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ES2156381T3 - Sales estables no higroscopicas de l(-)carnitina y alcanoil-l(-)carnitinas, un procedimiento para su preparacion y composiciones solidas, administrables por via oral, que contienen tales sales. - Google Patents

Sales estables no higroscopicas de l(-)carnitina y alcanoil-l(-)carnitinas, un procedimiento para su preparacion y composiciones solidas, administrables por via oral, que contienen tales sales.

Info

Publication number
ES2156381T3
ES2156381T3 ES97924007T ES97924007T ES2156381T3 ES 2156381 T3 ES2156381 T3 ES 2156381T3 ES 97924007 T ES97924007 T ES 97924007T ES 97924007 T ES97924007 T ES 97924007T ES 2156381 T3 ES2156381 T3 ES 2156381T3
Authority
ES
Spain
Prior art keywords
carnitine
alcanoil
oral
carnitins
administrable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97924007T
Other languages
English (en)
Inventor
Aldo Fassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT96MI001116 external-priority patent/IT1283086B1/it
Priority claimed from IT97MI000409A external-priority patent/IT1289974B1/it
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2156381T3 publication Critical patent/ES2156381T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

SE EXPONEN SALES ESTABLES Y NO HIGROSCOPICAS DE L(-)CARNITINA Y ALCANOIL L(-)CARNITINAS CON ACIDO MUCICO DE FORMULA (I), CARACTERIZADAS PORQUE LA RELACION MOLAR ENTRE LA MITAD DE CARNITINA Y EL ACIDO MUCICO ES DE 2:1. SE EXPONE IGUALMENTE UN PROCESO PARA PRODUCIR LAS SALES Y COMPOSICIONES SOLIDAS, PARA ADMINISTRACION ORAL, QUE LAS CONTIENEN.
ES97924007T 1996-05-31 1997-05-26 Sales estables no higroscopicas de l(-)carnitina y alcanoil-l(-)carnitinas, un procedimiento para su preparacion y composiciones solidas, administrables por via oral, que contienen tales sales. Expired - Lifetime ES2156381T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001116 IT1283086B1 (it) 1996-05-31 1996-05-31 Sali stabili e non igroscopici di l-carnitina e di alcanoil l-carnitine
IT97MI000409A IT1289974B1 (it) 1997-02-25 1997-02-25 Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine

Publications (1)

Publication Number Publication Date
ES2156381T3 true ES2156381T3 (es) 2001-06-16

Family

ID=26331398

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97924007T Expired - Lifetime ES2156381T3 (es) 1996-05-31 1997-05-26 Sales estables no higroscopicas de l(-)carnitina y alcanoil-l(-)carnitinas, un procedimiento para su preparacion y composiciones solidas, administrables por via oral, que contienen tales sales.

Country Status (24)

Country Link
US (1) US5952379A (es)
EP (1) EP0914315B1 (es)
JP (1) JP4160634B2 (es)
CN (1) CN1177807C (es)
AT (1) ATE200479T1 (es)
AU (1) AU718308B2 (es)
BR (1) BR9709627A (es)
CZ (1) CZ290902B6 (es)
DE (1) DE69704561T2 (es)
DK (1) DK0914315T3 (es)
EE (1) EE03604B1 (es)
ES (1) ES2156381T3 (es)
GR (1) GR3035969T3 (es)
HK (1) HK1024463A1 (es)
HU (1) HU228008B1 (es)
IL (1) IL127266A (es)
IS (1) IS2085B (es)
NO (1) NO323593B1 (es)
NZ (1) NZ333061A (es)
PL (1) PL188558B1 (es)
PT (1) PT914315E (es)
SK (1) SK283105B6 (es)
TR (1) TR199802492T2 (es)
WO (1) WO1997046512A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
IT1312018B1 (it) * 1999-03-19 2002-04-04 Fassi Aldo Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
ATE418978T1 (de) * 1999-09-03 2009-01-15 Sigma Tau Healthscience Spa Ultrafeines l-carnitin, verfahren zur dessen herstellung, dieses enthaltende zusammensetzungen,sowie verfahren zu dessen verwendung
IT1316988B1 (it) 2000-02-10 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine.
US8252309B2 (en) * 2000-04-04 2012-08-28 Sigma-Tau Industrie Farmaceutiche Riunite Spa Dietary supplement energy-providing to skeletal muscles
ITRM20010030A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr
ITRM20010029A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
ITRM20010044A1 (it) 2001-01-29 2002-07-29 Sigma Tau Healthscience Spa Integratore alimentare ad effetto dimagrante.
DE10133200A1 (de) * 2001-07-07 2003-01-23 Beiersdorf Ag Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut
ITRM20020055A1 (it) * 2002-02-04 2003-08-04 Aldo Fassi Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti
JP2006111550A (ja) * 2004-10-13 2006-04-27 Nisshin Pharma Inc カルニチン含有製品
AU2006265280B2 (en) * 2005-07-05 2011-07-14 Lonza Ag Spray-drying process for producing a dry carnitine powder or granulate
CN101209975B (zh) 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
CN102911067A (zh) * 2011-08-04 2013-02-06 广州市奥海生物科技有限公司 左旋肉碱丙酮酸盐及其制备方法与用途
CN102911068A (zh) * 2011-08-04 2013-02-06 广州市奥海生物科技有限公司 左旋肉碱l-苹果酸盐及其制备方法与用途
JP6393310B2 (ja) * 2013-04-26 2018-09-19 サノフイＳａｎｏｆｉ ５−クロロ−チオフェン−２−カルボン酸［（ｓ）−２−［メチル−３−（２−オキソ−ピロリジン−１−イル）−ベンゼンスルホニルアミノ］−３−（４−メチル−ピペラジン−１−イル）−３−オキソ−プロプリル］アミドの酒石酸塩
CN103664667A (zh) * 2013-12-16 2014-03-26 天津天成制药有限公司 乙酰左旋肉碱硝酸盐的制备方法
CN106045919B (zh) * 2016-07-07 2022-08-09 湖北楚维药业有限公司 一种左旋肉碱乳清酸盐的制备方法
CN106748845B (zh) * 2016-12-23 2018-11-20 东北制药集团股份有限公司 一种左旋肉碱盐微粉的制备方法
CN112250588B (zh) * 2020-11-06 2023-03-31 哈尔滨工业大学（深圳） 一种左旋肉碱离子液体及其制备方法、应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5656M (es) * 1965-10-12 1967-12-26
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1261808B (it) * 1993-07-06 1996-06-03 Impiego di l-carnitina o acido l-carnitine e valproato nel trattamentodei disosrdini convulsivi

Also Published As

Publication number Publication date
TR199802492T2 (xx) 1999-02-22
EP0914315A1 (en) 1999-05-12
US5952379A (en) 1999-09-14
CN1244191A (zh) 2000-02-09
DK0914315T3 (da) 2001-06-05
HUP9903455A2 (hu) 2000-03-28
WO1997046512A1 (en) 1997-12-11
SK164998A3 (en) 1999-05-07
PL330189A1 (en) 1999-04-26
IL127266A (en) 2002-09-12
HUP9903455A3 (en) 2001-01-29
CZ290902B6 (cs) 2002-11-13
JP4160634B2 (ja) 2008-10-01
IS2085B (is) 2006-02-15
PT914315E (pt) 2001-07-31
JP2000514413A (ja) 2000-10-31
EE9800422A (et) 1999-06-15
NO985562L (no) 1999-01-05
ATE200479T1 (de) 2001-04-15
SK283105B6 (sk) 2003-02-04
IL127266A0 (en) 1999-09-22
EP0914315B1 (en) 2001-04-11
NO985562D0 (no) 1998-11-27
DE69704561T2 (de) 2001-08-09
NO323593B1 (no) 2007-06-11
EE03604B1 (et) 2002-02-15
NZ333061A (en) 1999-05-28
BR9709627A (pt) 1999-08-10
GR3035969T3 (en) 2001-08-31
CN1177807C (zh) 2004-12-01
AU718308B2 (en) 2000-04-13
PL188558B1 (pl) 2005-02-28
HK1024463A1 (en) 2000-10-13
IS4914A (is) 1998-11-30
HU228008B1 (en) 2012-08-28
AU2961297A (en) 1998-01-05
CZ391598A3 (cs) 1999-04-14
DE69704561D1 (de) 2001-05-17

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