PL2254869T3 - Nowe pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób bazujących na ekspresji CX3CR1 i p40 - Google Patents

Nowe pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób bazujących na ekspresji CX3CR1 i p40

Info

Publication number: PL2254869T3
Authority: PL; Poland
Prior art keywords: cx3cr1; neue; und; benzyl; expression
Prior art date: 2008-03-07

Application number

PL09717638T

Other languages

English (en)

Inventor

Angelo Guglielmotti

Guido Furlotti

Giorgina Mangano

Nicola Cazzolla

Barbara Garofalo

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-07

Filing date

2009-03-05

Publication date

2017-10-31

2009-03-05 Application filed by Acraf filed Critical Acraf

2017-10-31 Publication of PL2254869T3 publication Critical patent/PL2254869T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Oncology (AREA)
Dermatology (AREA)
Virology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Molecular Biology (AREA)

PL09717638T 2008-03-07 2009-03-05 Nowe pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób bazujących na ekspresji CX3CR1 i p40 PL2254869T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08425139		2008-03-07
PCT/EP2009/052585 WO2009109613A2 (en)	2008-03-07	2009-03-05	Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
EP09717638.2A EP2254869B1 (en)	2008-03-07	2009-03-05	Neue 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of cx3cr1 und p40

Publications (1)

Publication Number	Publication Date
PL2254869T3 true PL2254869T3 (pl)	2017-10-31

Family

ID=39671487

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL09718467T PL2254870T3 (pl)	2008-03-07	2009-03-05	Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CX3CR1
PL09717638T PL2254869T3 (pl)	2008-03-07	2009-03-05	Nowe pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób bazujących na ekspresji CX3CR1 i p40

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL09718467T PL2254870T3 (pl)	2008-03-07	2009-03-05	Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CX3CR1

Country Status (25)

Country	Link
US (3)	US7919518B2 (pl)
EP (3)	EP3181551A1 (pl)
JP (2)	JP5509101B2 (pl)
KR (2)	KR101581828B1 (pl)
CN (2)	CN101945855B (pl)
AR (2)	AR070810A1 (pl)
AU (2)	AU2009221089B2 (pl)
BR (2)	BRPI0907977A2 (pl)
CA (2)	CA2712703C (pl)
CY (2)	CY1117584T1 (pl)
DK (2)	DK2254870T3 (pl)
EA (2)	EA018241B1 (pl)
ES (2)	ES2637009T3 (pl)
GE (2)	GEP20135912B (pl)
HR (2)	HRP20160462T1 (pl)
HU (1)	HUE027098T2 (pl)
IL (3)	IL206893A0 (pl)
LT (1)	LT2254869T (pl)
MX (2)	MX2010009623A (pl)
PL (2)	PL2254870T3 (pl)
PT (1)	PT2254869T (pl)
SG (1)	SG188177A1 (pl)
SI (2)	SI2254870T1 (pl)
UA (2)	UA105170C2 (pl)
WO (2)	WO2009109613A2 (pl)

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PT2262778T (pt)	2008-03-07	2019-11-19	Acraf	Derivados de 1-benzil-3-hidroximetilindazolo e utilização dos mesmos no tratamento de doenças baseadas na expressão de mcp-1, cxcr1 e p40
AU2009221063B2 (en)	2008-03-07	2013-03-21	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
ES2637009T3 (es) *	2008-03-07	2017-10-10	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Nuevos derivados de 1-bencil-3-hidroximetilindazol y su utilización en el tratamiento de enfermedades basadas en la expresión de CX3CR1 y p40
SG176885A1 (en) *	2009-08-03	2012-01-30	Acraf	Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates
UA108742C2 (uk) *	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8999292B2 (en) *	2012-05-01	2015-04-07	Translatum Medicus Inc.	Methods for treating and diagnosing blinding eye diseases
WO2013163758A1 (en) *	2012-05-01	2013-11-07	Boyd Shelley Romayne	Methods for treating and diagnosing blinding eye diseases
EP2850062B1 (en)	2012-05-18	2017-07-19	Sanofi	Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
KR20150010973A (ko) *	2012-05-18	2015-01-29	사노피	피라졸 유도체 및 lpar5 길항제로서의 그의 용도
US10918588B2 (en)	2012-11-09	2021-02-16	Colgate-Palmolive Company	Block copolymers for tooth enamel protection
ES2789849T3 (es) *	2014-05-15	2020-10-26	Translatum Medicus Inc	Composiciones y procedimientos para el tratamiento y diagnóstico de trastornos oculares
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US20180221339A1 (en) *	2015-06-16	2018-08-09	Translatum Medicus, Inc.	Compositions and methods for treating and diagnosing ocular disorders
DK3551625T3 (da)	2016-12-12	2024-09-02	Vettore Llc	Heterocykliske inhibitorer af mct4
GB201811169D0 (en)	2018-07-06	2018-08-29	Kancera Ab	New compounds
JP6612004B1 (ja) *	2018-07-31	2019-11-27	株式会社親広産業	グルコース消費促進剤および解糖系促進剤
WO2020026471A1 (ja) *	2018-07-31	2020-02-06	株式会社親広産業	グルコース消費促進剤および解糖系促進剤
WO2020261158A1 (en) *	2019-06-25	2020-12-30	Translatum Medicus Inc.	Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) *	2021-10-19	2022-01-14	吕梁学院	一种宾达利的合成方法
WO2024108386A1 (zh) *	2022-11-22	2024-05-30	中国科学院深圳先进技术研究院	抗mcp1中和抗体在制备治疗神经退行性疾病引起的系统性炎症药物中的应用
WO2024165925A1 (en) *	2023-02-10	2024-08-15	Translatum Medicus Inc.	Bindarit conjugates, compositions and methods for treating ocular diseases or disorders

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PT2262778T (pt) *	2008-03-07	2019-11-19	Acraf	Derivados de 1-benzil-3-hidroximetilindazolo e utilização dos mesmos no tratamento de doenças baseadas na expressão de mcp-1, cxcr1 e p40
ES2637009T3 (es) *	2008-03-07	2017-10-10	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Nuevos derivados de 1-bencil-3-hidroximetilindazol y su utilización en el tratamiento de enfermedades basadas en la expresión de CX3CR1 y p40
AU2009221063B2 (en) *	2008-03-07	2013-03-21	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1

2009
- 2009-03-05 ES ES09717638.2T patent/ES2637009T3/es active Active
- 2009-03-05 CA CA2712703A patent/CA2712703C/en not_active Expired - Fee Related
- 2009-03-05 GE GEAP200911965A patent/GEP20135912B/en unknown
- 2009-03-05 EA EA201071038A patent/EA018241B1/ru not_active IP Right Cessation
- 2009-03-05 DK DK09718467.5T patent/DK2254870T3/en active
- 2009-03-05 KR KR1020107017806A patent/KR101581828B1/ko not_active IP Right Cessation
- 2009-03-05 MX MX2010009623A patent/MX2010009623A/es active IP Right Grant
- 2009-03-05 PT PT97176382T patent/PT2254869T/pt unknown
- 2009-03-05 CN CN200980105073.4A patent/CN101945855B/zh not_active Expired - Fee Related
- 2009-03-05 BR BRPI0907977-7A patent/BRPI0907977A2/pt not_active IP Right Cessation
- 2009-03-05 EP EP17153930.7A patent/EP3181551A1/en not_active Withdrawn
- 2009-03-05 CA CA2712403A patent/CA2712403C/en not_active Expired - Fee Related
- 2009-03-05 SG SG2013013123A patent/SG188177A1/en unknown
- 2009-03-05 BR BRPI0907976-9A patent/BRPI0907976A2/pt not_active IP Right Cessation
- 2009-03-05 HU HUE09718467A patent/HUE027098T2/en unknown
- 2009-03-05 AU AU2009221089A patent/AU2009221089B2/en not_active Ceased
- 2009-03-05 JP JP2010549146A patent/JP5509101B2/ja active Active
- 2009-03-05 JP JP2010549143A patent/JP5509099B2/ja active Active
- 2009-03-05 WO PCT/EP2009/052585 patent/WO2009109613A2/en active Application Filing
- 2009-03-05 CN CN200980105556.4A patent/CN101952256B/zh not_active Expired - Fee Related
- 2009-03-05 GE GEAP200911963A patent/GEP20135983B/en unknown
- 2009-03-05 EP EP09718467.5A patent/EP2254870B1/en active Active
- 2009-03-05 WO PCT/EP2009/052590 patent/WO2009109618A2/en active Application Filing
- 2009-03-05 DK DK09717638.2T patent/DK2254869T3/en active
- 2009-03-05 KR KR1020107017445A patent/KR101599867B1/ko not_active IP Right Cessation
- 2009-03-05 ES ES09718467.5T patent/ES2569330T3/es active Active
- 2009-03-05 MX MX2010009626A patent/MX2010009626A/es active IP Right Grant
- 2009-03-05 PL PL09718467T patent/PL2254870T3/pl unknown
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Also Published As

Publication number	Publication date
EP3181551A1 (en)	2017-06-21
EA018241B1 (ru)	2013-06-28
CN101945855B (zh)	2014-12-17
EA201071038A1 (ru)	2011-02-28
CN101952256A (zh)	2011-01-19
BRPI0907976A2 (pt)	2015-08-04
SG188177A1 (en)	2013-03-28
GEP20135983B (en)	2013-12-10
PL2254870T3 (pl)	2016-07-29
CA2712403C (en)	2017-06-06
AU2009221083B2 (en)	2013-11-28
BRPI0907977A2 (pt)	2015-08-04
JP2011513367A (ja)	2011-04-28
JP2011513365A (ja)	2011-04-28
HRP20160462T1 (hr)	2016-06-03
IL206893A0 (en)	2010-12-30
KR20100133957A (ko)	2010-12-22
LT2254869T (lt)	2017-08-10
UA105170C2 (en)	2014-04-25
CA2712703C (en)	2016-10-11
US20110160205A1 (en)	2011-06-30
MX2010009623A (es)	2010-09-28
US7919518B2 (en)	2011-04-05
WO2009109613A3 (en)	2009-12-10
PT2254869T (pt)	2017-07-18
DK2254870T3 (en)	2016-05-17
HUE027098T2 (en)	2016-08-29
AR070810A1 (es)	2010-05-05
CA2712403A1 (en)	2009-09-11
IL215579A0 (en)	2011-11-30
GEP20135912B (en)	2013-08-26
DK2254869T3 (en)	2017-09-04
ES2569330T3 (es)	2016-05-10
EP2254870B1 (en)	2016-02-24
CY1117584T1 (el)	2017-04-26
US20110003874A1 (en)	2011-01-06
EP2254870A2 (en)	2010-12-01
EA201071040A1 (ru)	2011-02-28
IL207131A (en)	2013-02-28
EA019711B1 (ru)	2014-05-30
US8835481B2 (en)	2014-09-16
MX2010009626A (es)	2010-12-20
AU2009221089A1 (en)	2009-09-11
KR20100131432A (ko)	2010-12-15
US20100311744A1 (en)	2010-12-09
AR070811A1 (es)	2010-05-05
US8283348B2 (en)	2012-10-09
EP2254869A2 (en)	2010-12-01
ES2637009T3 (es)	2017-10-10
JP5509099B2 (ja)	2014-06-04
CN101945855A (zh)	2011-01-12
CN101952256B (zh)	2016-03-16
AU2009221083A1 (en)	2009-09-11
HRP20171208T1 (hr)	2017-10-06
EP2254869B1 (en)	2017-05-31
SI2254869T1 (sl)	2017-10-30
IL215579A (en)	2015-06-30
WO2009109613A2 (en)	2009-09-11
KR101599867B1 (ko)	2016-03-04
CA2712703A1 (en)	2009-09-11
UA103605C2 (en)	2013-11-11
JP5509101B2 (ja)	2014-06-04
WO2009109618A2 (en)	2009-09-11
AU2009221089B2 (en)	2013-12-05
CY1119252T1 (el)	2018-02-14
SI2254870T1 (sl)	2016-05-31
WO2009109618A3 (en)	2009-12-10
IL207131A0 (en)	2010-12-30
KR101581828B1 (ko)	2015-12-31

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