DK1809750T3 - Selektion af værtsceller, der udtrykker protein ved høje niveauer - Google Patents
Selektion af værtsceller, der udtrykker protein ved høje niveauerInfo
- Publication number
- DK1809750T3 DK1809750T3 DK05810935.6T DK05810935T DK1809750T3 DK 1809750 T3 DK1809750 T3 DK 1809750T3 DK 05810935 T DK05810935 T DK 05810935T DK 1809750 T3 DK1809750 T3 DK 1809750T3
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptide
- interest
- host cells
- selectable marker
- cells expressing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62630104P | 2004-11-08 | 2004-11-08 | |
EP04105593 | 2004-11-08 | ||
US69661005P | 2005-07-05 | 2005-07-05 | |
PCT/EP2005/055794 WO2006048459A2 (en) | 2004-11-08 | 2005-11-07 | Selection of host cells expressing protein at high levels |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1809750T3 true DK1809750T3 (da) | 2012-06-25 |
Family
ID=34929819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05810935.6T DK1809750T3 (da) | 2004-11-08 | 2005-11-07 | Selektion af værtsceller, der udtrykker protein ved høje niveauer |
Country Status (8)
Country | Link |
---|---|
US (3) | US20060172382A1 (da) |
CN (1) | CN101090968B (da) |
AT (1) | ATE550432T1 (da) |
DK (1) | DK1809750T3 (da) |
ES (1) | ES2384391T3 (da) |
NZ (1) | NZ553700A (da) |
SI (1) | SI1809750T1 (da) |
ZA (1) | ZA200702046B (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1573058T3 (da) * | 2002-12-18 | 2012-01-16 | Chromagenics Bv | Fremgangsmåde til forbedring af proteinproduktion |
EP1572994B1 (en) * | 2002-12-20 | 2007-02-21 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
DK1809750T3 (da) * | 2004-11-08 | 2012-06-25 | Chromagenics Bv | Selektion af værtsceller, der udtrykker protein ved høje niveauer |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
EP1809750B1 (en) * | 2004-11-08 | 2012-03-21 | ChromaGenics B.V. | Selection of host cells expressing protein at high levels |
US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
CA2587712C (en) * | 2004-11-18 | 2013-02-12 | National University Of Corporation Hiroshima University | Method and kit for expressing protein under regulation of the expression from repeated sequence formed by gene amplification and transformant |
KR101328300B1 (ko) * | 2006-02-21 | 2013-11-14 | 크로마제닉스 비.브이. | 고수준으로 단백질을 발현하는 숙주세포의 선택 |
ES2388003T3 (es) * | 2006-09-20 | 2012-10-05 | Genzyme Corporation | Un sistema basado en FACS y en la proteína indicadora para un desarrollo de alto rendimiento de proteínas terapéuticas |
AU2009218069B2 (en) * | 2008-02-27 | 2014-05-01 | Fuso Pharmaceutical Industries, Ltd. | Expression vector for mass production of foreign gene-derived protein using animal cell and use thereof |
WO2010147462A2 (en) | 2009-06-15 | 2010-12-23 | Cellagenics B.V. | Novel stringent selectable markers |
DK2462237T3 (da) | 2009-08-06 | 2016-03-29 | Cmc Icos Biolog Inc | Fremgangsmåder til forbedring af rekombinant proteinekspression |
DK2611915T3 (da) | 2010-09-01 | 2015-06-22 | Cellagenics B V | Nukleinsyrefragmenter fra en ribosomal proteinpromoter til forstærkning af genekspression |
WO2013020087A2 (en) * | 2011-08-03 | 2013-02-07 | Texas Biomedical Research Insitute | Nucleic acid compositions, methods and kits for rapid pairing of affinity agents |
TWI702955B (zh) | 2012-05-15 | 2020-09-01 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
AU2015231439B2 (en) * | 2014-03-17 | 2019-11-14 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
CN104531699B (zh) * | 2014-10-09 | 2017-03-15 | 河南农业大学 | 一种增强外源基因表达的猪的ucoe调控元件片段 |
MY187898A (en) | 2015-03-02 | 2021-10-27 | Adverum Biotechnologies Inc | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
US10317329B2 (en) | 2015-10-09 | 2019-06-11 | Genzyme Corporation | Early post-transfection isolation of cells (EPIC) for biologics production |
GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
CA3039598A1 (en) | 2016-10-07 | 2018-04-12 | Genzyme Corporation | Early post-transfection isolation of cells (epic) for biologics production |
WO2020223160A1 (en) * | 2019-04-30 | 2020-11-05 | Chan Zuckerberg Biohub, Inc. | A novel chromatin-opening element for stable long term gene expression |
CN110484563B (zh) * | 2019-07-25 | 2023-04-07 | 新乡医学院 | 哺乳动物细胞组合表达载体、表达系统、制备方法和应用 |
IL302786A (en) | 2020-11-19 | 2023-07-01 | Genzyme Corp | Flow cytometry Attenuated reporter expression (flaring) Multi-reporter system and methods of using it |
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EP1572994B1 (en) * | 2002-12-20 | 2007-02-21 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
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CN1981057B (zh) * | 2004-07-08 | 2012-07-04 | 科罗迈吉尼科斯公司 | 改良核酸表达的新序列 |
DK1809750T3 (da) | 2004-11-08 | 2012-06-25 | Chromagenics Bv | Selektion af værtsceller, der udtrykker protein ved høje niveauer |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
EP1809750B1 (en) * | 2004-11-08 | 2012-03-21 | ChromaGenics B.V. | Selection of host cells expressing protein at high levels |
US20060195935A1 (en) * | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8039230B2 (en) * | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
WO2007107578A1 (en) * | 2006-03-20 | 2007-09-27 | Chromagenics B.V. | Expression augmenting dna fragments, use thereof, and methods for finding thereof |
JP5501054B2 (ja) | 2010-03-25 | 2014-05-21 | 株式会社トクヤマ | 3,3−ジアミノアクリル酸(1−ジフェニルメチルアゼチジン−3−イル)エステル酢酸塩の製造方法 |
-
2005
- 2005-11-07 DK DK05810935.6T patent/DK1809750T3/da active
- 2005-11-07 CN CN200580037896XA patent/CN101090968B/zh not_active Expired - Fee Related
- 2005-11-07 US US11/269,525 patent/US20060172382A1/en not_active Abandoned
- 2005-11-07 AT AT05810935T patent/ATE550432T1/de active
- 2005-11-07 ES ES05810935T patent/ES2384391T3/es active Active
- 2005-11-07 NZ NZ553700A patent/NZ553700A/en not_active IP Right Cessation
- 2005-11-07 SI SI200531538T patent/SI1809750T1/sl unknown
-
2007
- 2007-03-08 ZA ZA200702046A patent/ZA200702046B/xx unknown
-
2010
- 2010-08-26 US US12/807,133 patent/US8771984B2/en not_active Expired - Fee Related
-
2014
- 2014-01-27 US US14/165,374 patent/US20140186890A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110014655A1 (en) | 2011-01-20 |
ES2384391T3 (es) | 2012-07-04 |
US20140186890A1 (en) | 2014-07-03 |
ZA200702046B (en) | 2008-09-25 |
US8771984B2 (en) | 2014-07-08 |
SI1809750T1 (sl) | 2012-08-31 |
ATE550432T1 (de) | 2012-04-15 |
CN101090968B (zh) | 2011-10-26 |
CN101090968A (zh) | 2007-12-19 |
US20060172382A1 (en) | 2006-08-03 |
NZ553700A (en) | 2010-09-30 |
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