FI946189A0 - 17-alkyl ketone steroids useful as 5-alpha-reductase inhibitors - Google Patents

17-alkyl ketone steroids useful as 5-alpha-reductase inhibitors

Info

Publication number: FI946189A0
Authority: FI; Finland
Prior art keywords: alpha; reductase inhibitors; alkyl ketone; steroids useful; ketone steroids
Prior art date: 1992-06-30

Application number

FI946189A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI946189A (en

Inventor

Dennis Alan Holt

Mark Alan Levy

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-30

Filing date

1994-12-30

Publication date

1994-12-30

1994-12-30 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1994-12-30 Publication of FI946189A0 publication Critical patent/FI946189A0/en

1994-12-30 Publication of FI946189A publication Critical patent/FI946189A/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI946189A 1992-06-30 1994-12-30 17-Alkyl ketone steroids useful as 5-alpha reductase inhibitors FI946189A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929213835A GB9213835D0 (en)	1992-06-30	1992-06-30	Compounds
PCT/US1993/006238 WO1994000125A1 (en)	1992-06-30	1993-06-30	17-ALKYLKETONE STEROIDS USEFUL AS 5-α-REDUCTASE INHIBITORS

Publications (2)

Publication Number	Publication Date
FI946189A0 true FI946189A0 (en)	1994-12-30
FI946189A FI946189A (en)	1994-12-30

Family

ID=10717920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI946189A FI946189A (en)	1992-06-30	1994-12-30	17-Alkyl ketone steroids useful as 5-alpha reductase inhibitors

Country Status (23)

Country	Link
EP (1)	EP0651643A4 (en)
JP (1)	JPH08500821A (en)
KR (1)	KR950702118A (en)
CN (1)	CN1095382A (en)
AP (1)	AP412A (en)
AU (1)	AU4545993A (en)
BG (1)	BG99313A (en)
BR (1)	BR9306748A (en)
CA (1)	CA2138956A1 (en)
CZ (1)	CZ334694A3 (en)
FI (1)	FI946189A (en)
GB (1)	GB9213835D0 (en)
HU (1)	HUT69409A (en)
IL (1)	IL106158A0 (en)
MA (1)	MA22927A1 (en)
MX (1)	MX9303970A (en)
NO (1)	NO945074L (en)
OA (1)	OA10122A (en)
RU (1)	RU94046378A (en)
SI (1)	SI9300350A (en)
SK (1)	SK159994A3 (en)
WO (1)	WO1994000125A1 (en)
ZA (1)	ZA934645B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925774A (en) *	1991-01-07	1999-07-20	Pherin Corporation	Estrenes for inducing hypothalamic effects
EP0646007B1 (en) *	1992-05-20	1997-08-13	Merck & Co. Inc.	NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17$g(b)-SUBSTITUTED-4-AZA-5$g(a)-ANDROSTAN-3-ONES AS 5$g(a)-REDUCTASE INHIBITORS
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic
JP2015129095A (en)	2013-12-19	2015-07-16	ロレアル	composition
BR112020016269A2 (en) *	2018-02-11	2020-12-15	Jiangsu Hansoh Pharmaceutical Group Co., Ltd.	STEROID DERIVED REGULATORS, METHOD TO PREPARE THEM AND THEIR USES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954446A (en) *	1988-05-25	1990-09-04	Smithkline Beecham Corporation	Aromatic steroid 5-α-reductase inhibitors

1992
- 1992-06-30 GB GB929213835A patent/GB9213835D0/en active Pending
1993
- 1993-06-26 ZA ZA934645A patent/ZA934645B/en unknown
- 1993-06-28 MA MA23217A patent/MA22927A1/en unknown
- 1993-06-28 IL IL106158A patent/IL106158A0/en unknown
- 1993-06-30 BR BR9306748A patent/BR9306748A/en not_active Application Discontinuation
- 1993-06-30 RU RU94046378/04A patent/RU94046378A/en unknown
- 1993-06-30 CN CN93109540A patent/CN1095382A/en active Pending
- 1993-06-30 AU AU45459/93A patent/AU4545993A/en not_active Abandoned
- 1993-06-30 MX MX9303970A patent/MX9303970A/en unknown
- 1993-06-30 SI SI9300350A patent/SI9300350A/en unknown
- 1993-06-30 CZ CZ943346A patent/CZ334694A3/en unknown
- 1993-06-30 WO PCT/US1993/006238 patent/WO1994000125A1/en not_active Application Discontinuation
- 1993-06-30 EP EP93915499A patent/EP0651643A4/en not_active Withdrawn
- 1993-06-30 JP JP6502660A patent/JPH08500821A/en active Pending
- 1993-06-30 SK SK1599-94A patent/SK159994A3/en unknown
- 1993-06-30 HU HU9403833A patent/HUT69409A/en unknown
- 1993-06-30 CA CA002138956A patent/CA2138956A1/en not_active Abandoned
- 1993-06-30 AP APAP/P/1993/000542A patent/AP412A/en active
1994
- 1994-12-29 BG BG99313A patent/BG99313A/en unknown
- 1994-12-29 NO NO945074A patent/NO945074L/en unknown
- 1994-12-29 KR KR1019940704802A patent/KR950702118A/en not_active Application Discontinuation
- 1994-12-29 OA OA60599A patent/OA10122A/en unknown
- 1994-12-30 FI FI946189A patent/FI946189A/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPH08500821A (en)	1996-01-30
NO945074D0 (en)	1994-12-29
SK159994A3 (en)	1996-01-10
BR9306748A (en)	1998-12-08
MX9303970A (en)	1994-04-29
WO1994000125A1 (en)	1994-01-06
ZA934645B (en)	1994-01-25
AP9300542A0 (en)	1993-07-31
BG99313A (en)	1995-09-29
EP0651643A4 (en)	1995-10-04
RU94046378A (en)	1996-10-10
IL106158A0 (en)	1993-10-20
AU4545993A (en)	1994-01-24
CA2138956A1 (en)	1994-01-06
CN1095382A (en)	1994-11-23
CZ334694A3 (en)	1995-10-18
FI946189A (en)	1994-12-30
OA10122A (en)	1996-12-18
HUT69409A (en)	1995-09-28
AP412A (en)	1995-09-29
MA22927A1 (en)	1994-04-01
NO945074L (en)	1995-02-16
KR950702118A (en)	1995-06-19
GB9213835D0 (en)	1992-08-12
EP0651643A1 (en)	1995-05-10
SI9300350A (en)	1993-12-31

Publication	Publication Date	Title
DK0802184T3 (en)	2002-09-16	N-Benzyl-2-phenylindoles as estrogenic agents
NO940305D0 (en)	1994-01-28	Kinazoline derivatives as acetylcholine esterase inhibitors
AU531537B2 (en)	1983-08-25	Method for sanitizing toilets
NO980467L (en)	1998-04-03	4-mercaptopyrrolidine derivatives as farnesyl transerase inhibitors
IS7292A (en)	2004-06-02	Substituted benzenesulfonamide derivatives as progenitors for COX-2 inhibitors
DK0818448T3 (en)	2004-03-22	Cycloalkanopyridines as CETP inhibitors
NO961432D0 (en)	1996-04-11	Benzophiophenes and related compounds as estrogen agonists
NO881857L (en)	1988-10-31	STEROID 5-ALFA REDUCTASE INHIBITORS.
NO992725D0 (en)	1999-06-04	6-Phenylpyridyl-2-amine derivatives useful as NOS inhibitors
NO992821D0 (en)	1999-06-10	Ketobenzamides as Calpain Inhibitors
FI931069A0 (en)	1993-03-10	KOLLOIDALT ROSTAT KAFFE SOM AROMATISERINGSPRODUKT
DK0606248T3 (en)	2003-06-23	Heteroberlamines as novel acetylcholinesterase inhibitors
FI891438A0 (en)	1989-03-23	FOERFARANDE FOER FRAMSTAELLNING AV PHARMACEUTISKA SAMMANSAETTNINGAR SOM INVERKAR I SYNNERHET PAO DET KARDIOVASKULAERA SYSTEMET.
DE69526475D1 (en)	2002-05-29	5-alpha-reductase inhibitors
MX9200731A (en)	1992-09-01	HYDRAZONE COMPOUNDS, PROCEDURES FOR ITS HYDRAZONE COMPOUNDS, PROCEDURES FOR ITS PREPARATION, INTERMEDIATE COMPOUNDS USEFUL FOR ITS OPERATION, INTERMEDIATE COMPOUNDS USEFUL FOR ITS OBTAINMENT AND PESTICIDED COMPOSITIONS THAT CONTAIN MESSAGE AND MISCELLANEOUS COMPOSITIONS CONTAINING BTENTIONAL COMPOSITIONS. THE SAME.
FI946189A0 (en)	1994-12-30	17-alkyl ketone steroids useful as 5-alpha-reductase inhibitors
NO922167D0 (en)	1992-06-01	AMINODECTS AS CORROSION INHIBITORS
EP0650358A4 (en)	1995-06-07	17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors.
IS2271B (en)	2007-07-15	Anti-inflammatory agent for topical use
NO965165D0 (en)	1996-12-03	Use of 8,9-dehydroestrone as an antioxidant
NO933622D0 (en)	1993-10-08	BENZENDIMETANOL SUITABLE FOR MICRONIZATION
FI930385A0 (en)	1993-01-29	LATEXFAERG SOM TAOL LOESNINGSMEDEL
MX9203759A (en)	1992-08-01	STEROIDAL 5-ALPHA-REDUCTASE INHIBITORS.
FI944023A0 (en)	1994-09-01	Foerfarande Foer identifiering av avelselser i en yta som granskas
ES1029636Y (en)	1995-12-01	INFORMATIVE PANEL FOR INVIDENTS.

Legal Events

Date	Code	Title	Description
1997-01-14	FD	Application lapsed