EE9800422A - L(-)-karnitiini ja alkanoüül-L(-)-karnitiini stabiilsed mittehügroskoopsed soolad, nende valmistamismeetod ja neid sooli sisaldavad tahked peroraalselt manustatavad kompositsioonid - Google Patents

L(-)-karnitiini ja alkanoüül-L(-)-karnitiini stabiilsed mittehügroskoopsed soolad, nende valmistamismeetod ja neid sooli sisaldavad tahked peroraalselt manustatavad kompositsioonid

Info

Publication number: EE9800422A
Authority: EE; Estonia
Prior art keywords: carnitine; salts; alkanoyl; compositions containing; pct
Prior art date: 1996-05-31

Application number

EE9800422A

Other languages

English (en)

Other versions

EE03604B1 (et

Inventor

Fassi Aldo

Original Assignee

Fassi Aldo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-31

Filing date

1997-05-26

Publication date

1999-06-15

1996-05-31 Priority claimed from IT96MI001116 external-priority patent/IT1283086B1/it

1997-02-25 Priority claimed from IT97MI000409A external-priority patent/IT1289974B1/it

1997-05-26 Application filed by Fassi Aldo filed Critical Fassi Aldo

1999-06-15 Publication of EE9800422A publication Critical patent/EE9800422A/et

2002-02-15 Publication of EE03604B1 publication Critical patent/EE03604B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)

EE9800422A 1996-05-31 1997-05-26 L(-)-karnitiini ja alkanoüül-L(-)-karnitiini stabiilsed mittehügroskoopsed soolad, nende valmistamismeetod ja neid sooli sisaldavad tahked peroraalselt manustatavad kompositsioonid EE03604B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT96MI001116 IT1283086B1 (it)	1996-05-31	1996-05-31	Sali stabili e non igroscopici di l-carnitina e di alcanoil l-carnitine
IT97MI000409A IT1289974B1 (it)	1997-02-25	1997-02-25	Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
PCT/EP1997/002693 WO1997046512A1 (en)	1996-05-31	1997-05-26	Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts

Publications (2)

Publication Number	Publication Date
EE9800422A true EE9800422A (et)	1999-06-15
EE03604B1 EE03604B1 (et)	2002-02-15

Family

ID=26331398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800422A EE03604B1 (et)	1996-05-31	1997-05-26	L(-)-karnitiini ja alkanoüül-L(-)-karnitiini stabiilsed mittehügroskoopsed soolad, nende valmistamismeetod ja neid sooli sisaldavad tahked peroraalselt manustatavad kompositsioonid

Country Status (24)

Country	Link
US (1)	US5952379A (et)
EP (1)	EP0914315B1 (et)
JP (1)	JP4160634B2 (et)
CN (1)	CN1177807C (et)
AT (1)	ATE200479T1 (et)
AU (1)	AU718308B2 (et)
BR (1)	BR9709627A (et)
CZ (1)	CZ290902B6 (et)
DE (1)	DE69704561T2 (et)
DK (1)	DK0914315T3 (et)
EE (1)	EE03604B1 (et)
ES (1)	ES2156381T3 (et)
GR (1)	GR3035969T3 (et)
HK (1)	HK1024463A1 (et)
HU (1)	HU228008B1 (et)
IL (1)	IL127266A (et)
IS (1)	IS2085B (et)
NO (1)	NO323593B1 (et)
NZ (1)	NZ333061A (et)
PL (1)	PL188558B1 (et)
PT (1)	PT914315E (et)
SK (1)	SK283105B6 (et)
TR (1)	TR199802492T2 (et)
WO (1)	WO1997046512A1 (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1289974B1 (it) *	1997-02-25	1998-10-19	Aldo Fassi	Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
IT1312018B1 (it) *	1999-03-19	2002-04-04	Fassi Aldo	Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
ATE418978T1 (de) *	1999-09-03	2009-01-15	Sigma Tau Healthscience Spa	Ultrafeines l-carnitin, verfahren zur dessen herstellung, dieses enthaltende zusammensetzungen,sowie verfahren zu dessen verwendung
IT1316988B1 (it)	2000-02-10	2003-05-26	Sigma Tau Ind Farmaceuti	Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine.
US8252309B2 (en) *	2000-04-04	2012-08-28	Sigma-Tau Industrie Farmaceutiche Riunite Spa	Dietary supplement energy-providing to skeletal muscles
ITRM20010030A1 (it) *	2001-01-23	2002-07-23	Aldo Fassi	Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr
ITRM20010029A1 (it) *	2001-01-23	2002-07-23	Aldo Fassi	Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
ITRM20010044A1 (it)	2001-01-29	2002-07-29	Sigma Tau Healthscience Spa	Integratore alimentare ad effetto dimagrante.
DE10133200A1 (de) *	2001-07-07	2003-01-23	Beiersdorf Ag	Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut
ITRM20020055A1 (it) *	2002-02-04	2003-08-04	Aldo Fassi	Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti
JP2006111550A (ja) *	2004-10-13	2006-04-27	Nisshin Pharma Inc	カルニチン含有製品
AU2006265280B2 (en) *	2005-07-05	2011-07-14	Lonza Ag	Spray-drying process for producing a dry carnitine powder or granulate
CN101209975B (zh)	2006-12-29	2010-12-01	沈阳科硕营养科技有限公司	左旋肉碱富马酸钙及其制备方法与用途
EP2425834A1 (en) *	2010-09-06	2012-03-07	Lonza Ltd.	Process for the production of l-carnitine tartrate
CN102911067A (zh) *	2011-08-04	2013-02-06	广州市奥海生物科技有限公司	左旋肉碱丙酮酸盐及其制备方法与用途
CN102911068A (zh) *	2011-08-04	2013-02-06	广州市奥海生物科技有限公司	左旋肉碱l-苹果酸盐及其制备方法与用途
JP6393310B2 (ja) *	2013-04-26	2018-09-19	サノフイＳａｎｏｆｉ	５−クロロ−チオフェン−２−カルボン酸［（ｓ）−２−［メチル−３−（２−オキソ−ピロリジン−１−イル）−ベンゼンスルホニルアミノ］−３−（４−メチル−ピペラジン−１−イル）−３−オキソ−プロプリル］アミドの酒石酸塩
CN103664667A (zh) *	2013-12-16	2014-03-26	天津天成制药有限公司	乙酰左旋肉碱硝酸盐的制备方法
CN106045919B (zh) *	2016-07-07	2022-08-09	湖北楚维药业有限公司	一种左旋肉碱乳清酸盐的制备方法
CN106748845B (zh) *	2016-12-23	2018-11-20	东北制药集团股份有限公司	一种左旋肉碱盐微粉的制备方法
CN112250588B (zh) *	2020-11-06	2023-03-31	哈尔滨工业大学（深圳）	一种左旋肉碱离子液体及其制备方法、应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR5656M (et) *	1965-10-12	1967-12-26
DE3463261D1 (en) *	1983-12-28	1987-05-27	Sigma Tau Ind Farmaceuti	Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) *	1989-12-22	1991-12-17	Lonza Ltd.	Preparations containing l-carnitine
IT1258370B (it) *	1992-03-02	1996-02-26	Sigma Tau Ind Farmaceuti	Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1261808B (it) *	1993-07-06	1996-06-03		Impiego di l-carnitina o acido l-carnitine e valproato nel trattamentodei disosrdini convulsivi

1997
- 1997-05-26 CZ CZ19983915A patent/CZ290902B6/cs not_active IP Right Cessation
- 1997-05-26 SK SK1649-98A patent/SK283105B6/sk not_active IP Right Cessation
- 1997-05-26 EP EP97924007A patent/EP0914315B1/en not_active Expired - Lifetime
- 1997-05-26 IL IL12726697A patent/IL127266A/en not_active IP Right Cessation
- 1997-05-26 NZ NZ333061A patent/NZ333061A/xx not_active IP Right Cessation
- 1997-05-26 HU HU9903455A patent/HU228008B1/hu unknown
- 1997-05-26 PL PL97330189A patent/PL188558B1/pl unknown
- 1997-05-26 BR BR9709627A patent/BR9709627A/pt not_active IP Right Cessation
- 1997-05-26 US US09/194,608 patent/US5952379A/en not_active Expired - Lifetime
- 1997-05-26 DK DK97924007T patent/DK0914315T3/da active
- 1997-05-26 ES ES97924007T patent/ES2156381T3/es not_active Expired - Lifetime
- 1997-05-26 JP JP50017398A patent/JP4160634B2/ja not_active Expired - Lifetime
- 1997-05-26 AT AT97924007T patent/ATE200479T1/de active
- 1997-05-26 DE DE69704561T patent/DE69704561T2/de not_active Expired - Lifetime
- 1997-05-26 PT PT97924007T patent/PT914315E/pt unknown
- 1997-05-26 AU AU29612/97A patent/AU718308B2/en not_active Expired
- 1997-05-26 WO PCT/EP1997/002693 patent/WO1997046512A1/en active IP Right Grant
- 1997-05-26 TR TR1998/02492T patent/TR199802492T2/xx unknown
- 1997-05-26 EE EE9800422A patent/EE03604B1/et unknown
- 1997-05-26 CN CNB971951454A patent/CN1177807C/zh not_active Expired - Lifetime
1998
- 1998-11-27 NO NO19985562A patent/NO323593B1/no not_active IP Right Cessation
- 1998-11-30 IS IS4914A patent/IS2085B/is unknown
2000
- 2000-06-21 HK HK00103735A patent/HK1024463A1/xx not_active IP Right Cessation
2001
- 2001-05-31 GR GR20010400820T patent/GR3035969T3/el unknown

Also Published As

Publication number	Publication date
ES2156381T3 (es)	2001-06-16
TR199802492T2 (xx)	1999-02-22
EP0914315A1 (en)	1999-05-12
US5952379A (en)	1999-09-14
CN1244191A (zh)	2000-02-09
DK0914315T3 (da)	2001-06-05
HUP9903455A2 (hu)	2000-03-28
WO1997046512A1 (en)	1997-12-11
SK164998A3 (en)	1999-05-07
PL330189A1 (en)	1999-04-26
IL127266A (en)	2002-09-12
HUP9903455A3 (en)	2001-01-29
CZ290902B6 (cs)	2002-11-13
JP4160634B2 (ja)	2008-10-01
IS2085B (is)	2006-02-15
PT914315E (pt)	2001-07-31
JP2000514413A (ja)	2000-10-31
NO985562L (no)	1999-01-05
ATE200479T1 (de)	2001-04-15
SK283105B6 (sk)	2003-02-04
IL127266A0 (en)	1999-09-22
EP0914315B1 (en)	2001-04-11
NO985562D0 (no)	1998-11-27
DE69704561T2 (de)	2001-08-09
NO323593B1 (no)	2007-06-11
EE03604B1 (et)	2002-02-15
NZ333061A (en)	1999-05-28
BR9709627A (pt)	1999-08-10
GR3035969T3 (en)	2001-08-31
CN1177807C (zh)	2004-12-01
AU718308B2 (en)	2000-04-13
PL188558B1 (pl)	2005-02-28
HK1024463A1 (en)	2000-10-13
IS4914A (is)	1998-11-30
HU228008B1 (en)	2012-08-28
AU2961297A (en)	1998-01-05
CZ391598A3 (cs)	1999-04-14
DE69704561D1 (de)	2001-05-17

Publication	Publication Date	Title
EE9800422A (et)	1999-06-15	L(-)-karnitiini ja alkanoüül-L(-)-karnitiini stabiilsed mittehügroskoopsed soolad, nende valmistamismeetod ja neid sooli sisaldavad tahked peroraalselt manustatavad kompositsioonid
ES533009A0 (es)	1985-08-01	Un procedimiento para la preparacion de nuevos derivados de 8-cloro71,5-benzotiazepina.
TR200800474T2 (tr)	2008-04-21	Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
ES8801920A1 (es)	1988-03-01	Procedimiento para la obtencio de enaminas
CA2281630A1 (en)	1998-09-03	Process for the preparation of stable, non-hygroscopic salts of l(-)carnitine
ES8607218A1 (es)	1986-05-16	Un procedimiento para preparar compuestos de amidina
TR199802297T2 (xx)	1999-02-22	Eritromisin t�revlerinin 10-metil radikallerinin izomerizasyonu i�in yeni y�ntem.
ES8800122A1 (es)	1987-10-16	Un procedimiento para la preparacion de derivados de indeno y naftaleno.
CA2009074A1 (en)	1990-08-03	Improvements in and relating to guanidine derivatives
NO871575L (no)	1987-10-16	Fremgangsmaate for fremstilling av 1,5-benztiazepin-derivater.
DE3374005D1 (en)	1987-11-12	1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
YU43499A (sh)	2000-12-28	Kristalna hidratovana natrijumova so (e)-4,6-dihloro-3- (2-okso-1-fenilpirolidin-3-iliden metil)-1h-indol-2- karboksilne kiseline
TR200101279T2 (tr)	2001-10-22	Vankoremisin, üretimi için işlem ve farmatik olarak kullanımı
MY113874A (en)	2002-06-29	Zwitterionic forms of trovafloxacin
AU562643B2 (en)	1987-06-18	N-arylpiperazine derivatives
CA2256712A1 (en)	1997-12-11	Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts
TR200003517T2 (tr)	2001-06-21	Amoksilin kristalin tuzlarını hazırlama prosesi
AR243159A1 (es)	1993-07-30	Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico o sus sales farmaceuticamente aceptables.
MY101628A (en)	1991-12-31	Sulfonamide compounds and salts thereof, herbicidal compositions containing them, and process for producing them.
ES2006164A6 (es)	1989-04-16	Un metodo para preparar derivados de acido benzoico
ES8707727A1 (es)	1987-08-16	Un procedimiento para producir un derivado de tiofenosulfonamida.
ES8705454A1 (es)	1987-05-01	Procedimiento para la obtencion de derivados del acido imidazoalquenoico
JPS5430126A (en)	1979-03-06	Benzyl alcohol derivatives and their preparation
FI882421A0 (fi)	1988-05-23	5-fenyl-1,2,3a,4,5,9b-hexahydro-3h -benz(e)indol, deras framstaellning och anvoendning som laekemedel.

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231