PT2254869T - Novos derivados de 1-benzil-3-hidroximetilindazole e suas utilizações no tratamento de doenças com base na expressão de cx3cr1 e p40 - Google Patents

Novos derivados de 1-benzil-3-hidroximetilindazole e suas utilizações no tratamento de doenças com base na expressão de cx3cr1 e p40

Info

Publication number: PT2254869T
Authority: PT; Portugal
Prior art keywords: cx3cr1; benzyl; expression; novel; treatment
Prior art date: 2008-03-07

Application number

PT97176382T

Other languages

English (en)

Inventor

Guglielmotti Angelo

Furlotti Guido

Mangano Giorgina

Cazzolla Nicola

Garofalo Barbara

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-07

Filing date

2009-03-05

Publication date

2017-07-18

2009-03-05 Application filed by Acraf filed Critical Acraf

2017-07-18 Publication of PT2254869T publication Critical patent/PT2254869T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Oncology (AREA)
Dermatology (AREA)
Virology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Molecular Biology (AREA)

PT97176382T 2008-03-07 2009-03-05 Novos derivados de 1-benzil-3-hidroximetilindazole e suas utilizações no tratamento de doenças com base na expressão de cx3cr1 e p40 PT2254869T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP08425139		2008-03-07

Publications (1)

Publication Number	Publication Date
PT2254869T true PT2254869T (pt)	2017-07-18

Family

ID=39671487

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97176382T PT2254869T (pt)	2008-03-07	2009-03-05	Novos derivados de 1-benzil-3-hidroximetilindazole e suas utilizações no tratamento de doenças com base na expressão de cx3cr1 e p40

Country Status (25)

Country	Link
US (3)	US7919518B2 (pt)
EP (3)	EP3181551A1 (pt)
JP (2)	JP5509101B2 (pt)
KR (2)	KR101581828B1 (pt)
CN (2)	CN101945855B (pt)
AR (2)	AR070810A1 (pt)
AU (2)	AU2009221089B2 (pt)
BR (2)	BRPI0907977A2 (pt)
CA (2)	CA2712703C (pt)
CY (2)	CY1117584T1 (pt)
DK (2)	DK2254870T3 (pt)
EA (2)	EA018241B1 (pt)
ES (2)	ES2637009T3 (pt)
GE (2)	GEP20135912B (pt)
HR (2)	HRP20160462T1 (pt)
HU (1)	HUE027098T2 (pt)
IL (3)	IL206893A0 (pt)
LT (1)	LT2254869T (pt)
MX (2)	MX2010009623A (pt)
PL (2)	PL2254870T3 (pt)
PT (1)	PT2254869T (pt)
SG (1)	SG188177A1 (pt)
SI (2)	SI2254870T1 (pt)
UA (2)	UA105170C2 (pt)
WO (2)	WO2009109613A2 (pt)

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PT2262778T (pt)	2008-03-07	2019-11-19	Acraf	Derivados de 1-benzil-3-hidroximetilindazolo e utilização dos mesmos no tratamento de doenças baseadas na expressão de mcp-1, cxcr1 e p40
AU2009221063B2 (en)	2008-03-07	2013-03-21	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
ES2637009T3 (es) *	2008-03-07	2017-10-10	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Nuevos derivados de 1-bencil-3-hidroximetilindazol y su utilización en el tratamiento de enfermedades basadas en la expresión de CX3CR1 y p40
SG176885A1 (en) *	2009-08-03	2012-01-30	Acraf	Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates
UA108742C2 (uk) *	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8999292B2 (en) *	2012-05-01	2015-04-07	Translatum Medicus Inc.	Methods for treating and diagnosing blinding eye diseases
WO2013163758A1 (en) *	2012-05-01	2013-11-07	Boyd Shelley Romayne	Methods for treating and diagnosing blinding eye diseases
EP2850062B1 (en)	2012-05-18	2017-07-19	Sanofi	Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
KR20150010973A (ko) *	2012-05-18	2015-01-29	사노피	피라졸 유도체 및 lpar5 길항제로서의 그의 용도
US10918588B2 (en)	2012-11-09	2021-02-16	Colgate-Palmolive Company	Block copolymers for tooth enamel protection
ES2789849T3 (es) *	2014-05-15	2020-10-26	Translatum Medicus Inc	Composiciones y procedimientos para el tratamiento y diagnóstico de trastornos oculares
EP3942934A1 (en) *	2015-06-12	2022-01-26	Vettore, LLC	Mct4 inhibitors for treating disease
US20180221339A1 (en) *	2015-06-16	2018-08-09	Translatum Medicus, Inc.	Compositions and methods for treating and diagnosing ocular disorders
DK3551625T3 (da)	2016-12-12	2024-09-02	Vettore Llc	Heterocykliske inhibitorer af mct4
GB201811169D0 (en)	2018-07-06	2018-08-29	Kancera Ab	New compounds
JP6612004B1 (ja) *	2018-07-31	2019-11-27	株式会社親広産業	グルコース消費促進剤および解糖系促進剤
WO2020026471A1 (ja) *	2018-07-31	2020-02-06	株式会社親広産業	グルコース消費促進剤および解糖系促進剤
WO2020261158A1 (en) *	2019-06-25	2020-12-30	Translatum Medicus Inc.	Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) *	2021-10-19	2022-01-14	吕梁学院	一种宾达利的合成方法
WO2024108386A1 (zh) *	2022-11-22	2024-05-30	中国科学院深圳先进技术研究院	抗mcp1中和抗体在制备治疗神经退行性疾病引起的系统性炎症药物中的应用
WO2024165925A1 (en) *	2023-02-10	2024-08-15	Translatum Medicus Inc.	Bindarit conjugates, compositions and methods for treating ocular diseases or disorders

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US364371A (en) *		1887-06-07		peice
IT1230441B (it) *	1989-02-07	1991-10-23	Acraf	Eteri della serie dell'indazolo
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IT1293795B1 (it) *	1997-07-28	1999-03-10	Angelini Ricerche Spa	Farmaco attivo nel ridurre la produzione di proteina mcp-1
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PT2262778T (pt) *	2008-03-07	2019-11-19	Acraf	Derivados de 1-benzil-3-hidroximetilindazolo e utilização dos mesmos no tratamento de doenças baseadas na expressão de mcp-1, cxcr1 e p40
ES2637009T3 (es) *	2008-03-07	2017-10-10	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Nuevos derivados de 1-bencil-3-hidroximetilindazol y su utilización en el tratamiento de enfermedades basadas en la expresión de CX3CR1 y p40
AU2009221063B2 (en) *	2008-03-07	2013-03-21	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1

2009
- 2009-03-05 ES ES09717638.2T patent/ES2637009T3/es active Active
- 2009-03-05 CA CA2712703A patent/CA2712703C/en not_active Expired - Fee Related
- 2009-03-05 GE GEAP200911965A patent/GEP20135912B/en unknown
- 2009-03-05 EA EA201071038A patent/EA018241B1/ru not_active IP Right Cessation
- 2009-03-05 DK DK09718467.5T patent/DK2254870T3/en active
- 2009-03-05 KR KR1020107017806A patent/KR101581828B1/ko not_active IP Right Cessation
- 2009-03-05 MX MX2010009623A patent/MX2010009623A/es active IP Right Grant
- 2009-03-05 PT PT97176382T patent/PT2254869T/pt unknown
- 2009-03-05 CN CN200980105073.4A patent/CN101945855B/zh not_active Expired - Fee Related
- 2009-03-05 BR BRPI0907977-7A patent/BRPI0907977A2/pt not_active IP Right Cessation
- 2009-03-05 EP EP17153930.7A patent/EP3181551A1/en not_active Withdrawn
- 2009-03-05 CA CA2712403A patent/CA2712403C/en not_active Expired - Fee Related
- 2009-03-05 SG SG2013013123A patent/SG188177A1/en unknown
- 2009-03-05 BR BRPI0907976-9A patent/BRPI0907976A2/pt not_active IP Right Cessation
- 2009-03-05 HU HUE09718467A patent/HUE027098T2/en unknown
- 2009-03-05 AU AU2009221089A patent/AU2009221089B2/en not_active Ceased
- 2009-03-05 JP JP2010549146A patent/JP5509101B2/ja active Active
- 2009-03-05 JP JP2010549143A patent/JP5509099B2/ja active Active
- 2009-03-05 WO PCT/EP2009/052585 patent/WO2009109613A2/en active Application Filing
- 2009-03-05 CN CN200980105556.4A patent/CN101952256B/zh not_active Expired - Fee Related
- 2009-03-05 GE GEAP200911963A patent/GEP20135983B/en unknown
- 2009-03-05 EP EP09718467.5A patent/EP2254870B1/en active Active
- 2009-03-05 WO PCT/EP2009/052590 patent/WO2009109618A2/en active Application Filing
- 2009-03-05 DK DK09717638.2T patent/DK2254869T3/en active
- 2009-03-05 KR KR1020107017445A patent/KR101599867B1/ko not_active IP Right Cessation
- 2009-03-05 ES ES09718467.5T patent/ES2569330T3/es active Active
- 2009-03-05 MX MX2010009626A patent/MX2010009626A/es active IP Right Grant
- 2009-03-05 PL PL09718467T patent/PL2254870T3/pl unknown
- 2009-03-05 SI SI200931404A patent/SI2254870T1/sl unknown
- 2009-03-05 LT LTEP09717638.2T patent/LT2254869T/lt unknown
- 2009-03-05 EA EA201071040A patent/EA019711B1/ru not_active IP Right Cessation
- 2009-03-05 US US12/864,767 patent/US7919518B2/en not_active Expired - Fee Related
- 2009-03-05 US US12/865,923 patent/US8835481B2/en not_active Expired - Fee Related
- 2009-03-05 EP EP09717638.2A patent/EP2254869B1/en active Active
- 2009-03-05 PL PL09717638T patent/PL2254869T3/pl unknown
- 2009-03-05 AU AU2009221083A patent/AU2009221083B2/en not_active Ceased
- 2009-03-05 SI SI200931705T patent/SI2254869T1/sl unknown
- 2009-03-06 AR ARP090100800A patent/AR070810A1/es unknown
- 2009-03-06 AR ARP090100801A patent/AR070811A1/es unknown
- 2009-05-03 UA UAA201008570A patent/UA105170C2/uk unknown
- 2009-05-03 UA UAA201008883A patent/UA103605C2/uk unknown
2010
- 2010-07-08 IL IL206893A patent/IL206893A0/en not_active IP Right Cessation
- 2010-07-21 IL IL207131A patent/IL207131A/en not_active IP Right Cessation
2011
- 2011-03-07 US US13/041,557 patent/US8283348B2/en not_active Expired - Fee Related
- 2011-10-06 IL IL215579A patent/IL215579A/en not_active IP Right Cessation
2016
- 2016-05-02 HR HRP20160462TT patent/HRP20160462T1/hr unknown
- 2016-05-13 CY CY20161100406T patent/CY1117584T1/el unknown
2017
- 2017-08-07 HR HRP20171208TT patent/HRP20171208T1/hr unknown
- 2017-08-09 CY CY20171100858T patent/CY1119252T1/el unknown

Also Published As

Publication number	Publication date
EP3181551A1 (en)	2017-06-21
EA018241B1 (ru)	2013-06-28
CN101945855B (zh)	2014-12-17
EA201071038A1 (ru)	2011-02-28
PL2254869T3 (pl)	2017-10-31
CN101952256A (zh)	2011-01-19
BRPI0907976A2 (pt)	2015-08-04
SG188177A1 (en)	2013-03-28
GEP20135983B (en)	2013-12-10
PL2254870T3 (pl)	2016-07-29
CA2712403C (en)	2017-06-06
AU2009221083B2 (en)	2013-11-28
BRPI0907977A2 (pt)	2015-08-04
JP2011513367A (ja)	2011-04-28
JP2011513365A (ja)	2011-04-28
HRP20160462T1 (hr)	2016-06-03
IL206893A0 (en)	2010-12-30
KR20100133957A (ko)	2010-12-22
LT2254869T (lt)	2017-08-10
UA105170C2 (en)	2014-04-25
CA2712703C (en)	2016-10-11
US20110160205A1 (en)	2011-06-30
MX2010009623A (es)	2010-09-28
US7919518B2 (en)	2011-04-05
WO2009109613A3 (en)	2009-12-10
DK2254870T3 (en)	2016-05-17
HUE027098T2 (en)	2016-08-29
AR070810A1 (es)	2010-05-05
CA2712403A1 (en)	2009-09-11
IL215579A0 (en)	2011-11-30
GEP20135912B (en)	2013-08-26
DK2254869T3 (en)	2017-09-04
ES2569330T3 (es)	2016-05-10
EP2254870B1 (en)	2016-02-24
CY1117584T1 (el)	2017-04-26
US20110003874A1 (en)	2011-01-06
EP2254870A2 (en)	2010-12-01
EA201071040A1 (ru)	2011-02-28
IL207131A (en)	2013-02-28
EA019711B1 (ru)	2014-05-30
US8835481B2 (en)	2014-09-16
MX2010009626A (es)	2010-12-20
AU2009221089A1 (en)	2009-09-11
KR20100131432A (ko)	2010-12-15
US20100311744A1 (en)	2010-12-09
AR070811A1 (es)	2010-05-05
US8283348B2 (en)	2012-10-09
EP2254869A2 (en)	2010-12-01
ES2637009T3 (es)	2017-10-10
JP5509099B2 (ja)	2014-06-04
CN101945855A (zh)	2011-01-12
CN101952256B (zh)	2016-03-16
AU2009221083A1 (en)	2009-09-11
HRP20171208T1 (hr)	2017-10-06
EP2254869B1 (en)	2017-05-31
SI2254869T1 (sl)	2017-10-30
IL215579A (en)	2015-06-30
WO2009109613A2 (en)	2009-09-11
KR101599867B1 (ko)	2016-03-04
CA2712703A1 (en)	2009-09-11
UA103605C2 (en)	2013-11-11
JP5509101B2 (ja)	2014-06-04
WO2009109618A2 (en)	2009-09-11
AU2009221089B2 (en)	2013-12-05
CY1119252T1 (el)	2018-02-14
SI2254870T1 (sl)	2016-05-31
WO2009109618A3 (en)	2009-12-10
IL207131A0 (en)	2010-12-30
KR101581828B1 (ko)	2015-12-31

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