CY1119252T1 - Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40 - Google Patents
Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40Info
- Publication number
- CY1119252T1 CY1119252T1 CY20171100858T CY171100858T CY1119252T1 CY 1119252 T1 CY1119252 T1 CY 1119252T1 CY 20171100858 T CY20171100858 T CY 20171100858T CY 171100858 T CY171100858 T CY 171100858T CY 1119252 T1 CY1119252 T1 CY 1119252T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cx3cr1
- expression
- hydroxymethylundazolis
- benzylo
- new products
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
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- Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε νέα παράγωγα της 1-βενζυλο-3-υδροξυμεθυλινδαζόλης σύμφωνα με τον Τύπο (I) που περιγράφεται στις αξιώσεις και σε μια φαρμακευτική σύνθεση που περιέχει αυτά, μαζί με ένα φαρμακευτικά αποδεκτό κυστίδιο. Επιπλέον, η παρούσα εφεύρεση σχετίζεται με τη χρήση παραγώγων της 1-βενζυλο-3-υδροξυμεθυλινδαζόλης για την παρασκευή μιας φαρμακευτικής σύνθεσης η οποία είναι δραστική στη θεραπεία νόσων που βασίζονται στην έκφραση των MCP-1, CX3CR1 και p40, και στη χρήση αυτών σε μια μέθοδο αντιμετώπισης ή πρόληψης νόσων που βασίζονται στην έκφραση των MCP-1, CX3CR1 και p40.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08425139 | 2008-03-07 | ||
| PCT/EP2009/052585 WO2009109613A2 (en) | 2008-03-07 | 2009-03-05 | Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 |
| EP09717638.2A EP2254869B1 (en) | 2008-03-07 | 2009-03-05 | Neue 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of cx3cr1 und p40 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119252T1 true CY1119252T1 (el) | 2018-02-14 |
Family
ID=39671487
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100406T CY1117584T1 (el) | 2008-03-07 | 2016-05-13 | Παραγωγα 1-βενζυλ-3-υδροξυμεθυλινδαζολης και η χρηση τους στη θεραπευτικη αντιμετωπιση νοσων που βασιζονται στην εκφραση των mcp-1, cx3cr1 |
| CY20171100858T CY1119252T1 (el) | 2008-03-07 | 2017-08-09 | Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100406T CY1117584T1 (el) | 2008-03-07 | 2016-05-13 | Παραγωγα 1-βενζυλ-3-υδροξυμεθυλινδαζολης και η χρηση τους στη θεραπευτικη αντιμετωπιση νοσων που βασιζονται στην εκφραση των mcp-1, cx3cr1 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7919518B2 (el) |
| EP (3) | EP3181551A1 (el) |
| JP (2) | JP5509101B2 (el) |
| KR (2) | KR101581828B1 (el) |
| CN (2) | CN101945855B (el) |
| AR (2) | AR070810A1 (el) |
| AU (2) | AU2009221089B2 (el) |
| BR (2) | BRPI0907977A2 (el) |
| CA (2) | CA2712703C (el) |
| CY (2) | CY1117584T1 (el) |
| DK (2) | DK2254870T3 (el) |
| EA (2) | EA018241B1 (el) |
| ES (2) | ES2637009T3 (el) |
| GE (2) | GEP20135912B (el) |
| HR (2) | HRP20160462T1 (el) |
| HU (1) | HUE027098T2 (el) |
| IL (3) | IL206893A0 (el) |
| LT (1) | LT2254869T (el) |
| MX (2) | MX2010009623A (el) |
| PL (2) | PL2254870T3 (el) |
| PT (1) | PT2254869T (el) |
| SG (1) | SG188177A1 (el) |
| SI (2) | SI2254870T1 (el) |
| UA (2) | UA105170C2 (el) |
| WO (2) | WO2009109613A2 (el) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2262778T (pt) | 2008-03-07 | 2019-11-19 | Acraf | Derivados de 1-benzil-3-hidroximetilindazolo e utilização dos mesmos no tratamento de doenças baseadas na expressão de mcp-1, cxcr1 e p40 |
| AU2009221063B2 (en) | 2008-03-07 | 2013-03-21 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1 |
| ES2637009T3 (es) * | 2008-03-07 | 2017-10-10 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Nuevos derivados de 1-bencil-3-hidroximetilindazol y su utilización en el tratamiento de enfermedades basadas en la expresión de CX3CR1 y p40 |
| SG176885A1 (en) * | 2009-08-03 | 2012-01-30 | Acraf | Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates |
| UA108742C2 (uk) * | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
| US8999292B2 (en) * | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| WO2013163758A1 (en) * | 2012-05-01 | 2013-11-07 | Boyd Shelley Romayne | Methods for treating and diagnosing blinding eye diseases |
| EP2850062B1 (en) | 2012-05-18 | 2017-07-19 | Sanofi | Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation |
| KR20150010973A (ko) * | 2012-05-18 | 2015-01-29 | 사노피 | 피라졸 유도체 및 lpar5 길항제로서의 그의 용도 |
| US10918588B2 (en) | 2012-11-09 | 2021-02-16 | Colgate-Palmolive Company | Block copolymers for tooth enamel protection |
| ES2789849T3 (es) * | 2014-05-15 | 2020-10-26 | Translatum Medicus Inc | Composiciones y procedimientos para el tratamiento y diagnóstico de trastornos oculares |
| EP3942934A1 (en) * | 2015-06-12 | 2022-01-26 | Vettore, LLC | Mct4 inhibitors for treating disease |
| US20180221339A1 (en) * | 2015-06-16 | 2018-08-09 | Translatum Medicus, Inc. | Compositions and methods for treating and diagnosing ocular disorders |
| DK3551625T3 (da) | 2016-12-12 | 2024-09-02 | Vettore Llc | Heterocykliske inhibitorer af mct4 |
| GB201811169D0 (en) | 2018-07-06 | 2018-08-29 | Kancera Ab | New compounds |
| JP6612004B1 (ja) * | 2018-07-31 | 2019-11-27 | 株式会社親広産業 | グルコース消費促進剤および解糖系促進剤 |
| WO2020026471A1 (ja) * | 2018-07-31 | 2020-02-06 | 株式会社親広産業 | グルコース消費促進剤および解糖系促進剤 |
| WO2020261158A1 (en) * | 2019-06-25 | 2020-12-30 | Translatum Medicus Inc. | Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives |
| CN113929627A (zh) * | 2021-10-19 | 2022-01-14 | 吕梁学院 | 一种宾达利的合成方法 |
| WO2024108386A1 (zh) * | 2022-11-22 | 2024-05-30 | 中国科学院深圳先进技术研究院 | 抗mcp1中和抗体在制备治疗神经退行性疾病引起的系统性炎症药物中的应用 |
| WO2024165925A1 (en) * | 2023-02-10 | 2024-08-15 | Translatum Medicus Inc. | Bindarit conjugates, compositions and methods for treating ocular diseases or disorders |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US416359A (en) * | 1889-12-03 | Sash-fastener | ||
| US364371A (en) * | 1887-06-07 | peice | ||
| IT1230441B (it) * | 1989-02-07 | 1991-10-23 | Acraf | Eteri della serie dell'indazolo |
| IT1253703B (it) * | 1991-04-22 | 1995-08-23 | Angelini Francesco Ist Ricerca | Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie |
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| AU781849C (en) | 1999-06-17 | 2006-03-02 | Synta Pharmaceuticals Corp. | Inhibitors of IL-12 production |
| EP1188438A1 (en) | 2000-09-15 | 2002-03-20 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production |
| EP1199074A1 (en) | 2000-09-15 | 2002-04-24 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production |
| JP4234439B2 (ja) | 2001-03-15 | 2009-03-04 | 生化学工業株式会社 | Ｉｌ−１２発現調節剤 |
| KR100950122B1 (ko) | 2001-11-30 | 2010-03-30 | 신타 파마슈티칼스 코프. | 피리미딘 화합물 |
| JP2007507494A (ja) * | 2003-10-07 | 2007-03-29 | アストラゼネカ・アクチエボラーグ | ケモカイン受容体アンタゴニストとりわけＣＸ３ＣＲ１として有用な新規な２−置換４−アミノ−チアゾロ［４，５−ｄ］ピリミジン |
| WO2006046739A1 (ja) * | 2004-10-29 | 2006-05-04 | Eisai R & D Management Co., Ltd. | 炎症性疾患治療剤 |
| EP1819341A4 (en) | 2004-11-10 | 2011-06-29 | Synta Pharmaceuticals Corp | IL-12 MODULATORY CONNECTIONS |
| EP1827447A1 (en) | 2004-11-19 | 2007-09-05 | Synta Pharmaceuticals Corporation | Pyrimidine compounds and uses thereof |
| AR053347A1 (es) | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
| UA90707C2 (en) | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
| PT2262778T (pt) * | 2008-03-07 | 2019-11-19 | Acraf | Derivados de 1-benzil-3-hidroximetilindazolo e utilização dos mesmos no tratamento de doenças baseadas na expressão de mcp-1, cxcr1 e p40 |
| ES2637009T3 (es) * | 2008-03-07 | 2017-10-10 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Nuevos derivados de 1-bencil-3-hidroximetilindazol y su utilización en el tratamiento de enfermedades basadas en la expresión de CX3CR1 y p40 |
| AU2009221063B2 (en) * | 2008-03-07 | 2013-03-21 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1 |
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2009
- 2009-03-05 ES ES09717638.2T patent/ES2637009T3/es active Active
- 2009-03-05 CA CA2712703A patent/CA2712703C/en not_active Expired - Fee Related
- 2009-03-05 GE GEAP200911965A patent/GEP20135912B/en unknown
- 2009-03-05 EA EA201071038A patent/EA018241B1/ru not_active IP Right Cessation
- 2009-03-05 DK DK09718467.5T patent/DK2254870T3/en active
- 2009-03-05 KR KR1020107017806A patent/KR101581828B1/ko not_active IP Right Cessation
- 2009-03-05 MX MX2010009623A patent/MX2010009623A/es active IP Right Grant
- 2009-03-05 PT PT97176382T patent/PT2254869T/pt unknown
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