IL114987A - Modulators of body weight, corresponding nucleic acids and proteins and diagnostic and therapeutic uses thereof - Google Patents

Modulators of body weight, corresponding nucleic acids and proteins and diagnostic and therapeutic uses thereof

Info

Publication number: IL114987A
Authority: IL; Israel
Prior art keywords: polypeptide; seq; protein; amino acid; expression
Prior art date: 1994-08-17

Application number

IL11498795A

Other languages

English (en)

Other versions

IL114987A0 (en

Inventor

Jeffrey M Friedman

Yiying Zhang

Ricardo Proenca

Margherita Maffei

Jeffrey L Halaas

Ketan Gajiwala

Stephen K Burley

Original Assignee

Univ Rockefeller

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-17

Filing date

1995-08-17

Publication date

2004-07-25

1994-08-17 Priority claimed from US08/292,345 external-priority patent/US6001968A/en

1995-05-10 Priority claimed from US08/438,431 external-priority patent/US6429290B1/en

1995-08-17 Application filed by Univ Rockefeller filed Critical Univ Rockefeller

1995-12-08 Publication of IL114987A0 publication Critical patent/IL114987A0/xx

2004-07-25 Publication of IL114987A publication Critical patent/IL114987A/en

Links

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150000003626 triacylglycerols Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
125000005591 trimellitate group Chemical group 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
108020005087 unfolded proteins Proteins 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
229940045145 uridine Drugs 0.000 description 1
210000003934 vacuole Anatomy 0.000 description 1
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000012178 vegetable wax Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
229940070384 ventolin Drugs 0.000 description 1
239000011800 void material Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
230000007279 water homeostasis Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
210000005253 yeast cell Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Zoology (AREA)
Obesity (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Analytical Chemistry (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Toxicology (AREA)
Birds (AREA)
Dermatology (AREA)
Pathology (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Emergency Medicine (AREA)

IL11498795A 1994-08-17 1995-08-17 Modulators of body weight, corresponding nucleic acids and proteins and diagnostic and therapeutic uses thereof IL114987A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08/292,345 US6001968A (en)	1994-08-17	1994-08-17	OB polypeptides, modified forms and compositions
US08/347,563 US5935810A (en)	1994-08-17	1994-11-30	Mammalian ob polypeptides capable of modulating body weight, corresponding nucleic acids, and diagnostic and therapeutic uses thereof
US08/438,431 US6429290B1 (en)	1994-08-17	1995-05-10	OB polypeptides, modified forms and derivatives
US08/483,211 US6309853B1 (en)	1994-08-17	1995-06-07	Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof

Publications (2)

Publication Number	Publication Date
IL114987A0 IL114987A0 (en)	1995-12-08
IL114987A true IL114987A (en)	2004-07-25

Family

ID=27501568

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL11498795A IL114987A (en)	1994-08-17	1995-08-17	Modulators of body weight, corresponding nucleic acids and proteins and diagnostic and therapeutic uses thereof
IL16209304A IL162093A0 (en)	1994-08-17	2004-05-20	Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL16209304A IL162093A0 (en)	1994-08-17	2004-05-20	Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof

Country Status (32)

Country	Link
US (1)	US6309853B1 (fr)
EP (1)	EP0777732B1 (fr)
JP (1)	JP3479080B2 (fr)
CN (1)	CN1162978B (fr)
AP (1)	AP815A (fr)
BG (1)	BG64710B1 (fr)
BR (1)	BR9508596A (fr)
CA (1)	CA2195955C (fr)
CZ (1)	CZ295018B6 (fr)
DE (2)	DE777732T1 (fr)
EE (1)	EE04377B1 (fr)
ES (1)	ES2108663T3 (fr)
FI (1)	FI121709B (fr)
GB (1)	GB2292382B (fr)
GE (1)	GEP20022701B (fr)
GR (1)	GR970300021T1 (fr)
HK (1)	HK1001495A1 (fr)
HU (1)	HU223563B1 (fr)
IL (2)	IL114987A (fr)
IS (1)	IS4416A (fr)
LV (1)	LV11868B (fr)
MD (1)	MD2311G2 (fr)
MX (1)	MX9701200A (fr)
NO (2)	NO323847B1 (fr)
NZ (1)	NZ291689A (fr)
OA (1)	OA10596A (fr)
PL (1)	PL183352B1 (fr)
RO (1)	RO121036B1 (fr)
SI (1)	SI9520090A (fr)
SK (1)	SK287191B6 (fr)
TR (1)	TR199501021A2 (fr)
WO (1)	WO1996005309A2 (fr)

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US6350730B1 (en)	1994-08-17	2002-02-26	The Rockefeller University	OB polypeptides and modified forms as modulators of body weight
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US6395509B1 (en)	1995-05-26	2002-05-28	Eli Lilly And Company	DNA encoding Rhesus ob protein
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US5605886A (en)	1995-01-31	1997-02-25	Eli Lilly And Company	Anti-obesity proteins
AU4766196A (en)	1995-01-31	1996-08-21	Eli Lilly And Company	Anti-obesity proteins
US5567678A (en)	1995-01-31	1996-10-22	Eli Lilly And Company	Anti-obesity proteins
US5574133A (en)	1995-01-31	1996-11-12	Eli Lilly And Company	Anti-obesity proteins
US5559208A (en)	1995-01-31	1996-09-24	Eli Lilly And Company	Anti-obesity proteins
US5594101A (en)	1995-03-03	1997-01-14	Eli Lilly And Company	Anti-obesity proteins
US5719266A (en)	1995-03-17	1998-02-17	Eli Lilly And Company	Anti-obesity proteins
JPH08333394A (ja)	1995-04-03	1996-12-17	Takeda Chem Ind Ltd	ラット肥満遺伝子、その遺伝子産物およびその製造法
EP0736599A3 (fr)	1995-04-03	1996-12-11	Takeda Chemical Industries Ltd	Le gène d'obésité de rat, son produit génique et sa production
US5739277A (en)	1995-04-14	1998-04-14	Genentech Inc.	Altered polypeptides with increased half-life
US5614379A (en)	1995-04-26	1997-03-25	Eli Lilly And Company	Process for preparing anti-obesity protein
ES2093593T1 (es)	1995-05-05	1997-01-01	Hoffmann La Roche	Proteinas obesas (ob) recombinantes.
YU29596A (sh)	1995-05-19	1998-07-10	Eli Lilly And Company	Genski proizvodi koji regulišu gojaznost
CA2221824A1 (fr)	1995-05-26	1996-11-28	Eli Lilly And Company	Proteine et adn de gene ob de rhesus
IL122718A0 (en)	1995-06-30	1998-08-16	Lilly Co Eli	Methods for treating diabetes
EP0759441A3 (fr)	1995-06-30	1999-06-30	Eli Lilly And Company	Procédés de traitement des pathologies associées aux peptides neuropeptide Y
AU7072896A (en)	1995-09-19	1997-04-09	Eli Lilly And Company	Dna encoding medicinal proteins
US5698389A (en)	1995-11-16	1997-12-16	Tularik, Inc.	Transcriptional promoter of the murine obesity gene
WO1997026013A1 (fr)	1996-01-19	1997-07-24	Eli Lilly And Company	Preparations a base de proteine d'obesite
WO1997026011A1 (fr)	1996-01-19	1997-07-24	Eli Lilly And Company	Formulations de proteine de l'obesite
AU1750997A (en)	1996-01-19	1997-08-11	Eli Lilly And Company	Obesity protein formulations
WO1997026012A1 (fr)	1996-01-19	1997-07-24	Eli Lilly And Company	Formulations d'une proteine de l'obesite
AU2548097A (en)	1996-03-26	1997-10-17	Eli Lilly And Company	Formulations of ob protein

1995
- 1995-06-07 US US08/483,211 patent/US6309853B1/en not_active Expired - Lifetime
- 1995-08-17 CA CA2195955A patent/CA2195955C/fr not_active Expired - Lifetime
- 1995-08-17 ES ES95929591T patent/ES2108663T3/es not_active Expired - Lifetime
- 1995-08-17 HU HU9901249A patent/HU223563B1/hu active IP Right Grant
- 1995-08-17 SI SI9520090A patent/SI9520090A/sl not_active IP Right Cessation
- 1995-08-17 DE DE0777732T patent/DE777732T1/de active Pending
- 1995-08-17 EP EP95929591A patent/EP0777732B1/fr not_active Expired - Lifetime
- 1995-08-17 IL IL11498795A patent/IL114987A/en not_active IP Right Cessation
- 1995-08-17 CN CN951956752A patent/CN1162978B/zh not_active Expired - Lifetime
- 1995-08-17 BR BR9508596A patent/BR9508596A/pt not_active IP Right Cessation
- 1995-08-17 NZ NZ291689A patent/NZ291689A/xx not_active IP Right Cessation
- 1995-08-17 TR TR95/01021A patent/TR199501021A2/xx unknown
- 1995-08-17 DE DE19531931A patent/DE19531931A1/de not_active Ceased
- 1995-08-17 SK SK221-97A patent/SK287191B6/sk not_active IP Right Cessation
- 1995-08-17 RO RO97-00311A patent/RO121036B1/ro unknown
- 1995-08-17 MX MX9701200A patent/MX9701200A/es active IP Right Grant
- 1995-08-17 WO PCT/US1995/010479 patent/WO1996005309A2/fr active IP Right Grant
- 1995-08-17 JP JP50761896A patent/JP3479080B2/ja not_active Expired - Lifetime
- 1995-08-17 AP APAP/P/1997/000919A patent/AP815A/en active
- 1995-08-17 PL PL95319021A patent/PL183352B1/pl unknown
- 1995-08-17 EE EE9700030A patent/EE04377B1/xx unknown
- 1995-08-17 GB GB9516947A patent/GB2292382B/en not_active Expired - Lifetime
- 1995-08-17 GE GEAP19953625A patent/GEP20022701B/en unknown
- 1995-08-17 MD MD97-0100A patent/MD2311G2/ro not_active IP Right Cessation
- 1995-08-17 CZ CZ1997460A patent/CZ295018B6/cs not_active IP Right Cessation
1997
- 1997-01-17 IS IS4416A patent/IS4416A/is unknown
- 1997-02-06 OA OA60960A patent/OA10596A/en unknown
- 1997-02-12 BG BG101228A patent/BG64710B1/bg unknown
- 1997-02-14 NO NO19970683A patent/NO323847B1/no not_active IP Right Cessation
- 1997-02-17 FI FI970656A patent/FI121709B/fi not_active IP Right Cessation
- 1997-03-17 LV LVP-97-42A patent/LV11868B/en unknown
- 1997-07-30 GR GR970300021T patent/GR970300021T1/el unknown
1998
- 1998-01-16 HK HK98100386A patent/HK1001495A1/xx not_active IP Right Cessation
2004
- 2004-05-20 IL IL16209304A patent/IL162093A0/xx active IP Right Grant
2006
- 2006-11-17 NO NO20065287A patent/NO326376B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO20065287L (no)	1997-04-16
SK22197A3 (en)	1998-02-04
IL114987A0 (en)	1995-12-08
DE777732T1 (de)	1998-01-29
CN1162978B (zh)	2010-06-16
EP0777732A1 (fr)	1997-06-11
IS4416A (is)	1997-01-17
DE19531931A1 (de)	1996-03-07
RO121036B1 (ro)	2006-11-30
IL162093A0 (en)	2005-11-20
EP0777732B1 (fr)	2011-09-28
SK287191B6 (sk)	2010-02-08
MD2311G2 (ro)	2004-08-31
LV11868A (lv)	1997-10-20
GB2292382A (en)	1996-02-21
MX9701200A (es)	1998-05-31
CZ295018B6 (cs)	2005-05-18
BR9508596A (pt)	1997-10-21
NZ291689A (en)	2000-01-28
GB9516947D0 (en)	1995-10-18
JP3479080B2 (ja)	2003-12-15
AP815A (en)	2000-03-10
NO323847B1 (no)	2007-07-09
BG64710B1 (bg)	2005-12-30
WO1996005309A3 (fr)	1996-03-21
HUT78052A (hu)	1999-07-28
PL319021A1 (en)	1997-07-21
SI9520090A (sl)	1998-08-31
NO970683L (no)	1997-04-16
OA10596A (en)	2002-06-26
US6309853B1 (en)	2001-10-30
CN1162978A (zh)	1997-10-22
JPH09506264A (ja)	1997-06-24
NO970683D0 (no)	1997-02-14
BG101228A (en)	1997-09-30
FI970656A (fi)	1997-02-17
FI970656A0 (fi)	1997-02-17
GR970300021T1 (en)	1997-07-30
FI121709B (fi)	2011-03-15
HU223563B1 (hu)	2004-09-28
ES2108663T1 (es)	1998-01-01
NO326376B1 (no)	2008-11-17
GB2292382B (en)	1997-07-16
TR199501021A2 (tr)	1996-06-21
CA2195955A1 (fr)	1996-02-22
HK1001495A1 (en)	1998-06-19
MD2311F2 (en)	2003-11-30
PL183352B1 (pl)	2002-06-28
GEP20022701B (en)	2002-05-27
WO1996005309A2 (fr)	1996-02-22
CA2195955C (fr)	2012-03-13
EE9700030A (et)	1997-08-15
EE04377B1 (et)	2004-10-15
ES2108663T3 (es)	2012-02-17
CZ46097A3 (en)	1997-11-12
AP9700919A0 (en)	1997-01-31
LV11868B (en)	1998-01-20
MD970100A (en)	1998-04-30

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EP2402444A1 (fr)	2012-01-04	Modulateurs de poids corporel, acides nucléiques et protéines correspondants et utilisations associées au diagnostic et au traitement
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US7612171B2 (en)	2009-11-03	DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
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AU738966B2 (en)	2001-10-04	Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US7619079B2 (en)	2009-11-17	Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
KR100584177B1 (ko)	2006-10-24	체중 변조물질,상응하는 핵산 및 단백질,및 이들의 진단 및 치료학적 용도

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2016-04-21	EXP	Patent expired