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EP1578910A4 - Nitrilases - Google Patents

Nitrilases

Info

Publication number
EP1578910A4
EP1578910A4 EP02780877A EP02780877A EP1578910A4 EP 1578910 A4 EP1578910 A4 EP 1578910A4 EP 02780877 A EP02780877 A EP 02780877A EP 02780877 A EP02780877 A EP 02780877A EP 1578910 A4 EP1578910 A4 EP 1578910A4
Authority
EP
European Patent Office
Prior art keywords
nitrilases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02780877A
Other languages
German (de)
English (en)
Other versions
EP1578910A2 (fr
Inventor
Grace Desantis
Jennifer Ann Chaplin
David Paul Weiner
Aileen Milan
Ellen Chi
Jay M Short
Mark Madden
Mark Burk
Dan Robertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Enzymes LLC
Original Assignee
Verenium Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verenium Corp filed Critical Verenium Corp
Priority to EP10189100.0A priority Critical patent/EP2327765B1/fr
Priority to EP20100190399 priority patent/EP2327767B1/fr
Priority to EP08075753A priority patent/EP2039762A3/fr
Priority to EP10190397.9A priority patent/EP2327766B1/fr
Priority to EP10190401.9A priority patent/EP2319919B1/fr
Publication of EP1578910A2 publication Critical patent/EP1578910A2/fr
Publication of EP1578910A4 publication Critical patent/EP1578910A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/002Nitriles (-CN)
    • C12P13/004Cyanohydrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treatment Of Sludge (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Processing Of Solid Wastes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
EP02780877A 2001-06-21 2002-05-15 Nitrilases Withdrawn EP1578910A4 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP10189100.0A EP2327765B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP20100190399 EP2327767B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP08075753A EP2039762A3 (fr) 2001-06-21 2002-05-15 Nitralases
EP10190397.9A EP2327766B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP10190401.9A EP2319919B1 (fr) 2001-06-21 2002-05-15 Nitralases

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30018901P 2001-06-21 2001-06-21
US300189P 2001-06-21
US30900601P 2001-07-30 2001-07-30
US309006P 2001-07-30
US35133602P 2002-01-22 2002-01-22
US351336P 2002-01-22
PCT/US2002/015983 WO2003000840A2 (fr) 2001-06-21 2002-05-15 Nitrilases

Related Child Applications (5)

Application Number Title Priority Date Filing Date
EP10190397.9A Division EP2327766B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP08075753A Division EP2039762A3 (fr) 2001-06-21 2002-05-15 Nitralases
EP10189100.0A Division EP2327765B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP10190401.9A Division EP2319919B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP20100190399 Division EP2327767B1 (fr) 2001-06-21 2002-05-15 Nitralases

Publications (2)

Publication Number Publication Date
EP1578910A2 EP1578910A2 (fr) 2005-09-28
EP1578910A4 true EP1578910A4 (fr) 2008-06-04

Family

ID=27404717

Family Applications (6)

Application Number Title Priority Date Filing Date
EP10190401.9A Expired - Lifetime EP2319919B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP08075753A Withdrawn EP2039762A3 (fr) 2001-06-21 2002-05-15 Nitralases
EP10189100.0A Expired - Lifetime EP2327765B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP10190397.9A Expired - Lifetime EP2327766B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP02780877A Withdrawn EP1578910A4 (fr) 2001-06-21 2002-05-15 Nitrilases
EP20100190399 Expired - Lifetime EP2327767B1 (fr) 2001-06-21 2002-05-15 Nitralases

Family Applications Before (4)

Application Number Title Priority Date Filing Date
EP10190401.9A Expired - Lifetime EP2319919B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP08075753A Withdrawn EP2039762A3 (fr) 2001-06-21 2002-05-15 Nitralases
EP10189100.0A Expired - Lifetime EP2327765B1 (fr) 2001-06-21 2002-05-15 Nitralases
EP10190397.9A Expired - Lifetime EP2327766B1 (fr) 2001-06-21 2002-05-15 Nitralases

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20100190399 Expired - Lifetime EP2327767B1 (fr) 2001-06-21 2002-05-15 Nitralases

Country Status (6)

Country Link
EP (6) EP2319919B1 (fr)
JP (2) JP4405258B2 (fr)
AU (2) AU2006252258B2 (fr)
CA (2) CA2677781C (fr)
DK (3) DK2327766T3 (fr)
WO (1) WO2003000840A2 (fr)

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US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
US20040002147A1 (en) * 1999-12-29 2004-01-01 Desantis Grace Nitrilases
US7521216B2 (en) 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
WO2003106415A2 (fr) 2002-06-13 2003-12-24 Diversa Corporation Procedes de production d'acide (r)-ethyl 4-cyano-3-hydroxybutyrique
US7985572B2 (en) 2003-02-27 2011-07-26 Basf Se Modified nitrilases and their use in methods for the production of carboxylic acids
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
US7198926B2 (en) 2003-05-08 2007-04-03 E. I. Du Pont De Nemours And Company Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
US7485423B2 (en) 2004-11-11 2009-02-03 Modular Genetics, Inc. Ladder assembly and system for generating diversity
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
KR20080049113A (ko) 2005-10-21 2008-06-03 노파르티스 아게 Il-13에 대항한 인간 항체 및 치료적 용도
US20070178575A1 (en) * 2005-12-07 2007-08-02 Dunming Zhu Identification Of A Nitrilase From B. Japonicum By Rational Genome Mining And Methods Of Use
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
PT2322525E (pt) 2006-04-21 2013-12-26 Novartis Ag Derivados de purina para utilização como agonistas do recetor de adenosina a2a
CN100500832C (zh) * 2006-04-29 2009-06-17 浙江工业大学 枯草芽孢杆菌zjb-063及其应用
US20090286779A1 (en) 2006-09-29 2009-11-19 Novartis Ag Pyrazolopyrimidines as lipid kinase inhibitors
PT2104535E (pt) 2007-01-10 2011-03-31 Irm Llc Compostos e composições como inibidores da protease de activação de canal
WO2008106662A2 (fr) * 2007-03-01 2008-09-04 Verenium Corporation Nitrilases, acides nucléiques les codant et procédés de fabrication et d'utilisation de ceux-ci
EA200901489A1 (ru) 2007-05-07 2010-04-30 Новартис Аг Органические соединения
PE20091096A1 (es) 2007-12-10 2009-08-25 Novartis Ag Compuestos organicos
JP5165393B2 (ja) * 2008-01-10 2013-03-21 旭化成ケミカルズ株式会社 グリコール酸又はグリコール酸アンモニウムの製造方法
US8431578B2 (en) 2008-01-11 2013-04-30 Novartis Ag Organic compounds
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
MX2010013675A (es) 2008-06-10 2011-02-15 Novartis Ag Derivados de pirazina como bloqueadores del canal de sodio epitelial.
SI2391366T1 (sl) 2009-01-29 2013-01-31 Novartis Ag Substituirani benzimidazoli za zdravljenje astrocitomov
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
US8497368B2 (en) 2009-08-12 2013-07-30 Novartis Ag Heterocyclic hydrazone compounds
ES2709108T3 (es) 2009-08-17 2019-04-15 Intellikine Llc Compuestos heterocíclicos y usos de los mismos
EA201200318A1 (ru) 2009-08-20 2012-09-28 Новартис Аг Гетероциклические оксимы
CN102665715A (zh) 2009-10-22 2012-09-12 沃泰克斯药物股份有限公司 治疗囊性纤维化和其他慢性疾病的组合物
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (fr) 2010-09-09 2012-03-15 Irm Llc Composés et compositions comme inhibiteurs de trk
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
US20130324526A1 (en) 2011-02-10 2013-12-05 Novartis Ag [1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
WO2012116237A2 (fr) 2011-02-23 2012-08-30 Intellikine, Llc Composés hétérocycliques et leurs utilisations
JP5959541B2 (ja) 2011-02-25 2016-08-02 ノバルティス アーゲー Trk阻害剤としてのピラゾロ[1,5−a]ピリジン
GB201111639D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
GB201111637D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
EA026655B1 (ru) 2011-09-15 2017-05-31 Новартис Аг 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ
US9034879B2 (en) 2011-09-16 2015-05-19 Novartis Ag Heterocyclic compounds for the treatment of CF
WO2013038373A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Dérivés pyrimidinamides
WO2013038381A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Dérivés d'amide pyridine/pyrazine
WO2013038378A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Dérivés pyridinamides
WO2013038390A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Hétérocyclyle carboxamides n-substitués
EP2793893A4 (fr) 2011-11-23 2015-07-08 Intellikine Llc Régimes de traitement améliorés utilisant des inhibiteurs de mtor
CN102363775B (zh) * 2011-11-30 2014-04-02 重庆大学 一种纯化腈水解酶的方法
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
EP3964513A1 (fr) 2012-04-03 2022-03-09 Novartis AG Produits combinés comprenant des inhibiteurs de tyrosine kinase et leur utilisation
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
JP2016512835A (ja) 2013-03-15 2016-05-09 インテリカイン, エルエルシー キナーゼ阻害剤の組み合わせ及びそれらの使用
WO2015084804A1 (fr) 2013-12-03 2015-06-11 Novartis Ag Combinaison d'un inhibiteur de mdm2 et d'un inhibiteur de braf, et leur utilisation
AU2014391605A1 (en) 2014-04-24 2016-10-27 Novartis Ag Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
CN106458979B (zh) 2014-04-24 2020-03-27 诺华股份有限公司 作为磷脂酰肌醇3-激酶抑制剂的氨基吡嗪衍生物
MX2016013983A (es) 2014-04-24 2017-04-06 Novartis Ag Derivados de pirazina como inhibidores de fosfatidil-inositol-3-ci nasa.
WO2016011658A1 (fr) 2014-07-25 2016-01-28 Novartis Ag Polythérapie
US10195208B2 (en) 2014-07-31 2019-02-05 Novartis Ag Combination therapy
CN104774825B (zh) * 2015-03-23 2017-11-07 浙江工业大学 腈水解酶突变体及其应用
WO2017085747A2 (fr) * 2015-11-19 2017-05-26 Gsp Crop Science Pvt. Ltd, Nouveau procédé de préparation de trifloxystrobine
CN106854673B (zh) * 2016-12-23 2020-05-15 枣庄市杰诺生物酶有限公司 利用腈水解酶工程菌制备r-邻氯扁桃酸的方法
CN109111043B (zh) * 2018-09-16 2021-11-09 苏州渭中科技发展有限公司 一种高盐高cod废水的处理方法
BR112021014356A2 (pt) * 2019-01-22 2021-10-05 Basf Se Nitrilase isolada, sequência de nitrilase isolada, processos de produção de ácido 4-cianobenzóico, construção recombinante, vetor recombinante, microrganismo recombinante, microrganismo, método de produção de uma nitrilase, composição e método de fabricação de uma solução aquosa
WO2020250116A1 (fr) 2019-06-10 2020-12-17 Novartis Ag Dérivé de pyridine et de pyrazine pour le traitement de la fk, de la bpco et de la bronchiectasie
CN114341132A (zh) 2019-08-28 2022-04-12 诺华股份有限公司 经取代的1,3-苯基杂芳基衍生物及其在治疗疾病中的用途
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0780471A2 (fr) * 1995-07-31 1997-06-25 Nitto Chemical Industry Co., Ltd. Nouveau gène de la nitrilase

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Also Published As

Publication number Publication date
EP2319919A1 (fr) 2011-05-11
JP2007252382A (ja) 2007-10-04
EP1578910A2 (fr) 2005-09-28
JP2005509407A (ja) 2005-04-14
EP2327767A1 (fr) 2011-06-01
EP2039762A3 (fr) 2009-07-29
EP2327767B1 (fr) 2015-04-29
JP4405528B2 (ja) 2010-01-27
EP2327765B1 (fr) 2015-04-01
EP2039762A2 (fr) 2009-03-25
EP2327766B1 (fr) 2015-12-02
WO2003000840A2 (fr) 2003-01-03
AU2006252258A1 (en) 2007-01-25
EP2327765A1 (fr) 2011-06-01
EP2327766A1 (fr) 2011-06-01
DK2327767T3 (en) 2015-07-27
EP2319919B1 (fr) 2015-08-12
WO2003000840A3 (fr) 2007-11-15
AU2010212259A1 (en) 2010-09-02
DK2327765T3 (en) 2015-07-13
CA2445046A1 (fr) 2003-01-03
DK2327766T3 (en) 2016-03-07
CA2677781A1 (fr) 2003-01-03
CA2677781C (fr) 2013-01-29
CA2445046C (fr) 2009-11-24
JP4405258B2 (ja) 2010-01-27
AU2010212259B2 (en) 2012-11-29
AU2006252258B2 (en) 2010-07-22

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