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
ES2607802T3 (es)	2001-08-14	2017-04-04	Tel Aviv University Future Technology Development L.P.	Partículas lipidadas de glicosaminoglicano y su uso en el suministro de fármacos y genes para diagnóstico y terapia
US20030143165A1 (en) *	2002-01-25	2003-07-31	Allan Evans	NSAID-containing topical formulations that demonstrate chemopreventive activity
US7622117B2 (en)	2002-04-17	2009-11-24	Dynamis Therapeutics, Inc.	3-deoxyglucosone and skin
JP2005530768A (ja)	2002-05-09	2005-10-13	メディジーンズ	血漿または血清を含有した創傷治療用医薬組成物
WO2004050057A2 (en) *	2002-12-04	2004-06-17	Technologies Biolactis Inc.	An exopolysaccharides delivery system for active molecules
KR101142583B1 (ko) *	2004-01-07	2012-05-11	세이가가쿠 고교 가부시키가이샤	히알루론산 유도체 및 그것을 포함하는 약제
FR2865651B1 (fr) *	2004-01-29	2007-09-28	Fabre Pierre Dermo Cosmetique	Compositions topiques associant des fragments de hyaluronate de sodium et un retinoide utiles en dermatologie cosmetique et medicale
US20050266064A1 (en) *	2004-05-29	2005-12-01	Mccarthy Kathryn J	Cosmetic compositions and methods
EP1912658B1 (en)	2005-07-27	2017-01-25	Alchemia Oncology Pty Limited	Therapeutic protocols using hyaluronan
US7323184B2 (en)	2005-08-22	2008-01-29	Healagenics, Inc.	Compositions and methods for the treatment of wounds and the reduction of scar formation
US8623354B2 (en)	2005-09-07	2014-01-07	Alchemia Oncology Pty Limited	Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
CN101460060A (zh) *	2006-03-01	2009-06-17	特莱斯特拉塔公司	局部治疗焦油响应性皮肤病用的组合物和方法
CA2662581C (en)	2006-09-13	2018-01-30	Enhance Skin Products, Inc.	Cosmetic composition for the treatment of skin and methods thereof
US20080154241A1 (en) *	2006-12-07	2008-06-26	Burkstrand Michael J	Latent stabilization of bioactive agents releasable from implantable medical articles
ITMI20071267A1 (it) *	2007-06-22	2008-12-23	Fidia Farmaceutici	Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
GB0913442D0 (en)	2009-07-31	2009-09-16	Univ Ramot	Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
ITMI20110644A1 (it) *	2011-04-14	2012-10-15	Giuliani Spa	Sistema per il rilascio prolungato di agenti cosmetici
IN2014MN01886A (el)	2012-04-18	2015-07-10	Univ Ramot
FR2994846B1 (fr)	2012-08-29	2014-12-26	Vivacy Lab	Composition, sterilisee, comprenant au moins un acide hyaluronique et de l'ascorbyl phosphate de magnesium
KR101439032B1 (ko) *	2013-06-13	2014-09-05	동아에스티 주식회사	피록시캄과 히알루론산을 포함하는 골관절염 치료를 위한 액상 조성물
WO2015198326A1 (en)	2014-06-26	2015-12-30	Ramot At Tel-Aviv University Ltd.	Liposomal formulations for delivery of nucleic acids
CA2968357A1 (en)	2014-11-21	2016-05-26	Bristol-Myers Squibb Company	Antibodies against cd73 and uses thereof
DE202016008638U1 (de) *	2015-09-04	2018-10-01	Elena Poli	Medizinische Vorrichtung zur Behandlung von HPV-Hautinfektionen
CN109965104A (zh) *	2019-03-29	2019-07-05	华熙生物科技股份有限公司	一种含透明质酸钠的组合物及其制备方法和应用
BR122022019603A2 (pt) *	2020-02-25	2022-11-16	Amplifica, Inc.	Composições, seus usos e métodos para estimular o crescimento de cabelo e/ou para tratar perda de cabelo
KR102368100B1 (ko)	2020-07-20	2022-02-25	영인기술(주)	변압기용 단자 조립 어셈블리
CN112587475B (zh) *	2020-12-18	2022-09-13	华熙生物科技股份有限公司	一种载药凝胶及其制备方法
KR20240133242A (ko)	2023-02-28	2024-09-04	영인에너지솔루션 주식회사	변압기의 혼촉 및 방전 방지용 단자 어셈블리
CN117304368B (zh) *	2023-11-29	2024-03-01	杭州湃肽生化科技有限公司	一种透明质酸钠与胶原五肽的组合物及其应用

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2583096A (en) *	1949-01-15	1952-01-22	Searle & Co	Process for the production of high viscosity hyaluronic acid
GB769287A (en)	1954-08-18	1957-03-06	American Home Prod	Preparation of partially depolymerized hyaluronic acid and therapeutic compositions thereof
GB818336A (en)	1956-06-22	1959-08-12	Erba Carlo Spa	A new acid aminopolysaccharide and a process for the production thereof
US3042667A (en) *	1959-03-10	1962-07-03	Pharmacia Ab	Process for producing dextran derivatives and products resulting therefrom
FR1425265A (fr) *	1962-05-14	1966-01-24	Parke Davis & Co	Procédé de préparation d'un nouveau polysaccharide et de ses sels
NL123338C (el) *	1961-12-08
FR3715M (fr) *	1964-06-11	1965-11-29	Lucien Nouvel	Antithermiques et antirhumatismaux améliorés.
US3357784A (en) *	1964-09-30	1967-12-12	Kendall & Co	Exposure to intense ultraviolet light to improve characteristics of cellulosic fabrics in divinyl sulfone and glyoxal cross-linking processes
AT252264B (de) *	1965-03-17	1967-02-10	Etapharm Chem Pharm Lab Ges M	Verfahren zur Herstellung eines reinen hochviskosen Hyaluronsäurepräparates
US3887703A (en) *	1967-03-24	1975-06-03	Oreal	Mucopolysaccharides, their preparation and use in cosmetic and pharmaceutical compositions
US3792164A (en) *	1970-03-31	1974-02-12	Chemway Corp	Ophthalmic composition comprising water-soluble alkaloid salts of polyuronic acids
GB1283892A (en)	1970-06-08	1972-08-02	Irwin Irville Lubowe	Improvements in and relating to medicinal compositions for application to the skin and/or hair
US3845201A (en) *	1972-04-24	1974-10-29	S Loucas	Solid state ophthalmic medication delivery method
US3870791A (en) *	1972-04-24	1975-03-11	Heskel M Haddad	Solid state ophthalmic medication delivery method
DE2364373A1 (de) *	1973-12-22	1975-07-10	Hahn Carl Dr Gmbh	Pharmazeutische und kosmetische praeparate zur aeusserlichen anwendung
US4003991A (en) *	1974-08-27	1977-01-18	National Patent Development Corporation	Ophthalmic formulation
GB1515963A (en) *	1975-07-15	1978-06-28	Massachusetts Inst Technology	Crosslinked collagen-mucopolysaccharide composite materials
US4280954A (en) *	1975-07-15	1981-07-28	Massachusetts Institute Of Technology	Crosslinked collagen-mucopolysaccharide composite materials
US4045558A (en) *	1975-10-08	1977-08-30	Merck & Co., Inc.	Pilocarpine salts
US4141973A (en) *	1975-10-17	1979-02-27	Biotrics, Inc.	Ultrapure hyaluronic acid and the use thereof
US4061722A (en) *	1976-04-26	1977-12-06	Interx Research Corporation	Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals
US4470975A (en) *	1977-10-21	1984-09-11	The Johns Hopkins University	Method and composition for the elimination of water from an animal body
US4271143A (en) *	1978-01-25	1981-06-02	Alcon Laboratories, Inc.	Sustained release ophthalmic drug dosage
FR2478646A2 (fr) *	1980-03-20	1981-09-25	Choay Sa	Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4255415A (en) *	1978-11-22	1981-03-10	Schering Corporation	Polyvinyl alcohol ophthalmic gel
US4240163A (en) *	1979-01-31	1980-12-23	Galin Miles A	Medicament coated intraocular lens
US4272522A (en) *	1979-10-15	1981-06-09	Balazs Endre A	Method for stimulating phagocytic activity and synergistic compositions therefor
US4303676A (en)	1980-03-21	1981-12-01	Balazs Endre A	Hyaluronate based compositions and cosmetic formulations containing same
US4328803B1 (en) *	1980-10-20	1994-01-11	Opthalmic Systems, Inc.	Opthalmological procedures
JPS57185208A (en) *	1981-05-07	1982-11-15	Shiseido Co Ltd	Skin cosmetic
DE3273138D1 (en) *	1981-06-02	1986-10-16	Eupan Corp	Eustatic composition for nonspecifically facilitating and amplifying the generalized homeostatic regulation and maintenance, compensation and repair in living organisms
US4684627A (en) *	1981-09-08	1987-08-04	Leveen Harry H	Treatment of cancer with phlorizin and its derivatives
JPS58183611A (ja) *	1982-04-19	1983-10-26	Kanebo Ltd	多相乳化型化粧料
JPS58183938A (ja) *	1982-04-21	1983-10-27	Shiseido Co Ltd	乳化組成物
JPS5925311A (ja) *	1982-07-29	1984-02-09	Shiseido Co Ltd	化粧料
US5166331A (en) *	1983-10-10	1992-11-24	Fidia, S.P.A.	Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
IT1229075B (it) *	1985-04-05	1991-07-17	Fidia Farmaceutici	Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
US4517295A (en) *	1983-02-18	1985-05-14	Diagnostic, Inc.	Hyaluronic acid from bacterial culture
US4478822A (en) *	1983-05-16	1984-10-23	Merck & Co., Inc.	Drug delivery system utilizing thermosetting gels
JPS59219209A (ja) *	1983-05-28	1984-12-10	Kanebo Ltd	皮膚化粧料
AU555747B2 (en) *	1983-08-09	1986-10-09	Cilco Inc.	Chondroitin sulfate and sodium hyaluronate composition
IE57931B1 (en) *	1983-10-11	1993-05-19	Fidia Spa	Hyaluronic acid fractions having pharmaceutical activity,methods for preparation thereof,and pharmaceutical compositions containing the same
US4855134A (en) *	1983-10-14	1989-08-08	Sumitomo Pharmaceuticals Company, Limited	Sustained-release preparation
DE3486029T2 (de) *	1983-10-14	1993-05-13	Sumitomo Pharma	Ifn-praeparat mit verzoegerter abgabe fuer parentale verabreichung.
NO161573C (no) *	1983-11-25	1989-08-30	Miles Inc	Fremgangsmaate til fremstilling av hyaluronsyre.
US4500676A (en) *	1983-12-15	1985-02-19	Biomatrix, Inc.	Hyaluronate modified polymeric articles
US4487865A (en) *	1983-12-15	1984-12-11	Biomatrix, Inc.	Polymeric articles modified with hyaluronate
US4716224A (en) *	1984-05-04	1987-12-29	Seikagaku Kogyo Co. Ltd.	Crosslinked hyaluronic acid and its use
US4711780A (en) *	1984-06-11	1987-12-08	Fahim Mostafa S	Composition and process for promoting epithelial regeneration
US4629623A (en) *	1984-06-11	1986-12-16	Biomatrix, Inc.	Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations thereof
US4863907A (en) *	1984-06-29	1989-09-05	Seikagaku Kogyo Co., Ltd.	Crosslinked glycosaminoglycans and their use
JPS6156114A (ja) *	1984-08-27	1986-03-20	Kanebo Ltd	皮膚老化防止用化粧料
JPS6164701A (ja) *	1984-09-06	1986-04-03	Meito Sangyo Kk	カチオン化デキストラン誘導体とポリウロン酸の高分子電解質錯体及びその利用
JPS61106602A (ja) *	1984-10-31	1986-05-24	Meito Sangyo Kk	カチオン性デキストラン誘導体の高分子電解質錯体及びその利用
US4636524A (en) *	1984-12-06	1987-01-13	Biomatrix, Inc.	Cross-linked gels of hyaluronic acid and products containing such gels
US4582865A (en) *	1984-12-06	1986-04-15	Biomatrix, Inc.	Cross-linked gels of hyaluronic acid and products containing such gels
US4784990A (en) *	1985-01-18	1988-11-15	Bio-Technology General Corporation	High molecular weight sodium hyaluronate
US4713448A (en) *	1985-03-12	1987-12-15	Biomatrix, Inc.	Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
SE8501723L (sv) *	1985-04-09	1986-10-10	Pharmacia Ab	Preparation att anvendas vid behandling av ledinflammation
US4725585A (en) *	1985-04-26	1988-02-16	Pharmacia Ab	Method of enhancing the host defense
EP0207638B1 (en) *	1985-06-04	1990-12-19	Teijin Limited	Sustained-release pharmaceutical preparation
US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
US4820732A (en) *	1985-10-04	1989-04-11	The Upjohn Company	Method and compositions for reducing dysfunction in angioplasty procedures
SE449003B (sv) *	1985-10-18	1987-03-30	Pharmacia Ab	Sett att in vitro avskilja spermier med egen rorelseformaga medelst penetrationsmedium i vilket ingar hyaluronsyrasalt
IN166447B (el) *	1985-11-27	1990-05-12	Ethicon Inc
EP0224987B1 (en) *	1985-11-29	1992-04-15	Biomatrix, Inc.	Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same
US4912093A (en) *	1986-10-01	1990-03-27	Marion Laboratories, Inc.	Use of synthetic sulfated saccharides to enhance wound healing
US4784991A (en) *	1986-03-14	1988-11-15	Bio-Technology General Corp.	Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
US4746504A (en) *	1986-03-14	1988-05-24	Bio-Technology General Corp.	Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
DE3610037A1 (de) *	1986-03-21	1987-09-24	Schering Ag	Nifedipinkombinationspraeparat
EP0240098A3 (en) *	1986-04-04	1989-05-10	Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo	Oligo and polysaccharides for the treatment of diseases caused by retroviruses
US4808576A (en) *	1986-04-28	1989-02-28	Mobay Corporation	Remote administration of hyaluronic acid to mammals
EP0244178A3 (en) *	1986-04-28	1989-02-08	Iolab, Inc	Intraocular dosage compositions and method of use
US4946870A (en) *	1986-06-06	1990-08-07	Union Carbide Chemicals And Plastics Company Inc.	Delivery systems for pharmaceutical or therapeutic actives
SE452469B (sv) *	1986-06-18	1987-11-30	Pharmacia Ab	Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma
US4877619A (en) *	1986-08-25	1989-10-31	Vestar, Inc.	Liposomal vesicles for intraperitoneal administration of therapeutic agents
JPH0725689B2 (ja) *	1986-10-07	1995-03-22	中外製薬株式会社	顆粒球コロニ−刺激因子を含有する徐放性製剤
IT1198449B (it) *	1986-10-13	1988-12-21	F I D I Farmaceutici Italiani	Esteri di alcoli polivalenti di acido ialuronico
US4879282A (en) *	1987-03-17	1989-11-07	Saliba Jr Michael J	Medical application for heparin and related molecules
WO1988007060A1 (en) *	1987-03-19	1988-09-22	Arthropharm Pty. Limited	Anti-inflammatory compounds and compositions
US4795741A (en) *	1987-05-06	1989-01-03	Biomatrix, Inc.	Compositions for therapeutic percutaneous embolization and the use thereof
GB8713662D0 (en) *	1987-06-11	1987-07-15	Skandigen Ab	Hyaluronic acid derivatives
US4944941A (en) *	1987-08-07	1990-07-31	Genentech, Inc.	Methods and compositions for the treatment of lung conditions
US4900550A (en) *	1987-08-19	1990-02-13	Amy Allene Cosmetiques, Inc.	Skin care cosmetic regime
US4937270A (en) *	1987-09-18	1990-06-26	Genzyme Corporation	Water insoluble derivatives of hyaluronic acid
US4913898A (en) *	1988-04-06	1990-04-03	Altobella Hair Products Inc.	Hair treatment composition and method
IT1219587B (it) *	1988-05-13	1990-05-18	Fidia Farmaceutici	Polisaccaridi carbossiilici autoreticolati
CA2004740A1 (en) *	1988-12-07	1990-06-07	Cary Linsky	Low molecular weight heparin, heparinoid and hexuronyl hexosaminoglycan sulfate containing adhesion prevention barrier and process
ES2084688T3 (es) *	1988-12-20	1996-05-16	Jolla Cancer Res Found	Conjugados de polipeptido-polimero para el tratamiento de heridas.
DE3900198A1 (de) *	1989-01-05	1990-07-12	Merck Patent Gmbh	Topisch anwendbare pharmazeutische zubereitung
JPH0341033A (ja) *	1989-07-07	1991-02-21	Kyowa Hakko Kogyo Co Ltd	安定なモチリン類含有製剤
CA1340994C (en) *	1989-09-21	2000-05-16	Rudolf Edgar Dr. Falk	Treatment of conditions and disease
US5095037B1 (en) *	1989-12-21	1995-12-19	Nissho Kk	Combined anti-inflammatory agent
US5092841A (en) *	1990-05-17	1992-03-03	Wayne State University	Method for treating an arterial wall injured during angioplasty
US5116864A (en) *	1991-04-09	1992-05-26	Indiana University Foundation	Method for preventing restenosis following reconfiguration of body vessels
US5116331A (en) *	1991-04-23	1992-05-26	The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration	Pressure transducer and system for cryogenic environments

1992
- 1992-02-20 CA CA002061703A patent/CA2061703C/en not_active Expired - Lifetime
1993
- 1993-02-16 DK DK93903754T patent/DK0626863T3/da active
- 1993-02-16 RO RO94-01388A patent/RO117499B1/ro unknown
- 1993-02-16 AT AT93903754T patent/ATE200736T1/de active
- 1993-02-16 DE DE69330180T patent/DE69330180T2/de not_active Expired - Lifetime
- 1993-02-16 MD MD96-0307A patent/MD960307A/ro not_active Application Discontinuation
- 1993-02-16 WO PCT/CA1993/000061 patent/WO1993016732A1/en active IP Right Grant
- 1993-02-16 HU HU9303282A patent/HU225967B1/hu unknown
- 1993-02-16 SG SG1996004145A patent/SG52416A1/en unknown
- 1993-02-16 ES ES93903754T patent/ES2156124T3/es not_active Expired - Lifetime
- 1993-02-16 PL PL93301149A patent/PL173211B1/pl unknown
- 1993-02-16 NZ NZ249071A patent/NZ249071A/en not_active IP Right Cessation
- 1993-02-16 JP JP5514407A patent/JPH07506812A/ja active Pending
- 1993-02-16 EP EP93903754A patent/EP0626863B1/en not_active Expired - Lifetime
- 1993-02-16 NZ NZ299280A patent/NZ299280A/en not_active IP Right Cessation
- 1993-02-16 PT PT93903754T patent/PT626863E/pt unknown
- 1993-02-16 AU AU34888/93A patent/AU3488893A/en not_active Abandoned
- 1993-02-16 IN IN94CA1993 patent/IN175918B/en unknown
- 1993-02-18 CZ CZ1993230A patent/CZ290637B6/cs not_active IP Right Cessation
- 1993-02-19 AP APAP/P/1993/000491A patent/AP475A/en active
- 1993-02-19 MX MX9300904A patent/MX9300904A/es unknown
- 1993-02-20 CN CN93103488A patent/CN1103219C/zh not_active Expired - Lifetime
- 1993-05-05 SK SK11193A patent/SK11193A3/sk unknown
1994
- 1994-08-17 FI FI943789A patent/FI113522B/fi not_active IP Right Cessation
- 1994-08-17 NO NO19943044A patent/NO312939B1/no not_active IP Right Cessation
- 1994-08-19 KR KR1019940702859A patent/KR100315371B1/ko not_active IP Right Cessation
1995
- 1995-03-13 IN IN270CA1995 patent/IN182267B/en unknown
- 1995-03-13 IN IN272CA1995 patent/IN179130B/en unknown
- 1995-03-13 IN IN271CA1995 patent/IN182348B/en unknown
- 1995-03-14 IN IN293CA1995 patent/IN178280B/en unknown
- 1995-06-06 US US08/466,714 patent/US6140312A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00652P patent/HU211823A9/hu unknown
1998
- 1998-06-10 HK HK98105085A patent/HK1005983A1/xx not_active IP Right Cessation
2001
- 2001-07-02 GR GR20010401015T patent/GR3036164T3/el unknown

Also Published As

Publication number	Publication date
FI943789A (fi)	1994-10-03
DK0626863T3 (da)	2001-07-30
JPH07506812A (ja)	1995-07-27
WO1993016732A1 (en)	1993-09-02
MX9300904A (es)	1993-10-01
CA2061703C (en)	2002-07-02
MD960307A (ro)	1997-10-31
ES2156124T3 (es)	2001-06-16
CN1084064A (zh)	1994-03-23
RO117499B1 (ro)	2002-04-30
AP9300491A0 (en)	1993-04-30
GR3036164T3 (en)	2001-10-31
PL173211B1 (pl)	1998-02-27
EP0626863A1 (en)	1994-12-07
DE69330180T2 (de)	2001-11-29
NZ299280A (en)	2000-12-22
DE69330180D1 (de)	2001-05-31
FI943789A0 (fi)	1994-08-17
SK11193A3 (en)	1993-09-09
HUT75089A (en)	1997-04-28
NO943044D0 (no)	1994-08-17
HU225967B1 (en)	2008-01-28
PT626863E (pt)	2001-08-30
KR950700086A (ko)	1995-01-16
HU211823A9 (en)	1995-12-28
NZ249071A (en)	1997-01-29
ATE200736T1 (de)	2001-05-15
AP475A (en)	1996-03-08
CZ290637B6 (cs)	2002-09-11
CA2061703A1 (en)	1993-08-21
IN182348B (el)	1999-03-27
AU3488893A (en)	1993-09-13
FI113522B (fi)	2004-05-14
CZ9300230A3 (cs)	2002-06-12
EP0626863B1 (en)	2001-04-25
IN178280B (el)	1997-03-22
US6140312A (en)	2000-10-31
NO943044L (no)	1994-10-19
KR100315371B1 (ko)	2002-06-20
IN182267B (el)	1999-02-27
IN179130B (el)	1997-08-30
CN1103219C (zh)	2003-03-19
SG52416A1 (en)	1998-09-28
IN175918B (el)	1995-10-28
HK1005983A1 (en)	1999-02-05
HU9303282D0 (en)	1994-03-28

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NO312939B1 (no)	2002-07-22	Anvendelse av hyaluronsyre og/eller salter eller homologer derav
US5639738A (en)	1997-06-17	Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
US5824658A (en)	1998-10-20	Topical composition containing hyaluronic acid and NSAIDS
JP4005628B2 (ja)	2007-11-07	ヒアルロン酸とｎｓａｉｄｓ（非ステロイド系抗炎症剤）を含有する局所用組成物
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US6136793A (en)	2000-10-24	Formulations containing hyaluronic acid
US5962433A (en)	1999-10-05	Topical composition containing hyaluronic acid and NSAIDS
US6218373B1 (en)	2001-04-17	Formulations containing hyaluronic acid
US6114314A (en)	2000-09-05	Formulations containing hyaluronic acid
US6017900A (en)	2000-01-25	Topical composition containing hyaluronic acid and nsaids
US6103704A (en)	2000-08-15	Therapeutic methods using hyaluronic acid
US5990096A (en)	1999-11-23	Formulations containing hyaluronic acid
US6087344A (en)	2000-07-11	Formulations containing hyaluronic acid
CA2089621A1 (en)	1994-08-17	Formulations containing hyaluronic acid
CA2089635A1 (en)	1994-08-17	Treatment of disease employing hyaluronic acid and nsaids

Legal Events

Date	Code	Title	Description
2013-03-11	MK1K	Patent expired