BR9306748A - 17-alkylacetone steroids useful as 5-reductase inhibitors - Google Patents

17-alkylacetone steroids useful as 5-reductase inhibitors

Info

Publication number: BR9306748A
Authority: BR; Brazil
Prior art keywords: alkylacetone; reductase inhibitors; steroids useful; steroids; useful
Prior art date: 1992-06-30

Application number

BR9306748A

Other languages

Portuguese (pt)

Inventor

Dennis Alan Holt

Mark Alan Levy

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-30

Filing date

1993-06-30

Publication date

1998-12-08

1993-06-30 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1998-12-08 Publication of BR9306748A publication Critical patent/BR9306748A/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BR9306748A 1992-06-30 1993-06-30 17-alkylacetone steroids useful as 5-reductase inhibitors BR9306748A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929213835A GB9213835D0 (en)	1992-06-30	1992-06-30	Compounds
PCT/US1993/006238 WO1994000125A1 (en)	1992-06-30	1993-06-30	17-ALKYLKETONE STEROIDS USEFUL AS 5-α-REDUCTASE INHIBITORS

Publications (1)

Publication Number	Publication Date
BR9306748A true BR9306748A (en)	1998-12-08

Family

ID=10717920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9306748A BR9306748A (en)	1992-06-30	1993-06-30	17-alkylacetone steroids useful as 5-reductase inhibitors

Country Status (23)

Country	Link
EP (1)	EP0651643A4 (en)
JP (1)	JPH08500821A (en)
KR (1)	KR950702118A (en)
CN (1)	CN1095382A (en)
AP (1)	AP412A (en)
AU (1)	AU4545993A (en)
BG (1)	BG99313A (en)
BR (1)	BR9306748A (en)
CA (1)	CA2138956A1 (en)
CZ (1)	CZ334694A3 (en)
FI (1)	FI946189A (en)
GB (1)	GB9213835D0 (en)
HU (1)	HUT69409A (en)
IL (1)	IL106158A0 (en)
MA (1)	MA22927A1 (en)
MX (1)	MX9303970A (en)
NO (1)	NO945074L (en)
OA (1)	OA10122A (en)
RU (1)	RU94046378A (en)
SI (1)	SI9300350A (en)
SK (1)	SK159994A3 (en)
WO (1)	WO1994000125A1 (en)
ZA (1)	ZA934645B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925774A (en) *	1991-01-07	1999-07-20	Pherin Corporation	Estrenes for inducing hypothalamic effects
EP0646007B1 (en) *	1992-05-20	1997-08-13	Merck & Co. Inc.	NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17$g(b)-SUBSTITUTED-4-AZA-5$g(a)-ANDROSTAN-3-ONES AS 5$g(a)-REDUCTASE INHIBITORS
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic
JP2015129095A (en)	2013-12-19	2015-07-16	ロレアル	composition
BR112020016269A2 (en) *	2018-02-11	2020-12-15	Jiangsu Hansoh Pharmaceutical Group Co., Ltd.	STEROID DERIVED REGULATORS, METHOD TO PREPARE THEM AND THEIR USES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954446A (en) *	1988-05-25	1990-09-04	Smithkline Beecham Corporation	Aromatic steroid 5-α-reductase inhibitors

1992
- 1992-06-30 GB GB929213835A patent/GB9213835D0/en active Pending
1993
- 1993-06-26 ZA ZA934645A patent/ZA934645B/en unknown
- 1993-06-28 MA MA23217A patent/MA22927A1/en unknown
- 1993-06-28 IL IL106158A patent/IL106158A0/en unknown
- 1993-06-30 BR BR9306748A patent/BR9306748A/en not_active Application Discontinuation
- 1993-06-30 RU RU94046378/04A patent/RU94046378A/en unknown
- 1993-06-30 CN CN93109540A patent/CN1095382A/en active Pending
- 1993-06-30 AU AU45459/93A patent/AU4545993A/en not_active Abandoned
- 1993-06-30 MX MX9303970A patent/MX9303970A/en unknown
- 1993-06-30 SI SI9300350A patent/SI9300350A/en unknown
- 1993-06-30 CZ CZ943346A patent/CZ334694A3/en unknown
- 1993-06-30 WO PCT/US1993/006238 patent/WO1994000125A1/en not_active Application Discontinuation
- 1993-06-30 EP EP93915499A patent/EP0651643A4/en not_active Withdrawn
- 1993-06-30 JP JP6502660A patent/JPH08500821A/en active Pending
- 1993-06-30 SK SK1599-94A patent/SK159994A3/en unknown
- 1993-06-30 HU HU9403833A patent/HUT69409A/en unknown
- 1993-06-30 CA CA002138956A patent/CA2138956A1/en not_active Abandoned
- 1993-06-30 AP APAP/P/1993/000542A patent/AP412A/en active
1994
- 1994-12-29 BG BG99313A patent/BG99313A/en unknown
- 1994-12-29 NO NO945074A patent/NO945074L/en unknown
- 1994-12-29 KR KR1019940704802A patent/KR950702118A/en not_active Application Discontinuation
- 1994-12-29 OA OA60599A patent/OA10122A/en unknown
- 1994-12-30 FI FI946189A patent/FI946189A/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPH08500821A (en)	1996-01-30
NO945074D0 (en)	1994-12-29
SK159994A3 (en)	1996-01-10
MX9303970A (en)	1994-04-29
FI946189A0 (en)	1994-12-30
WO1994000125A1 (en)	1994-01-06
ZA934645B (en)	1994-01-25
AP9300542A0 (en)	1993-07-31
BG99313A (en)	1995-09-29
EP0651643A4 (en)	1995-10-04
RU94046378A (en)	1996-10-10
IL106158A0 (en)	1993-10-20
AU4545993A (en)	1994-01-24
CA2138956A1 (en)	1994-01-06
CN1095382A (en)	1994-11-23
CZ334694A3 (en)	1995-10-18
FI946189A (en)	1994-12-30
OA10122A (en)	1996-12-18
HUT69409A (en)	1995-09-28
AP412A (en)	1995-09-29
MA22927A1 (en)	1994-04-01
NO945074L (en)	1995-02-16
KR950702118A (en)	1995-06-19
GB9213835D0 (en)	1992-08-12
EP0651643A1 (en)	1995-05-10
SI9300350A (en)	1993-12-31

Publication	Publication Date	Title
BR9206577A (en)	1995-10-10	Heteroalylamines that act as new acetylcholinesterase inhibitors
FI933510A0 (en)	1993-08-09	GRAENSYTAKTIVA FOERENINGAR BASERADE PAO MODIFIERADE RISINOLJEFETTDERIVAT
NO307250B1 (en)	2000-03-06	gantry
FI931711A0 (en)	1993-04-15	STOEDFOT FOER KRAN I KOMPOSITMATERIAL
DE59304856D1 (en)	1997-02-06	Sterilization tunnel
FI933038A (en)	1994-01-29	MATNINGSSYSTEM FOER PRESSPARTIET I EN PAPPERMASKIN
BR9306748A (en)	1998-12-08	17-alkylacetone steroids useful as 5-reductase inhibitors
FI933395A (en)	1994-01-31	PAO UNDECYLENSYRAESTER BASERAT DESODORISERINGSMEDEL FOER PAPPERINDUSTRINS AVLOPP
FI946081A (en)	1994-12-23	Steroidal beta-O-cellobioside hepta-alkanoate method
FI931058A (en)	1993-10-26	RAKELBALK FOER FAERGNINGSANORDNINGEN I EN TRYCKMASKIN
FI933763A (en)	1994-03-01	Graensytaktiva foereningar baserade pao alkoxylerade fettaminer
FI931411A (en)	1993-10-02	TESTING DEVICES FOR BROMSSYSTEM
FI935011A0 (en)	1993-11-12	Mellanvaeggsystem i synnerhet Foer hyttdaeck pao fartyg
NO970329D0 (en)	1997-01-24	Tetracyclic triterpenes
FI933485A0 (en)	1993-08-06	AVRINNINGSINSATS FOER MONTERING I EXISTERANDE AVRINNINGSBASSAENG
FI925685A0 (en)	1992-12-15	FOERFARANDE I FOERBRAENNINGSMOTORPROCESS
FI931477A0 (en)	1993-04-01	FOERFARANDE FOER DATAOEVERFOERING PAO TELEFONLINJER
MX9203683A (en)	1992-08-01	4-AMINO-4-ENE-STEROIDS AND THEIR USE AS 5-ALPHA-REDUCTASE INHIBITORS.
FI934388A0 (en)	1993-10-06	MULTIFOKAL KONTAKTLINS MED AVVIKANDE STYRKA PAO BAKSIDAN
FI538U1 (en)	1993-02-17	Lockpipa Foer jakt pao jaerpe
FI924783A0 (en)	1992-10-22	KONSTRUKTIONSMATERIAL Foer BAOLEN PAO EN SKYLTDOCKA
FI924808A0 (en)	1992-10-23	HETGASMASKIN BASERANDE PAO ROTATIONSKOLVTEKNIK
FI932629A0 (en)	1993-06-09	remover
BR7300229U (en)	1994-10-04	Hand-Car
KR940009819U (en)	1994-05-21	Car tissue box fixture

Legal Events

Date	Code	Title	Description
1999-10-13	FA7	Application withdrawn (art. 18 par. 1 of law 5772/71) - being contrary to morals, good customs and public security, order and health