IT1254521B - Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare - Google Patents
Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolareInfo
- Publication number
- IT1254521B IT1254521B ITMI920608A ITMI920608A IT1254521B IT 1254521 B IT1254521 B IT 1254521B IT MI920608 A ITMI920608 A IT MI920608A IT MI920608 A ITMI920608 A IT MI920608A IT 1254521 B IT1254521 B IT 1254521B
- Authority
- IT
- Italy
- Prior art keywords
- amino
- cardiovascular system
- derivatives active
- tetraline derivatives
- tetraline
- Prior art date
Links
- LCGFVWKNXLRFIF-UHFFFAOYSA-N 1,2,3,4-tetrahydronaphthalen-2-amine Chemical class C1=CC=C2CC(N)CCC2=C1 LCGFVWKNXLRFIF-UHFFFAOYSA-N 0.000 title abstract 2
- 210000000748 cardiovascular system Anatomy 0.000 title 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Vengono descritti derivati della 2-ammino-tetralina ed il loro uso in campo terapeutico.I composti si sono dimostrati particolarmente utili per il trattamento dell'ipertensione arteriosa e dello scompenso cardiaco, dell'insufficienza renale, nel trattamento delle arteropatie periferiche e nelle insufficienze cerebrovascolari.
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920608A IT1254521B (it) | 1992-03-17 | 1992-03-17 | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
PCT/EP1993/000577 WO1993019036A1 (en) | 1992-03-17 | 1993-03-13 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them |
PL93301342A PL171844B1 (pl) | 1992-03-17 | 1993-03-13 | P ochodne 2-amino-1,2,3,4-tetrahydronaftalenu PL PL PL |
RU93058292A RU2120435C1 (ru) | 1992-03-17 | 1993-03-13 | Производные 2-амино-1,2,3,4-тетрагидронафталина или их фармацевтически приемлемые соли и композиция, обладающая кардиоваскулярной активностью |
DK93906515.7T DK0585440T3 (da) | 1992-03-17 | 1993-03-13 | 2-amino-1,2,3,4-tetrahydronaphtalen-derivater med virkning på det cardiovasculære system fremgangsmåde til fremstilling af disse og farmaceutiske præparater indeholdende disse |
AU37478/93A AU650201C (en) | 1992-03-17 | 1993-03-13 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them |
KR1019930703509A KR100283945B1 (ko) | 1992-03-17 | 1993-03-13 | 심장 혈관계에 활성인 2-아미노-1,2,3,4-테트라히드로나프탈렌유도체, 이들의 제조방법 및 이들을 함유하는 약제 조성물 |
HU9303266A HUT68936A (en) | 1992-03-17 | 1993-03-13 | Process for preparing 2-amino-1,2,3,4-tetrahydronaphtalene derivatives and pharmaceutical compositions containing them |
CA002102490A CA2102490C (en) | 1992-03-17 | 1993-03-13 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them |
JP51622793A JP3231775B2 (ja) | 1992-03-17 | 1993-03-13 | 心循環器系に作用する2−アミノ−1,2,3,4−テトラヒドロナフタレン誘導体、それらを製造する方法、及びそれらを含む医薬組成物 |
EP93906515A EP0585440B1 (en) | 1992-03-17 | 1993-03-13 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them |
ES93906515T ES2087729T3 (es) | 1992-03-17 | 1993-03-13 | Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos sobre el sistema cardiovascular, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. |
DE69302544T DE69302544T2 (de) | 1992-03-17 | 1993-03-13 | 2-amino-1,2,3,4-tetrahydronaphthalen derivate mit wirkung auf das kardiovasculäre system, verfahren zu deren herstellung und deren pharmazeutische zusammensetzungen |
AT93906515T ATE137737T1 (de) | 1992-03-17 | 1993-03-13 | 2-amino-1,2,3,4-tetrahydronaphthalen derivate mit wirkung auf das kardiovasculäre system, verfahren zu deren herstellung und deren pharmazeutische zusammensetzungen |
NZ249845A NZ249845A (en) | 1992-03-17 | 1993-03-13 | 2-aminotetralin derivatives, medicaments |
MD96-0271A MD1449G2 (ro) | 1992-03-17 | 1993-03-13 | Derivaţi ai 2-amino-1,2,3,4-tetrahidronaftalinei cu acţiune asupra sistemului cardiovascular, procedeu de obţinere a acestora şi compoziţii farmaceutice care îi conţin |
PL93315380A PL172056B1 (pl) | 1992-03-17 | 1993-03-13 | Sposób wytwarzania pochodnych 2-amino-1,2,3,4-tetrahydronaftalenu PL |
US08/032,845 US5407956A (en) | 1992-03-17 | 1993-03-17 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them |
OA60433A OA09843A (en) | 1992-03-17 | 1993-11-11 | 2-Amino-1, 2, 3, 4-tetahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them |
FI935066A FI935066A (fi) | 1992-03-17 | 1993-11-16 | 2-amino-1,2,3,4-tetrahydronaftalenderivat aktivt inverkande pao kardiovaskularsystemet, foerfaranden foer framstaellning av dem och farmaceutiska kompositioner innehaollande dem |
NO934160A NO180230C (no) | 1992-03-17 | 1993-11-17 | 2-amino-1,2,3,4-tetrahydronaftalenderivater med kardiovaskulær aktivitet samt farmasöytiske preparater inneholdende slike |
US08/281,698 US5451608A (en) | 1992-03-17 | 1994-07-28 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovasular system, processes for their preparation and pharmaceutical compositions containing them |
HU95P/P00509P HU211517A9 (en) | 1992-03-17 | 1995-06-28 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them |
GR960401792T GR3020419T3 (en) | 1992-03-17 | 1996-07-02 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920608A IT1254521B (it) | 1992-03-17 | 1992-03-17 | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI920608A0 ITMI920608A0 (it) | 1992-03-17 |
ITMI920608A1 ITMI920608A1 (it) | 1993-09-17 |
IT1254521B true IT1254521B (it) | 1995-09-25 |
Family
ID=11362451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI920608A IT1254521B (it) | 1992-03-17 | 1992-03-17 | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
Country Status (20)
Country | Link |
---|---|
US (2) | US5407956A (it) |
EP (1) | EP0585440B1 (it) |
JP (1) | JP3231775B2 (it) |
KR (1) | KR100283945B1 (it) |
AT (1) | ATE137737T1 (it) |
CA (1) | CA2102490C (it) |
DE (1) | DE69302544T2 (it) |
DK (1) | DK0585440T3 (it) |
ES (1) | ES2087729T3 (it) |
FI (1) | FI935066A (it) |
GR (1) | GR3020419T3 (it) |
HU (2) | HUT68936A (it) |
IT (1) | IT1254521B (it) |
MD (1) | MD1449G2 (it) |
NO (1) | NO180230C (it) |
NZ (1) | NZ249845A (it) |
OA (1) | OA09843A (it) |
PL (2) | PL171844B1 (it) |
RU (1) | RU2120435C1 (it) |
WO (1) | WO1993019036A1 (it) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1271411B (it) * | 1993-09-14 | 1997-05-28 | Zambon Spa | Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare |
IT1274673B (it) * | 1994-04-14 | 1997-07-24 | Zambon Spa | Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari |
IT1270260B (it) * | 1994-06-21 | 1997-04-29 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
IT1271009B (it) * | 1994-09-13 | 1997-05-26 | Zambon Spa | Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare |
IT1271008B (it) * | 1994-09-13 | 1997-05-26 | Zambon Spa | Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare |
IT1271007B (it) * | 1994-09-13 | 1997-05-26 | Zambon Spa | Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare |
IT1273455B (it) * | 1995-01-27 | 1997-07-08 | Zambon Spa | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
IT1276710B1 (it) * | 1995-06-14 | 1997-11-03 | Zambon Spa | Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi |
GB9625455D0 (en) * | 1996-12-07 | 1997-01-22 | Glaxo Group Ltd | Process for resolving mixtures of carbocyclic steroisomers |
IT1289980B1 (it) | 1997-02-26 | 1998-10-19 | Zambon Spa | Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare |
EP2376470B1 (en) * | 2008-12-09 | 2013-04-10 | Interquim, S.A | Process for the preparation of (6s)-(-)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol (rotigotine) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3263531D1 (en) * | 1981-08-05 | 1985-06-20 | Fisons Plc | Amine derivatives, processes for their production and pharmaceutical compositions containing them |
EP0375668A3 (en) * | 1983-10-25 | 1990-10-17 | FISONS plc | Phenylethylamines, process for their preparation and compositions containing them |
IT1224405B (it) * | 1987-12-23 | 1990-10-04 | Simes | Composti attivi sul sistema cardiovascolare |
-
1992
- 1992-03-17 IT ITMI920608A patent/IT1254521B/it active
-
1993
- 1993-03-13 EP EP93906515A patent/EP0585440B1/en not_active Expired - Lifetime
- 1993-03-13 CA CA002102490A patent/CA2102490C/en not_active Expired - Fee Related
- 1993-03-13 JP JP51622793A patent/JP3231775B2/ja not_active Expired - Fee Related
- 1993-03-13 MD MD96-0271A patent/MD1449G2/ro unknown
- 1993-03-13 PL PL93301342A patent/PL171844B1/pl unknown
- 1993-03-13 WO PCT/EP1993/000577 patent/WO1993019036A1/en active Application Filing
- 1993-03-13 ES ES93906515T patent/ES2087729T3/es not_active Expired - Lifetime
- 1993-03-13 DK DK93906515.7T patent/DK0585440T3/da active
- 1993-03-13 NZ NZ249845A patent/NZ249845A/en unknown
- 1993-03-13 AT AT93906515T patent/ATE137737T1/de not_active IP Right Cessation
- 1993-03-13 HU HU9303266A patent/HUT68936A/hu unknown
- 1993-03-13 KR KR1019930703509A patent/KR100283945B1/ko not_active IP Right Cessation
- 1993-03-13 PL PL93315380A patent/PL172056B1/pl unknown
- 1993-03-13 DE DE69302544T patent/DE69302544T2/de not_active Expired - Fee Related
- 1993-03-13 RU RU93058292A patent/RU2120435C1/ru not_active IP Right Cessation
- 1993-03-17 US US08/032,845 patent/US5407956A/en not_active Expired - Fee Related
- 1993-11-11 OA OA60433A patent/OA09843A/en unknown
- 1993-11-16 FI FI935066A patent/FI935066A/fi unknown
- 1993-11-17 NO NO934160A patent/NO180230C/no unknown
-
1994
- 1994-07-28 US US08/281,698 patent/US5451608A/en not_active Expired - Fee Related
-
1995
- 1995-06-28 HU HU95P/P00509P patent/HU211517A9/hu unknown
-
1996
- 1996-07-02 GR GR960401792T patent/GR3020419T3/el unknown
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