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RU2016147947A - Ингалятор для сухого порошка и система для доставки лекарственных средств - Google Patents

Ингалятор для сухого порошка и система для доставки лекарственных средств Download PDF

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RU2016147947A
RU2016147947A RU2016147947A RU2016147947A RU2016147947A RU 2016147947 A RU2016147947 A RU 2016147947A RU 2016147947 A RU2016147947 A RU 2016147947A RU 2016147947 A RU2016147947 A RU 2016147947A RU 2016147947 A RU2016147947 A RU 2016147947A
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cartridge
inhalation system
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RU2731107C2 (ru
RU2016147947A3 (ru
RU2731107C9 (ru
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Чад С. СМАТНИ
П. Спенсер КИНСИ
Карл Р. САХИ
Бенуа АДАМО
Джон М. ПОЛИДОРО
Скотт МакЛИН
Деннис ОУВЕРФИЛД
Энтони БРАЙАНТ
Том ХИ
Альфред МАНН
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Маннкайнд Корпорейшн
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Claims (45)

1. Картридж для сухого порошкообразного медикамента для ингалятора, содержащий:
камеру, выполненную для удерживания медикамента;
по меньшей мере одно входное отверстие, чтобы позволить вход потока в камеру и,
по меньшей мере одно выдачное отверстие, чтобы позволить выход потока из камеры;
причем указанное по меньшей мере одно входное отверстие выполнено для направления внутри камеры, в ответ на разность давлений, по меньшей мере части потока, поступающего в указанное по меньшей мере одно входное отверстие, к указанному по меньшей мере одному выдачному отверстию.
2. Картридж по п.1, в котором медикамент содержит активный ингредиент.
3. Картридж по п.2, в котором активный ингредиент представляет собой гормон, антикоагулянт, иммуномодулирующий агент, вакцину, цитотоксический агент, антибиотик, вазоактивный агент, нейроактивный агент, анестетик или седатив, стероид, декогнестант, антивирусный препарат, антисмысловой препарат, антиген или антитело.
4. Картридж по п.2, в котором активный ингредиент представляет собой инсулин, гепарин, кальцитонин, фельбамат, суматриптан, паратироидный гормон, гормон роста, эритропоэтин, AZT, DDI, фактор, стимулирующий колонии макрофагов гранулоцитов, ламотригин, рилизинг-фактор хорионического гонадотропина, лютеинизирующий высвобождающий гормон, бета-галактозидазу, эксендин, вазоактивный кишечный пептид, фолликуло-стимулирующий гормон, паратироидный гормон, белок, связанный с паратироидным гормоном, глюкагоноподобный пептид-1, эксендин, оксинтомодулин, пептид YY, тирозинкиназу, индуцируемую интерлейкином 2, тирозинкиназу Брутона, инозитол-зависимую киназу 1, модифицированные производные PC-DAC, или O-гликозилированные формы PC-DAC, паратироидный гормон 1-34, аргатробан или их комбинацию.
5. Картридж по п.4, в котором активный ингредиент представляет собой инсулин.
6. Картридж по п.4, в котором активный ингредиент представляет собой оксинтомодулин.
7. Картридж по п.4, в котором активный ингредиент представляет собой глюкагоноподобный пептид-1.
8. Картридж по п.1, в котором медикамент содержит дикетопиперазин.
9. Картридж по п.8, в котором дикетопиперазин представляет собой 3,6-ди(N-фумарил-4-аминобутил)-2,5-дикетопиперазин (FDKP).
10. Картридж по п.1, содержащий один или более цветов или маркировок для идентификации порошкообразной композиции.
11. Картридж для сухого порошкообразного медикамента для ингалятора, содержащий камеру, выполненную для удерживания медикамента, имеющую одно или более выходных отверстий, выполненных с наименьшим измерением менее 3 мм для предотвращения высвобождения более крупных агрегатов порошка.
12. Картридж по п.11, в котором медикамент содержит активный ингредиент.
13. Картридж по п.12, в котором активный ингредиент представляет собой гормон, антикоагулянт, иммуномодулирующий агент, вакцину, цитотоксический агент, антибиотик, вазоактивный агент, нейроактивный агент, анестетик или седатив, стероид, декогнестант, антивирусный препарат, антисмысловой препарат, антиген или антитело.
14. Картридж по п.12, в котором активный ингредиент представляет собой инсулин, гепарин, кальцитонин, фельбамат, суматриптан, паратироидный гормон, гормон роста, эритропоэтин, AZT, DDI, фактор, стимулирующий колонии макрофагов гранулоцитов, ламотригин, рилизинг-фактор хорионического гонадотропина, лютеинизирующий высвобождающий гормон, бета-галактозидазу, эксендин, вазоактивный кишечный пептид, фолликуло-стимулирующий гормон, паратироидный гормон, белок, связанный с паратироидным гормоном, глюкагоноподобный пептид-1, эксендин, оксинтомодулин, пептид YY, тирозинкиназу, индуцируемую интерлейкином 2, тирозинкиназу Брутона, инозитол-зависимую киназу 1, модифицированные производные PC-DAC, или O-гликозилированные формы PC-DAC, паратироидный гормон 1-34, аргатробан или их комбинацию.
15. Картридж по п.14, в котором активный ингредиент представляет собой инсулин.
16. Картридж по п.14, в котором активный ингредиент представляет собой оксинтомодулин.
17. Картридж по п.14, в котором активный ингредиент представляет собой глюкагоноподобный пептид-1.
18. Картридж по п.11, в котором медикамент содержит дикетопиперазин.
19. Картридж по п.18, в котором дикетопиперазин представляет собой 3,6-ди(N-фумарил-4-аминобутил)-2,5-дикетопиперазин (FDKP).
20. Картридж по п.11, содержащий один или более цветов или маркировок для идентификации порошкообразной композиции.
21. Система ингаляции для доставки сухого порошкообразного медикамента в респираторный тракт, содержащая ингалятор для сухого порошка, выполненный с по меньшей мере двумя входными отверстиями, причем первое входное отверстие находится в сообщении с первым каналом для воздушного потока, а второе входное отверстие находится в сообщении со вторым каналом для воздушного потока, при этом первый и второй каналы для воздушного потока сходятся по существу перпендикулярным образом во время действия ингаляции, и при этом система ингаляции имеет общее сопротивление потоку в конфигурации дозирования, находящееся в пределах значений от 0,065 до примерно 0,200 (√кПа)/литр в минуту.
22. Система ингаляции по п.21, дополнительно содержащая камеру для удерживания сухого порошкообразного медикамента для ингаляции.
23. Система ингаляции по п.22, в которой указанная камера содержит картридж.
24. Система ингаляции по п.22, в которой указанная камера имеет внутренний объем для содержания сухого порошкообразного медикамент и имеющий по меньшей мере одно входное отверстие, чтобы позволить поток в камеру, и по меньшей мере одно выдачное отверстие, чтобы позволить выход потока из камеры; причем указанное по меньшей мере одно входное отверстие выполнено для направления внутри камеры, в ответ на разность давлений, по меньшей мере части потока, поступающего в указанное по меньшей мере одно входное отверстие, к указанному по меньшей мере одному выдачному отверстию.
25. Система ингаляции по п.23, в которой картридж содержит верхнюю часть картриджа и нижнюю часть картриджа, при этом верхняя часть картриджа и контейнер выполнены с возможностью занимать положение удерживания и положение дозирования или выдачи.
26. Система ингаляции по п.21, в которой ингалятор для сухого порошка содержит мундштук и подвижный элемент.
27. Система ингаляции по п.26, дополнительно содержащая корпус.
28. Система ингаляции по п.27, в которой мундштук содержит канал для потока, имеющий первое входное отверстие в сообщении по текучей среде с окружающим воздухом, второе входное отверстие в сообщении по текучей среде с картриджем, и выходное отверстие.
29. Система ингаляции по п.26, в которой указанный подвижный элемент содержит салазки, выдвижную кассету или каретку.
30. Система ингаляции по п.21, в которой общее сопротивление потоку является относительно постоянным в диапазоне разности давлений в пределах между 0,5 кПа и 7 кПа.
31. Система ингаляции по п.21, дополнительно содержащая мундштук и контейнер для содержания сухого порошкообразного медикамента, причем сухой порошкообразный медикамент содержит частицы дикетопиперазина; при этом, при использовании, при разнице давлений 4 кПа, частицы дикетопиперазина, выпускаемые из мундштука, имеют объемный медианный геометрический диаметр менее 7 микрон, определяемый посредством анализа геометрических размеров частиц.
32. Система ингаляции по п.31, в которой частицы дикетопиперазина имеют индекс Карра от 16 до 50.
33. Система ингаляции по п.31, в которой частицы дикетопиперазина образованы кристаллами фумарил-дикетопиперазина (FDKP), причем отношение изомеров транс:цис FDKP находится в пределах от 50% до 65%.
34. Система ингаляции по п.31, в которой частицы дикетопиперазина образованы кристаллами FDKP, имеющими удельную площадь поверхности в пределах от 45 до 65 м2/г.
35. Система ингаляции для доставки сухого порошкообразного медикамента пациенту, содержащая ингалятор, содержащий область установки контейнера, выполненную для приема контейнера, и мундштук, имеющий по меньшей мере два входных отверстия и по меньшей мере одно выходное отверстие; причем первое входное отверстие из указанных по меньшей мере двух входных отверстий находится в сообщении по текучей среде с областью установки контейнера, а второе входное отверстие из указанных по меньшей мере двух входных отверстий находится в сообщении по текучей среде с указанным по меньшей мере одним выходным отверстием посредством прохода для потока, выполненного в обход области установки контейнера; при этом первое входное отверстие и второе входное отверстие включают потоки, которые сходятся по существу перпендикулярным образом, причем проход для потока, выполненный в обход области установки контейнера, доставляет 30-90% от общего потока, проходящего через ингалятор во время ингаляции.
36. Система ингаляции по п.35, дополнительно содержащая контейнер, содержащий сухой порошкообразный медикамент, установленный в области для установки контейнера.
37. Система ингаляции по п.36, в которой 10-70% потока, поступающего в ингалятор, проходит через контейнер перед его поступлением в указанный проход для потока.
38. Система ингаляции для доставки сухого порошкообразного медикамента пациенту, содержащая ингалятор для сухого порошка, содержащий область для контейнера и контейнер, причем ингалятор для сухого порошка и указанный контейнер соединены и выполнены для обеспечения жестких проходов для потока в конфигурации дозирования и множества структурных областей, которые обеспечивают механизмы для деагломерации порошка системы ингаляции при использовании, при этом, по меньшей мере, один из множества механизмов для деагломерации представляет собой отверстие в области контейнера, ограничивающее размер проходящих агломератов и имеющее наименьшее измерение менее 3 мм; при этом контейнер содержит верхнюю часть, и при этом указанная верхняя часть и контейнер выполнены с возможностью поступательного перемещения относительно друг друга.
39. Система ингаляции для доставки сухого порошкообразного медикамента пациенту, содержащая ингалятор для сухого порошка, содержащий мундштук и контейнер, причем ингалятор для сухого порошка и указанный контейнер соединены и выполнены для обеспечения жестких проходов для потока в конфигурации дозирования и множества структурных областей, которые обеспечивают механизмы для деагломерации порошка системы ингаляции при использовании, при этом, по меньшей мере, один из множества механизмов для деагломерации представляет собой выполненный в мундштуке канал для воздуха, который направляет поток к выходному отверстию, в сообщении по текучей среде с контейнером, причем указанный контейнер содержит верхнюю часть, и при этом указанная верхняя часть и контейнер выполнены с возможностью поступательного перемещения относительно друг друга.
40. Система ингаляции по п.38 или 39, в которой указанный контейнер дополнительно содержит один из механизмов для деагломерации, представляющий собой чашеобразную структуру, выполненную для направления потока, поступающего в контейнер, для подъема и циркуляции порошкообразного медикамента перед выходом из контейнера.
41. Система ингаляции по п.40, в которой указанная чашеобразная структура имеет один или более радиусов, выполненных для предотвращения застоя потока.
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Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DK1196430T3 (da) 1999-06-29 2012-05-21 Mannkind Corp Rensning og stabilisering af peptider og proteiner i farmaceutiske midler
US7080644B2 (en) * 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
US20070027063A1 (en) * 2004-01-12 2007-02-01 Mannkind Corporation Method of preserving the function of insulin-producing cells
JP2007523700A (ja) 2004-02-24 2007-08-23 マイクロドース・テクノロジーズ・インコーポレーテッド 流動方向検出吸入器
WO2006023849A2 (en) 2004-08-20 2006-03-02 Mannkind Corporation Catalysis of diketopiperazine synthesis
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
US8763605B2 (en) 2005-07-20 2014-07-01 Manta Devices, Llc Inhalation device
CA2621806C (en) 2005-09-14 2016-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
WO2007098500A2 (en) 2006-02-22 2007-08-30 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
KR101530050B1 (ko) 2007-03-02 2015-06-22 주식회사 노브메타파마 알츠하이머 질환 및 치매를 치료하기 위한 조성물 및 방법
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US11224704B2 (en) 2007-07-06 2022-01-18 Manta Devices, Llc Dose delivery device for inhalation
JP5528336B2 (ja) 2007-07-06 2014-06-25 マンタ デバイシス，エルエルシー デリバリー装置及び関連方法
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
EP2534958A1 (en) 2007-12-14 2012-12-19 AeroDesigns, Inc Delivering aerosolizable food products
NZ586105A (en) 2007-12-20 2012-09-28 Astrazeneca Ab Dispenser and method for entraining powder in an airflow by creating eddies over recessed powder containing cavity within flat upstrean and downstream surfaces
US8371294B2 (en) * 2008-02-29 2013-02-12 Microdose Therapeutx, Inc. Method and apparatus for driving a transducer of an inhalation device
US20190262557A1 (en) * 2010-03-04 2019-08-29 Mannkind Corporation Dry powder drug delivery system
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
AU2009257311B2 (en) 2008-06-13 2014-12-04 Mannkind Corporation A dry powder inhaler and system for drug delivery
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
WO2010071577A1 (en) * 2008-12-17 2010-06-24 Astrazeneca Ab Method of providing a target dose, powder provider device and its use
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010083042A1 (en) 2009-01-15 2010-07-22 Manta Devices, Llc Delivery device
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
JP5671519B2 (ja) * 2009-03-18 2015-02-18 マンカインド コーポレイション レーザ回折装置用の吸入器アダプタおよび粒径分布を測定するための方法
CN102438685B (zh) * 2009-05-21 2014-07-02 微剂量治疗技术公司 用于干粉吸入器的旋转盒系统
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
CN104721825B (zh) * 2009-06-12 2019-04-12 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
AU2010259939B2 (en) * 2009-06-12 2012-07-05 Mannkind Corporation Diketopiperazine microparticles with defined isomer contents
MX2011013368A (es) 2009-07-01 2012-01-20 Astrazeneca Ab Dispensador y metodo para arrastrar polvo en un flujo de aire.
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
CA2779488A1 (en) 2009-11-12 2011-05-19 Stc.Unm Dry powder inhaler with flutter dispersion member
AU2010336338B2 (en) * 2009-12-23 2015-02-19 Map Pharmaceuticals, Inc. Enhanced eductor design
JP6017961B2 (ja) 2010-01-05 2016-11-02 マイクロドース セラピューテクス，インコーポレイテッド 吸入デバイスおよび方法
WO2011116293A2 (en) 2010-03-19 2011-09-22 Manta Devices, Llc Delivery device and related methods
GB2492035B (en) * 2010-04-23 2014-03-05 Cambridge Consultants Dry powder inhaler assembly and containers
AU2016222336B2 (en) * 2010-06-21 2018-09-13 Mannkind Corporation Dry powder drug delivery system and methods
AU2015200705B2 (en) * 2010-06-21 2016-06-16 Mannkind Corporation Dry powder drug delivery system and methods
JP6385673B2 (ja) * 2010-06-21 2018-09-05 マンカインド コーポレイション 乾燥粉末薬物送達システム
AU2015249177B2 (en) * 2010-11-09 2017-08-03 Mannkind Corporation Composition comprising a serotonin receptor agonist and a diketopiperazine for treating migraines
MX340112B (es) 2010-11-09 2016-06-27 Mannkind Corp Composicion que comprende un agonista de receptor de serotonina y una dicetopiperazina para el tratamiento de migrañas.
GB201020638D0 (en) * 2010-12-06 2011-01-19 Liconsa Laboratorios Sa Inhalator
ES2646748T3 (es) 2010-12-07 2017-12-15 Respira Therapeutics, Inc. Inhalador de polvo seco
ES2842407T3 (es) 2010-12-22 2021-07-14 Syqe Medical Ltd Sistema de administración de fármacos
USD742503S1 (en) * 2011-01-12 2015-11-03 Vectura Gmbh Mobile inhaler device
BR112013024021A2 (pt) * 2011-03-21 2016-12-06 Simplified Solutions Sweden Ab inalador para substâncias em forma de pó
RU2569776C2 (ru) * 2011-04-01 2015-11-27 Маннкайнд Корпорейшн Блистерная упаковка для фармацевтических картриджей
ITBO20110289A1 (it) * 2011-05-20 2012-11-21 Health Robotics Srl Scatola di contenimento di una sacca per prodotti farmaceutici
WO2012163704A2 (de) * 2011-05-27 2012-12-06 Boehringer Ingelheim International Gmbh Inhalator und kapsel für einen inhalator
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US11103659B2 (en) 2011-07-06 2021-08-31 Manta Devices, Llc Delivery device and related methods
US9446209B2 (en) 2011-09-07 2016-09-20 Concentrx Pharmaceuticals, Inc. Dry powder inhalation device
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CN103998087B (zh) * 2011-12-16 2017-04-05 诺华股份有限公司 用于吸入分布独立性给药的雾化装置
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
US9649454B2 (en) 2012-05-03 2017-05-16 Manta Devices, Llc Delivery device and related methods
EP2872205B1 (en) * 2012-07-12 2017-02-08 MannKind Corporation Dry powder drug delivery systems
AU2013308693A1 (en) * 2012-08-29 2015-03-12 Mannkind Corporation Method and composition for treating hyperglycemia
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
WO2014074797A1 (en) * 2012-11-09 2014-05-15 Civitas Therapeutics, Inc. Ultra low density pulmonary powders
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
SG11201503576XA (en) 2012-12-21 2015-06-29 Sanofi Sa Exendin-4 Derivatives
SG11201507564PA (en) 2013-03-15 2015-10-29 Mannkind Corp Microcrystalline diketopiperazine compositions and methods
WO2014178891A1 (en) 2013-04-30 2014-11-06 Otitopic Inc. Dry powder formulations and methods of use
RU2533727C1 (ru) * 2013-06-11 2014-11-20 Открытое Акционерное Общество "Фармацевтическая Фабрика Санкт-Петербурга" Ингалятор
US10207065B2 (en) 2013-07-12 2019-02-19 John H. Silva Mouthpiece for inhalers
MX2020009878A (es) 2013-07-18 2022-07-27 Mannkind Corp Composiciones farmaceuticas en polvo seco estables al calor y metodos.
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／ｇｉｐ受體促效劑
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
USD769438S1 (en) 2014-01-08 2016-10-18 Glaxo Group Limited Inhaler device
ES2922206T3 (es) 2014-02-20 2022-09-09 Otitopic Inc Formulaciones de polvo seco para la inhalación
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
US11147936B2 (en) 2014-05-02 2021-10-19 Manta Devices, Llc Dose delivery device with cover connected to dose chamber seal
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
EP3160558B1 (en) 2014-06-30 2020-02-12 Syqe Medical Ltd. Flow regulating inhaler device
WO2016001922A1 (en) 2014-06-30 2016-01-07 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
US11298477B2 (en) 2014-06-30 2022-04-12 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
US10099020B2 (en) 2014-06-30 2018-10-16 Syqe Medical Ltd. Drug dose cartridge for an inhaler device
IL294077A (en) 2014-06-30 2022-08-01 Syqe Medical Ltd Method and device for vaporizing and inhaling substances
CN113616883B (zh) 2014-06-30 2023-06-06 Syqe医药有限公司 向受试者肺部递送植物材料中的至少一药理活性剂的系统
USD748242S1 (en) 2014-07-11 2016-01-26 H. Stuart Campbell Inhaler mouthpiece
US10765817B2 (en) 2014-08-13 2020-09-08 Elwha, Llc Methods, systems, and devices related to delivery of alcohol with an inhaler
US10245393B2 (en) 2014-08-13 2019-04-02 Elwha Llc Methods, systems, and devices related to a supplemental inhaler
US10987048B2 (en) 2014-08-13 2021-04-27 Elwha Llc Systems, methods, and devices to incentivize inhaler use
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10014085B2 (en) 2014-10-03 2018-07-03 Illinois Tool Works Inc. Reuseable holder for a radioactive source capsule
WO2016083102A1 (en) 2014-11-26 2016-06-02 Vectura Delivery Devices Limited Dry powder inhaler
DE102014017409B4 (de) 2014-11-26 2016-06-09 Klaus Dieter Beller Einzeldosis-Pulverinhalator und Verfahren zu dessen Herstellung
CA2972826C (en) 2015-01-14 2023-09-12 Respira Therapeutics, Inc. Powder dispersion methods and devices
US10668015B2 (en) * 2015-01-20 2020-06-02 Incarda Therapeutics, Inc. Unit aerosol doses for anticoagulation
CN104644435B (zh) * 2015-03-05 2018-02-02 四川海思科制药有限公司 粉雾剂药盒
AU2016247916B2 (en) 2015-04-15 2020-07-02 Philip Morris Products S.A. Flavoring element for an inhalation device
WO2016168274A1 (en) * 2015-04-15 2016-10-20 Sansa Corporation (Barbados) Inc. Dry powder inhaler and method of use
WO2016181142A1 (en) * 2015-05-12 2016-11-17 Cipla Europe Nv Inhaler device
EA201792305A1 (ru) 2015-05-19 2018-06-29 ДжейТи ИНТЕРНЭШНЛ СА Генерирующее аэрозоль устройство и капсула
USD778707S1 (en) * 2015-05-22 2017-02-14 G.T. Line S.R.L. Closing device
SE539111C2 (en) * 2015-06-03 2017-04-11 Iconovo Ab Single dose dry powder inhaler
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
USD780906S1 (en) * 2015-09-02 2017-03-07 Trudell Medical International Respiratory treatment device
CA3009599A1 (en) 2016-01-06 2017-07-13 Syqe Medical Ltd. Low dose therapeutic treatment
USD841798S1 (en) * 2016-01-29 2019-02-26 Mannkind Corporation Inhaler
USD824510S1 (en) * 2016-01-29 2018-07-31 Mannkind Corporation Inhaler
CN114904100A (zh) * 2016-01-29 2022-08-16 曼金德公司 干粉吸入器
USD824016S1 (en) * 2016-01-29 2018-07-24 Mannkind Corporation Inhaler
USD824015S1 (en) * 2016-01-29 2018-07-24 Mannkind Corporation Inhaler
US20190321290A1 (en) * 2016-01-29 2019-10-24 Mannkind Corporation Composition and method for inhalation
CN109259332B (zh) * 2016-05-06 2021-06-25 卓尔悦欧洲控股有限公司 雾化装置及带有该雾化装置的电子烟
US11478591B2 (en) 2016-05-19 2022-10-25 Mannkind Corporation Apparatus, system and method for detecting and monitoring inhalations
IT201600093878A1 (it) * 2016-09-19 2018-03-19 Hollycon Italy Pte Ltd S R L Inalatore monodose a perdere per medicinali in polvere
WO2018071443A1 (en) 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
GB2557358B (en) * 2016-12-08 2019-04-03 Coppel Jonny A device for increasing the efficacy of a metered dose inhaler
CN108328122B (zh) * 2017-01-17 2024-04-12 李和伟 一种制剂盒
CN110913934B (zh) * 2017-03-15 2022-06-14 Csp技术公司 吸入器及其使用方法和制作方法
CN110494181B (zh) * 2017-03-28 2022-03-18 康森特里克斯药物公司 用于输送干粉药物的装置和方法
USD834178S1 (en) * 2017-05-19 2018-11-20 Mannkind Corporation Inhaler
US20190054260A1 (en) * 2017-08-17 2019-02-21 Monzano Group LLC Nebulizer devices and methods
RU2664154C1 (ru) * 2017-11-08 2018-08-15 Общество с ограниченной ответственностью "Отдел Инноваций" Устройство для доставки растворов в виде аэрозоля в анатомические полости
USD851748S1 (en) * 2017-11-08 2019-06-18 Mannkind Corporation Inhaler
RU176194U1 (ru) * 2017-11-08 2018-01-11 Общество с ограниченной ответственностью "Отдел Инноваций" Устройство для доставки растворов в виде аэрозоля в анатомические полости
AU2019225031B2 (en) * 2018-02-26 2024-04-18 Shin Nippon Biomedical Laboratories, Ltd. Powder preparation, cartridge, and device
US20210187212A1 (en) * 2018-03-30 2021-06-24 Nick Mariani Inhaler and method
CN113015547B (zh) * 2018-07-10 2023-04-07 麦兰公司 装置计数器
CN117717679A (zh) * 2018-10-28 2024-03-19 Syqe医药有限公司 和吸入器一起使用的送药盒
KR102051791B1 (ko) 2018-11-16 2020-01-08 고려대학교 산학협력단 토양가스를 모니터링하고 모니터링 결과에 기반하여 대응 처리하는 시스템 및 방법
KR102104741B1 (ko) * 2019-02-15 2020-06-01 국민대학교산학협력단 슬라이딩 방식의 교체형 유체 분석 챔버 모듈
CN109954361A (zh) * 2019-03-07 2019-07-02 泉州丰泽春信机械设计有限公司 一种炼铁高炉用环保防回旋除尘装置
EP3941438A4 (en) * 2019-03-22 2022-09-21 MannKind Corporation INHALABLE DRY POWDER
USD898187S1 (en) * 2019-05-21 2020-10-06 Receptor Holdings, Inc. Inhaler device
RU197124U1 (ru) * 2019-12-20 2020-04-02 Общество с ограниченной ответственностью "Научно-производственный Инновационный внедренческий центр" Одноразовый картридж для ингалятора
WO2021150878A1 (en) * 2020-01-22 2021-07-29 Virginia Commonwealth University Dry powder inhalers and interfaces for improved aerosol delivery to children
US11864953B2 (en) 2020-01-23 2024-01-09 Covidien Lp Smoke evacuating tissue guard for tissue removal and other surgical procedures
US11654036B2 (en) 2020-05-26 2023-05-23 Elixir Medical Corporation Anticoagulant compounds and methods and devices for their use
WO2022108939A1 (en) 2020-11-17 2022-05-27 United Therapeutics Corporation Inhaled imatinib for pulmonary hypertension field
JP2024505429A (ja) 2021-01-15 2024-02-06 アクエスティブ セラピューティクス インコーポレイテッド プロドラッグ組成物及び治療の方法
CN112892390B (zh) * 2021-01-28 2022-07-15 江西省奋发粘胶化工有限公司 一种硅酮胶用智能化调色设备
JP2024510930A (ja) 2021-03-03 2024-03-12 ユナイテッド セラピューティクス コーポレイション トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物
KR20240141319A (ko) 2022-02-08 2024-09-26 유나이티드 쎄러퓨틱스 코포레이션 트레프로스티닐 일로프로스트 조합 치료 요법
WO2023178158A1 (en) * 2022-03-18 2023-09-21 Mannkind Corporation Optimization of dosing and prescribing of medication
WO2024059819A2 (en) 2022-09-15 2024-03-21 Tff Pharmaceuticals, Inc. Compositions of cannabinoids for delivery by inhalation

Family Cites Families (1123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB475440A (en) 1935-09-23 1937-11-19 Mine Safety Appliances Co Improvements in or relating to apparatus for determining the flow resistance of breathing apparatus elements
US2549303A (en) * 1949-04-20 1951-04-17 Bristol Lab Inc Inhaler for crystalline pencilllin or the like
BE509861A (ru) 1952-03-13
US2754276A (en) 1953-02-12 1956-07-10 Du Pont Cellular compositions utilizing dinitrosopentamethylene-tetramine as the blowing agent
US3337740A (en) 1962-02-13 1967-08-22 Deering Milliken Res Corp Process for separating acrylic acid from impurities
US4187129A (en) * 1962-05-14 1980-02-05 Aerojet-General Corporation Gelled mechanically stable high energy fuel composition containing metal platelets
FR1451293A (fr) * 1964-05-18 1966-01-07 Entoleter Matière composite et son procédé de préparation
US3407203A (en) 1965-03-22 1968-10-22 Union Carbide Corp Novel process for the preparation of diketopiperazines
US3669113A (en) 1966-03-07 1972-06-13 Fisons Ltd Inhalation device
US3518340A (en) 1968-04-15 1970-06-30 Dow Corning Method of forming silicone rubber drug carriers
US3622053A (en) 1969-12-10 1971-11-23 Schering Corp Aerosol inhaler with flip-up nozzle
US3673698A (en) 1970-11-25 1972-07-04 Albert S Guerard Process for freeze drying with carbon dioxide
BE794951A (fr) 1972-02-03 1973-05-29 Parke Davis & Co Conditionnement soluble dans l'eau
US3873651A (en) 1972-05-12 1975-03-25 Atomic Energy Commission Freeze drying method for preparing radiation source material
US3823843A (en) 1972-10-26 1974-07-16 Lilly Co Eli Locking capsule
US3856142A (en) 1973-01-24 1974-12-24 Mine Safety Appliances Co Inhalant package
FR2224175B1 (ru) 1973-04-04 1978-04-14 Isf Spa
US3980074A (en) 1973-07-18 1976-09-14 Beecham Group Limited Device for the administration of powders
GB1479283A (en) 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
GB1459488A (en) 1974-03-19 1976-12-22 Wyeth John & Brother Ltd Piperazinedione derivatives
IT1017153B (it) * 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
US4018619A (en) * 1974-09-23 1977-04-19 Iu Technology Corporation Highly activated mixtures for constructing load bearing surfaces and method of making the same
US4005711A (en) 1975-01-13 1977-02-01 Syntex Puerto Rico, Inc. Inhalation device
DE2502251A1 (de) 1975-01-17 1976-07-22 Schering Ag Vorrichtung zur inhalation pulverfoermiger feststoffe
US4040536A (en) 1975-05-05 1977-08-09 R. P. Scherer Corporation Locking hard gelatin capsule
BR7603665A (pt) * 1975-06-09 1977-02-01 Nat Distillers Chem Corp Processo para comunicar resistencia a aglomeracao a um polimero de etileno-acetano de vinila e o polimero resultant
US4153689A (en) 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
US3998226A (en) 1975-09-22 1976-12-21 Edward G. Gomez Inhalation device for encapsulated concentrates
GB1509979A (en) 1975-11-28 1978-05-10 Fisons Ltd Pharmaceutical compositions containing aspirin or indomethacin
US4102953A (en) 1976-05-25 1978-07-25 The United States Of America As Represented By The Secretary Of The Navy Method for making extruded, solventless, composite-modified double base propellant
USD252707S (en) 1977-01-03 1979-08-21 Joel Besnard Inhaler
GB1598081A (en) 1977-02-10 1981-09-16 Allen & Hanburys Ltd Inhaler device for dispensing medicaments
US4171000A (en) 1977-03-23 1979-10-16 Uhle Klaus P Smoking device
IE46865B1 (en) 1977-04-29 1983-10-19 Allen & Hanburys Ltd Device for dispensing medicaments
US4148308A (en) 1977-05-31 1979-04-10 Sayer William J Mouthpiece with a tongue retractor
US4110240A (en) 1977-07-29 1978-08-29 Wyrough And Loser, Inc. Coprecipitation process
US4091077A (en) * 1977-08-12 1978-05-23 The United States Of America As Represented By The United States Department Of Energy Process for recovering filler from polymer
US4211769A (en) 1977-08-24 1980-07-08 Takeda Chemical Industries, Ltd. Preparations for vaginal administration
US4268460A (en) 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
CA1113044A (en) 1977-12-16 1981-11-24 J. Paul Leblond Personal repellant device
US4356167A (en) 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
US4175556A (en) 1978-04-07 1979-11-27 Freezer Winthrop J Inhaler with flow-through cap
US4196196A (en) 1978-06-19 1980-04-01 Tiholiz Ivan C Divalen/monovalent bipolar cation therapy for enhancement of tissue perfusion and reperfusion in disease states
US4168002A (en) 1978-08-03 1979-09-18 Crosby Leslie O Multiple-seed package card
US4272398A (en) 1978-08-17 1981-06-09 The United States Of America As Represented By The Secretary Of Agriculture Microencapsulation process
US4227522A (en) * 1978-09-05 1980-10-14 Syntex Puerto Rico, Inc. Inhalation device
DE2840442C2 (de) 1978-09-16 1982-02-11 C.H. Boehringer Sohn, 6507 Ingelheim Verwendung des Diketopiperazins L-Leu-L-Trp als Geschmacksstoff für Getränke mit bitterer Geschmacksrichtung
DE2849493C2 (de) 1978-11-15 1982-01-14 Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems In der Hand zu haltender Aerosolspender
USD269463S (en) 1978-12-08 1983-06-21 Fisons Limited Container for a medicinal inhaler
JPS5837833Y2 (ja) 1979-04-27 1983-08-26 凸版印刷株式会社 アンプル収納容器
JPS6034925B2 (ja) 1979-07-31 1985-08-12 帝人株式会社 持続性鼻腔用製剤およびその製造法
US4407525A (en) 1979-10-04 1983-10-04 Gao Gesellschaft Fur Automation Und Organisation Mbh Identification card with hallmark for authentication by incident and transmitted light
GB2072536B (en) 1980-03-25 1983-12-07 Malem H Nebuliser
US4289759A (en) 1980-06-23 1981-09-15 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
DE3167658D1 (en) 1980-12-12 1985-01-17 Combi Co Inhaler
US4900730A (en) 1981-01-14 1990-02-13 Toyo Jozo Co., Ltd. Preparation which promotes the absorption of peptides
GB2092136B (en) 1981-01-17 1985-06-05 Mitsui Toatsu Chemicals Production of n-substituted amide compounds
JPS58140026A (ja) 1982-01-14 1983-08-19 Toyo Jozo Co Ltd 吸収性良好な製剤
IT1220979B (it) * 1981-06-04 1990-06-21 Lofarma Farma Lab Capsule contenenti un allergene e procedimento per la loro preparazione
DE3274065D1 (de) * 1981-07-08 1986-12-11 Draco Ab Powder inhalator
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US5260306A (en) 1981-07-24 1993-11-09 Fisons Plc Inhalation pharmaceuticals
USD276654S (en) 1981-09-15 1984-12-04 Aktiebolaget Draco Medical aerosol inhalation device
KR890000664B1 (ko) 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
US4659696A (en) 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use
US4483922A (en) 1982-05-14 1984-11-20 Amf Inc. Inactivation of enzymes
US4526804A (en) 1982-08-30 1985-07-02 Ball Corporation Method for providing sheet metal stock with finely divided powder
US4487327A (en) 1982-12-21 1984-12-11 Grayson Robert E Locking capsule
JPS59163313A (ja) 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
US4481139A (en) 1983-04-13 1984-11-06 Board Of Regents, The University Of Texas System Peptide antagonists of substance P
AU90762S (en) * 1983-06-29 1985-08-15 Glaxo Group Ltd Inhaler
US4581020A (en) 1983-07-18 1986-04-08 Trimedyne, Inc. Medication delivery device and system for percutaneous administration of medication
GB8325529D0 (en) 1983-09-23 1983-10-26 Lilly Industries Ltd Medicinal forms
CH661878A5 (de) 1983-11-04 1987-08-31 Warner Lambert Co Kapsel-dosierungsformen.
US4671954A (en) 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
USD295321S (en) 1984-03-13 1988-04-19 Glaxo Group Limited Inhaler container for a medical aerosol
JPS60248618A (ja) 1984-05-24 1985-12-09 Nippon Zoki Pharmaceut Co Ltd ジペプチドを含有する潰瘍治療剤
US4927555A (en) * 1984-08-13 1990-05-22 Colgate-Palmolive Company Process for making thixotropic detergent compositions
USD288852S (en) * 1984-08-29 1987-03-17 Aruman Co., Ltd. Disposable inhaler
US4757066A (en) 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
IE58468B1 (en) 1984-10-25 1993-09-22 Warner Lambert Co Method for sealing capsules and capsule
US4592348A (en) 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4946828A (en) 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
SE448277B (sv) * 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
JPS6320301Y2 (ru) 1985-04-18 1988-06-06
US5785989A (en) 1985-05-01 1998-07-28 University Utah Research Foundation Compositions and methods of manufacturing of oral dissolvable medicaments
US4615817A (en) * 1985-05-17 1986-10-07 Mccoy Frederic C Additives containing polytetrafluoroethylene for making stable lubricants
CA1318730C (en) * 1985-05-30 1993-06-01 C. Edward Capes Method of separating carbonaceous components from particulate coal containing inorganic solids and apparatus therefor
US5098590A (en) * 1988-02-04 1992-03-24 Colgate Palmolive Co. Thixotropic aqueous automatic dishwasher detergent compositions with improved stability
CH672600A5 (ru) 1985-07-30 1989-12-15 Glaxo Group Ltd
AT384552B (de) 1985-08-01 1987-12-10 Hurka Wilhelm Inhalationsgeraet zur dosierung und verteilung von festkoerpern in die atemluft
US4624861A (en) * 1985-09-05 1986-11-25 Gte Products Corporation Rare earth oxysulfide phosphors and processes for creating same
US4742156A (en) 1985-09-30 1988-05-03 Mcneilab, Inc. Peptide antagonists of neurokinin B and opthalmic solutions containing them
PT83613B (en) 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
EP0248051A1 (en) 1985-11-29 1987-12-09 FISONS plc Pharmaceutical composition including sodium cromoglycate
LU86258A1 (fr) 1986-01-21 1987-09-03 Rech Dermatologiques C I R D S Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US6849708B1 (en) 1986-05-05 2005-02-01 The General Hospital Corporation Insulinotropic hormone and uses thereof
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US4926852B1 (en) 1986-06-23 1995-05-23 Univ Johns Hopkins Medication delivery system phase one
USD301273S (en) * 1986-07-10 1989-05-23 Leonard G Darin Hand held fly suction device
JPS6320301A (ja) 1986-07-11 1988-01-28 Dainichi Color & Chem Mfg Co Ltd キトサン微小粒体
US5042975A (en) 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
EP0318492A1 (en) 1986-08-11 1989-06-07 Innovata Biomed Limited Pharmaceutical formulations comprising microcapsules
NL8720442A (nl) 1986-08-18 1989-04-03 Clinical Technologies Ass Afgeefsystemen voor farmacologische agentia.
USRE35862E (en) 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
ES2032831T5 (es) 1986-08-19 2001-02-16 Genentech Inc Dispositivo y dispersion para suministro intrapulmonar de factores de crecimiento polipeptidos y citoquinas.
DE3639836A1 (de) 1986-11-21 1988-06-01 Sigrid Bechter Mundstueck fuer ein inhalationsgeraet
KR890003520Y1 (ko) 1986-12-20 1989-05-27 주식회사 서흥캅셀 의약용 캅셀
US4861627A (en) 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US4981295A (en) * 1987-05-11 1991-01-01 City Of Hope Respiratory training using feedback
US6645504B1 (en) 1987-06-24 2003-11-11 Autoimmune Inc. Bystander suppression of type I diabetes by oral administration of glucagon
US4913173A (en) 1987-06-25 1990-04-03 International Beauty Distributors, Inc. High efficiency wrap package, and process, for nails
DE3727894A1 (de) 1987-08-21 1989-03-02 Stephan Dieter Kapsel fuer pharmazeutisch wirksame inhaltsstoffe einer droge
GB8723846D0 (en) 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
US4887722A (en) 1987-12-11 1989-12-19 Greenward Sr Edward H Method for beneficiating by carbonaceous refuse
DE3801326A1 (de) 1988-01-19 1989-07-27 Asea Brown Boveri Verfahren zur herstellung einer keramiksuspension
US4981625A (en) 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
GB8813338D0 (en) 1988-06-06 1988-07-13 Osprey Metals Ltd Powder production
USD316902S (en) 1988-09-02 1991-05-14 Hoelfing H Curt Meter hose inhaler reservoir
GB8821287D0 (en) 1988-09-12 1988-10-12 Ici Plc Device
EP0360340A1 (en) 1988-09-19 1990-03-28 Akzo N.V. Composition for nasal administration containing a peptide
USD321570S (en) 1988-09-30 1991-11-12 Blasdell Richard J Inhaler
DE68914932T2 (de) 1988-10-04 1994-08-11 Univ Johns Hopkins Inhalationsgerät für Aerosolen.
JPH02104531A (ja) 1988-10-14 1990-04-17 Toyo Jozo Co Ltd 経鼻投与用生理活性ペプチド組成物
US4984158A (en) 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
JPH02115154A (ja) 1988-10-25 1990-04-27 Kao Corp イミド化合物及びその用途
USD326517S (en) 1988-10-27 1992-05-26 Glaxo Group Limited Inhalator
JP2692742B2 (ja) 1988-11-30 1997-12-17 株式会社ツムラ 新規なリグナン類
US5006343A (en) 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5075027A (en) 1989-02-06 1991-12-24 Colgate Palmolive Co. Thixotropic aqueous scented automatic dishwasher detergent compositions
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
IT1228460B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore monouso con capsula pre-forata
US4983402A (en) 1989-02-24 1991-01-08 Clinical Technologies Associates, Inc. Orally administerable ANF
SE466684B (sv) 1989-03-07 1992-03-23 Draco Ab Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator
US5358734A (en) 1989-03-30 1994-10-25 Gte Products Corporation Process for producing a blue emitting lamp phosphor
US5215739A (en) 1989-04-05 1993-06-01 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
US4991605A (en) 1989-04-24 1991-02-12 Philip Morris Incorporated Container for additive materials for smoking articles
US5067500A (en) 1989-04-24 1991-11-26 Philip Morris Incorporated Container for additive materials for smoking articles
GB8909891D0 (en) 1989-04-28 1989-06-14 Riker Laboratories Inc Device
JPH05501505A (ja) 1989-04-28 1993-03-25 ライカー　ラボラトリーズ，インコーポレイティド 乾燥粉末吸入装置
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
ATE99546T1 (de) 1989-05-01 1994-01-15 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen.
US5017383A (en) 1989-08-22 1991-05-21 Taisho Pharmaceutical Co., Ltd. Method of producing fine coated pharmaceutical preparation
GB8919131D0 (en) * 1989-08-23 1989-10-04 Riker Laboratories Inc Inhaler
US5270305A (en) 1989-09-08 1993-12-14 Glaxo Group Limited Medicaments
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
DK544589D0 (da) 1989-11-01 1989-11-01 Novo Nordisk As Manuel betjent apparat til dispensering af en forudbestemt maengde af et pulverformet stof
JPH0741428Y2 (ja) 1989-11-04 1995-09-27 アップリカ葛西株式会社 ベビーバス
EP0550436A1 (en) 1989-11-06 1993-07-14 Alkermes Controlled Therapeutics, Inc. Protein microspheres and methods of using them
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5105291A (en) 1989-11-20 1992-04-14 Ricoh Company, Ltd. Liquid crystal display cell with electrodes of substantially amorphous metal oxide having low resistivity
AU6774790A (en) 1989-12-06 1991-06-13 Canon Kabushiki Kaisha Package for ink jet cartridge
USD331106S (en) 1989-12-30 1992-11-17 Ing. Erich Pfeiffer Gmbh & Co. Kg Single use inhaler
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
GB9001635D0 (en) 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
US5201308A (en) 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
DE4004904A1 (de) * 1990-02-16 1990-09-13 Gerhard Brendel Trommel-applikator
SK280968B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Balenie medikamentu na použite v inhalačnom prístroji
YU48707B (sh) 1990-03-02 1999-07-28 Glaxo Group Limited Aparat za inhaliranje - inhalator
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
US5615670A (en) 1990-03-07 1997-04-01 Fisons Plc Powder inhaler with centrifugal force used to meter powder
IT1240750B (it) 1990-04-12 1993-12-17 Chiesi Farma Spa Dispositivo per la somministrazione di sostanze medicamentose in polvere
JPH05963A (ja) 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
US5328464A (en) 1990-04-24 1994-07-12 Science Incorporated Closed drug delivery system
USD338268S (en) * 1990-05-04 1993-08-10 Omron Corporation Heating inhaler
AU7908791A (en) 1990-05-08 1991-11-27 Liposome Technology, Inc. Direct spray-dried drug/lipid powder composition
NZ238489A (en) 1990-06-14 1995-09-26 Rhone Poulenc Rorer Ltd Inhaler with capsule in swirling chamber: capsule pierced in chamber
DE4021263C2 (de) 1990-07-04 1996-04-11 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5451410A (en) 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
JPH04103585A (ja) 1990-08-24 1992-04-06 Nisshin Flour Milling Co Ltd ピロリジン環を有する化合物
US5074418A (en) 1990-09-12 1991-12-24 Pitney Bowes Inc. Ink replenishing system transport and storage container
SE9002895D0 (sv) 1990-09-12 1990-09-12 Astra Ab Inhalation devices for dispensing powders i
WO1992004928A2 (en) 1990-09-26 1992-04-02 Pharbita B.V. Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
US5170801A (en) 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
FR2667509B1 (fr) 1990-10-04 1995-08-25 Valois Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes.
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
GB9024760D0 (en) 1990-11-14 1991-01-02 Riker Laboratories Inc Inhalation device and medicament carrier
US5124291A (en) 1990-11-15 1992-06-23 The Standard Oil Company Method for deagglomerating and re-exposing catalyst in a fluid bed reactor
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
GB9027234D0 (en) 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
DE69127826T2 (de) 1990-12-17 1998-04-09 Minnesota Mining & Mfg Inhalationsgerät
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
GB2253200A (en) 1991-02-01 1992-09-02 Harris Pharma Ltd Inhalation apparatus and fracturable capsule for use therewith
WO1992014449A1 (en) 1991-02-20 1992-09-03 Nova Pharmaceutical Corporation Controlled release microparticulate delivery system for proteins
US5208998A (en) 1991-02-25 1993-05-11 Oyler Jr James R Liquid substances freeze-drying systems and methods
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
WO1994017370A2 (en) 1991-03-05 1994-08-04 Miris Medical Corporation Method and device for correcting the drift offset of a pressure sensor of a flowmeter
US5394866A (en) 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
USD338062S (en) 1991-03-06 1993-08-03 Innovata Biomed Limited Inhaler
USD347057S (en) * 1991-03-14 1994-05-17 Technosystem Limited Inhaler
US5797391A (en) 1991-03-28 1998-08-25 Rhone-Poulenc Rorer Limited Inhaler
US5413804A (en) 1991-04-23 1995-05-09 Cacique, Inc. Process for making whey-derived fat substitute product and products thereof
US5244653A (en) 1991-05-01 1993-09-14 Isp Chemicals Inc. Glycine anhydride dimethylol as a biocide and preservative
US6060069A (en) 1991-05-20 2000-05-09 Dura Pharmaceuticals, Inc. Pulmonary delivery of pharmaceuticals
US5327883A (en) 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5492112A (en) 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6055980A (en) 1991-05-20 2000-05-02 Dura Pharmaceuticals, Inc. Dry powder inhaler
FR2676929B1 (fr) 1991-05-30 1994-02-11 Aerosols Bouchage Ste Fse Inhalateur de poudres.
CA2070061C (en) 1991-06-07 2004-02-10 Shigeyuki Takama Physiologically active polypeptide-containing pharmaceutical composition
IT1248059B (it) 1991-06-14 1995-01-05 Miat Spa Insufflatore multidose per farmaci in polvere
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
JP3230056B2 (ja) 1991-07-02 2001-11-19 インヘイル・インコーポレーテッド 薬剤のエーロゾル化服用量を形成する装置
US5203768A (en) 1991-07-24 1993-04-20 Alza Corporation Transdermal delivery device
US5337740A (en) 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US5139878A (en) 1991-08-12 1992-08-18 Allied-Signal Inc. Multilayer film constructions
ES2089474T3 (es) 1991-08-16 1996-10-01 Sandoz Ltd Inhalador para la administracion de sustancias en polvo.
US5287850A (en) 1991-08-20 1994-02-22 Habley Medical Technology Corporation Timing and velocity controlled powered pharmaceutical inhaler
US6029661A (en) 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
USD337636S (en) 1991-09-12 1993-07-20 Devilbiss Health Care, Inc. Ultrasonic medicament nebulizer
US5167506A (en) 1991-10-24 1992-12-01 Minnesota Mining And Manufacturing Company Inhalation device training system
USD348100S (en) 1991-10-29 1994-06-21 Fisons Plc Medicament inhaler
JPH0828037B2 (ja) 1991-10-31 1996-03-21 富士通株式会社 スピンドルシンク制御方式
USD350602S (en) 1991-11-01 1994-09-13 Rhone-Poulenc Rorer Limited Combined dry powder inhaler and cap
US6063910A (en) 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
USD350821S (en) 1991-11-18 1994-09-20 Smithkline Beecham P.L.C. Oral inhaler
SE9103572D0 (sv) * 1991-11-29 1991-11-29 Astra Ab Organic salts of n,n'-diacetyl cystine
USD340975S (en) 1991-12-02 1993-11-02 Thayer Medical Corporation Combined expansion chamber metered dose inhaler dispenser and adaptor
US5338837A (en) 1991-12-13 1994-08-16 The Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making same
DE4211475A1 (de) * 1991-12-14 1993-06-17 Asta Medica Ag Pulverinhalator
GB2262452B (en) 1991-12-19 1995-12-20 Minnesota Mining & Mfg Inhalation device
JP3121080B2 (ja) 1991-12-19 2000-12-25 アール・ピー・シーラー コーポレイション カプセル封入用溶液
US5363842A (en) * 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
US5525519A (en) 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
US5320094A (en) 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
ATE146359T1 (de) 1992-01-21 1997-01-15 Stanford Res Inst Int Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln
JPH06241668A (ja) * 1992-01-24 1994-09-02 Kyodo Kumiai Alum Sanka High Kaishiyuu Syst Kenkyukai アルミ溶解炉におけるアルミ酸化灰の掻出し装置
DE9209050U1 (de) 1992-02-13 1992-10-01 Schrader, Barthold von, 2400 Travemünde Inhalationseinrichtung
US5476093A (en) 1992-02-14 1995-12-19 Huhtamaki Oy Device for more effective pulverization of a powdered inhalation medicament
US5469971A (en) 1992-02-26 1995-11-28 Estee Lauder Inc. Method and apparatus for deagglomerating powder
EP0558879B1 (en) 1992-03-04 1997-05-14 Astra Aktiebolag Disposable inhaler
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5352461A (en) 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
DK36392D0 (da) 1992-03-19 1992-03-19 Novo Nordisk As Anvendelse af kemisk forbindelse
USD348929S (en) 1992-04-03 1994-07-19 Norton Healthcare Limited Medicament inhaler
CA2096302A1 (en) 1992-05-15 1993-11-16 David Kilis Air flow controller and recording system
USD344796S (en) * 1992-06-11 1994-03-01 Schering Corporation Combined inhaler and cover
USD344797S (en) * 1992-06-11 1994-03-01 Schering Corporation Combined inhaler and cover
USD345013S (en) 1992-06-11 1994-03-08 Schering Corporation Combined inhaler and cover
USD350193S (en) * 1992-06-11 1994-08-30 Schering Corporation Combined inhaler and cover
WO1993025193A1 (en) 1992-06-12 1993-12-23 Teijin Limited Pharmaceutical preparation for intra-airway administration
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5394868A (en) 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
JP3413876B2 (ja) 1992-07-08 2003-06-09 セイコーエプソン株式会社 半導体装置
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
GB9214819D0 (en) 1992-07-13 1992-08-26 Minnesota Mining & Mfg Valve assemblies
GB9216038D0 (en) 1992-07-28 1992-09-09 Bespak Plc Dispensing apparatus for powdered medicaments
GB2269992A (en) 1992-08-14 1994-03-02 Rh Ne Poulenc Rorer Limited Powder inhalation formulations
US5239993A (en) 1992-08-26 1993-08-31 Glaxo Inc. Dosage inhalator providing optimized compound inhalation trajectory
GB2270293A (en) 1992-09-05 1994-03-09 Medix Ltd Drug dispensing system
USD348928S (en) * 1992-09-21 1994-07-19 Schering Corporation Inhaler
US5333106A (en) 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
AU5171293A (en) 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
EP0665759B1 (en) 1992-10-19 1998-12-23 Dura Pharmaceuticals, Inc. Dry powder inhaler
AU121578S (en) * 1992-10-22 1994-09-20 Fisons Plc An inhalation device
USD359555S (en) * 1992-11-18 1995-06-20 Nippon Glaxo Limited Nasal medicine inhaler
USD349572S (en) 1992-12-10 1994-08-09 Schering Corporation Aerosol inhaler
USD352107S (en) 1992-12-10 1994-11-01 Ciba-Geigy Corporation Inhaler
US6250300B1 (en) 1992-12-11 2001-06-26 Ab Astra System for dispensing pharmaceutically active compounds
SE9203743D0 (sv) 1992-12-11 1992-12-11 Astra Ab Efficient use
US5829434A (en) 1992-12-18 1998-11-03 Schering Corporation Inhaler for powdered medications
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US6105571A (en) 1992-12-22 2000-08-22 Electrosols, Ltd. Dispensing device
US6880554B1 (en) 1992-12-22 2005-04-19 Battelle Memorial Institute Dispensing device
US5896855A (en) 1992-12-24 1999-04-27 Rhone-Poulenc Rorer Limited Multi dose inhaler apparatus
FR2700279B1 (fr) 1993-01-14 1995-03-17 Valois Dispositif portatif pour projeter des doses d'une substance fluide à l'aide d'un flux d'air comprimé.
AU119600S (en) 1993-01-21 1994-03-07 Boehringer Ingelheim Kg Inhaler device
US6131567A (en) 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5441060A (en) 1993-02-08 1995-08-15 Duke University Dry powder delivery system
IL108780A (en) 1993-02-27 1999-06-20 Fisons Plc inhaler
EP0692990B1 (en) * 1993-04-06 1998-09-23 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
US5372128A (en) 1993-04-14 1994-12-13 Habley Medical Technology Corporation Fluidizing powder inhaler
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
EP1077070A3 (en) 1993-04-22 2001-05-23 Emisphere Technologies, Inc. Oral drug delivery compositions
ZA939608B (en) 1993-04-22 1994-08-24 Emisphere Tech Inc Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof.
US5360614A (en) 1993-04-26 1994-11-01 The Estee Corporation Method of controlling the release of carbohydrates by encapsulation and composition therefor
WO1994025005A1 (en) 1993-04-28 1994-11-10 Akzo Nobel N.V. Lyospheres comprising gonadotropin
KR100244690B1 (ko) 1993-05-12 2000-02-15 야스이 쇼사꾸 분말상 약제 멀티도스 시약장치
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US5533502A (en) 1993-05-28 1996-07-09 Vortran Medical Technology, Inc. Powder inhaler with aerosolization occurring within each individual powder receptacle
USD365876S (en) * 1993-06-16 1996-01-02 Chawla Brindra P S Medicament inhaler
US5747445A (en) 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
TW402506B (en) 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5506203C1 (en) 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US5562909A (en) 1993-07-12 1996-10-08 Massachusetts Institute Of Technology Phosphazene polyelectrolytes as immunoadjuvants
GB9314614D0 (en) * 1993-07-14 1993-08-25 Minnesota Mining & Mfg Dry powder inhalers
US5371046A (en) * 1993-07-22 1994-12-06 Taiwan Semiconductor Manufacturing Company Method to solve sog non-uniformity in the VLSI process
JPH0741428A (ja) 1993-07-30 1995-02-10 Teijin Ltd ペプチド、蛋白質性薬物経鼻・経肺製剤
JP3545764B2 (ja) 1993-08-18 2004-07-21 フアイソンズ・ピーエルシー 吸息率制御器を備えた吸入装置
US5306453A (en) 1993-08-18 1994-04-26 Edward Shulman Apparatus and method of making a non-woven fabric
US5524613A (en) 1993-08-25 1996-06-11 Habley Medical Technology Corporation Controlled multi-pharmaceutical inhaler
ES2124417T3 (es) 1993-08-26 1999-02-01 Ford Motor Co Metodo para formar un conjunto de bobina de encendido.
BE1007551A3 (nl) 1993-09-24 1995-08-01 Philips Electronics Nv Werkwijze voor het in een rekenmachine automatisch herstellen van consistentie in een hierarchische objektstruktuur na een interaktie door een gebruiker en rekenmachine voorzien van zo een systeem voor automatische consistentieherstelling.
US5477285A (en) 1993-10-06 1995-12-19 Thomson Consumer Electronics, Inc. CRT developing apparatus
GB9322014D0 (en) 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5726156A (en) 1995-03-06 1998-03-10 Trega Biosciences, Inc. Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels
NZ276305A (en) 1993-11-16 1997-10-24 Depotech Corp Controlled release vesicle compositions
EP0655237A1 (de) 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
USD358880S (en) 1993-12-02 1995-05-30 Tenax Corporation Dry powder inhalator
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
DE4422710C1 (de) 1994-06-29 1995-09-14 Boehringer Ingelheim Kg Inhalationsgerät mit einem Elektronikmodul zur Funktionsüberwachung
EE03225B1 (et) 1993-12-18 1999-10-15 Merck Patent Gmbh Seade osakeste kujul oleva materjali dispenseerimiseks üksikute dooside kaupa
USD357603S (en) 1993-12-20 1995-04-25 Wolff Stephen H Base for displaying or holding items
US5415162A (en) 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
US5484606A (en) 1994-01-24 1996-01-16 The Procter & Gamble Company Process for reducing the precipitation of difficulty soluble pharmaceutical actives
PT101450B (pt) 1994-02-02 1999-11-30 Hovione Produtos Farmaceuticos Novo dispositivo para inalacao
WO1995022036A1 (en) 1994-02-09 1995-08-17 Kinerton Limited Process for drying a material from solution
SE9400462D0 (sv) * 1994-02-11 1994-02-11 Astra Ab Filling device
PT748213E (pt) * 1994-03-07 2004-08-31 Nektar Therapeutics Metodos e composicoes para administracao pulmonar de insulina
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5505194A (en) 1994-03-23 1996-04-09 Abbott Laboratories Aerosol inhalation device having slideably and rotatably connected elliptical cylinder portions
US5839429A (en) 1994-03-25 1998-11-24 Astra Aktiebolag Method and apparatus in connection with an inhaler
AU124387S (en) * 1994-03-25 1995-08-11 Astra Ab Training device for an inhaler
ATE156677T1 (de) 1994-04-15 1997-08-15 Fissler Gmbh Gar- und/oder kochgerät, welches für eine bodenseitige zuführung von wärmeenergie durch wärmeleitung oder durch elektromagnetische induktion eingerichtet ist
US6395744B1 (en) 1994-04-22 2002-05-28 Queen's University At Kingston Method and compositions for the treatment or amelioration of female sexual dysfunction
FI942196A (fi) 1994-05-11 1995-11-12 Orion Yhtymae Oy Jauheinhalaattori
DE69534318T2 (de) 1994-05-18 2006-04-20 Nektar Therapeutics, San Carlos Methoden und zusammensetzungen für die trockenpuderarznei aus interferonen
WO1995031979A1 (en) 1994-05-19 1995-11-30 R.P. Scherer International Corporation Solutions of aryl or heteroaryl substituted alkanoic acids in lipophilic solvents and soft gelatin capsules containing such solutions
JP3372105B2 (ja) 1994-05-26 2003-01-27 株式会社日立ユニシアオートモティブ 吸入式投薬器
US5483954A (en) 1994-06-10 1996-01-16 Mecikalski; Mark B. Inhaler and medicated package
IL110024A (en) 1994-06-15 1998-04-05 Yissum Res Dev Co Controlled release oral drug delivery system containing hydrogel- forming polymer
USD363775S (en) 1994-06-21 1995-10-31 Rhone-Poulenc Rorer Limited Multidose dry powder inhaler
USD362500S (en) * 1994-06-28 1995-09-19 Thayer Medical Corporation Medication inhaler spacer
US5641510A (en) 1994-07-01 1997-06-24 Genentech, Inc. Method for treating capsules used for drug storage
US6039208A (en) * 1994-07-29 2000-03-21 Ortho Pharmaceutical Corporation Variable day start tablet dispenser
US5562231A (en) 1994-07-29 1996-10-08 Ortho Pharmaceutical Corporation Variable day start tablet dispenser
US5603702A (en) * 1994-08-08 1997-02-18 United States Surgical Corporation Valve system for cannula assembly
US5623724A (en) * 1994-08-09 1997-04-22 Northrop Grumman Corporation High power capacitor
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
USD359153S (en) 1994-08-25 1995-06-13 Viggiano Bernard J Muffin top
US5574008A (en) 1994-08-30 1996-11-12 Eli Lilly And Company Biologically active fragments of glucagon-like insulinotropic peptide
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
CA2200727C (en) 1994-09-21 2006-11-28 Adrian E. Smith Apparatus and methods for dispersing dry powder medicaments
DE69529043T2 (de) 1994-09-30 2003-05-08 L'oreal S.A., Paris Verwendung von einem Agonisten eines mit einem Chloridkanal assozierten Rezeptors zur Behandlung von Hautfalten
FR2725626A1 (fr) 1994-10-18 1996-04-19 Sofab Dispositif pour l'inhalation de produits en poudre
AU4010395A (en) 1994-10-27 1996-05-23 Amgen, Inc. Compositions for increased bioavailability of orally delivered therapeutic agents
SE9404140D0 (sv) 1994-11-29 1994-11-29 Astra Ab Dose indicating device
HUT77309A (hu) 1994-12-01 1998-03-30 Toyama Chemical Co. Ltd. Új 2,3-dioxo-piperazin-származékok és sóik, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
SE9404439D0 (sv) 1994-12-21 1994-12-21 Astra Ab Inhalation device
SA95160463B1 (ar) * 1994-12-22 2005-10-04 استرا أكتيبولاج مساحيق للاستنشاق
US6485726B1 (en) 1995-01-17 2002-11-26 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
PL179487B1 (pl) 1995-01-23 2000-09-29 Direct Haler As Inhalator PL PL PL PL PL PL PL PL
USD368364S (en) 1995-02-02 1996-04-02 Reitano Joseph R Inhaler case
US5901703A (en) 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities
US5660835A (en) 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
US5772085A (en) 1995-03-10 1998-06-30 Minnesota Mining And Manufacturing Free flow aerosol valves
US5653961A (en) 1995-03-31 1997-08-05 Minnesota Mining And Manufacturing Company Butixocort aerosol formulations in hydrofluorocarbon propellant
US5542539A (en) 1995-04-04 1996-08-06 Ethicon Endo-Surgery, Inc. Container for quick release packages for surgical instruments
USD377215S (en) 1995-04-13 1997-01-07 Glaxo Group Limited Inhaler
US5990077A (en) 1995-04-14 1999-11-23 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
US6309671B1 (en) 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
US5645051A (en) 1995-04-21 1997-07-08 Dura Pharmaceuticals, Inc. Unit dose dry powder inhaler
US5622166A (en) 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
US5921237A (en) 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
US5922253A (en) 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
US5809997A (en) 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
US5924419A (en) 1995-05-22 1999-07-20 Kotliar; Igor K. Apparatus for passive hypoxic training and therapy
DE19519840A1 (de) 1995-05-31 1996-12-05 Kaewert Klaus Gelantinekapsel
AU128811S (en) 1995-06-06 1996-12-03 Orion Yhtymae Oy A protective cover for example a moisture protective cover for a powder inhaler
US5714007A (en) 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US6193844B1 (en) 1995-06-07 2001-02-27 Mclaughlin John R. Method for making paper using microparticles
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5641861A (en) 1995-06-07 1997-06-24 Torrey Pines Institute For Molecular Studies μopioid receptor ligands: agonists and antagonists
US5919897A (en) 1995-06-07 1999-07-06 Torrey Pines Institute For Molecular Studies MU opioid receptor ligands: agonists and antagonists
US5610271A (en) 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides
US6357442B1 (en) 1995-06-08 2002-03-19 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIS)
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
KR100269060B1 (ko) 1995-06-21 2000-11-01 패르난대즈 마르케스 일체된 미터링 장치를 가진 약제 분말 카트리지 및 분말 약흡입기
GB9513218D0 (en) 1995-06-29 1995-09-06 Fisons Plc Inhalation device and method
DE19523516C1 (de) 1995-06-30 1996-10-31 Asta Medica Ag Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen
AU131838S (en) 1995-07-01 1997-10-21 Glaxo Group Ltd Inhalation device
JP3098401B2 (ja) 1995-07-12 2000-10-16 株式会社エルティーティー研究所 経鼻投与用製剤
US5758638A (en) 1995-07-24 1998-06-02 Kreamer; Jeffry W. Indicator for a medicament inhaler
US5642727A (en) 1995-07-25 1997-07-01 David Sarnoff Research Center, Inc. Inhaler apparatus using a tribo-electric charging technique
WO1997004747A1 (en) 1995-07-27 1997-02-13 Dunn James M Drug delivery systems for macromolecular drugs
US6209538B1 (en) 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
SE9502799D0 (sv) 1995-08-10 1995-08-10 Astra Ab Device in inhalers
SE9502800D0 (sv) 1995-08-10 1995-08-10 Astra Ab Disposable inhaler
JP3317823B2 (ja) 1995-08-11 2002-08-26 株式会社ユニシアジェックス 投薬器
US5690910A (en) 1995-08-18 1997-11-25 Baker Norton Pharmaceuticals, Inc. Method for treating asthma
US5746197A (en) 1995-08-18 1998-05-05 Williams; Jeffery W. Extension for metered dose inhaler
US5980865A (en) 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
US6852690B1 (en) 1995-08-22 2005-02-08 Amylin Pharmaceuticals, Inc. Method and composition for enhanced parenteral nutrition
FR2738153B1 (fr) 1995-09-04 1998-01-02 Valois Appareil d'inhalation destine a distribuer des doses precises et reproductibles de produit pulverulent
US5617844A (en) 1995-09-21 1997-04-08 King; Russell W. Aerosol medication delivery system
KR0124764Y1 (ko) 1995-09-23 1998-09-15 양주환 의약 및 식품용 하드 공 캅셀
SE9503344D0 (sv) 1995-09-27 1995-09-27 Astra Ab Inhalation device
US5849322A (en) 1995-10-23 1998-12-15 Theratech, Inc. Compositions and methods for buccal delivery of pharmaceutical agents
US5766620A (en) 1995-10-23 1998-06-16 Theratech, Inc. Buccal delivery of glucagon-like insulinotropic peptides
DK0861089T3 (da) 1995-11-13 2002-10-07 Medtronic Minimed Inc Metoder og sammensætninger til indgivelse af monomere proteiner
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
CA2392466C (en) 1995-12-07 2004-05-04 Jago Research Ag Inhaler for multiple dosed administration of a pharmacological dry powder
US7131441B1 (en) 1995-12-07 2006-11-07 Skyepharma Ag Inhaler for multiple dosed administration of a pharmacological dry powder
BR9612410A (pt) 1996-01-03 1999-07-13 Glaxo Group Ltd Aparelho para inalação
US6026809A (en) 1996-01-25 2000-02-22 Microdose Technologies, Inc. Inhalation device
US6470884B2 (en) 1996-01-29 2002-10-29 Aventis Pharma Limited Capsule opening arrangement for use in a powder inhaler
JPH09208485A (ja) 1996-01-31 1997-08-12 Teijin Ltd ペプチド・蛋白質性薬物の水難溶性組成物
KR19990082348A (ko) 1996-02-06 1999-11-25 이.아이,듀우판드네모아앤드캄파니 플라즈마 활성화 종을 갖는 탈집괴 입자의 처리
USD381416S (en) 1996-02-08 1997-07-22 Astra Aktiebolag Unit dose inhaler
UA49878C2 (ru) 1996-02-21 2002-10-15 Шерінг Корпорейшн Устройство для ингаляции порошка (варианты)
USD377861S (en) 1996-02-21 1997-02-11 Medport, Inc. Inhaler carrying case
ATE247456T1 (de) 1996-02-27 2003-09-15 Teijin Ltd Puderförmige zusammensetzung zur nasalen anwendung
US6509313B1 (en) 1996-02-28 2003-01-21 Cornell Research Foundation, Inc. Stimulation of immune response with low doses of cytokines
US5699789A (en) 1996-03-11 1997-12-23 Hendricks; Mark R. Dry powder inhaler
JP3328132B2 (ja) 1996-03-21 2002-09-24 株式会社ユニシアジェックス 吸入式投薬器
GB9606188D0 (en) 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
USD395499S (en) 1996-04-08 1998-06-23 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
US5858099A (en) 1996-04-09 1999-01-12 Sarnoff Corporation Electrostatic chucks and a particle deposition apparatus therefor
AU724503B2 (en) 1996-04-29 2000-09-21 Dura Pharmaceuticals, Inc. Methods of dry powder inhalation
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
AU132977S (en) 1996-05-17 1998-02-17 Astrazeneca Ab Container for inhaling apparatus
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
USRE37053E1 (en) 1996-05-24 2001-02-13 Massachusetts Institute Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
JPH1053765A (ja) 1996-06-04 1998-02-24 Denso Corp スメクチック液晶組成物及び液晶セル
EP0959896B1 (en) 1996-06-05 2011-05-25 RAPOPORT, Basil Method of producing secreted truncated variants of human thyrotropin receptor
JPH09322938A (ja) * 1996-06-06 1997-12-16 Unisia Jecs Corp 吸入式投薬器
US5871010A (en) 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
AUPO066096A0 (en) 1996-06-26 1996-07-18 Peptide Delivery Systems Pty Ltd Oral delivery of peptides
US5769276A (en) 1996-07-10 1998-06-23 Terronics Development Corporation Powder atomizer
US5783556A (en) 1996-08-13 1998-07-21 Genentech, Inc. Formulated insulin-containing composition
AU133903S (en) 1996-08-19 1998-05-29 Orion Yhtymae Oy Inhaler device
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
JP3890099B2 (ja) 1996-09-30 2007-03-07 キヤノン株式会社 パターン認識装置及びその方法、及びそのプログラムを記憶した記憶媒体
JP3020141B2 (ja) 1996-10-07 2000-03-15 株式会社富士薬品 経鼻投与用製剤
US6532437B1 (en) 1996-10-23 2003-03-11 Cornell Research Foundation, Inc. Crystalline frap complex
UA65549C2 (ru) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Применение аналогов и производных glp-1 для периферического введения для борьбы с ожирением
US6441172B1 (en) 1996-11-07 2002-08-27 Torrey Pines Institute For Molecular Studies Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
DE69732572T2 (de) 1996-11-12 2005-12-29 Novo Nordisk A/S Verwendung von glp-1 peptiden
DE19647947A1 (de) 1996-11-20 1998-05-28 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
US5868774A (en) 1996-11-21 1999-02-09 Reil; Vladimir Unique cartridge and earring stud gun system
US6159360A (en) 1996-11-22 2000-12-12 Heinkel Industriezentrifugen Gmbh & Co. Invertible filter centrifuge including a solids drier
AU7845698A (en) 1996-12-11 1998-07-03 John Hugo Nellmapius Methods and apparatus for use in processing and treating particulate materia
USD390651S (en) 1996-12-12 1998-02-10 Inhale Therapeutics Systems Medicament inhaler housing
GB9626263D0 (en) 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
GB9626233D0 (en) 1996-12-18 1997-02-05 Chawla Brinda P S Medicament packaging and deliveery device
GB2320489A (en) 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
US6001336A (en) 1996-12-31 1999-12-14 Inhale Therapeutic Systems Processes for spray drying aqueous suspensions of hydrophobic drugs and compositions thereof
USD397435S (en) 1997-01-03 1998-08-25 GGU Gesellschaft fuer Gesundheits-und Umweltforschung mbH Combined inhaler and cover
US5794613A (en) 1997-01-09 1998-08-18 Sepracor, Inc. Multiple-dose dispenser for dry powder inhalers
USD389238S (en) 1997-01-24 1998-01-13 Healthscan Products, Inc. Inhaler mask
US6884435B1 (en) 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
EP1350532B1 (en) 1997-01-30 2008-04-09 Hitachi, Ltd. Capsule type powder Inhaler
SE9700421D0 (sv) 1997-02-07 1997-02-07 Astra Ab Single dose inhaler I
SE9700423D0 (sv) 1997-02-07 1997-02-07 Astra Ab Disposable inhaler
SE9700422D0 (sv) 1997-02-07 1997-02-07 Astra Ab Single dose inhaler II
SE9700424D0 (sv) 1997-02-07 1997-02-07 Astra Ab Powder inhaler
JP3011898B2 (ja) 1997-02-20 2000-02-21 フォルテ グロウ メディカル株式会社 吸引器
DE19708406A1 (de) 1997-03-03 1998-09-10 Alfred Von Schuckmann Gerät zur dosierten Ausgabe von Substanzen
USD390653S (en) 1997-03-04 1998-02-10 Blasdell Richard J Inhaler
SE9700937D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler I
SE9700938D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler II and a method of construction thereof
SE9700948D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler X
SE9700936D0 (sv) 1997-03-14 1997-03-14 Astra Ab Inhalation device
SE9700935D0 (sv) 1997-03-14 1997-03-14 Astra Ab Inhalation device
SE9700940D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler IV
TW469832U (en) 1997-03-14 2001-12-21 Astra Ab Inhalation device
SE9700943D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler V
US6043214A (en) 1997-03-20 2000-03-28 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6006747A (en) 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5904139A (en) 1997-03-28 1999-05-18 Hauser; Stephen G. Breath coordinated inhaler
JP2002510193A (ja) 1997-03-31 2002-04-02 イーライ・リリー・アンド・カンパニー グルカゴン様ペプチド−１類似体
ES2296331T3 (es) 1997-04-01 2008-04-16 Cima Labs Inc. Envase de tipo blister y comprimido envasado.
JP2002512607A (ja) 1997-04-02 2002-04-23 パーデュー・リサーチ・ファウンデーション タンパク質の経口デリバリー法
PT101988B (pt) 1997-04-04 2004-02-27 Hovione Farmaciencia Sa Sistema de orientacao e posicionamento de um objecto
USD410541S (en) 1997-06-30 1999-06-01 Novartis Ag Inhaler
SE9702796D0 (sv) 1997-07-25 1997-07-25 Pharmacia & Upjohn Ab A device at a pharmaceutical container or inhaler
CA2212430A1 (en) 1997-08-07 1999-02-07 George Volgyesi Inhalation device
GB2327895B (en) 1997-08-08 2001-08-08 Electrosols Ltd A dispensing device
US5855564A (en) * 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
US5846447A (en) 1997-08-26 1998-12-08 E. I. Du Pont De Nemours And Company Process for forming a dispersion of polytetrafluoroethylene
USD416621S (en) 1997-09-05 1999-11-16 Pharmacia & Upjohn Two piece inhaler
USD417271S (en) 1997-09-10 1999-11-30 Medic-Aid Limited Drug delivery device
WO1999014239A1 (de) 1997-09-12 1999-03-25 Wolf Georg Forssmann Zusammensetzung zur therapie von diabetes mellitus und fettsucht
US5848589A (en) 1997-09-18 1998-12-15 Welnetz; Robert J. Altitude mask simulator
AU135340S (en) 1997-09-24 1998-10-12 Innovata Biomed Ltd An inhaler
US6394085B1 (en) 1997-09-25 2002-05-28 Norton Healthcare Ltd. Inhaler spacer
US6073629A (en) 1997-09-25 2000-06-13 Norton Healthcare Ltd. Inhaler spacer
USD463544S1 (en) 1997-09-26 2002-09-24 1263152 Ontario Inc. Aerosol medication delivery inhaler
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
WO1999016417A1 (en) 1997-10-01 1999-04-08 Flemington Pharmaceutical Corporation Buccal, polar and non-polar spray or capsule
US6228394B1 (en) 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules
NZ504021A (en) 1997-10-17 2003-04-29 Systemic Pulmonary Delivery Lt Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
USD398992S (en) 1997-10-21 1998-09-29 Schering-Plough Healthcare Products, Inc. Nasal inhaler
ZA989744B (en) 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
IN188720B (ru) 1997-11-06 2002-11-02 Panacea Biotec Ltd
SE9704184D0 (sv) 1997-11-14 1997-11-14 Astra Ab Inhalation device
AU135120S (en) 1997-11-14 1998-09-21 Astrazeneca Ab Inhaler
US6116238A (en) 1997-12-02 2000-09-12 Dura Pharmaceuticals, Inc. Dry powder inhaler
USD412978S (en) 1997-12-02 1999-08-17 Dura Pharmaceuticals, Inc. Inhaler
AU746970B2 (en) * 1997-12-02 2002-05-09 Dura Pharmaceuticals, Inc. Dry powder inhaler
USD418600S (en) 1997-12-04 2000-01-04 Charmaine Haerle Inhaler clip
JP2001525371A (ja) 1997-12-05 2001-12-11 イーライ・リリー・アンド・カンパニー Ｇｌｐ−１製剤
US6192876B1 (en) 1997-12-12 2001-02-27 Astra Aktiebolag Inhalation apparatus and method
US6380357B2 (en) 1997-12-16 2002-04-30 Eli Lilly And Company Glucagon-like peptide-1 crystals
US5965701A (en) 1997-12-23 1999-10-12 Ferring Bv Kappa receptor opioid peptides
US6077940A (en) 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
US6358058B1 (en) 1998-01-30 2002-03-19 1263152 Ontario Inc. Aerosol dispensing inhaler training device
JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
US6158431A (en) 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
USD421800S (en) 1998-02-19 2000-03-21 Pierre Fabre Medicament Powder and compressed-air inhaler
USD412979S (en) 1998-02-27 1999-08-17 Diemolding Corporation Metered dose inhaler spacer
DE69923061T2 (de) * 1998-03-04 2006-01-05 Sarnoff Corp. Spendervorrichtung für einen medizinischen trockenpulver inhalator
US7143764B1 (en) 1998-03-13 2006-12-05 Astrazeneca Ab Inhalation device
EP1066074A1 (en) 1998-03-16 2001-01-10 Inhale Therapeutic Systems, Inc. Aerosolized active agent delivery
US6998387B1 (en) 1998-03-19 2006-02-14 Amylin Pharmaceuticals, Inc. Human appetite control by glucagon-like peptide receptor binding compounds
SE9801078D0 (sv) 1998-03-27 1998-03-27 Shl Medical Ab Inhalator
AU138849S (en) 1998-03-30 1999-11-22 Astra Ab Inhaler with cap
AU138848S (en) 1998-03-30 1999-11-22 Astra Ab Inhaler with cap
AU138847S (en) 1998-03-30 1999-11-22 Astra Ab Inhaler with cap
EA003328B1 (ru) 1998-04-08 2003-04-24 Эли Лилли Энд Компани Легочная и назальная доставка ралоксифена
KR20010034755A (ko) 1998-04-09 2001-04-25 악시바 게엠베하 폐에 투여하기 위한 미립자 활성 지지체
FR2777283B1 (fr) 1998-04-10 2000-11-24 Adir Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6578571B1 (en) 1998-04-20 2003-06-17 Infamed Ltd. Drug delivery device and methods therefor
GB9810126D0 (ru) 1998-05-13 1998-07-08 Glaxo Group Ltd
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
SE9802080D0 (sv) 1998-06-11 1998-06-11 Hellstroem Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein
US6152130A (en) 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
SK19042000A3 (sk) 1998-06-12 2001-11-06 Bionebraska, Inc. Glukagónu podobný peptid-1 zlepšujúci odpoveď beta-bunkiek na glukózu u subjektov so zhoršenou toleranciou glukózy
USD412572S (en) 1998-06-19 1999-08-03 Gray Gene W Nasal inhaler adaptor for left and right nostril
JP4225692B2 (ja) 1998-06-22 2009-02-18 アストラゼネカ・アクチエボラーグ 粉末含有キャビティを吸入により空にするための装置
JP2002519366A (ja) 1998-07-07 2002-07-02 トランスダーマル・テクノロジーズ・インコーポレーテツド 医薬的に活性な作用物質を迅速かつ非刺激的に経皮送達するための組成物、およびそのような組成物の調剤法およびそれらの送達
DE19831525A1 (de) 1998-07-14 2000-01-20 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6087334A (en) 1998-08-21 2000-07-11 Amylin Pharmaceuticals, Inc. Anti-diabetic peptides
CN1160127C (zh) 1998-08-26 2004-08-04 帝人株式会社 粉状经鼻组合物
BR9913284A (pt) 1998-08-28 2001-05-15 Lilly Co Eli Métodos para administrar peptìdeos insulinotrópicos
US6720407B1 (en) * 1998-08-28 2004-04-13 Eli Lilly And Company Method for administering insulinotropic peptides
CA2344383A1 (en) 1998-09-24 2000-03-30 Astrazeneca Ab Inhaler
US20020088458A1 (en) 1998-09-24 2002-07-11 Astrazeneca Ab Inhaler
GB9820886D0 (en) 1998-09-26 1998-11-18 Glaxo Group Ltd Inhalation device
GB9820938D0 (en) * 1998-09-26 1998-11-18 Glaxo Group Ltd Inhalation device
GB9820937D0 (en) * 1998-09-26 1998-11-18 Glaxo Group Ltd Inhalation device
US6187291B1 (en) 1998-09-28 2001-02-13 Robert Weinstein Method and device for facilitating combined aerosol and oral treatments for diabetes mellitus
USD411005S (en) 1998-09-29 1999-06-15 Pharmadesign Inc. Arthritic aid for metered dose inhaler
UA73924C2 (en) 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
US6279511B1 (en) 1998-10-23 2001-08-28 Instech Laboratories, Inc. Powered multichannel infusion and monitoring system
US6263871B1 (en) 1998-10-29 2001-07-24 Richard I. Brown Mouthpiece with coupler
US6235725B1 (en) 1998-10-30 2001-05-22 Baker Norton Pharmaceuticals, Inc. Methods and compositions for the prevention of tolerance to medications
JP3747134B2 (ja) 1998-11-04 2006-02-22 キヤノン株式会社 インクジェット記録ヘッドカートリッジの保管容器
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
US6540672B1 (en) 1998-12-09 2003-04-01 Novo Nordisk A/S Medical system and a method of controlling the system for use by a patient for medical self treatment
GB9827145D0 (en) 1998-12-09 1999-02-03 Co Ordinated Drug Dev Improvements in or relating to powders
US6086603A (en) * 1998-12-14 2000-07-11 Syntheon, Llc Luminal port device having internal and external sealing mechanisms
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
SE9900215D0 (sv) 1999-01-26 1999-01-26 Pharmacia & Upjohn Ab New use
JP2000217917A (ja) 1999-01-27 2000-08-08 Unisia Jecs Corp 吸入式投薬器
GB9902493D0 (en) * 1999-02-05 1999-03-24 Glaxo Group Ltd Inhalation device
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
IT1309592B1 (it) 1999-03-05 2002-01-24 Chiesi Farma Spa Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e
AU3409399A (en) 1999-03-05 2000-09-28 Chiesi Farmaceutici S.P.A. Improved powdery pharmaceutical compositions for inhalation
US6632258B1 (en) 1999-03-16 2003-10-14 The United States Of America As Represented By The United States Department Of Energy Coal beneficiation by gas agglomeration
US6803044B1 (en) 1999-03-24 2004-10-12 Zengen, Inc. Antimicrobial and anti-inflammatory peptides for use in human immunodeficiency virus
US6630169B1 (en) 1999-03-31 2003-10-07 Nektar Therapeutics Particulate delivery systems and methods of use
WO2000059476A1 (en) 1999-04-05 2000-10-12 Pharmaceutical Discovery Corporation Methods for fine powder formation
USD441859S1 (en) 1999-04-06 2001-05-08 Istituto Biochimico Pavese Pharma S.P.A. Disposable dry-powder inhaler
BR0010346A (pt) 1999-05-07 2002-02-19 Imerys Pigments Inc Método de tratamento de um material particulado de caulim
US6417920B1 (en) 1999-05-11 2002-07-09 Shimadzu Corporation Particle size analyzer based on laser diffraction method
US6514500B1 (en) 1999-10-15 2003-02-04 Conjuchem, Inc. Long lasting synthetic glucagon like peptide {GLP-!}
GB9911388D0 (en) 1999-05-18 1999-07-14 Glaxo Group Ltd Dispenser
JP2003500365A (ja) 1999-05-20 2003-01-07 ファルマソル ゲーエムベーハー 体液性および細胞性免疫応答を増強するための安定性、生体適合性最適化アジュバント（ｓｂａ）
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
ES2207123T3 (es) 1999-06-14 2004-05-16 Baxter International Inc. Microesferas de liberacion sostenida.
SE516826C2 (sv) * 1999-06-18 2002-03-05 Shl Medical Ab Anordning i en inhalator med organ för aktivering och avaktivering av en kanister som svar på ett luftflöde
US6644315B2 (en) 1999-06-18 2003-11-11 Saeed Ziaee Nasal mask
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6660716B1 (en) 1999-06-21 2003-12-09 Eli Lilly And Company Method for treating non-insulin dependent diabetes using thiazolidinediones with glucagon-like peptide-1 and agonists thereof
US6858199B1 (en) 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
GB2353222B (en) 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
USD444226S1 (en) 1999-06-24 2001-06-26 Novo Nordisk A/S Inhaler
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DK1196430T3 (da) 1999-06-29 2012-05-21 Mannkind Corp Rensning og stabilisering af peptider og proteiner i farmaceutiske midler
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
ITMI991582A1 (it) * 1999-07-16 2001-01-16 Chiesi Farma Spa Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala
WO2001007086A1 (en) 1999-07-22 2001-02-01 Aventis Pharmaceuticals, Inc. Preserved pharmaceutical formulations
US7464706B2 (en) * 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
JP2003508184A (ja) * 1999-07-23 2003-03-04 ファーマシューティカル ディスカバリー コーポレイション 単位用量カプセルおよび乾燥粉末吸入器
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US20010036481A1 (en) 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
DE19942791A1 (de) * 1999-09-08 2001-03-15 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
CN1175961C (zh) 1999-09-17 2004-11-17 株式会社新王磁材 稀土合金的切割方法和切割装置
USD438612S1 (en) 1999-09-27 2001-03-06 G-Intek Co., Ltd. Snivel inhaler
EP1220700B1 (de) 1999-10-06 2003-04-09 Eckardt, Angela Atemzugskontrolliertes Inhalationsgerät für Trockenpulver
JP3827894B2 (ja) 1999-10-12 2006-09-27 株式会社ソディック ワイヤカット放電加工機のシール装置
CN1188111C (zh) 1999-10-29 2005-02-09 耐科塔医药公司 分散性得到改进的干粉组合物
SE9903990D0 (sv) 1999-11-02 1999-11-02 Shl Medical Ab Inhalator with aerosolizing unit
GB9928311D0 (en) 1999-11-30 2000-01-26 Novartis Ag Organic compounds
IT1308581B1 (it) 1999-12-03 2002-01-08 Medel Italiana Srl Apparato per nebulizzare un liquido, in particolare per uso medico.
SE9904706D0 (sv) 1999-12-21 1999-12-21 Astra Ab An inhalation device
PE20010720A1 (es) 1999-12-11 2001-07-26 Glaxo Group Ltd Distribuidor de medicamento
US7022674B2 (en) 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
US7204250B1 (en) 1999-12-16 2007-04-17 Compumedics Limited Bio-mask
DE19961300A1 (de) * 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator
AU2729101A (en) 1999-12-21 2001-07-03 Rxkinetix, Inc. Particulate drug-containing products and method of manufacture
US7080642B2 (en) 1999-12-22 2006-07-25 3M Innovative Properties Company Refillable device with counting means
IL150461A0 (en) 1999-12-30 2002-12-01 Chiron Corp Methods for pulmonary delivery of interleukin-2
US6894026B1 (en) 2000-01-11 2005-05-17 Atossa Healthcare, Inc. Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
AU2353701A (en) 2000-01-11 2001-07-24 Novo Nordisk A/S Transepithelial delivery of glp-1 derivatives
ATE312595T1 (de) 2000-01-19 2005-12-15 Mannkind Corp Formulierung mit mehrfach gepulster wirkstofffreisetzung
US7833549B2 (en) 2000-01-19 2010-11-16 Mannkind Corporation Dry powder formulations of antihistamine for nasal administration
US6468686B1 (en) 2000-01-24 2002-10-22 Graftech Inc. Fluid permeable flexible graphite fuel cell electrode with enhanced electrical and thermal conductivity
US6540982B1 (en) 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US6540983B1 (en) 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
AU2001232735A1 (en) 2000-01-27 2001-08-07 Eli Lilly And Company Process for solubilizing glucagon-like peptide 1 compounds
US6427688B1 (en) 2000-02-01 2002-08-06 Dura Pharmaceuticals, Icn. Dry powder inhaler
US7171965B2 (en) 2000-02-01 2007-02-06 Valois S.A.S. Breath actuated dry powder inhaler and tape dose strip
USD439325S1 (en) 2000-02-08 2001-03-20 Baker Norton Pharmaceuticals, Inc. Cover for a nasal inhaler
EP1129705A1 (en) 2000-02-17 2001-09-05 Rijksuniversiteit te Groningen Powder formulation for inhalation
GB0004456D0 (en) 2000-02-26 2000-04-19 Glaxo Group Ltd Medicament dispenser
CA2401288A1 (en) 2000-02-28 2001-09-07 Vectura Limited Improvements in or relating to the delivery of oral drugs
USD439656S1 (en) 2000-03-06 2001-03-27 Astrazeneca Uk Limited Inhaler
US6443151B1 (en) 2000-03-08 2002-09-03 Aradigm Corporation Fluid velocity-sensitive trigger mechanism
WO2001068169A1 (en) 2000-03-10 2001-09-20 University Of North Carolina At Chapel Hill Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods
US6608038B2 (en) 2000-03-15 2003-08-19 Novartis Ag Methods and compositions for treatment of diabetes and related conditions via gene therapy
GB0006525D0 (en) 2000-03-18 2000-05-10 Astrazeneca Uk Ltd Inhaler
GB2360216A (en) 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
GB2360218A (en) 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
US6823863B2 (en) 2000-03-18 2004-11-30 Astrazeneca Ab Inhaler
SE0000935D0 (sv) 2000-03-21 2000-03-21 Astrazeneca Ab An inhalation device
AU145610S (en) 2000-03-24 2001-10-18 Astrazeneca U K Ltd Inhaler
US6432383B1 (en) 2000-03-30 2002-08-13 Generex Pharmaceuticals Incorporated Method for administering insulin
AU5173701A (en) 2000-04-03 2001-10-15 Iep Pharmaceutical Devices Inc Method for improving lung delivery of pharmaceutical aerosols
US6998137B2 (en) 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
US6557549B2 (en) 2000-04-11 2003-05-06 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
DE10019879A1 (de) 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
MY136453A (en) 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
US6447750B1 (en) 2000-05-01 2002-09-10 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6468507B1 (en) 2000-05-01 2002-10-22 Aeropharm Technology, Inc. Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer
USD442685S1 (en) 2000-05-02 2001-05-22 Salter Labs Medication inhaler spacer
US8336545B2 (en) * 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US20010039442A1 (en) 2000-05-06 2001-11-08 Sal Gorge Headache relief device
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US20020000225A1 (en) 2000-06-02 2002-01-03 Carlos Schuler Lockout mechanism for aerosol drug delivery devices
CN1141974C (zh) 2000-06-07 2004-03-17 张昊 结肠定位释放的口服生物制剂
CA2412004C (en) 2000-06-16 2010-12-21 Eli Lilly And Company Glucagon-like peptide-1 analogs
RU2181297C2 (ru) 2000-06-20 2002-04-20 Эпштейн Олег Ильич Способ лечения патологического синдрома и лекарственное средство
GB0015034D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Inhalation device
GB0015043D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
AR028747A1 (es) 2000-06-23 2003-05-21 Norton Health Care Ltd Desaglomerador para inhalador de polvo seco accionado por la respiracion, un inhalador de polvo seco y un metodo de desaglomeracion de polvo seco.
US6562807B2 (en) 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
TWI224515B (en) 2000-06-23 2004-12-01 Norton Healthcare Ltd Pre-metered dose magazine for breath-actuated dry powder inhaler
PE20020074A1 (es) 2000-06-23 2002-02-05 Norton Healthcare Ltd Sistema dosificador para inhalador de medicamento
USD450117S1 (en) 2000-06-29 2001-11-06 Innovata Biomed Limited Inhaler
USD452910S1 (en) 2000-06-29 2002-01-08 Innovata Biomend Limited Inhaler
PL360856A1 (en) 2000-07-04 2004-09-20 Novo Nordisk A/S Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv)
US6363932B1 (en) 2000-07-06 2002-04-02 Clinical Technologies, Inc. Aerosol enhancement device
US6951215B1 (en) 2000-07-14 2005-10-04 Tufts University Drug delivery device for animals
US6360929B1 (en) 2000-07-17 2002-03-26 Mccarthy Madeleine Medicinal atomizing inhaler pouch/retainer
GB2364919A (en) 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
SE0002822L (sv) 2000-08-04 2002-01-29 Microdrug Ag Elektropulver
ATE547101T1 (de) 2000-08-04 2012-03-15 Dmi Biosciences Inc Verfahren zur verwendung von diketopiperazinen und zusammensetzungen, die diese enthalten
US6967202B2 (en) 2000-08-04 2005-11-22 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
SI2348032T1 (sl) 2000-08-05 2015-10-30 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)-11beta-hidroksi- 16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
EP1309312A2 (en) 2000-08-07 2003-05-14 Inhale Therapeutic Systems, Inc. Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
AU2001283546A1 (en) 2000-08-14 2002-02-25 Advanced Inhalation Research, Inc. Inhalation device and method
US6704255B2 (en) 2000-08-22 2004-03-09 Ricoh Company, Ltd. Lens actuator
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6514482B1 (en) 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
CN1299779C (zh) 2000-09-20 2007-02-14 弗朗哥·德伯恩 用于吸入设备的喷雾装置及带有喷雾装置的吸入设备
USD460173S1 (en) 2000-09-20 2002-07-09 P.A. Knowledge Limited Inhaler device
SE517225C2 (sv) 2000-09-21 2002-05-14 Microdrug Ag Optimering av en elektrostatiskt doserad inhalator för torrt pulver
SE517226C2 (sv) 2000-09-25 2002-05-14 Microdrug Ag Inhalator med luftbroms för torrt pulver
SE517228C2 (sv) 2000-09-25 2002-05-14 Microdrug Ag Inhalator för torrt pulver med andningsaktivering
GB0023653D0 (en) 2000-09-27 2000-11-08 Cambridge Consultants Device for dispensing particulate material
ES2336544T3 (es) 2000-09-29 2010-04-14 Pfizer Limited Dispositivo medico de inhalacion.
US6756062B2 (en) 2000-11-03 2004-06-29 Board Of Regents University Of Texas System Preparation of drug particles using evaporation precipitation into aqueous solutions
CN100400031C (zh) 2000-11-29 2008-07-09 伊藤火腿株式会社 粉末制剂及其制备方法
GB0029562D0 (en) 2000-12-04 2001-01-17 Novartis Ag Organic compounds
USD455208S1 (en) 2000-12-05 2002-04-02 Clinical Designs Limited Inhaler
JP2004521093A (ja) 2000-12-13 2004-07-15 イーライ・リリー・アンド・カンパニー グルカゴン様インスリン刺激性ペプチドを用いる長期治療計画
US6896906B2 (en) 2000-12-21 2005-05-24 Nektar Therapeutics Storage stable powder compositions of interleukin-4 receptor
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US20020141946A1 (en) 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
WO2002053190A2 (en) 2000-12-29 2002-07-11 Advanced Inhalation Research, Inc. Particles for inhalation having sustained release properties
US6626173B2 (en) 2001-01-08 2003-09-30 Iep Pharmaceutical Devices Inc. Dry powder inhaler
US6644309B2 (en) 2001-01-12 2003-11-11 Becton, Dickinson And Company Medicament respiratory delivery device and method
FI20010144A0 (fi) 2001-01-24 2001-01-24 Valtion Teknillinen Menetelmä ja laite aerosolilähteiden tutkimiseksi
AUPR272901A0 (en) 2001-01-25 2001-02-22 Gainful Plan Limited Method of preparing biological materials and preparations produced using same
US20040022861A1 (en) 2001-01-30 2004-02-05 Williams Robert O. Process for production of nanoparticles and microparticles by spray freezing into liquid
GB2374010B (en) 2001-02-26 2004-12-29 Council Scient Ind Res Novel vitamin B12 - biodegradable micro particulate conjugate carrier systems for peroral delivery of drugs, therapeutic peptides/proteins and vaccines
ATE255929T1 (de) 2001-03-05 2003-12-15 Ivo Pera Inhalationsvorrichtung zum dispergieren von in kapseln enthaltenen pulverförmigen medikamente durch den respirationstrakt
US6698422B2 (en) 2001-03-12 2004-03-02 Birdsong Medical Devices, Inc. Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece
US6523536B2 (en) 2001-03-12 2003-02-25 Birdsong Medical Devices, Inc. Dual-canister inhaler having a spacer and easy to operate lever mechanism
USD453264S1 (en) 2001-03-30 2002-02-05 Benjamin Acevedo, Jr. Pouch for medical inhaler
GB0108213D0 (en) 2001-04-02 2001-05-23 Glaxo Group Ltd Medicament dispenser
US6652838B2 (en) 2001-04-05 2003-11-25 Robert E. Weinstein Method for treating diabetes mellitus
SE0101233L (sv) 2001-04-05 2002-10-01 Microdrug Ag Förfarande och anordning för frigörande av pulver och inhalatoranordning för administrering av medicinskt pulver
ES2258141T3 (es) 2001-04-11 2006-08-16 Bristol-Myers Squibb Company Complejos de aminoacidos de glucosidos c-arilo para el tratamiento de la diabetes y procedimiento.
US6766799B2 (en) 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
US6447751B1 (en) 2001-04-18 2002-09-10 Robert E. Weinstein Method and device for facilitating combined aerosol and oral treatments for diabetes mellitus
DE60234825D1 (de) * 2001-04-19 2010-02-04 Technology Innovation Ltd Arzneimittelbehälter
USD451597S1 (en) 2001-04-24 2001-12-04 G-Intek Co.,Ltd Snivel inhaler
US7232897B2 (en) 2001-04-24 2007-06-19 Harvard University, President And Fellows Of Harvard College Compositions and methods for modulating NH2-terminal Jun Kinase activity
JP4663906B2 (ja) 2001-04-26 2011-04-06 富士フイルム株式会社 セルロースアシレートフイルム
JP2005506855A (ja) 2001-05-10 2005-03-10 ベクトゥラ デリバリー デバイシーズ リミテッド 吸入器
US6838076B2 (en) 2001-05-21 2005-01-04 Nektar Therapeutics Pulmonary administration of chemically modified insulin
SE0101825D0 (sv) 2001-05-22 2001-05-22 Astrazeneca Ab An Inhalation device
JP2005506956A (ja) 2001-06-01 2005-03-10 イーライ・リリー・アンド・カンパニー 長時間作用性ｇｌｐ−１製剤
US7035294B2 (en) * 2001-06-04 2006-04-25 Calix Networks, Inc. Backplane bus
EG24184A (en) 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
FI20011317A0 (fi) 2001-06-20 2001-06-20 Orion Corp Jauheinhalaattori
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
WO2003000570A1 (en) 2001-06-22 2003-01-03 3M Innovative Properties Company Metering valve for a metered dose inhaler
US6614197B2 (en) 2001-06-30 2003-09-02 Motorola, Inc. Odd harmonics reduction of phase angle controlled loads
US7414720B2 (en) 2001-07-27 2008-08-19 Herbert Wachtel Measuring particle size distribution in pharmaceutical aerosols
DE10136555A1 (de) 2001-07-27 2003-02-13 Boehringer Ingelheim Int Optimierte Verfahren zur Bestimmung der Aerosol-Partikelgrößenverteilung und Vorrichtung zur Durchführung derartiger Verfahren
GB0120018D0 (en) 2001-08-16 2001-10-10 Meridica Ltd Pack containing medicament and dispensing device
WO2003018059A2 (de) 2001-08-22 2003-03-06 Aventis Pharma Deutschland Gmbh Kombinationspräparate von arylsubstituierten propanolaminderivaten mit weiteren wirkstoffen und deren verwendung
BR0212080A (pt) 2001-08-23 2006-04-04 Lilly Co Eli composto de glp-1, método de estimulação de receptor de glp-1 em um indivìduo necessitando de tal estimulação, e, uso de um composto de glp-1
WO2003020201A2 (en) 2001-08-28 2003-03-13 Eli Lilly And Company Pre-mixes of glp-1 and basal insulin
GB0121709D0 (en) 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
EP1487417A4 (en) 2001-09-17 2010-03-17 Glaxo Group Ltd DRY POWDER DRUG FORMULATIONS
US6871647B2 (en) 2001-09-19 2005-03-29 Advent Pharmaceuticals Pty Ltd Inhaler
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
AU2002340083A1 (en) 2001-09-28 2003-04-07 Kurve Technology, Inc Nasal nebulizer
EP1436030A1 (en) 2001-10-08 2004-07-14 Eli Lilly And Company Portable medication inhalation kit
NZ532694A (en) 2001-10-16 2005-03-24 Internat Non Toxic Composites High density non-toxic composites comprising tungsten, another metal and polymer powder
USD461239S1 (en) 2001-10-18 2002-08-06 Anna L. Cassidy Inhaler sleeve with spring clip
CA2463803A1 (en) 2001-10-19 2003-05-01 Eli Lilly And Company Biphasic mixtures of glp-1 and insulin
AU2002350622B2 (en) 2001-10-24 2006-09-14 Pari Pharma Gmbh Kit for the preparation of a pharmaceutical composition
USD473298S1 (en) 2001-11-01 2003-04-15 Astrazeneca Ab Inhaler refill
WO2003063770A2 (en) 2001-11-07 2003-08-07 Mannkind Corporation Expression vectors encoding epitopes of target-associated antigens and methods for their design
CA2468958C (en) 2001-12-19 2012-07-03 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US6994083B2 (en) 2001-12-21 2006-02-07 Trudell Medical International Nebulizer apparatus and method
GB0130857D0 (en) 2001-12-22 2002-02-06 Glaxo Group Ltd Medicament dispenser
USD474536S1 (en) 2002-01-07 2003-05-13 Aerogen, Inc. Inhaler for dispensing medications
USD469866S1 (en) 2002-01-07 2003-02-04 Aerogen, Inc. Inhaler for dispensing medication
US20030198666A1 (en) 2002-01-07 2003-10-23 Richat Abbas Oral insulin therapy
USD471273S1 (en) 2002-01-07 2003-03-04 Aerogen, Inc. Inhaler for dispensing medication
USD479745S1 (en) 2002-01-07 2003-09-16 Aerogen, Inc. Inhaler for dispensing medications
ITMI20020078A1 (it) * 2002-01-16 2003-07-16 Fabrizio Niccolai Dispositivo utilizzabile nel tratamento di affezzioni delle vie respiratorie
WO2003061578A2 (en) 2002-01-18 2003-07-31 Mannkind Corporation Compositions for treatment or prevention of bioterrorism
US7105489B2 (en) 2002-01-22 2006-09-12 Amylin Pharmaceuticals, Inc. Methods and compositions for treating polycystic ovary syndrome
US7258118B2 (en) 2002-01-24 2007-08-21 Sofotec Gmbh & Co, Kg Pharmaceutical powder cartridge, and inhaler equipped with same
MXPA04008068A (es) 2002-02-20 2004-11-26 Lilly Co Eli Metodo para administrar moleculas de glp-1.
US6591832B1 (en) 2002-02-21 2003-07-15 Saint-Gobain Calmar Inc. Dry powder dispenser
US6830149B2 (en) 2002-03-08 2004-12-14 Musculoskeletal Transplant Foundation Package with insert for holding allograft implant to preclude lipid transfer
US7008644B2 (en) 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
GR1004350B (el) * 2002-03-29 2003-09-26 Συσκευη εισπνοων ξηρης σκονης
UA80123C2 (en) * 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US20030194420A1 (en) 2002-04-11 2003-10-16 Richard Holl Process for loading a drug delivery device
USD475133S1 (en) 2002-04-18 2003-05-27 Mcluckie Lynne E. Luminescent-colored inhaler
US7316748B2 (en) * 2002-04-24 2008-01-08 Wisconsin Alumni Research Foundation Apparatus and method of dispensing small-scale powders
US6830046B2 (en) 2002-04-29 2004-12-14 Hewlett-Packard Development Company, L.P. Metered dose inhaler
USD478983S1 (en) 2002-05-01 2003-08-26 Chrysalis Technologies Incorporated Inhaler
US20040151059A1 (en) 2002-05-01 2004-08-05 Roberts Ii William Leroy Deagglomerator apparatus and method
AU2003218635A1 (en) 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising insulin aspart and insulin detemir
US6889690B2 (en) 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
USD473640S1 (en) 2002-05-13 2003-04-22 Iep Pharmaceutical Devices Inc. Breath actuated inhaler
USD492769S1 (en) 2002-05-24 2004-07-06 Glaxosmithkline K.K. Lens for an inhaler
USD477665S1 (en) 2002-06-12 2003-07-22 Microdrug Ag Inhaler
US8003179B2 (en) 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
AU154760S (en) 2002-06-20 2004-03-02 Astrazeneca Ab Inhaler
WO2004002551A2 (en) 2002-06-28 2004-01-08 Advanced Inhalation Research, Inc. Inhalable epinephrine
US20060003316A1 (en) 2002-07-15 2006-01-05 John Simard Immunogenic compositions derived from poxviruses and methods of using same
GB0217198D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
GB0217382D0 (en) 2002-07-26 2002-09-04 Pfizer Ltd Process for making orally consumable dosage forms
EP1658872B2 (en) 2002-07-31 2019-08-21 CHIESI FARMACEUTICI S.p.A. Powder inhaler
USD489448S1 (en) 2002-07-31 2004-05-04 Advanced Inhalations Revolutions, Inc. Vaporization apparatus
DE10235168A1 (de) 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
US20080260838A1 (en) 2003-08-01 2008-10-23 Mannkind Corporation Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
US20150283213A1 (en) 2002-08-01 2015-10-08 Mannkind Corporation Method for treating hyperglycemia with glp-1
WO2004012672A2 (en) 2002-08-01 2004-02-12 Mannkind Corporation Cell transport compositions and uses thereof
US20040038865A1 (en) 2002-08-01 2004-02-26 Mannkind Corporation Cell transport compositions and uses thereof
GB0315791D0 (en) 2003-07-07 2003-08-13 3M Innovative Properties Co Two component molded valve stems
US20040121964A1 (en) 2002-09-19 2004-06-24 Madar David J. Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
USD509296S1 (en) 2002-09-21 2005-09-06 Aventis Pharma Limited Inhaler
GB0222023D0 (en) * 2002-09-21 2002-10-30 Aventis Pharma Ltd Inhaler
US7322352B2 (en) * 2002-09-21 2008-01-29 Aventis Pharma Limited Inhaler
JP2004121061A (ja) 2002-10-01 2004-04-22 Sanei Gen Ffi Inc 粉末組成物の製造方法
SG134169A1 (en) 2002-10-11 2007-08-29 Otsuka Pharma Co Ltd Powder inhalator
CN1176649C (zh) 2002-10-16 2004-11-24 上海医药工业研究院 舒马普坦干粉吸入剂及其制备方法
ITMO20020297A1 (it) 2002-10-16 2004-04-17 Roberto Oliva Inalatore per preparati monodose in capsule.
US20040151774A1 (en) 2002-10-31 2004-08-05 Pauletti Giovanni M. Therapeutic compositions for drug delivery to and through covering epithelia
GB0225621D0 (en) 2002-11-02 2002-12-11 Glaxo Group Ltd Medicament carrier
WO2004041338A1 (en) 2002-11-04 2004-05-21 Cambridge Consultants Limited Inhalers
USD493220S1 (en) 2002-11-06 2004-07-20 Merck Patent Gmbh Inhaler
US20080015457A1 (en) 2002-11-07 2008-01-17 Silva Carlos D Device for Monitoring Respiratory Movements
USD483860S1 (en) 2002-11-12 2003-12-16 Pari Gmbh Spezialisten Fur Effektive Inhalation Electronic inhaler and control unit
US6904907B2 (en) 2002-11-19 2005-06-14 Honeywell International Inc. Indirect flow measurement through a breath-operated inhaler
GB0227128D0 (en) * 2002-11-20 2002-12-24 Glaxo Group Ltd A capsule
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20040138099A1 (en) 2002-11-29 2004-07-15 Draeger Eberhard Kurt Insulin administration regimens for the treatment of subjects with diabetes
AU2003285246A1 (en) 2002-12-02 2004-06-23 The Governors Of The University Of Alberta Device and method for deagglomeration of powder for inhalation
US7284553B2 (en) 2002-12-12 2007-10-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
CA2507794C (en) * 2002-12-13 2012-04-24 Otsuka Pharmaceutical Co., Ltd. Inhalation device for transpulmonary administration
AU2003285776A1 (en) * 2002-12-13 2004-07-09 Otsuka Pharmaceutical Co., Ltd. FREEZE-DRIED INTERFERON-Gamma COMPOSITION FOR TRANSPULMONARY ADMINISTRATION AND INHALATION SYSTEM THEREFOR
AU2003299722A1 (en) 2002-12-17 2004-07-14 Mdrna, Inc. Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity
US6941947B2 (en) 2002-12-18 2005-09-13 Quadrant Technologies Limited Unit dose dry powder inhaler
US6962006B2 (en) 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US7185650B2 (en) 2002-12-19 2007-03-06 Arie Huber Systems and methods for determining a minimum effective dose of an inhaled drug for an individual patient at a given time
EP1578437A4 (en) 2002-12-27 2006-08-09 Diobex Inc COMPOSITIONS AND METHODS FOR PREVENTING AND REDUCING INSULIN-INDUCED HYPOGLYCEMIA
DE10300032B3 (de) 2003-01-03 2004-05-27 E. Braun Gmbh Pulverinhalator
GB0309154D0 (en) 2003-01-14 2003-05-28 Aventis Pharma Inc Use of insulin glargine to reduce or prevent cardiovascular events in patients being treated for dysglycemia
WO2004064705A2 (en) 2003-01-17 2004-08-05 Schering Corporation Training device for medicament inhalers
JP2006514119A (ja) 2003-02-12 2006-04-27 アール アンド ピー コリア カンパニー リミテッド 溶解率が向上した難溶性薬剤の溶媒系
GB0303870D0 (en) * 2003-02-20 2003-03-26 Norton Healthcare Ltd Pre-metered dose magazine for breath-actuated dry powder inhaler
US20040171518A1 (en) 2003-02-27 2004-09-02 Medtronic Minimed, Inc. Compounds for protein stabilization and methods for their use
US7544656B2 (en) 2003-03-04 2009-06-09 The Technology Development Company, Ltd. Long acting injectable insulin composition and methods of making and using thereof
EP1599243B1 (en) 2003-03-04 2013-12-25 Norton Healthcare Limited Medicament dispensing device with a display indicative of the state of an internal medicament reservoir
WO2004080401A2 (en) 2003-03-06 2004-09-23 Emisphere Technologies, Inc. Oral insulin therapies and protocol
CA2458288A1 (en) 2003-03-11 2004-09-11 Institut De Cardiologie De Montreal / Montreal Heart Institute Method and compound to reduce the incidence of diabetes in a subject with chronic heart failure
USD499802S1 (en) 2003-04-01 2004-12-14 Chiesi Farmaceutici S.P.A. Powder inhaler
EP1615689B1 (en) 2003-04-09 2016-02-03 Novartis AG Aerosolization apparatus with capsule puncture alignment guide
US20040204439A1 (en) 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
EP1468935A1 (de) 2003-04-16 2004-10-20 Alcan Technology & Management Ltd. Blisterverpackung
AU155845S (en) 2003-05-15 2004-07-13 Glaxo Group Ltd A dispensing device for example an inhaler device
AU2004241101B2 (en) 2003-05-15 2010-05-13 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
AU155633S (en) 2003-05-16 2004-06-01 Henkel Kgaa Blister pack
US20070006876A1 (en) 2003-05-16 2007-01-11 University Of Alberta Add-on spacer design concept for dry-powder inhalers
GB0312007D0 (en) * 2003-05-24 2003-07-02 Innovata Biomed Ltd Container
EP1631264B8 (en) 2003-06-02 2017-05-24 GlaxoSmithKline Biologicals SA Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen
US7954491B2 (en) 2003-06-13 2011-06-07 Civitas Therapeutics, Inc. Low dose pharmaceutical powders for inhalations
EP1641671B1 (en) 2003-06-27 2015-06-24 Portaclave LLP Portable fuel cartridge for fuel cells
US7001622B1 (en) 2003-06-30 2006-02-21 Robert Berndt Composition and method for treatment and prevention of pruritis
GB0315509D0 (en) * 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
AU158576S (en) 2003-07-05 2006-08-22 Clinical Designs Ltd Inhaler
US7462367B2 (en) 2003-07-11 2008-12-09 Boehringer Ingelheim International Gmbh Anticholinergic powder formulations for inhalation
US8921311B2 (en) 2003-08-01 2014-12-30 Mannkind Corporation Method for treating hyperglycemia
USD569967S1 (en) 2003-08-06 2008-05-27 Meridica Limited Inhaler
DE10338402A1 (de) 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Sprühgetrocknetes, amorphes BIBN 4096, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
US20050043247A1 (en) 2003-08-18 2005-02-24 Boehringer Ingelheim International Gmbh Spray-dried amorphous BIBN 4096, process for preparing and the use thereof as inhalative
US20050056535A1 (en) 2003-09-15 2005-03-17 Makoto Nagashima Apparatus for low temperature semiconductor fabrication
DE10343668A1 (de) 2003-09-18 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arzneimittelblister
EP1675822A2 (en) 2003-10-16 2006-07-05 Cara Therapeutics, Inc. Amide or thioamide derivatives and their use in the treatment of pain
GB2398065A (en) 2003-10-16 2004-08-11 Bespak Plc Dispensing apparatus
US20050187749A1 (en) 2003-10-24 2005-08-25 Judy Singley Method, system, and computer program for performing carbohydrate/insulin calculation based upon food weight
USD511208S1 (en) 2003-10-24 2005-11-01 Valois Sas Metered dose inhaler
US7377277B2 (en) 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7451761B2 (en) 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
WO2005044173A1 (en) 2003-10-27 2005-05-19 Oriel Therapeutics, Inc. Blister packages and associated methods of fabricating dry powder drug containment systems
US20050147581A1 (en) 2003-11-19 2005-07-07 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes having improved stability and therapeutic use of the same
CA2450837A1 (en) 2003-11-25 2005-05-25 University Of New Brunswick Induction magnetometer
SE0303269L (sv) 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
GB0329884D0 (en) 2003-12-23 2004-01-28 Glaxo Group Ltd Method
US7192919B2 (en) 2004-01-07 2007-03-20 Stelios Tzannis Sustained release compositions for delivery of pharmaceutical proteins
US20070027063A1 (en) 2004-01-12 2007-02-01 Mannkind Corporation Method of preserving the function of insulin-producing cells
KR100985126B1 (ko) 2004-01-12 2010-10-05 맨카인드 코포레이션 제2형 당뇨병에서 혈청 프로인슐린 수치의 감소 방법
EP1711220A1 (en) 2004-01-16 2006-10-18 Biodel, Inc. Sublingual drug delivery device
DE102004006450B4 (de) 2004-02-05 2012-09-27 Ing. Erich Pfeiffer Gmbh Dosiervorrichtung
USD512777S1 (en) 2004-02-19 2005-12-13 Chrysalis Technologies Incorporated Inhaler
DE102004008141A1 (de) 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
JP2007523700A (ja) 2004-02-24 2007-08-23 マイクロドース・テクノロジーズ・インコーポレーテッド 流動方向検出吸入器
AU2005216061B2 (en) 2004-02-24 2010-05-27 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
PT1740154E (pt) 2004-03-12 2009-09-11 Biodel Inc Composições de insulina com absorção melhorada
ITMO20040060A1 (it) 2004-03-18 2004-06-18 Roberto Oliva Inalatore per preparati in polvere
USD515696S1 (en) 2004-03-19 2006-02-21 Innovata Biomed Limited Inhaler
US7625865B2 (en) * 2004-03-26 2009-12-01 Universita Degli Studi Di Parma Insulin highly respirable microparticles
US8071552B2 (en) 2004-04-05 2011-12-06 Universite Bordeaux 2 Peptides and peptidomimetics binding to CD23
USD533268S1 (en) 2004-04-18 2006-12-05 Bahram Olfati Inhaler
JP2007533387A (ja) 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
WO2005102428A1 (en) 2004-04-23 2005-11-03 The Governors Of The University Of Alberta Enhanced drug delivery for inhaled aerosols
HUE026152T2 (en) 2004-04-23 2016-05-30 Philip Morris Products Sa Aerosol Generator and Method for Aerosol Production
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
USD527817S1 (en) 2004-05-13 2006-09-05 Novartis Ag Inhaler
US20050265927A1 (en) 2004-05-17 2005-12-01 Yale University Intranasal delivery of nucleic acid molecules
TW200607538A (en) 2004-05-19 2006-03-01 Cipla Ltd Medicament inhaler device
USD548833S1 (en) 2004-05-28 2007-08-14 Quadrant Technologies Limited Dry powder inhaler
USD529604S1 (en) 2004-05-28 2006-10-03 Quadrant Technologies Limited Dry powder inhaler
CA2569343A1 (en) 2004-06-07 2005-12-22 Mederio Ag Securing dose quality of inhalable drug
SE528190C2 (sv) 2004-06-07 2006-09-19 Mederio Ag Inhalator
PE20091567A1 (es) 2004-06-25 2009-11-03 Takeda Pharmaceutical Derivados de metastina en el tratamiento del cancer
US20060000469A1 (en) 2004-07-02 2006-01-05 Tseng Daniel C Nebulizing apparatus for medical use with improved nozzle positioning structure
JP2008507316A (ja) 2004-07-23 2008-03-13 インターキュア リミティド 非接触マイクを使用する呼吸パターン決定のための装置と方法
US8171930B2 (en) 2004-07-26 2012-05-08 135540 Ontario Inc. Powder inhaler featuring reduced compaction inhaler
US20060026077A1 (en) * 2004-08-02 2006-02-02 Silverman Mitchell S Method and apparatus for bartering items
BRPI0514115A (pt) 2004-08-03 2008-05-27 Biorexis Technology Inc terapia de combinação empregando-se proteìnas de fusão de transferrina compreendendo glp-1
WO2006023849A2 (en) 2004-08-20 2006-03-02 Mannkind Corporation Catalysis of diketopiperazine synthesis
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
KR20070057829A (ko) 2004-08-23 2007-06-07 맨카인드 코포레이션 포스포디에스테라아제 5형의 억제제의 폐 전달
GB0419849D0 (en) 2004-09-07 2004-10-13 Pfizer Ltd Pharmaceutical combination
US8210171B2 (en) 2004-09-13 2012-07-03 Oriel Therapeutics, Inc. Tubular dry powder drug containment systems, associated inhalers and methods
US8365725B2 (en) 2004-09-13 2013-02-05 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
USD537522S1 (en) 2004-09-15 2007-02-27 Glaxo Group Limited Telescopic strap, particularly for a dust cap of a metered dose inhaler
USD537936S1 (en) 2004-09-15 2007-03-06 Glaxo Group Limited Cap with an extension, particularly for a dust cap of a metered dose inhaler
USD518170S1 (en) 2004-09-28 2006-03-28 Vectura, Ltd. Inhaler
JP4908419B2 (ja) 2004-10-06 2012-04-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ディスペンサ、貯蔵装置及び粉末の小出し方法
US7469696B2 (en) 2004-10-13 2008-12-30 Hewlett-Packard Development Company, L.P. Thermal drop generator
USD515924S1 (en) 2004-11-01 2006-02-28 Warner-Lambert Company Llc Blister card
DE102005033398A1 (de) 2004-11-10 2006-05-11 Alfred Von Schuckmann Inhalier-Gerät
SE0402976L (sv) 2004-12-03 2006-06-04 Mederio Ag Medicinsk produkt
AU2005310367A1 (en) 2004-12-03 2006-06-08 Mederio Ag A medical product comprising a glucagon-like peptide medicament intended for pulmonary inhalation
GB0427028D0 (en) 2004-12-09 2005-01-12 Cambridge Consultants Dry powder inhalers
EP1843788A4 (en) 2004-12-22 2009-11-18 Centocor Ortho Biotech Inc GLP-1 AGONISTS, COMPOSITIONS, PROCESSES AND USES
AU2006213084A1 (en) 2005-01-10 2006-08-17 Mannkind Corporation Methods and compositions for minimizing accrual of inhalable insulin in the lungs
US20060165756A1 (en) 2005-01-27 2006-07-27 Catani Steven J Method for weight management
USD538423S1 (en) 2005-02-04 2007-03-13 Berube-White Panda bear inhaler
GB0503738D0 (en) 2005-02-23 2005-03-30 Optinose As Powder delivery devices
US20060219242A1 (en) 2005-03-30 2006-10-05 Boehringer Ingelheim International Method for the Administration of an Anticholinergic by Inhalation
JP4656397B2 (ja) 2005-03-31 2011-03-23 株式会社吉野工業所 粉体用容器
CN100431634C (zh) 2005-04-04 2008-11-12 陈庆堂 干粉气溶胶化吸入器
US7762953B2 (en) 2005-04-20 2010-07-27 Adidas Ag Systems and methods for non-invasive physiological monitoring of non-human animals
US7694676B2 (en) 2005-04-22 2010-04-13 Boehringer Ingelheim Gmbh Dry powder inhaler
AU2006241145B2 (en) 2005-04-27 2011-04-28 Baxter Healthcare S. A. Surface-modified microparticles and methods of forming and using the same
US7219664B2 (en) 2005-04-28 2007-05-22 Kos Life Sciences, Inc. Breath actuated inhaler
CN101171182A (zh) 2005-05-02 2008-04-30 阿斯利康(瑞典)有限公司 用于开启凹部的装置和方法、医用密封包及分配设备
USD544093S1 (en) 2005-06-02 2007-06-05 Bang & Olufsen A/S Inhaler
HUE038177T2 (hu) 2005-06-17 2018-09-28 Wisconsin Alumni Res Found Topikális érösszehúzó készítmények és eljárás sejtek védelmére rák kemoterápia és radioterápia alatt
WO2007007110A1 (en) 2005-07-13 2007-01-18 Cipla Limited Inhaler device
US8763605B2 (en) * 2005-07-20 2014-07-01 Manta Devices, Llc Inhalation device
USD550835S1 (en) 2005-07-22 2007-09-11 Omron Healthcare Co., Ltd. Atomizer for inhaler
CN101232899A (zh) 2005-08-01 2008-07-30 曼金德公司 维持产胰岛素细胞功能的方法
CA2617909C (en) 2005-08-05 2014-02-04 3M Innovative Properties Company Compositions exhibiting improved flowability
EP1934805A4 (en) * 2005-08-25 2017-01-11 Oriel Therapeutics, Inc. Drug containment systems with sticks, related kits, dry powder inhalers and methods
US7900625B2 (en) 2005-08-26 2011-03-08 North Carolina State University Inhaler system for targeted maximum drug-aerosol delivery
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2007061281A (ja) 2005-08-30 2007-03-15 Hitachi Ltd 吸入量測定システム
US20100041612A1 (en) 2005-09-08 2010-02-18 Martin Beinborn Fragments of the Glucagon-Like Peptide-1 and Uses Thereof
CA2621806C (en) 2005-09-14 2016-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
USD540671S1 (en) 2005-09-21 2007-04-17 The Procter & Gamble Company Cap for product dispenser
US20070086952A1 (en) 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
US20070074989A1 (en) 2005-09-30 2007-04-05 Musculoskeletal Transplant Foundation Container for lyophilization and storage of tissue
GB0520794D0 (en) 2005-10-12 2005-11-23 Innovata Biomed Ltd Inhaler
ITMI20051999A1 (it) 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
USD566549S1 (en) 2005-10-26 2008-04-15 Reckitt Benckiser (Uk) Limited Cap
WO2007053946A1 (en) 2005-11-09 2007-05-18 Conjuchem Biotechnologies Inc. Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin
AR058290A1 (es) 2005-12-12 2008-01-30 Glaxo Group Ltd Dispensador de medicamento
AR058289A1 (es) 2005-12-12 2008-01-30 Glaxo Group Ltd Colector para ser usado en dispensador de medicamento
JP5096363B2 (ja) 2005-12-16 2012-12-12 ネクター セラピューティックス Ｇｌｐ−１のポリマ複合体
CA2932997C (en) 2006-01-24 2019-07-30 Nexbio, Inc. Technology for preparation of macromolecular microspheres
USD557798S1 (en) 2006-01-25 2007-12-18 Valois S.A.S. Inhaler
US7390949B2 (en) 2006-02-01 2008-06-24 Wanne, Inc. Saxophone and clarinet mouthpiece cap
GB0602897D0 (en) 2006-02-13 2006-03-22 Jagotec Ag Improvements In Or Relating To Dry Powder Inhaler Devices
EP1991840A1 (en) 2006-02-14 2008-11-19 Battelle Memorial Institute Accurate metering system
AU2007221366B2 (en) 2006-02-22 2012-08-23 Msd Italia S.R.L. Oxyntomodulin derivatives
WO2007098500A2 (en) 2006-02-22 2007-08-30 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
DE102006010089A1 (de) * 2006-02-24 2007-10-18 Aha-Kunststofftechnik Gmbh Trockenpulver-Inhalator
USD541151S1 (en) 2006-03-20 2007-04-24 The Procter & Gamble Company Cap for product dispenser
US8037880B2 (en) 2006-04-07 2011-10-18 The University Of Western Ontario Dry powder inhaler
EP2012817A2 (en) 2006-04-12 2009-01-14 Biodel, Inc. Rapid acting and long acting insulin combination formulations
EP1844809A1 (de) 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH & Co. KG Medikamentenmagazin für einen Inhalator, sowie Mehrdosispulverinhalator
EP1844806A1 (de) * 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH Medikamenten-Ausgabevorrichtung, Medikamentenmagazin dafür, und Verfahren zur Entnahme eines Medikaments aus einer Medikamentenkammer
US20070243216A1 (en) * 2006-04-14 2007-10-18 Stanley Kepka Stable solutions of prostaglandin and uses of same
KR20150042304A (ko) 2006-04-14 2015-04-20 맨카인드 코포레이션 글루카곤 유사 펩타이드 1 （ｇｌｐ-1） 약제학적 제제
GR1005620B (el) 2006-05-09 2007-09-03 Βελτιωση συσκευης εισπνοων ξηρης σκονης
US20090151720A1 (en) 2006-05-10 2009-06-18 S.K.I. Net, Inc. Small animal anesthesia system
DE102006021978A1 (de) 2006-05-10 2007-11-15 Robert Bosch Gmbh Vorrichtung und Verfahen zum Verstärken eines Blisters
PT103481B (pt) 2006-05-16 2008-08-01 Hovione Farmaciencia S A Inalador de uso simples e método de inalação
GB0611656D0 (en) 2006-06-13 2006-07-19 Cambridge Consultants Dry powder inhalers
GB0611659D0 (en) 2006-06-13 2006-07-19 Cambridge Consultants Dry powder inhalers
CN104841045A (zh) * 2006-06-16 2015-08-19 希普拉有限公司 改进的干燥粉末吸入器
WO2008001132A1 (en) 2006-06-27 2008-01-03 Brintech International Limited Inhaler
RU2436599C2 (ru) 2006-06-27 2011-12-20 Оцука Фармасьютикал Ко., Лтд. Порошковый ингалятор
GB0613161D0 (en) 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
USD550826S1 (en) 2006-07-05 2007-09-11 Daikin Industries Ltd. Air purifier
CN2917673Y (zh) * 2006-07-06 2007-07-04 兴安药业有限公司 一种胶囊型干粉吸入器
US20090250058A1 (en) 2006-07-14 2009-10-08 Astrazeneca Ab Inhalation System and Delivery Device for the Administration of a Drug in the Form of Dry Powder
JP2009544716A (ja) 2006-07-27 2009-12-17 ノバルティス アクチエンゲゼルシャフト 肺送達のためのインスリン含有エアロゾル化可能製剤
JP5357022B2 (ja) 2006-08-04 2013-12-04 マヌス ファーマシューティカルズ （カナダ） リミテッド 多機能生物活性化合物
GB0616299D0 (en) 2006-08-16 2006-09-27 Cambridge Consultants Drug Capsules for dry power inhalers
US20080066739A1 (en) 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
WO2008039863A2 (en) 2006-09-27 2008-04-03 Braincells, Inc. Composition comprising a melanocortin receptor (mcr) modulating agent alone or in combination with a second neurogenic agent for treating nervous system disorders
MX2009004349A (es) * 2006-10-25 2009-07-22 Novartis Ag Aparato de dispersion de polvo, metodo para hacer y usar el aparato, y componentes que se pueden usar en el aparato y otros dispositivos.
CA2667335A1 (en) 2006-11-10 2008-05-22 Proveris Scientific Corporation Automated nasal spray pump testing
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
MX2009005000A (es) 2006-11-10 2009-10-12 Cara Therapeutics Inc Amidas de peptidos sinteticos.
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US7824014B2 (en) 2006-12-05 2010-11-02 Canon Kabushiki Kaisha Head substrate, printhead, head cartridge, and printing apparatus
USD548618S1 (en) 2006-12-06 2007-08-14 Eveready Battery Company, Inc. Zinc-air hearing aid battery package
USD548619S1 (en) 2006-12-06 2007-08-14 Eveready Battery Company, Inc. Zinc-air hearing aid battery package
USD549111S1 (en) 2006-12-06 2007-08-21 Eveready Battery Company, Inc. Zinc-air hearing aid battery package
PT2063940E (pt) * 2006-12-22 2012-03-27 Almirall Sa Dispositivo de inalação para fármacos em forma de pó
WO2008092864A1 (en) 2007-01-29 2008-08-07 Novo Nordisk A/S Method and devices for aerosolizing a drug formulation
US8172817B2 (en) 2007-01-31 2012-05-08 Allegiance Corporation Liquid collection system and related methods
JP6017754B2 (ja) 2007-02-15 2016-11-02 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ グルカゴン／ｇｌｐ−１受容体コアゴニスト
US8196576B2 (en) * 2007-02-28 2012-06-12 Microdose Therapeutx, Inc. Inhaler
WO2009005546A1 (en) 2007-03-05 2009-01-08 Board of Governors for Higher Education, State of Rhode Island and the Providence Plantations High efficiency mouthpiece/adaptor for inhalers
JP2008212436A (ja) 2007-03-06 2008-09-18 Canon Inc 吸入装置
US8146745B2 (en) 2007-03-09 2012-04-03 Cardpak, Inc. Environmentally separable packaging device with attaching base
GB0704928D0 (en) 2007-03-14 2007-04-25 Cambridge Consultants Dry powder inhalers
US8688184B2 (en) 2007-04-11 2014-04-01 Starr Life Sciences Corporation Noninvasive photoplethysmographic sensor platform for mobile animals
JP4417400B2 (ja) 2007-04-16 2010-02-17 アンリツ株式会社 はんだ検査ライン集中管理システム、及びそれに用いられる管理装置
PL2157967T3 (pl) 2007-04-23 2013-06-28 Intarcia Therapeutics Inc Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania
HUE034380T2 (en) * 2007-04-30 2018-02-28 Sun Pharma Advanced Res Co Ltd Inhalation device
USD583463S1 (en) * 2007-04-30 2008-12-23 Sun Pharma Advanced Research Company Limited Inhaler
USD577815S1 (en) 2007-04-30 2008-09-30 Sun Pharma Advanced Research Company Limited Inhaler
CN101715428B (zh) 2007-05-16 2016-08-24 神秘制药公司 用于输送药物组成物的剂型和包括该剂型的剂量带
EP1992378A1 (en) 2007-05-16 2008-11-19 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device
USD579550S1 (en) 2007-06-07 2008-10-28 Novartis Ag Inhaler
KR101605210B1 (ko) 2007-06-21 2016-03-21 케러 테라퓨틱스, 인코포레이티드 치환된 이미다조헤테로사이클
JP5528336B2 (ja) 2007-07-06 2014-06-25 マンタ デバイシス，エルエルシー デリバリー装置及び関連方法
WO2009046072A1 (en) 2007-10-02 2009-04-09 Baxter International Inc Dry powder inhaler
EP2048112A1 (en) 2007-10-09 2009-04-15 Kemira Kemi AB Use of a nozzle for manufacturing sodium percarbonate
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
CN101969928B (zh) 2007-10-24 2014-05-07 曼金德公司 活性剂的递送
PL2211842T3 (pl) 2007-10-24 2015-12-31 Mannkind Corp Preparat suchego proszku do inhalacji zawierający glp-1 do stosowania w leczeniu hiperglikemii i cukrzycy w podawaniu płucnym
WO2009055030A2 (en) 2007-10-25 2009-04-30 Nektar Therapeutics Powder conditioning of unit dose drug packages
GB0721394D0 (en) 2007-10-31 2007-12-12 Vectura Group Plc Compositions for trating parkinson's disease
WO2009061895A2 (en) 2007-11-06 2009-05-14 3M Innovative Properties Company Medicinal inhalation devices and components thereof
EP2060268A1 (en) 2007-11-15 2009-05-20 Novo Nordisk A/S Pharmaceutical compositions for pulmonary or nasal delivery of peptides
TWM333904U (en) * 2007-11-27 2008-06-11 Jeng Chwei Entpr Co Ltd Asthma medication inhaler
USD594753S1 (en) 2007-12-14 2009-06-23 The Procter & Gamble Company Blister card
EP2534958A1 (en) 2007-12-14 2012-12-19 AeroDesigns, Inc Delivering aerosolizable food products
NZ586105A (en) 2007-12-20 2012-09-28 Astrazeneca Ab Dispenser and method for entraining powder in an airflow by creating eddies over recessed powder containing cavity within flat upstrean and downstream surfaces
US7584846B2 (en) 2007-12-21 2009-09-08 S.C. Johnson & Son, Inc. Shaped packaging for a refill
WO2009095684A1 (en) 2008-02-01 2009-08-06 Vectura Limited Pulmonary formulations of triptans
GB0802028D0 (en) * 2008-02-05 2008-03-12 Dunne Stephen T Powder inhaler flow regulator
USD614045S1 (en) 2008-02-22 2010-04-20 Ima Safe S.R.L. Blister packaging
BRPI0910875B8 (pt) 2008-03-27 2021-06-22 Mannkind Corp sistema de inalação de pó seco
US20110034385A1 (en) 2008-04-07 2011-02-10 National Institute Of Immunology Compositions Useful for the Treatment of Diabetes and Other Chronic Disorder
DE102008023376A1 (de) 2008-05-13 2009-11-19 Alfred Von Schuckmann Spender für in einer gesonderten Verpackung enthaltenen, pulverförmigen Massen
EP2285345A1 (en) 2008-05-15 2011-02-23 Novartis AG Pulmonary delivery of a fluoroquinolone
USD597418S1 (en) 2008-05-22 2009-08-04 Wm. Wrigley Jr. Company Blister card
USD598785S1 (en) 2008-05-22 2009-08-25 Wm. Wrigley Jr. Company Blister card
USD605753S1 (en) 2008-06-13 2009-12-08 Mannkind Corporation Cartridge for a dry powder inhaler
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
AU2009257311B2 (en) 2008-06-13 2014-12-04 Mannkind Corporation A dry powder inhaler and system for drug delivery
USD605752S1 (en) 2008-06-13 2009-12-08 Mannkind Corporation Dry powder inhaler
USD613849S1 (en) 2008-06-13 2010-04-13 Mannkind Corporation Cartridge for a dry powder inhaler
USD614760S1 (en) 2008-06-13 2010-04-27 Mannkind Corporation Dry powder inhaler
USD635241S1 (en) 2008-06-13 2011-03-29 Mannkind Corporation Dry powder inhaler
USD597657S1 (en) 2008-06-13 2009-08-04 Mannkind Corporation Dry powder inhaler
USD604832S1 (en) 2008-06-13 2009-11-24 Mannkind Corporation Cartridge for a dry powder inhaler
USD604833S1 (en) 2008-06-13 2009-11-24 Mannkind Corporation Dry powder inhaler
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
WO2010036355A2 (en) * 2008-09-26 2010-04-01 Oriel Therapeutics, Inc. Inhaler mechanisms with radially biased piercers and related methods
USD629505S1 (en) 2008-12-01 2010-12-21 Mannkind Corporation Dry powder inhaler
USD635243S1 (en) 2008-12-01 2011-03-29 Mannkind Corporation Dry powder inhaler
USD635242S1 (en) 2008-12-01 2011-03-29 Mannkind Corporation Dry powder inhaler
USD629886S1 (en) 2008-12-01 2010-12-28 Mannkind Corporation Dry powder inhaler
USD629506S1 (en) 2008-12-01 2010-12-21 Mannkind Corporation Dry powder inhaler
USD629887S1 (en) 2008-12-01 2010-12-28 Mannkind Corporation Dry powder inhaler
USD629888S1 (en) 2008-12-01 2010-12-28 Mannkind Corporation Dry powder inhaler
ES2531009T3 (es) 2008-12-29 2015-03-09 Mannkind Corp Análogos sustituidos de dicetopiperazina para su uso como agentes para la administración de fármacos
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2749099A1 (en) 2009-01-08 2010-07-15 Mannkind Corporation Method for treating hyperglycemia with glp-1
WO2010083042A1 (en) * 2009-01-15 2010-07-22 Manta Devices, Llc Delivery device
WO2010102148A2 (en) 2009-03-04 2010-09-10 Mannkind Corporation An improved dry powder drug delivery system
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
JP5671519B2 (ja) 2009-03-18 2015-02-18 マンカインド コーポレイション レーザ回折装置用の吸入器アダプタおよび粒径分布を測定するための方法
GB0907425D0 (en) 2009-04-29 2009-06-10 Glaxo Group Ltd Compounds
USD626836S1 (en) 2009-04-30 2010-11-09 Bryce Lien Bottle cap
USD628090S1 (en) 2009-05-07 2010-11-30 Mccormick & Company, Incorporated Seasoning package
USD620375S1 (en) 2009-05-11 2010-07-27 Mcneil-Ppc, Inc. Blister
CN102438685B (zh) 2009-05-21 2014-07-02 微剂量治疗技术公司 用于干粉吸入器的旋转盒系统
CN107412212B (zh) 2009-05-29 2021-01-22 珍珠治疗公司 经肺递送长效毒蕈碱拮抗剂及长效β2肾上腺素能受体激动剂的组合物及相关方法与系统
CN104721825B (zh) 2009-06-12 2019-04-12 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
AU2010259939B2 (en) 2009-06-12 2012-07-05 Mannkind Corporation Diketopiperazine microparticles with defined isomer contents
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US8642548B2 (en) 2009-08-07 2014-02-04 Mannkind Corporation Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome
US8962063B2 (en) 2009-08-27 2015-02-24 St.Unm Methods and systems for dosing and coating inhalation powders onto carrier particles
IT1395945B1 (it) 2009-09-30 2012-11-02 Oliva Inalatore perfezionato per preparati in polvere
USD647195S1 (en) 2009-10-09 2011-10-18 Vectura Delivery Devices Limited Inhaler having cover
USD647196S1 (en) 2009-10-09 2011-10-18 Vectura Delivery Devices Limited Inhaler having cover
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
USD650295S1 (en) 2009-11-13 2011-12-13 Avidiamed Gmbh Blister pack for pharmaceuticals
AU2010336338B2 (en) 2009-12-23 2015-02-19 Map Pharmaceuticals, Inc. Enhanced eductor design
EP3443977A1 (en) 2009-12-31 2019-02-20 Stealth Peptides International, Inc. Methods for performing a coronary artery bypass graft procedure
AU332056S (en) 2010-01-08 2010-08-04 Teva Pharma Ireland Inhaler
USD641076S1 (en) 2010-03-26 2011-07-05 Oriel Therapeutics, Inc. Dry powder inhaler
GB201006901D0 (en) 2010-04-26 2010-06-09 Sagentia Ltd Device for monitoring status and use of an inhalation or nasal drug delivery device
PT105065B (pt) 2010-04-26 2012-07-31 Hovione Farmaciencia S A Um inalador simples de cápsulas
USD645954S1 (en) 2010-05-21 2011-09-27 Consort Medical Plc Mechanical dosage counter apparatus
USD636868S1 (en) 2010-06-14 2011-04-26 Mannkind Corporation Dry powder inhaler
USD636869S1 (en) 2010-06-14 2011-04-26 Mannkind Corporation Dry powder inhaler
USD636867S1 (en) 2010-06-14 2011-04-26 Mannkind Corporation Dry powder inhaler
CN101851213A (zh) 2010-06-21 2010-10-06 于清 3，6-双(4-双反丁烯二酰基氨丁基)-2，5-二酮哌嗪及其盐取代物的合成方法
JP6385673B2 (ja) 2010-06-21 2018-09-05 マンカインド コーポレイション 乾燥粉末薬物送達システム
USD643308S1 (en) 2010-09-28 2011-08-16 Mannkind Corporation Blister packaging
PT3470057T (pt) 2010-09-29 2021-12-03 Pulmatrix Operating Co Inc Pós secos catiónicos compreendendo sais de magnésio
MX340112B (es) 2010-11-09 2016-06-27 Mannkind Corp Composicion que comprende un agonista de receptor de serotonina y una dicetopiperazina para el tratamiento de migrañas.
AU337357S (en) 2010-12-01 2011-06-27 Teva Pharma Inhaler
USD642483S1 (en) 2010-12-03 2011-08-02 Mccormick & Company, Incorporated Seasoning package
CA2826973C (en) 2011-02-10 2020-03-24 Mannkind, Corp Formation of n-protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine
RU2569776C2 (ru) 2011-04-01 2015-11-27 Маннкайнд Корпорейшн Блистерная упаковка для фармацевтических картриджей
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
LT2739268T (lt) 2011-08-01 2019-03-25 Monash University Inhaliacijos būdas ir kompozicija
USD674893S1 (en) 2011-10-20 2013-01-22 Mannkind Corporation Inhaler device
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CN102436238B (zh) 2011-11-03 2014-04-16 广东轻工职业技术学院 基于生产线数据采集及信息管理系统的数据采集方法
MX361470B (es) 2012-04-27 2018-12-06 Mannkind Corp Métodos para la síntesis de etilfumaratos y su uso como intermediarios.
EP2872205B1 (en) 2012-07-12 2017-02-08 MannKind Corporation Dry powder drug delivery systems
AU2013308693A1 (en) 2012-08-29 2015-03-12 Mannkind Corporation Method and composition for treating hyperglycemia
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
USD711740S1 (en) 2013-01-22 2014-08-26 H204K9, Inc. Bottle cap
SG11201507564PA (en) 2013-03-15 2015-10-29 Mannkind Corp Microcrystalline diketopiperazine compositions and methods
MX2020009878A (es) 2013-07-18 2022-07-27 Mannkind Corp Composiciones farmaceuticas en polvo seco estables al calor y metodos.
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
GB201319265D0 (en) 2013-10-31 2013-12-18 Norton Waterford Ltd Medicament inhaler
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
USD771237S1 (en) 2014-10-02 2016-11-08 Mannkind Corporation Mouthpiece cover
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN114904100A (zh) 2016-01-29 2022-08-16 曼金德公司 干粉吸入器

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