[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

HRP20201184T1 - Spojevi alkilamida i njihove uporabe - Google Patents

Spojevi alkilamida i njihove uporabe Download PDF

Info

Publication number
HRP20201184T1
HRP20201184T1 HRP20201184TT HRP20201184T HRP20201184T1 HR P20201184 T1 HRP20201184 T1 HR P20201184T1 HR P20201184T T HRP20201184T T HR P20201184TT HR P20201184 T HRP20201184 T HR P20201184T HR P20201184 T1 HRP20201184 T1 HR P20201184T1
Authority
HR
Croatia
Prior art keywords
treatment
pharmaceutically acceptable
compound
darrier
ichthyosis
Prior art date
Application number
HRP20201184TT
Other languages
English (en)
Inventor
Sergio Baroni
Salvatore Bellinvia
Francesca Viti
Original Assignee
Nogra Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nogra Pharma Limited filed Critical Nogra Pharma Limited
Publication of HRP20201184T1 publication Critical patent/HRP20201184T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Claims (4)

1. Spoj formule: [image] koji ima S konfiguraciju, ili njegovu farmaceutski prihvatljivu sol, za uporabu u liječenju dermatološkog stanja.
2. Spoj za uporabu prema zahtjevu 1 u liječenju ihtioze, Darrierove bolesti, kožnih poremećaja uslijed izlaganja UV zračenju, starenja kože, jednostavne seboreje ili seboroičnog dermatitisa, atopijskog dermatitisa ili psorijaze.
3. Farmaceutski pripravak koji sadrži spoj prema zahtjevu 1, ili njegovu farmaceutski prihvatljivu sol, i farmaceutski prihvatljiv nosač, za uporabu u liječenju dermatološkog stanja.
4. Farmaceutski pripravak za uporabu prema zahtjevu 3 u liječenju ihtioze, Darrierove bolesti, kožnih poremećaja uslijed izlaganja UV zračenju, starenja kože, jednostavne seboreje ili seboroičnog dermatitisa, atopijskog dermatitisa ili psorijaze.
HRP20201184TT 2009-02-16 2020-07-29 Spojevi alkilamida i njihove uporabe HRP20201184T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09425056 2009-02-16
US17906209P 2009-05-18 2009-05-18
US28746109P 2009-12-17 2009-12-17
EP14170446.0A EP2805746B1 (en) 2009-02-16 2010-02-16 Alkylamido compounds and uses thereof

Publications (1)

Publication Number Publication Date
HRP20201184T1 true HRP20201184T1 (hr) 2020-12-11

Family

ID=42562114

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20170936TT HRP20170936T1 (hr) 2009-02-16 2017-06-20 Alkilamido spojevi i njihova uporaba
HRP20201184TT HRP20201184T1 (hr) 2009-02-16 2020-07-29 Spojevi alkilamida i njihove uporabe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20170936TT HRP20170936T1 (hr) 2009-02-16 2017-06-20 Alkilamido spojevi i njihova uporaba

Country Status (25)

Country Link
US (11) US8796334B2 (hr)
EP (4) EP3744398A1 (hr)
JP (4) JP5715070B2 (hr)
KR (2) KR101776337B1 (hr)
CN (3) CN102316932B (hr)
AR (1) AR080596A1 (hr)
AU (2) AU2010213093B2 (hr)
BR (2) BRPI1011226B1 (hr)
CA (2) CA2752626C (hr)
CY (2) CY1119225T1 (hr)
DK (2) DK2396081T3 (hr)
EA (2) EA020198B1 (hr)
ES (3) ES2429143T3 (hr)
HR (2) HRP20170936T1 (hr)
HU (2) HUE032999T2 (hr)
IL (2) IL214664A (hr)
LT (2) LT2396081T (hr)
MX (2) MX2011008601A (hr)
NZ (2) NZ595076A (hr)
PL (1) PL2396081T3 (hr)
PT (3) PT2805746T (hr)
SI (2) SI2396081T1 (hr)
UA (2) UA105037C2 (hr)
WO (2) WO2010091892A2 (hr)
ZA (1) ZA201106256B (hr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20050389A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
ITRM20050390A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
UA107562C2 (uk) 2008-12-05 2015-01-26 Спосіб лікування псоріазу
EA020198B1 (ru) 2009-02-16 2014-09-30 Джулиани Интернэшнл Лимитед N-ацетил-(r)-(-)-3-(4-аминофенил)-2-метоксипропионовая кислота, содержащая ее фармацевтическая композиция, способ лечения
ES2711100T3 (es) 2011-03-07 2019-04-30 Celgene Corp Métodos para tratar enfermedades usando compuestos isoindolina
CN116602950A (zh) * 2012-02-09 2023-08-18 诺格拉制药有限公司 治疗纤维化的方法
IN2014DN08157A (hr) 2012-04-18 2015-05-01 Nogra Pharma Ltd
EA035986B1 (ru) * 2012-09-13 2020-09-09 Ногра Фарма Лимитед Способы лечения или облегчения плоского фолликулярного лишая
CA2883836A1 (en) * 2012-09-13 2014-03-20 Nogra Pharma Limited Methods of inhibiting hair growth
KR101441278B1 (ko) * 2013-11-17 2014-09-17 한규나 머리카락 분말을 이용한 재활용 방법
JP6371520B2 (ja) * 2013-12-26 2018-08-08 日本メナード化粧品株式会社 皮脂合成促進剤
WO2016164460A2 (en) 2015-04-06 2016-10-13 The Trustees Of The University Of Pennsylvania Compositions and methods for decreasing, or preventing or reversing gain of, skin pigmentation in a mammalian subject
WO2017210600A1 (en) * 2016-06-03 2017-12-07 The Scripps Research Institute Compositions and methods of modulating immune response
WO2020152350A1 (en) * 2019-01-25 2020-07-30 Nogra Pharma Limited Compositions for use in preventing acne
US11905232B2 (en) 2019-02-08 2024-02-20 Nogra Pharma Limited Process of making 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof
JP6925072B1 (ja) * 2020-12-07 2021-08-25 株式会社Ｄｒ．Ｃｈｅｒｒｙ 毛髪改善のための組成物

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB767788A (en) * 1953-12-28 1957-02-06 Schering Corp Polyiodinated phenyl fatty acid compounds and process for their manufacture
US3211610A (en) 1961-09-29 1965-10-12 Merck & Co Inc Benzoic acid ester derivatives for treating coccidiosis and method of using same
US3444232A (en) 1966-05-18 1969-05-13 Squibb & Sons Inc O-alkyl or phenylalkyl benzohydroxamic acids
GB1359560A (en) 1972-02-25 1974-07-10 Merck & Co Inc Preparation of pyrrylsalicylic acid
US4036951A (en) 1973-03-12 1977-07-19 Synergistics, Inc. Ultra-violet filtration with certain aminosalicylic acid esters
FR2440353A1 (fr) 1978-11-03 1980-05-30 Science Union & Cie Nouveaux arylethanols, leurs procedes d'obtention et leur emploi comme medicament
US4348223A (en) 1980-12-05 1982-09-07 Ppg Industries, Inc. N-Alkyl-N-[3-(alkoxyalkyl)phenyl]-2-haloacetamide herbicides
DE3164618D1 (en) 1980-12-22 1984-08-09 Schering Ag 3-substituted 2,4,6-trihalogenobenzamides and their salts, their preparation and their use as substitutes for natural sweetening agents, and sweeteners containing them
JPS58194814A (ja) 1982-05-11 1983-11-12 Nippon Shinyaku Co Ltd 免疫調節作用を有する薬剤
IL69282A (en) 1982-09-02 1988-06-30 Euro Celtique Sa Method for the carboxylation of potassium phenoxide with carbon dioxide
GB8302708D0 (en) 1983-02-01 1983-03-02 Efamol Ltd Pharmaceutical and dietary composition
DE3786452T2 (de) 1987-02-05 1993-10-21 Kureha Chemical Ind Co Ltd Benzylether-Verbindungen und Verfahren zu ihrer Herstellung.
NZ224087A (en) * 1987-04-01 1990-08-28 Dak Lab As Topical pharmaceutical compositions containing 4- or 5- amino salicylic acid or a functional derivative thereof
ATE113209T1 (de) 1988-05-05 1994-11-15 Tillotts Pharma Ag Verwendung von 5-amino-salicylsäure für die behandlung von hautkrankheiten.
US5519014A (en) 1990-10-22 1996-05-21 Borody; Thomas J. Treatment of non-inflammatory and non-infectious bowel disorders
JP3425441B2 (ja) 1990-10-22 2003-07-14 ガストロ サービシイズ ピーティーワイ リミテッド 非炎症性及び非感染性腸障害の処置
US5262549A (en) 1991-05-30 1993-11-16 Polaroid Corporation Benzpyrylium dyes, and processes for their preparation and use
US5302751A (en) 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution
DE122005000058I1 (de) 1992-03-17 2006-04-27 Astellas Pharma Inc Depsipeptide, Herstellung und Anwendung
CA2120367C (en) 1992-06-30 2004-05-11 Howard K. Shapiro Compositions and use of pharmaceutical compositions in the treatment of symptoms of disorders related to chronic inflammatory diseases and etiologically related symptomology
US5594151A (en) 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
EP0759750A4 (en) 1994-05-11 1998-05-27 Howard K Shapiro PREPARATIONS FOR TREATING CHRONIC FLAMMABLE DISEASES
US5594015A (en) 1994-06-22 1997-01-14 Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis
EP0817631A2 (en) 1995-03-28 1998-01-14 Janssen Pharmaceutica N.V. Low dose ridogrel formulations and their use for the treatment of inflammatory bowel diseases
GB9600464D0 (en) 1996-01-09 1996-03-13 Smithkline Beecham Plc Novel method
GB9617001D0 (en) 1996-08-13 1996-09-25 Tillotts Pharma Ag Oral composition
DE19647582A1 (de) 1996-11-18 1998-05-20 Hoechst Ag Verfahren zur Herstellung von aromatischen Olefinen mittels Katalyse durch Palladaphosphacyclobutane
AU6773598A (en) 1997-03-26 1998-10-20 Institut Pasteur Treatment of gastrointestinal disease with ppar modulators
AU8588798A (en) 1997-07-25 1999-02-16 Institut Pasteur Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor
AU9002798A (en) 1997-09-19 1999-04-12 Ono Pharmaceutical Co. Ltd. Fused or nonfused benzene compounds
US7015249B1 (en) 1997-12-12 2006-03-21 Purdue Research Foundation Methods and compositions for treating diabetes
FR2773075B1 (fr) 1997-12-31 2000-05-05 Cird Galderma Utilisation d'activateurs de ppar-gamma en dermatologie
US6114382A (en) 1998-11-11 2000-09-05 Moretti; Itagiba G. Methods for treating inflammatory bowel disease
US6326364B1 (en) 1999-02-08 2001-12-04 Cedars-Sinai Medical Center Use of 5-aminosalicylates as antimicrobial agents
FR2791671B1 (fr) * 1999-04-01 2001-05-11 Oreal Nouveaux composes derives d'esters d'acide benzoique, composition les comprenant et utilisation
GB9908647D0 (en) 1999-04-15 1999-06-09 Smithkline Beecham Plc Novel compounds
US20040034067A1 (en) 1999-04-15 2004-02-19 Macphee Colin Houston Novel method of treatment
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
AU7995300A (en) 1999-10-05 2001-05-10 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
US7736661B1 (en) 2000-03-07 2010-06-15 Avon Products, Inc Method of treating skin conditions
CA2405518C (en) 2000-04-19 2009-07-07 Neurotech Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
JP4803946B2 (ja) * 2000-05-29 2011-10-26 杏林製薬株式会社 置換フェニルプロピオン酸誘導体
US7049342B2 (en) 2000-05-29 2006-05-23 Kyorin Pharmaceutical Co., Ltd. Substituted phenylpropionic acid derivatives
ATE448194T1 (de) 2000-08-29 2009-11-15 Biocon Ltd Verwendung einer pharmazeutischen zusammensetzung mit einem para-aminophenylessigsäurederivat für die behandlung von entzündlichen erkrankungen des magen-darmtrakts
EP1348698A4 (en) * 2000-12-05 2005-01-19 Kyorin Seiyaku Kk SUBSTITUTED CARBOXYLENE DERIVATIVES
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
FR2822955B1 (fr) 2001-03-27 2003-10-03 Chru Lille Methode de diagnostic de maladies inflammatoires chroniques de l'intestin
CA2443935A1 (en) 2001-04-18 2002-10-31 Merck & Co., Inc. Ppar-alpha-gamma ligands or agonists for the treatment of inflammation
CA2354921A1 (en) 2001-05-24 2002-11-24 Yasuo Konishi Drug evolution: drug design at hot spots
IL161431A0 (en) 2001-10-16 2004-09-27 Reddys Lab Ltd Dr beta-PHENYL-alpha-OXYSUBSTITUTED PROPIONIC ACID DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
WO2003043569A2 (en) 2001-11-16 2003-05-30 Nutrition 21, Inc. Trans-10, cis-12 conjugated linoleic acid isomer for the treatment of diseases
GB0127916D0 (en) 2001-11-21 2002-01-16 Rowett Res Inst Method
AU2002343094A1 (en) 2001-11-26 2003-06-10 Arachnova Therapeutics Ltd. Use of ppar activators for the treatment of pulmonary fibrosis
UA82835C2 (en) 2001-12-03 2008-05-26 Reddys Lab Ltd Dr ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon
US20030113815A1 (en) 2001-12-19 2003-06-19 Pfizer Inc. Canine peroxisome proliferator activated receptor gamma
WO2003053974A1 (en) 2001-12-21 2003-07-03 Dr. Reddy's Laboratories Ltd. Novel compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
US20030220374A1 (en) 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20040115127A1 (en) 2002-04-12 2004-06-17 Wright Samuel D. Ppar-alpha-gamma ligands or agonists for the treatment of inflammation
US8492438B2 (en) 2002-04-26 2013-07-23 Asan Laboratories Company (Cayman), Limited Treatment skin disorders
AU2003228744A1 (en) 2002-04-29 2003-11-17 The Ohio State University Inhibition of protein tyrosine phosphatases and sh2 domains by a neutral phosphotyrosine mimetic
DE10250080A1 (de) 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US20060159648A1 (en) 2003-02-17 2006-07-20 Davis Adrian F Novel therapeutic method and compositions for topical administration
GB0303609D0 (en) 2003-02-17 2003-03-19 Glaxo Group Ltd Novel therapeutic method and compositions
WO2004082715A1 (ja) 2003-03-20 2004-09-30 Eisai Co., Ltd. 炎症性腸疾患治療剤としての併用医薬
WO2005012280A1 (en) 2003-07-21 2005-02-10 Applied Research Systems Ars Holding N.V. Alkynyl aryl carboxamides
UA60954C2 (en) 2003-07-25 2006-03-15 Subsidiary Entpr With Foreign Method for measuring conductivity of electrolyte by a contactless measuring transducer
WO2005039590A1 (en) 2003-10-21 2005-05-06 Inspire Pharmaceuticals, Inc. Non-nucleotide compositions and method for treating pain
EP1680397A2 (en) 2003-10-28 2006-07-19 Dr. Reddy's Laboratories Ltd. Novel compounds and their use as antidiabetic and hypolipidemic agents, process for their preparation and pharmaceutical compositions containing them
FR2862870A1 (fr) 2003-12-01 2005-06-03 Galderma Res & Dev Utilisation d'activateurs de recepteurs ppar en cosmetique et dermatologie.
WO2005055933A2 (en) 2003-12-03 2005-06-23 Smithkline Beecham Corporation Treatment of psoriasis with rosiglitazone
CA2553775A1 (en) 2004-01-20 2005-08-11 Richard F. Harty Compositions and methods of treatment for inflammatory diseases
WO2005084658A1 (en) * 2004-03-04 2005-09-15 Arakis Ltd. Derivatives of actarit and their therapeutic use
US20050277693A1 (en) 2004-06-10 2005-12-15 Dr. Reddy's Laboratories Limited Basic salts and monohydrates of certain alpha, beta-propionic acid derivative
AR050631A1 (es) 2004-09-09 2006-11-08 Novartis Ag Combinacion de compuestos organicos
WO2006037052A2 (en) 2004-09-27 2006-04-06 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Modulating mxa expression
US20060286046A1 (en) 2005-01-05 2006-12-21 Haber C Andrew Skin care compositions
EP1719543A1 (en) 2005-05-04 2006-11-08 Asan Labs., Ltd. Use of histone deacetylase inhibitors for the treatment of gastrointestinal distress
US20060270635A1 (en) 2005-05-27 2006-11-30 Wallace John L Derivatives of 4- or 5-aminosalicylic acid
ITRM20050390A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
ITRM20050389A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
DE102005061472A1 (de) 2005-12-22 2007-07-05 Saltigo Gmbh Verfahren zur Herstellung von enantiomerenangereicherten 2-Alkoxy-3-phenylpropionsäuren
WO2007096148A1 (en) 2006-02-23 2007-08-30 Lipid Nutrition B.V. Immunoregulation
US7645801B2 (en) 2007-01-29 2010-01-12 Alaven Pharmaceutical Llc Reduced irritant enema for treatment of inflammatory bowel disease (IBD)
IE20070129A1 (en) 2007-02-28 2008-12-24 Giuliani Int Ltd Ppar-gamma agonists stimulate enteric defensin expression
US8796282B2 (en) 2007-03-28 2014-08-05 Case Western Reserve University Method of treating dermatological disorders
US20090054312A1 (en) 2007-08-22 2009-02-26 Wolf Dieter A SMIPs: Small molecule inhibitors of p27 depletion in cancers and other proliferative diseases
ITMI20072429A1 (it) 2007-12-24 2009-06-25 Giuliani Int Ltd Composti per il trattamento selettivo della componente immuno-infiammatoria intestinale della malattia celiaca
US8030520B2 (en) 2008-03-31 2011-10-04 Saltigo Gmbh Process for preparing organic compounds by a transition metal-catalysed cross-coupling reaction of an aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide
UA107562C2 (uk) 2008-12-05 2015-01-26 Спосіб лікування псоріазу
EA020198B1 (ru) 2009-02-16 2014-09-30 Джулиани Интернэшнл Лимитед N-ацетил-(r)-(-)-3-(4-аминофенил)-2-метоксипропионовая кислота, содержащая ее фармацевтическая композиция, способ лечения
EP2298321A1 (en) 2009-08-26 2011-03-23 Nordic Pharma Novel pharmaceutical compositions for treating IBD
US20140256661A1 (en) 2011-07-15 2014-09-11 David Nigel Armstrong Pharmaceutical compositions for rectal administration
US9491942B2 (en) 2011-10-17 2016-11-15 The Regents Of The University Of California Methods for assessing repellant quality of organic materials and methods and compositions for repelling arthropods
US9809557B2 (en) 2011-10-31 2017-11-07 Claus Selch Larsen Prodrugs of non-steroid anti-inflammatory agents (NSAIDS)
CN116602950A (zh) 2012-02-09 2023-08-18 诺格拉制药有限公司 治疗纤维化的方法
IN2014DN08157A (hr) 2012-04-18 2015-05-01 Nogra Pharma Ltd
WO2013168438A1 (ja) 2012-05-10 2013-11-14 国立大学法人岩手大学 ラクターゼ活性を有するタンパク質、該タンパク質をコードする遺伝子、該遺伝子を含有する組み換えベクター、形質転換体、及びその製造方法並びに用途
BR112014030039A2 (pt) 2012-06-01 2017-06-27 Nogra Pharma Ltd heterociclos bicíclicos capazes de modular respostas de células t e métodos de uso dos mesmos
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
WO2013184755A2 (en) 2012-06-07 2013-12-12 Georgia State University Research Foundation, Inc. Seca inhibitors and methods of making and using thereof
CA2883836A1 (en) 2012-09-13 2014-03-20 Nogra Pharma Limited Methods of inhibiting hair growth
EA035986B1 (ru) 2012-09-13 2020-09-09 Ногра Фарма Лимитед Способы лечения или облегчения плоского фолликулярного лишая
CN105377247B (zh) 2013-03-26 2019-04-26 脂质治疗有限公司 用于治疗溃疡性结肠炎含磷脂酰胆碱的药物制剂
CN105566153B (zh) 2014-10-14 2019-05-31 中国医学科学院药物研究所 偶氮苯衍生物及其制法和药物组合物与用途
WO2016154730A1 (en) 2015-04-02 2016-10-06 University Health Network Gut anti-inflammatory agents for regulation of high blood glucose levels
WO2016202341A1 (en) 2015-06-15 2016-12-22 Nmd Pharma Aps Compounds for use in treating neuromuscular disorders
WO2017046343A1 (en) 2015-09-17 2017-03-23 Nogra Pharma Limited Compositions for rectal administration in the treatment of ulcerative colitis and methods of using same
WO2017093444A1 (en) 2015-12-01 2017-06-08 Nogra Pharma Limited Compositions for oral administration in the treatment of inflammatory bowel disease
MA43682A (fr) 2016-02-26 2018-11-28 Nogra Pharma Ltd Procédés de traitement de l'intolérance au lactose

Also Published As

Publication number Publication date
EP2396082A2 (en) 2011-12-21
AU2010213095A1 (en) 2011-09-08
KR101776337B1 (ko) 2017-09-07
JP2014237692A (ja) 2014-12-18
JP5715070B2 (ja) 2015-05-07
IL214665A (en) 2017-02-28
US9901557B2 (en) 2018-02-27
IL214665A0 (en) 2011-09-27
EP2396081B1 (en) 2017-04-05
SI2396081T1 (sl) 2017-09-29
SI2805746T1 (sl) 2020-10-30
CA2752623C (en) 2017-07-04
US20220354809A1 (en) 2022-11-10
EA020198B1 (ru) 2014-09-30
IL214664A (en) 2015-09-24
AU2010213095B2 (en) 2015-09-17
ES2429143T3 (es) 2013-11-13
US20160338927A1 (en) 2016-11-24
AR080596A1 (es) 2012-04-25
US10137101B2 (en) 2018-11-27
US20120053245A1 (en) 2012-03-01
CN104666288B (zh) 2017-08-04
MX2011008601A (es) 2011-09-09
WO2010091892A2 (en) 2010-08-19
JP5820030B2 (ja) 2015-11-24
KR101800901B1 (ko) 2017-11-23
CN102316932A (zh) 2012-01-11
PT2396082E (pt) 2013-10-03
CN102316931A (zh) 2012-01-11
ES2630044T3 (es) 2017-08-17
US20150148418A1 (en) 2015-05-28
HUE032999T2 (hu) 2017-11-28
EP2805746B1 (en) 2020-05-06
US20200383942A1 (en) 2020-12-10
HRP20170936T1 (hr) 2017-09-22
US20190269637A1 (en) 2019-09-05
AU2010213093A1 (en) 2011-09-08
LT2396081T (lt) 2017-09-11
US20120053244A1 (en) 2012-03-01
US20200188340A1 (en) 2020-06-18
EP2805746A1 (en) 2014-11-26
ZA201106256B (en) 2012-05-30
BRPI1008752A2 (pt) 2016-03-08
US20170172956A1 (en) 2017-06-22
UA105037C2 (uk) 2014-04-10
US8754127B2 (en) 2014-06-17
EP2396081A2 (en) 2011-12-21
CA2752623A1 (en) 2010-08-19
US10959970B2 (en) 2021-03-30
DK2805746T3 (da) 2020-08-10
LT2805746T (lt) 2020-09-25
BRPI1008752B1 (pt) 2020-02-11
EP2396082B1 (en) 2013-07-31
WO2010091894A2 (en) 2010-08-19
AU2010213093B2 (en) 2016-01-07
PT2805746T (pt) 2020-08-17
CY1123213T1 (el) 2021-12-31
BRPI1011226B1 (pt) 2019-10-29
EA201171063A1 (ru) 2012-01-30
KR20110120945A (ko) 2011-11-04
EP3744398A1 (en) 2020-12-02
NZ595076A (en) 2013-09-27
DK2396081T3 (en) 2017-07-10
JP2012517968A (ja) 2012-08-09
NZ595080A (en) 2013-09-27
CN102316932B (zh) 2014-07-09
WO2010091892A3 (en) 2010-10-21
US20150051285A1 (en) 2015-02-19
CA2752626A1 (en) 2010-08-19
US10398667B2 (en) 2019-09-03
WO2010091894A3 (en) 2010-11-11
CA2752626C (en) 2018-03-27
EA201171062A1 (ru) 2012-01-30
CN104666288A (zh) 2015-06-03
CY1119225T1 (el) 2018-02-14
EA020856B1 (ru) 2015-02-27
IL214664A0 (en) 2011-09-27
JP2012517969A (ja) 2012-08-09
US9511041B2 (en) 2016-12-06
JP5645851B2 (ja) 2014-12-24
KR20110120946A (ko) 2011-11-04
JP2015155427A (ja) 2015-08-27
PT2396081T (pt) 2017-07-11
UA109525C2 (xx) 2015-09-10
ES2806691T3 (es) 2021-02-18
US8796334B2 (en) 2014-08-05
MX2011008602A (es) 2011-09-09
BRPI1011226A2 (pt) 2016-03-15
PL2396081T3 (pl) 2017-10-31
HUE050267T2 (hu) 2020-11-30
CN102316931B (zh) 2014-11-19
US20180369178A1 (en) 2018-12-27

Similar Documents

Publication Publication Date Title
HRP20201184T1 (hr) Spojevi alkilamida i njihove uporabe
HRP20201243T1 (hr) N-piperidinil acetamidni derivati kao blokatori kalcijevog kanala
HRP20171512T1 (hr) Derivati betulina
HRP20180237T4 (hr) Metode za liječenje hcv-a
GB2465703B (en) Cosmetic treatment using p-coumaric acid derivatives for the reduction of skin pigmentation
JP2013511534A5 (hr)
HRP20150770T1 (hr) Terapijska kombinacija koja sadrži dolutegravir, abakavir i lamivudin
EA201201664A1 (ru) Производные 6-циклоалкил-1,5-дигидропипазоло[3,4-d]пиримидин-4-она и их применение в качестве ингибиторов pde9a
HRP20171648T1 (hr) Supstituirani piperidil-etil-pirimidin kao inhibitor grelin-o-acil-transferaze
FR2924024B1 (fr) Nanoparticules d'actifs therapeutiques de faible solubilite aqueuse
CA2869599C (en) Compounds which inhibit neuronal exocytosis (ii)
JP2013538853A5 (hr)
RU2016106829A (ru) Применение ингибиторов ацетил-СоА карбоксилазы для лечения обыкновенных угрей
HRP20171742T4 (hr) 2,4,6-trifluor-n-[6-(1-metilpiperidin-4-karbonil)piridin-2-il]benzamid, namijenjen liječenju migrene oralnom ili intravenskom primjenom
JP2011513501A5 (hr)
BR112014009910A2 (pt) formulações de sal de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico
HRP20210245T1 (hr) Primjena fk506 za liječenje plućne arterijske hipertenzije
FR2935378B1 (fr) Utiisation de n-acyl aminoacides comme principes actifs cosmetiques et pharmaceutiques, capables de reduire l'etat inflammatoire des fibroblastes replicatifs senescents issus du derme humain adulte; compositions cosmetiques anti-age
BR112014011176A2 (pt) enxaguante bucal livre de álcool
RU2016116155A (ru) Композиция, содержащая эвгенол в качестве активного ингредиента, для предупреждения или лечения атопического дерматита
EA201591021A1 (ru) 4-гидрокси-2-метил-5-(пропан-2-илиден)циклогекс-3-энекарбальдегид в профилактике и лечении когнитивных, нейродегенеративных или нейронных заболеваний
RU2009127747A (ru) Применение непафенака или его производных для лечения дерматологических расстройств, связанных с нарушением кератинизации, которое может иметь иммуно-аллергическую воспалительную составляющую
ITMI20031941A1 (it) Composizioni farmaceutiche topiche per il trattamento delle dermatiti
TWI365753B (en) Use of adamantyl methoxydiphenyl propenoic acid for the treatment of dermatological diseases
RU2011121659A (ru) Депигментирующие местные композиции и их применение