SI1809750T1 - Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina - Google Patents
Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteinaInfo
- Publication number
- SI1809750T1 SI1809750T1 SI200531538T SI200531538T SI1809750T1 SI 1809750 T1 SI1809750 T1 SI 1809750T1 SI 200531538 T SI200531538 T SI 200531538T SI 200531538 T SI200531538 T SI 200531538T SI 1809750 T1 SI1809750 T1 SI 1809750T1
- Authority
- SI
- Slovenia
- Prior art keywords
- polypeptide
- interest
- host cells
- selectable marker
- cells expressing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62630104P | 2004-11-08 | 2004-11-08 | |
EP04105593 | 2004-11-08 | ||
US69661005P | 2005-07-05 | 2005-07-05 | |
PCT/EP2005/055794 WO2006048459A2 (en) | 2004-11-08 | 2005-11-07 | Selection of host cells expressing protein at high levels |
EP05810935A EP1809750B1 (en) | 2004-11-08 | 2005-11-07 | Selection of host cells expressing protein at high levels |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1809750T1 true SI1809750T1 (sl) | 2012-08-31 |
Family
ID=34929819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200531538T SI1809750T1 (sl) | 2004-11-08 | 2005-11-07 | Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina |
Country Status (8)
Country | Link |
---|---|
US (3) | US20060172382A1 (sl) |
CN (1) | CN101090968B (sl) |
AT (1) | ATE550432T1 (sl) |
DK (1) | DK1809750T3 (sl) |
ES (1) | ES2384391T3 (sl) |
NZ (1) | NZ553700A (sl) |
SI (1) | SI1809750T1 (sl) |
ZA (1) | ZA200702046B (sl) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1573058T3 (da) * | 2002-12-18 | 2012-01-16 | Chromagenics Bv | Fremgangsmåde til forbedring af proteinproduktion |
WO2004056986A2 (en) * | 2002-12-20 | 2004-07-08 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
NZ553700A (en) * | 2004-11-08 | 2010-09-30 | Chromagenics Bv | Selection of host cells expressing protein at high levels using a selectable marker with a non-optimal start codon |
WO2006048459A2 (en) * | 2004-11-08 | 2006-05-11 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
KR100959456B1 (ko) * | 2004-11-18 | 2010-05-25 | 고쿠리츠다이가쿠호진 히로시마다이가쿠 | 유전자 증폭에 의해 형성된 반복서열로부터, 발현이 억제된단백질을 발현시키는 방법, 키트, 및 형질전환체 |
SI1987150T1 (sl) * | 2006-02-21 | 2011-09-30 | Chromagenics Bv | Selekcija gostiteljskih celic, ki eksprimirajo protein pri visokih nivojih |
ES2388003T3 (es) * | 2006-09-20 | 2012-10-05 | Genzyme Corporation | Un sistema basado en FACS y en la proteína indicadora para un desarrollo de alto rendimiento de proteínas terapéuticas |
WO2009107775A1 (ja) * | 2008-02-27 | 2009-09-03 | 国立大学法人北海道大学 | 動物細胞を用いて外来遺伝子由来タンパク質を大量に生産するための発現ベクター、およびその利用 |
DK2443239T3 (en) | 2009-06-15 | 2016-02-15 | Cellagenics B V | New stringent selection markers |
DK2462237T3 (da) * | 2009-08-06 | 2016-03-29 | Cmc Icos Biolog Inc | Fremgangsmåder til forbedring af rekombinant proteinekspression |
CN103180443B (zh) | 2010-09-01 | 2016-01-13 | 萨拉基尼克有限公司 | 用于增强基因表达的来自核糖体蛋白启动子的核酸片段 |
US20140243234A1 (en) * | 2011-08-03 | 2014-08-28 | Texas Biomedical Research Institute | Nucleic acid compositions, methods and kits for rapid pairing of affinity agents |
TWI775096B (zh) | 2012-05-15 | 2022-08-21 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
EP3119798B1 (en) | 2014-03-17 | 2020-08-05 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
CN104531699B (zh) * | 2014-10-09 | 2017-03-15 | 河南农业大学 | 一种增强外源基因表达的猪的ucoe调控元件片段 |
JP7095994B2 (ja) | 2015-03-02 | 2022-07-05 | アドヴェラム バイオテクノロジーズ, インコーポレイテッド | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
CA3001364A1 (en) | 2015-10-09 | 2017-04-13 | Genzyme Corporation | Improved flare (flow cytometry attenuated reporter expression) technology for rapid bulk sorting |
GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
US20180119192A1 (en) | 2016-10-07 | 2018-05-03 | Genzyme Corporation | Early post-transfection isolation of cells (epic) for biologics production |
US20220193266A1 (en) * | 2019-04-30 | 2022-06-23 | Chan Zuckerberg Biohub, Inc. | A novel chromatin-opening element for stable long term gene expression |
CN110484563B (zh) * | 2019-07-25 | 2023-04-07 | 新乡医学院 | 哺乳动物细胞组合表达载体、表达系统、制备方法和应用 |
WO2022109172A1 (en) | 2020-11-19 | 2022-05-27 | Genzyme Corporation | Flow cytometry attenuated reporter expression (flare) multiple reporter system and methods of use thereof |
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JP2686025B2 (ja) * | 1992-08-25 | 1997-12-08 | 理化学研究所 | ブラストサイジンsデアミナーゼ遺伝子 |
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DK1573058T3 (da) * | 2002-12-18 | 2012-01-16 | Chromagenics Bv | Fremgangsmåde til forbedring af proteinproduktion |
WO2004056986A2 (en) | 2002-12-20 | 2004-07-08 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
ATE557099T1 (de) * | 2003-09-05 | 2012-05-15 | Genencor Int | Hpv cd8+ t-zell-epitope |
EA011747B1 (ru) * | 2004-07-08 | 2009-06-30 | Хромагеникс Б.В. | Молекула рекомбинантной нуклеиновой кислоты, обладающая антирепрессорной активностью, и способы ее применения |
US8039230B2 (en) * | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
NZ553700A (en) | 2004-11-08 | 2010-09-30 | Chromagenics Bv | Selection of host cells expressing protein at high levels using a selectable marker with a non-optimal start codon |
US20060195935A1 (en) * | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
WO2006048459A2 (en) * | 2004-11-08 | 2006-05-11 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
WO2007107578A1 (en) * | 2006-03-20 | 2007-09-27 | Chromagenics B.V. | Expression augmenting dna fragments, use thereof, and methods for finding thereof |
JP5501054B2 (ja) | 2010-03-25 | 2014-05-21 | 株式会社トクヤマ | 3,3−ジアミノアクリル酸(1−ジフェニルメチルアゼチジン−3−イル)エステル酢酸塩の製造方法 |
-
2005
- 2005-11-07 NZ NZ553700A patent/NZ553700A/en not_active IP Right Cessation
- 2005-11-07 CN CN200580037896XA patent/CN101090968B/zh not_active Expired - Fee Related
- 2005-11-07 ES ES05810935T patent/ES2384391T3/es active Active
- 2005-11-07 US US11/269,525 patent/US20060172382A1/en not_active Abandoned
- 2005-11-07 AT AT05810935T patent/ATE550432T1/de active
- 2005-11-07 SI SI200531538T patent/SI1809750T1/sl unknown
- 2005-11-07 DK DK05810935.6T patent/DK1809750T3/da active
-
2007
- 2007-03-08 ZA ZA200702046A patent/ZA200702046B/xx unknown
-
2010
- 2010-08-26 US US12/807,133 patent/US8771984B2/en not_active Expired - Fee Related
-
2014
- 2014-01-27 US US14/165,374 patent/US20140186890A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101090968A (zh) | 2007-12-19 |
CN101090968B (zh) | 2011-10-26 |
ES2384391T3 (es) | 2012-07-04 |
ZA200702046B (en) | 2008-09-25 |
US20140186890A1 (en) | 2014-07-03 |
NZ553700A (en) | 2010-09-30 |
US20060172382A1 (en) | 2006-08-03 |
DK1809750T3 (da) | 2012-06-25 |
ATE550432T1 (de) | 2012-04-15 |
US8771984B2 (en) | 2014-07-08 |
US20110014655A1 (en) | 2011-01-20 |
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