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ES2181866T3 - Compuestos heterociclicos sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Compuestos heterociclicos sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2181866T3
ES2181866T3 ES96902305T ES96902305T ES2181866T3 ES 2181866 T3 ES2181866 T3 ES 2181866T3 ES 96902305 T ES96902305 T ES 96902305T ES 96902305 T ES96902305 T ES 96902305T ES 2181866 T3 ES2181866 T3 ES 2181866T3
Authority
ES
Spain
Prior art keywords
sub
substituted
procedure
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96902305T
Other languages
English (en)
Inventor
Xavier Emonds-Alt
Isabelle Grossriether
Patrick Gueule
Vincenzo Proietto
Didier Van Broeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9501016A external-priority patent/FR2729952B1/fr
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2181866T3 publication Critical patent/ES2181866T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
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    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE COMPUESTOS DE FORMULA (I) EN LA QUE A REPRESENTA UN RADICAL BIVALENTE ELEGIDO ENTRE: A {SUB,1})-O-CO-, A {SUB,2})-CH {SUB,2}-O-CO-, A {SUB,3})-O-CH {SUB,E}-CH {SUB,2}-, A {SUB,5}-N {(} R {SUB,1} {-CO-, A {SUB,7})-N {(} R {SUB,1} {-CH {SUB,2}-CH {SUB,2}-, A {SUB,8})O-CH {SUB,2}EN LOS QUE R {SUB,1} REPRESENTA UN HIDROGENO O UN (C {SUB,1}-C {SUB,4}) ALQUILO, A REPRESENTA UN HETEROCICLICO NITROGENADO. APLICACION: ANTAGONISTAS DE LOS RECEPTORES DE LAS NEUROQUININAS.
ES96902305T 1995-01-30 1996-01-30 Compuestos heterociclicos sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2181866T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9501016A FR2729952B1 (fr) 1995-01-30 1995-01-30 Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR9508046A FR2729953B1 (fr) 1995-01-30 1995-07-04 Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR9513005A FR2729954B1 (fr) 1995-01-30 1995-11-03 Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant

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ES2181866T3 true ES2181866T3 (es) 2003-03-01

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ES01119949T Expired - Lifetime ES2243373T3 (es) 1995-01-30 1996-01-30 Compuestos heterociclicos sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES96902305T Expired - Lifetime ES2181866T3 (es) 1995-01-30 1996-01-30 Compuestos heterociclicos sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

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FR2729954A1 (fr) 1996-08-02
DE69622992D1 (de) 2002-09-19
EP1688416A1 (fr) 2006-08-09
JP2002138088A (ja) 2002-05-14
DE69634806D1 (de) 2005-07-07
RU2157807C2 (ru) 2000-10-20
EP0807111B1 (fr) 2002-08-14
IL116957A0 (en) 1996-05-14
EP1156049B1 (fr) 2005-06-01
EP1923391A1 (fr) 2008-05-21
MY117527A (en) 2004-07-31
JP2001131171A (ja) 2001-05-15
ATE222251T1 (de) 2002-08-15
CN1295221C (zh) 2007-01-17
DK0807111T3 (da) 2002-12-16
CN1636983A (zh) 2005-07-13
CY2537B1 (fr) 2006-06-28
FI973148A (fi) 1997-09-29
US5977359A (en) 1999-11-02
FI973148A0 (fi) 1997-07-29
CN1136189C (zh) 2004-01-28
NZ301285A (en) 2000-01-28
JP3234228B2 (ja) 2001-12-04
US5869663A (en) 1999-02-09
JP3357660B2 (ja) 2002-12-16
CZ294267B6 (cs) 2004-11-10
AU707901B2 (en) 1999-07-22
DE69622992T2 (de) 2003-04-10
PL192164B1 (pl) 2006-09-29
CN1502612A (zh) 2004-06-09
CN1321639A (zh) 2001-11-14
CA2211668C (en) 2005-09-20
MX9705590A (es) 1997-11-29
PT807111E (pt) 2002-12-31
PT1156049E (pt) 2005-10-31
AU4666996A (en) 1996-08-21
DE69634806T2 (de) 2006-04-27
CN1394855A (zh) 2003-02-05
IL127114A (en) 2004-09-27
JP3943369B2 (ja) 2007-07-11
CN1321634A (zh) 2001-11-14
PL321640A1 (en) 1997-12-22
WO1996023787A1 (fr) 1996-08-08
SI0807111T1 (en) 2003-02-28
ES2243373T3 (es) 2005-12-01
CN1293063C (zh) 2007-01-03
FR2729954B1 (fr) 1997-08-01
CN1179954C (zh) 2004-12-15
IL116957A (en) 1999-06-20
CZ243697A3 (en) 1997-11-12
DK1156049T3 (da) 2005-09-05
CN1089764C (zh) 2002-08-28
CN1172483A (zh) 1998-02-04
AR036027A2 (es) 2004-08-04
CN1202093C (zh) 2005-05-18
HUP9800295A3 (en) 2000-02-28
AR002955A1 (es) 1998-05-27
US5641777A (en) 1997-06-24
EP1156049A1 (fr) 2001-11-21
JP2001172279A (ja) 2001-06-26
SI1156049T1 (en) 2005-10-31
CZ293134B6 (cs) 2004-02-18
NO973479L (no) 1997-09-29
NO973479D0 (no) 1997-07-29
NO308795B1 (no) 2000-10-30
ATE296823T1 (de) 2005-06-15
CA2211668A1 (en) 1996-08-08
CY2369B1 (en) 2004-06-04
EP0807111A1 (fr) 1997-11-19
EP1340754A1 (fr) 2003-09-03
JPH11507324A (ja) 1999-06-29
US6242637B1 (en) 2001-06-05
HUP9800295A2 (hu) 1999-10-28

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