[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

PL330189A1 - Stable non-hygroscopic salts of l(-)carniotin and alkanoyl l(-)carnitins, method of obtaining them and soil compositions for oral administration containing such salts - Google Patents

Stable non-hygroscopic salts of l(-)carniotin and alkanoyl l(-)carnitins, method of obtaining them and soil compositions for oral administration containing such salts

Info

Publication number
PL330189A1
PL330189A1 PL97330189A PL33018997A PL330189A1 PL 330189 A1 PL330189 A1 PL 330189A1 PL 97330189 A PL97330189 A PL 97330189A PL 33018997 A PL33018997 A PL 33018997A PL 330189 A1 PL330189 A1 PL 330189A1
Authority
PL
Poland
Prior art keywords
salts
alkanoyl
carnitins
carniotin
obtaining
Prior art date
Application number
PL97330189A
Other versions
PL188558B1 (en
Inventor
Aldo Fassi
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT96MI001116 external-priority patent/IT1283086B1/en
Priority claimed from IT97MI000409A external-priority patent/IT1289974B1/en
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of PL330189A1 publication Critical patent/PL330189A1/en
Publication of PL188558B1 publication Critical patent/PL188558B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

PCT No. PCT/EP97/02693 Sec. 371 Date Nov. 30, 1998 Sec. 102(e) Date Nov. 30, 1998 PCT Filed May 26, 1997 PCT Pub. No. WO97/46512 PCT Pub. Date Dec. 11, 1997Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines with mucic acid of formula (I) are disclosed wherein the molar ratio between the carnitine moiety and mucic acid is 2:1. A process for producing the salts and solid orally administrable compositions containing same are also disclosed.
PL97330189A 1996-05-31 1997-05-26 Stable non-hygroscopic salts of l(-)carniotin and alkanoyl l(-)carnitins, method of obtaining them and soil compositions for oral administration containing such salts PL188558B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT96MI001116 IT1283086B1 (en) 1996-05-31 1996-05-31 New stable and non-hygroscopic mucate(s) of L(-)carnitine and alkanoyl L(-)carnitine(s) - useful for making oral compositions for use as e.g. pharmaceutical compositions, food supplements, health foods, veterinary products and fodders
IT97MI000409A IT1289974B1 (en) 1997-02-25 1997-02-25 PROCESS FOR THE PRODUCTION OF STABLE AND NON-HYGROSCOPIC SALTS OF L (-) CARNITINE AND OF ALCANOLS L (-) - CARNITINE
PCT/EP1997/002693 WO1997046512A1 (en) 1996-05-31 1997-05-26 Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts

Publications (2)

Publication Number Publication Date
PL330189A1 true PL330189A1 (en) 1999-04-26
PL188558B1 PL188558B1 (en) 2005-02-28

Family

ID=26331398

Family Applications (1)

Application Number Title Priority Date Filing Date
PL97330189A PL188558B1 (en) 1996-05-31 1997-05-26 Stable non-hygroscopic salts of l(-)carniotin and alkanoyl l(-)carnitins, method of obtaining them and soil compositions for oral administration containing such salts

Country Status (24)

Country Link
US (1) US5952379A (en)
EP (1) EP0914315B1 (en)
JP (1) JP4160634B2 (en)
CN (1) CN1177807C (en)
AT (1) ATE200479T1 (en)
AU (1) AU718308B2 (en)
BR (1) BR9709627A (en)
CZ (1) CZ290902B6 (en)
DE (1) DE69704561T2 (en)
DK (1) DK0914315T3 (en)
EE (1) EE03604B1 (en)
ES (1) ES2156381T3 (en)
GR (1) GR3035969T3 (en)
HK (1) HK1024463A1 (en)
HU (1) HU228008B1 (en)
IL (1) IL127266A (en)
IS (1) IS2085B (en)
NO (1) NO323593B1 (en)
NZ (1) NZ333061A (en)
PL (1) PL188558B1 (en)
PT (1) PT914315E (en)
SK (1) SK283105B6 (en)
TR (1) TR199802492T2 (en)
WO (1) WO1997046512A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1289974B1 (en) * 1997-02-25 1998-10-19 Aldo Fassi PROCESS FOR THE PRODUCTION OF STABLE AND NON-HYGROSCOPIC SALTS OF L (-) CARNITINE AND OF ALCANOLS L (-) - CARNITINE
IT1312018B1 (en) * 1999-03-19 2002-04-04 Fassi Aldo IMPROVED PROCEDURE FOR THE PRODUCTION OF NON HYGROSCOPICIDAL SALTS OF L (-) - CARNITINE.
ATE418978T1 (en) * 1999-09-03 2009-01-15 Sigma Tau Healthscience Spa ULTRAFINE L-CARNITINE, METHOD FOR THE PRODUCTION THEREOF, COMPOSITIONS CONTAINING SAME, AND METHOD FOR THE USE THEREOF
IT1316988B1 (en) 2000-02-10 2003-05-26 Sigma Tau Ind Farmaceuti IMPROVED INDUSTRIAL PREPARATION PROCEDURE OF MUCATI DELLAL-CARNITINA AND ALCANOIL L-CARNITINE.
US8252309B2 (en) * 2000-04-04 2012-08-28 Sigma-Tau Industrie Farmaceutiche Riunite Spa Dietary supplement energy-providing to skeletal muscles
ITRM20010030A1 (en) * 2001-01-23 2002-07-23 Aldo Fassi CARNITINE SALTS USEFUL AS DIET / NUTRITIONAL SUPPLEMENTS OR AS DRUGS, COMPOSITIONS CONTAINING THEM AND PROCEDURES FOR THEIR PR
ITRM20010029A1 (en) * 2001-01-23 2002-07-23 Aldo Fassi METALLIC SALTS OF CARNITINE USEFUL AS DIET / NUTRITIONAL SUPPLEMENTS OR AS DRUGS, COMPOSITIONS CONTAINING THEM AND PROCEDURES FOR
ITRM20010044A1 (en) 2001-01-29 2002-07-29 Sigma Tau Healthscience Spa SLIMMING FOOD SUPPLEMENT.
DE10133200A1 (en) * 2001-07-07 2003-01-23 Beiersdorf Ag Use of topical compositions containing carnitine and its precursors, derivatives or metabolites to, e.g. improve skin condition or to treat or prevent skin disorders, abnormal lipid peroxidation, reduced cell-cell communication or dandruff
ITRM20020055A1 (en) * 2002-02-04 2003-08-04 Aldo Fassi METALLIC SALTS OF CARNITINE, DIET / NUTRITIONAL SUPPLEMENTS THAT CONTAIN THEM AND DIET KITS TO COUNTER SEXUAL DISORDERS IN SUBJECTS
JP2006111550A (en) * 2004-10-13 2006-04-27 Nisshin Pharma Inc Carnitine-containing product
AU2006265280B2 (en) * 2005-07-05 2011-07-14 Lonza Ag Spray-drying process for producing a dry carnitine powder or granulate
CN101209975B (en) 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 Levulorotation carnitine calcium fumarate and its preparing method and use
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
CN102911067A (en) * 2011-08-04 2013-02-06 广州市奥海生物科技有限公司 L-carnitine pyruvate, and preparation method and application thereof
CN102911068A (en) * 2011-08-04 2013-02-06 广州市奥海生物科技有限公司 L-carnitine L-malate, and preparation method and application thereof
JP6393310B2 (en) * 2013-04-26 2018-09-19 サノフイＳａｎｏｆｉ 5-chloro-thiophene-2-carboxylic acid [(S) -2- [methyl-3- (2-oxo-pyrrolidin-1-yl) -benzenesulfonylamino] -3- (4-methyl-piperazine-1- Yl) -3-oxo-propryl] amide tartrate
CN103664667A (en) * 2013-12-16 2014-03-26 天津天成制药有限公司 Preparation method for acetyl-L-carnitine nitrate
CN106045919B (en) * 2016-07-07 2022-08-09 湖北楚维药业有限公司 Preparation method of L-carnitine orotate
CN106748845B (en) * 2016-12-23 2018-11-20 东北制药集团股份有限公司 A kind of preparation method of L-carnitine salt micro mist
CN112250588B (en) * 2020-11-06 2023-03-31 哈尔滨工业大学（深圳） L-carnitine ionic liquid and preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5656M (en) * 1965-10-12 1967-12-26
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
IT1258370B (en) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti ESTERS OF L-CARNITINE AND ACIL L-CARNITINE EQUIPPED WITH SELECTIVE MYO-RELAXING ACTIVITY ON THE GASTRO-INTESTINAL APPARATUS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IT1261808B (en) * 1993-07-06 1996-06-03 USE OF L-CARNITINE OR L-CARNITINE AND VALPROATE ACID IN THE TREATMENT OF CONVULSIVE DISSODS

Also Published As

Publication number Publication date
ES2156381T3 (en) 2001-06-16
TR199802492T2 (en) 1999-02-22
EP0914315A1 (en) 1999-05-12
US5952379A (en) 1999-09-14
CN1244191A (en) 2000-02-09
DK0914315T3 (en) 2001-06-05
HUP9903455A2 (en) 2000-03-28
WO1997046512A1 (en) 1997-12-11
SK164998A3 (en) 1999-05-07
IL127266A (en) 2002-09-12
HUP9903455A3 (en) 2001-01-29
CZ290902B6 (en) 2002-11-13
JP4160634B2 (en) 2008-10-01
IS2085B (en) 2006-02-15
PT914315E (en) 2001-07-31
JP2000514413A (en) 2000-10-31
EE9800422A (en) 1999-06-15
NO985562L (en) 1999-01-05
ATE200479T1 (en) 2001-04-15
SK283105B6 (en) 2003-02-04
IL127266A0 (en) 1999-09-22
EP0914315B1 (en) 2001-04-11
NO985562D0 (en) 1998-11-27
DE69704561T2 (en) 2001-08-09
NO323593B1 (en) 2007-06-11
EE03604B1 (en) 2002-02-15
NZ333061A (en) 1999-05-28
BR9709627A (en) 1999-08-10
GR3035969T3 (en) 2001-08-31
CN1177807C (en) 2004-12-01
AU718308B2 (en) 2000-04-13
PL188558B1 (en) 2005-02-28
HK1024463A1 (en) 2000-10-13
IS4914A (en) 1998-11-30
HU228008B1 (en) 2012-08-28
AU2961297A (en) 1998-01-05
CZ391598A3 (en) 1999-04-14
DE69704561D1 (en) 2001-05-17

Similar Documents

Publication Publication Date Title
PL330189A1 (en) Stable non-hygroscopic salts of l(-)carniotin and alkanoyl l(-)carnitins, method of obtaining them and soil compositions for oral administration containing such salts
ES8801920A1 (en) Process for the preparation of 1,8-bridged 4-quinolone-3-carboxylic acids.
NO943093L (en) Process for the preparation of clavulanic acid
ES8707732A1 (en) Triazoloquinazoline compounds.
IL123212A0 (en) Preparation of acid salts of amine compounds
CA2281630A1 (en) Process for the preparation of stable, non-hygroscopic salts of l(-)carnitine
GEP19971030B (en) Method for preparation of derivatives of 1-benzil-3-oximetil-indazolului or salts with pharmaceutically acceptable bases
ES8607218A1 (en) Novel amidine compounds.
EG19361A (en) A process for the preparation of piperidine compound having local anaesthetica and analgetic
TR199802297T2 (en) New method for isomerization of 10-methyl radicals of erythromycin derivatives.
CA2009074A1 (en) Improvements in and relating to guanidine derivatives
MX9804828A (en) Biologically active benzothiazolone ethanamines.
ES2000907A6 (en) 2-Oxa-isocephem compounds, compositions containing same and processes for preparing same.
ES8702489A1 (en) Alpha-glucosidase inhibitor, method for its preparation, its use and pharmaceutical compositions.
ZA976637B (en) The preparation of 3-pyrroline-2-carboxylic acid derivatives
HUT57720A (en) Process for producing indole derivatives and pharmaceutical compositions comprising such compounds
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
MY113874A (en) Zwitterionic forms of trovafloxacin
TR200101279T2 (en) Process and pharmaceutical use of vancomemia for its production
CA2256712A1 (en) Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts
ES2001662A6 (en) Method for preparing 6beta-halopenicillanic acids and salts thereof.
AU1466592A (en) Gem-diphosphonic acid nitrosocarbamoyl derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
ES8705454A1 (en) Imidazoalkylcarboxylic-acid derivatives, process for their preparation and their use in the preparation of pharmaceutically active compounds.
ES2000283A6 (en) Cycloaliphatic ketoamines.
ES8307832A1 (en) Anti-inflammatory, analgesic, antipyretic, water-soluble compound and process for its preparation