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NO945074L - 17-Alkylethone steroids useful as 5-itators - Google Patents

17-Alkylethone steroids useful as 5-itators

Info

Publication number
NO945074L
NO945074L NO945074A NO945074A NO945074L NO 945074 L NO945074 L NO 945074L NO 945074 A NO945074 A NO 945074A NO 945074 A NO945074 A NO 945074A NO 945074 L NO945074 L NO 945074L
Authority
NO
Norway
Prior art keywords
compounds
steroid
itators
alkylethone
steroids useful
Prior art date
Application number
NO945074A
Other languages
Norwegian (no)
Other versions
NO945074D0 (en
Inventor
Dennis Alan Holt
Mark Alan Levy
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO945074D0 publication Critical patent/NO945074D0/en
Publication of NO945074L publication Critical patent/NO945074L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen tilveiebringer 17a og 17/3-alkylketon-3- karboksyaromatiske A-ringanaloger av steroide syntetiske forbindelser, farmasøytiske blandinger og preparater som inneholder disse forbindelser og fremgangsmåter for bruken av forbindelsene for å hemme steroid 5-o-reduktaseisozym l og steroid 5-a-reduktaseisozym 2. Oppfinnelsen tilveiebringer også mellomprodukter og fremgangsmåter som anvendes for frem- stilling av disse forbindelser. H-OC (D hvor Z er a eller O 1 -C-R hvor R er en c^ lineær eller grenet, mettet eller umettet alkylgruppe og farmasøytisk akseptable salter, hydrater, solvater og estere av en slik forbindelse.The invention provides 17a and 17/3 alkyl ketone-3-carboxy aromatic A-ring analogues of steroid synthetic compounds, pharmaceutical compositions and compositions containing these compounds and methods for the use of the compounds to inhibit steroid 5-o-reductase isozyme 1 and steroid 5-a The reductase isozyme 2. The invention also provides intermediates and processes used for the preparation of these compounds. H-OC (D where Z is a or O 1 -C-R where R is a linear or branched, saturated or unsaturated alkyl group and pharmaceutically acceptable salts, hydrates, solvates and esters of such a compound.

NO945074A 1992-06-30 1994-12-29 17-Alkylethone steroids useful as 5-itators NO945074L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929213835A GB9213835D0 (en) 1992-06-30 1992-06-30 Compounds
PCT/US1993/006238 WO1994000125A1 (en) 1992-06-30 1993-06-30 17-ALKYLKETONE STEROIDS USEFUL AS 5-α-REDUCTASE INHIBITORS

Publications (2)

Publication Number Publication Date
NO945074D0 NO945074D0 (en) 1994-12-29
NO945074L true NO945074L (en) 1995-02-16

Family

ID=10717920

Family Applications (1)

Application Number Title Priority Date Filing Date
NO945074A NO945074L (en) 1992-06-30 1994-12-29 17-Alkylethone steroids useful as 5-itators

Country Status (23)

Country Link
EP (1) EP0651643A4 (en)
JP (1) JPH08500821A (en)
KR (1) KR950702118A (en)
CN (1) CN1095382A (en)
AP (1) AP412A (en)
AU (1) AU4545993A (en)
BG (1) BG99313A (en)
BR (1) BR9306748A (en)
CA (1) CA2138956A1 (en)
CZ (1) CZ334694A3 (en)
FI (1) FI946189A (en)
GB (1) GB9213835D0 (en)
HU (1) HUT69409A (en)
IL (1) IL106158A0 (en)
MA (1) MA22927A1 (en)
MX (1) MX9303970A (en)
NO (1) NO945074L (en)
OA (1) OA10122A (en)
RU (1) RU94046378A (en)
SI (1) SI9300350A (en)
SK (1) SK159994A3 (en)
WO (1) WO1994000125A1 (en)
ZA (1) ZA934645B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925774A (en) * 1991-01-07 1999-07-20 Pherin Corporation Estrenes for inducing hypothalamic effects
EP0646007B1 (en) * 1992-05-20 1997-08-13 Merck & Co. Inc. NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17$g(b)-SUBSTITUTED-4-AZA-5$g(a)-ANDROSTAN-3-ONES AS 5$g(a)-REDUCTASE INHIBITORS
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
JP2015129095A (en) 2013-12-19 2015-07-16 ロレアル composition
BR112020016269A2 (en) * 2018-02-11 2020-12-15 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. STEROID DERIVED REGULATORS, METHOD TO PREPARE THEM AND THEIR USES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors

Also Published As

Publication number Publication date
JPH08500821A (en) 1996-01-30
NO945074D0 (en) 1994-12-29
SK159994A3 (en) 1996-01-10
BR9306748A (en) 1998-12-08
MX9303970A (en) 1994-04-29
FI946189A0 (en) 1994-12-30
WO1994000125A1 (en) 1994-01-06
ZA934645B (en) 1994-01-25
AP9300542A0 (en) 1993-07-31
BG99313A (en) 1995-09-29
EP0651643A4 (en) 1995-10-04
RU94046378A (en) 1996-10-10
IL106158A0 (en) 1993-10-20
AU4545993A (en) 1994-01-24
CA2138956A1 (en) 1994-01-06
CN1095382A (en) 1994-11-23
CZ334694A3 (en) 1995-10-18
FI946189A (en) 1994-12-30
OA10122A (en) 1996-12-18
HUT69409A (en) 1995-09-28
AP412A (en) 1995-09-29
MA22927A1 (en) 1994-04-01
KR950702118A (en) 1995-06-19
GB9213835D0 (en) 1992-08-12
EP0651643A1 (en) 1995-05-10
SI9300350A (en) 1993-12-31

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