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KR920000313A - 제어성 약학 제제 - Google Patents

제어성 약학 제제 Download PDF

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Publication number
KR920000313A
KR920000313A KR1019910010955A KR910010955A KR920000313A KR 920000313 A KR920000313 A KR 920000313A KR 1019910010955 A KR1019910010955 A KR 1019910010955A KR 910010955 A KR910010955 A KR 910010955A KR 920000313 A KR920000313 A KR 920000313A
Authority
KR
South Korea
Prior art keywords
water
coating layer
acrylic polymer
salt
insoluble
Prior art date
Application number
KR1019910010955A
Other languages
English (en)
Other versions
KR0133511B1 (ko
Inventor
가즈오 노다
마사오 고바야시
다까시 오오사와
시게유끼 이시까와
Original Assignee
지바따 이찌로
다나베세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26494375&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR920000313(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 지바따 이찌로, 다나베세이야꾸 가부시끼가이샤 filed Critical 지바따 이찌로
Publication of KR920000313A publication Critical patent/KR920000313A/ko
Application granted granted Critical
Publication of KR0133511B1 publication Critical patent/KR0133511B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surgical Instruments (AREA)
  • Stringed Musical Instruments (AREA)
  • Pens And Brushes (AREA)

Abstract

내용 없음

Description

제어성 약학 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 시험 실시예 1에서 얻은, 코팅층의 양이 서로 다른 여러 제어성 과립(a)~(e)에 대한 물과의 용해도 시험결과를 나타낸 그래프이다.
제2도는 시험 실시예 1에서 얻은 제어성 과립(d)에 대한 물, 제1차 유체 및 제2차 유체와의 용해도 시험결과를 나타낸 그래프이다.

Claims (4)

  1. 의약품 화합물을 포함하는 코어 및 방수포제염과 트리메틸 암모늄에틸기를 갖는 비수용성이고 약간 수 - 침투성인 아크릴 중합체를 포함하는 코팅층으로 이루어진 제어성 약학적 제제.
  2. 제1항에 있어서, 코팅층의 방수포제염 1중량부당 아크릴 중합체 0.5~5중량부를 포함하는 약학적 제제.
  3. 제1항에 있어서, 아크릴 중합체가 비수용성이고 약간 수-침투성인 에틸아크릴레이트, 메틸 메타크릴레이트 및 β - 아크릴로일옥시 에틸트리메틸암모늄 클로라이드의 공중합체 이고, 방수포제 염은 알칼리 토금속 스테아레이트인 약학적 제제.
  4. 제1항에 있어서, 에틸 셀룰로스, 히드록시프로필셀룰로스와 의약품 화합물로 구성되는 군에서 선택되는 적어도 1개 재료료 만들어지는 또 다른 코팅층이 방수 포제염과 트리메틸모늄에틸기를 갖는 비수용성이고 약간 수 - 침투성인 아크릴 중합체를 포함하는 코팅층 주위에 제공되는 약학적 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910010955A 1990-06-28 1991-06-28 방출 제어성 약학 제제 KR0133511B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP171762/90 1990-06-28
JP90-171762 1990-06-28
JP17176290 1990-06-28
SG4995A SG4995G (en) 1990-06-28 1995-01-13 Controlled release pharmaceutical preparation

Publications (2)

Publication Number Publication Date
KR920000313A true KR920000313A (ko) 1992-01-29
KR0133511B1 KR0133511B1 (ko) 1998-04-23

Family

ID=26494375

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910010955A KR0133511B1 (ko) 1990-06-28 1991-06-28 방출 제어성 약학 제제

Country Status (17)

Country Link
US (1) US5137733A (ko)
EP (1) EP0463877B2 (ko)
JP (1) JP2558396B2 (ko)
KR (1) KR0133511B1 (ko)
CN (1) CN1040061C (ko)
AT (1) ATE106241T1 (ko)
CA (1) CA2045358C (ko)
DE (1) DE69102211T3 (ko)
DK (1) DK0463877T3 (ko)
ES (1) ES2055962T5 (ko)
FI (1) FI103476B1 (ko)
GR (1) GR3024471T3 (ko)
HK (1) HK33895A (ko)
HU (1) HU214590B (ko)
IE (1) IE64629B1 (ko)
IL (1) IL98611A (ko)
SG (1) SG4995G (ko)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5286493A (en) * 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5472712A (en) * 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US7070806B2 (en) 1992-01-27 2006-07-04 Purdue Pharma Lp Controlled release formulations coated with aqueous dispersions of acrylic polymers
CN1053808C (zh) * 1993-04-24 2000-06-28 章修纲 尼非地平控释剂型
JP2916978B2 (ja) * 1993-08-25 1999-07-05 エスエス製薬株式会社 放出開始制御型製剤
US5834024A (en) 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
US5567441A (en) * 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US5830503A (en) * 1996-06-21 1998-11-03 Andrx Pharmaceuticals, Inc. Enteric coated diltiazem once-a-day formulation
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
WO1999001111A1 (en) 1997-07-02 1999-01-14 Euro-Celtique, S.A. Stabilized sustained release tramadol formulations
CN1296417A (zh) 1998-02-10 2001-05-23 卫福有限公司 控释制剂
FR2778848B1 (fr) * 1998-05-20 2001-11-23 Prographarm Lab Forme pharmaceutique multiparticulaire a liberation programmee et pulsee et son procede de preparation
US6524620B2 (en) 1998-07-20 2003-02-25 Andrx Pharmaceuticals, Inc. Diltiazem controlled release formulation and method of manufacture
DE19845358A1 (de) * 1998-10-02 2000-04-06 Roehm Gmbh Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe
US6322819B1 (en) 1998-10-21 2001-11-27 Shire Laboratories, Inc. Oral pulsed dose drug delivery system
US6270805B1 (en) 1998-11-06 2001-08-07 Andrx Pharmaceuticals, Inc. Two pellet controlled release formulation for water soluble drugs which contains an alkaline metal stearate
US6039979A (en) * 1999-01-13 2000-03-21 Laboratoires Prographarm Multiparticulate pharmaceutical form with programmed and pulsed release and process for its preparation
ES2267491T3 (es) * 1999-01-21 2007-03-16 Circ Pharma Research And Development Limited Formulacion de bisoprolol de multiples particulas.
US6733789B1 (en) 1999-01-21 2004-05-11 Biovail Laboratories, Inc. Multiparticulate bisoprolol formulation
GEP20053427B (en) 1999-12-23 2005-01-25 Pfizer Prod Inc Pharmaceutical Compositions Providing Enhanced Drug Concentrations
CN1402632A (zh) * 1999-12-23 2003-03-12 辉瑞产品公司 水凝胶驱动的药物剂型
US20040185099A1 (en) * 2000-01-20 2004-09-23 Biovail Laboratories, Inc. Multiparticulate bisoprolol formulation
US6635277B2 (en) 2000-04-12 2003-10-21 Wockhardt Limited Composition for pulsatile delivery of diltiazem and process of manufacture
US6620439B1 (en) * 2000-10-03 2003-09-16 Atul M. Mehta Chrono delivery formulations and method of use thereof
US6984402B2 (en) 2000-10-03 2006-01-10 Elite Laboratories, Inc. Chrono delivery formulations and method of treating atrial fibrillation
SE0100200D0 (sv) 2001-01-24 2001-01-24 Astrazeneca Ab New film coating
AU2002339378A1 (en) * 2001-05-22 2002-12-03 Euro-Celtique Compartmentalized dosage form
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US20030118652A1 (en) * 2001-11-15 2003-06-26 John Kelly Methods and compositions for use of (S)-bisoprolol
US20030091633A1 (en) * 2001-11-15 2003-05-15 John Kelly Methods and compositions for use of (S)-bisoprolol
US20050025824A1 (en) * 2001-12-14 2005-02-03 Eurand Pharmaceuticals Ltd. Pulsatile release histamine H2 antagonist dosage form
US6663888B2 (en) * 2001-12-14 2003-12-16 Eurand Pharmaceuticals Ltd. Pulsatile release histamine H2 antagonist dosage form
US8367111B2 (en) * 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
CA2518806C (en) * 2003-03-11 2012-05-01 Seikagaku Corporation Photocrosslinked-polysaccharide composition and production process of the same
MXPA05011446A (es) 2003-04-24 2006-05-31 Jagotec Ag Tableta con liberacion retardada con geometria de nucleo definida.
FR2861990B1 (fr) * 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
EP1759719B1 (en) * 2004-05-07 2015-01-07 Seikagaku Corporation Nucleus pulposus filler
DE102004043863A1 (de) 2004-09-10 2006-03-16 Nitec Pharma Ag Tabletten mit orts- und zeitgesteuerter Wirkstofffreisetzung im Gastrointestinum
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ728442A (en) 2004-10-21 2018-05-25 Adare Pharmaceuticals Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
WO2006063256A2 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment using d-threo methylphenidate
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US8846100B2 (en) * 2006-05-12 2014-09-30 Shire Llc Controlled dose drug delivery system
KR101430089B1 (ko) 2006-08-03 2014-08-13 호라이즌 파르마 에이쥐 류마티스 질환의 지연-방출형 글루코코르티코이드 치료제
JP2008024708A (ja) * 2007-08-20 2008-02-07 Euro-Celtique Sa アクリル系ポリマーの水性分散液で被膜した放出制御型製剤及びその方法
PT2358360T (pt) * 2008-11-18 2016-11-15 Ucb Biopharma Sprl Formulações de libertação prolongada compreendendo um derivado de 2-oxo-1-pirrolidina
BRPI1001091A2 (pt) * 2009-04-22 2011-03-22 Dr Suwelack Skin & Health Care Ag artigo moldado revestido secado por congelamento
KR101765357B1 (ko) 2009-12-02 2017-08-04 아데어 파마수티컬스 에스.알.엘. 펙소페나딘 마이크로캡슐 및 그것을 함유하는 조성물
WO2012074042A1 (ja) * 2010-12-03 2012-06-07 日本曹達株式会社 ヒドロキシアルキルセルロース
US8927010B2 (en) 2011-03-23 2015-01-06 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US10905652B2 (en) 2011-03-23 2021-02-02 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US8916588B2 (en) 2011-03-23 2014-12-23 Ironshore Pharmaceuticals & Development, Inc. Methods for treatment of attention deficit hyperactivity disorder
US9119809B2 (en) 2011-03-23 2015-09-01 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9603809B2 (en) 2011-03-23 2017-03-28 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US10292937B2 (en) 2011-03-23 2019-05-21 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
MX357551B (es) 2011-03-23 2018-07-13 Ironshore Pharmaceuticals & Dev Inc Metodos y composiciones para el tratamiento de trastorno por deficit de atencion.
US11241391B2 (en) 2011-03-23 2022-02-08 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9283214B2 (en) 2011-03-23 2016-03-15 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9498447B2 (en) 2011-03-23 2016-11-22 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
JP5146859B2 (ja) * 2011-07-11 2013-02-20 ユーロ−セルティーク エス．エイ． アクリル系ポリマーの水性分散液で被膜した放出制御型製剤及びその方法
CA2936748C (en) 2014-10-31 2017-08-08 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5944311A (ja) * 1982-09-07 1984-03-12 Santen Pharmaceut Co Ltd 徐放性顆粒およびその製造法
IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
US5002776A (en) * 1983-12-22 1991-03-26 Elan Corporation, Plc Controlled absorption diltiazem formulations
US4559225A (en) * 1984-02-16 1985-12-17 Fourman Robert G Sunscreen composition
JPH0621066B2 (ja) * 1984-03-14 1994-03-23 杏林製薬株式会社 ３―イソブチリル―２―イソプロピルピラゾロ〔１，５―ａ〕ピリジンの徐放性医薬品組成物
GB8518301D0 (en) * 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
IL88083A (en) * 1987-11-06 1992-11-15 Tanabe Seiyaku Co Controlled release pharmaceutical dosage form and its preparation
ATE79029T1 (de) * 1989-02-11 1992-08-15 Bayer Ag Arzneimittel mit kontrollierter wirkstoffabgabe.
US4983401A (en) * 1989-05-22 1991-01-08 Kinaform Technology, Inc. Sustained release pharmaceutical preparations having pH controlled membrane coatings
US5013557A (en) * 1989-10-03 1991-05-07 Warner-Lambert Company Taste masking compositions comprising spray dried microcapsules containing sucralfate and methods for preparing same
JPH0674206B2 (ja) * 1989-12-28 1994-09-21 田辺製薬株式会社 放出制御型製剤およびその製法

Also Published As

Publication number Publication date
JP2558396B2 (ja) 1996-11-27
DK0463877T3 (da) 1994-06-27
ATE106241T1 (de) 1994-06-15
EP0463877B1 (en) 1994-06-01
EP0463877A1 (en) 1992-01-02
HK33895A (en) 1995-03-17
IE64629B1 (en) 1995-08-23
DE69102211T2 (de) 1994-09-15
CA2045358A1 (en) 1991-12-29
FI103476B (fi) 1999-07-15
CA2045358C (en) 1998-04-28
SG4995G (en) 1995-06-16
US5137733A (en) 1992-08-11
EP0463877B2 (en) 1997-07-02
AU634400B2 (en) 1993-02-18
ES2055962T3 (es) 1994-09-01
HUT59321A (en) 1992-05-28
FI912952A (fi) 1991-12-29
CN1040061C (zh) 1998-10-07
IL98611A (en) 1998-10-30
GR3024471T3 (en) 1997-11-28
HU214590B (hu) 1998-04-28
FI103476B1 (fi) 1999-07-15
IE912166A1 (en) 1992-01-01
KR0133511B1 (ko) 1998-04-23
HU912170D0 (en) 1991-12-30
CN1058533A (zh) 1992-02-12
FI912952A0 (fi) 1991-06-18
AU7924391A (en) 1992-01-02
DE69102211D1 (de) 1994-07-07
JPH04235123A (ja) 1992-08-24
DE69102211T3 (de) 1997-08-28
IL98611A0 (en) 1992-07-15
ES2055962T5 (es) 1997-09-16

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