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EE200200326A - Asendatud homopiperidüülbensimidasooli analoog, meetod selle valmistamiseks ning seda sisaldav farmatseutiline kompositsioon - Google Patents

Asendatud homopiperidüülbensimidasooli analoog, meetod selle valmistamiseks ning seda sisaldav farmatseutiline kompositsioon

Info

Publication number
EE200200326A
EE200200326A EEP200200326A EEP200200326A EE200200326A EE 200200326 A EE200200326 A EE 200200326A EE P200200326 A EEP200200326 A EE P200200326A EE P200200326 A EEP200200326 A EE P200200326A EE 200200326 A EE200200326 A EE 200200326A
Authority
EE
Estonia
Prior art keywords
homopiperidylbenzimidazole
analog
substituted
preparation
pharmaceutical composition
Prior art date
Application number
EEP200200326A
Other languages
English (en)
Inventor
Eduard Janssens Frans
Maria Sommen Fran�ois
Emile Georges Guillemont J�r�me
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200200326A publication Critical patent/EE200200326A/et
Publication of EE05182B1 publication Critical patent/EE05182B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
EEP200200326A 1999-12-21 2000-12-14 Asendatud homopiperidlbensimidasooli analoog, meetod selle valmistamiseks ning seda sisaldav farmatseutiline kompositsioon EE05182B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204441 1999-12-21
PCT/EP2000/012858 WO2001046189A1 (en) 1999-12-21 2000-12-14 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Publications (2)

Publication Number Publication Date
EE200200326A true EE200200326A (et) 2003-10-15
EE05182B1 EE05182B1 (et) 2009-06-15

Family

ID=8241040

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200326A EE05182B1 (et) 1999-12-21 2000-12-14 Asendatud homopiperidlbensimidasooli analoog, meetod selle valmistamiseks ning seda sisaldav farmatseutiline kompositsioon

Country Status (33)

Country Link
US (1) US7304052B2 (et)
EP (1) EP1250337B1 (et)
JP (1) JP4852210B2 (et)
KR (1) KR100715351B1 (et)
CN (1) CN100343251C (et)
AT (1) ATE416174T1 (et)
AU (1) AU781144B2 (et)
BG (1) BG65784B1 (et)
BR (1) BRPI0016638B8 (et)
CA (1) CA2393158C (et)
CY (1) CY1108844T1 (et)
CZ (1) CZ299803B6 (et)
DE (1) DE60041001D1 (et)
DK (1) DK1250337T3 (et)
EA (1) EA005851B1 (et)
EE (1) EE05182B1 (et)
ES (1) ES2317856T3 (et)
HK (1) HK1053109B (et)
HR (1) HRP20020518B1 (et)
HU (1) HU229929B1 (et)
IL (2) IL150310A0 (et)
MX (1) MXPA02006346A (et)
MY (1) MY127758A (et)
NO (1) NO322362B1 (et)
NZ (1) NZ518816A (et)
PL (1) PL199678B1 (et)
PT (1) PT1250337E (et)
SI (1) SI1250337T1 (et)
SK (1) SK287113B6 (et)
TW (1) TWI225488B (et)
UA (1) UA73963C2 (et)
WO (1) WO2001046189A1 (et)
ZA (1) ZA200204983B (et)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
EP1465635A4 (en) 2002-01-10 2005-04-13 Neurogen Corp MELANIN-CONCENTRATING HORMONIC RECEPTOR LIGANDS: SUBSTITUTED 2- (4-BENZYL-PIPERAZIN-1-YLMETHYL) AND 2- (4-BENZYL-DIAZEPAN-1-YLMETHYL) -1H-BENZOIMIDAZOLE ANALOGUES
US7691860B2 (en) 2004-02-19 2010-04-06 Banyu Pharmaceutical Co., Ltd. Sulfonamide derivatives
EP2121683B1 (en) * 2007-01-25 2011-08-31 Janssen Pharmaceutica, N.V. 2-piperazin-1-yl-3h-imidazo[4,5-b]pyridine derivatives
BR112012033117A2 (pt) 2010-06-24 2016-11-22 Gilead Sciences Inc pirazolo[1,5-a]pirimidinas como agentes antivirais
WO2012070069A2 (en) * 2010-11-24 2012-05-31 Sequent Scientific Limited A process for preparation of albendazole
JP2014159375A (ja) * 2011-06-15 2014-09-04 Takeda Chem Ind Ltd アゼパン化合物
ES2647486T3 (es) 2011-12-22 2017-12-21 Gilead Sciences, Inc. Pirazolo[1,5-a]pirimidinas como agentes antivirales
HUE045727T2 (hu) 2012-04-17 2021-12-28 Gilead Sciences Inc Vegyületek és eljárások vírusellenes kezeléshez
WO2015091584A1 (en) * 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060197C3 (de) 1970-12-08 1979-02-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von 2-Aminobenzothiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
ES482789A0 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
FR2528526A1 (fr) * 1982-06-09 1983-12-16 Sfr Sa Robinetterie Butee se fixant dans un alesage d'un dispositif
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
DE3634066A1 (de) * 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
JPH0260197A (ja) * 1988-08-26 1990-02-28 Nec Corp パッケージ構造
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
RU95105442A (ru) * 1992-07-08 1997-02-20 Монсанто Компани (US) Способ лечения язвы желудка у свиней, изделие для лечения язвы желудка у свиней
ES2048109B1 (es) 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
CA2168016C (en) * 1994-05-31 2000-09-26 Akio Matsunaga Benzimidazole derivatives
FR2766822B1 (fr) * 1997-07-30 2001-02-23 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues

Also Published As

Publication number Publication date
HU229929B1 (en) 2015-01-28
CN1411460A (zh) 2003-04-16
EA005851B1 (ru) 2005-06-30
HRP20020518B1 (en) 2009-02-28
CN100343251C (zh) 2007-10-17
EP1250337A1 (en) 2002-10-23
US20030139393A1 (en) 2003-07-24
IL150310A (en) 2008-07-08
DK1250337T3 (da) 2009-03-30
BR0016638B1 (pt) 2013-02-05
PT1250337E (pt) 2009-03-05
CA2393158A1 (en) 2001-06-28
CZ20022055A3 (cs) 2003-06-18
NO322362B1 (no) 2006-09-25
MXPA02006346A (es) 2002-12-13
MY127758A (en) 2006-12-29
SI1250337T1 (sl) 2009-04-30
JP4852210B2 (ja) 2012-01-11
NZ518816A (en) 2003-01-31
ES2317856T3 (es) 2009-05-01
ATE416174T1 (de) 2008-12-15
UA73963C2 (uk) 2005-10-17
CZ299803B6 (cs) 2008-12-03
NO20022977L (no) 2002-08-08
AU2167301A (en) 2001-07-03
HK1053109A1 (en) 2003-10-10
SK8542002A3 (en) 2003-07-01
HK1053109B (zh) 2008-08-01
PL199678B1 (pl) 2008-10-31
KR20020062643A (ko) 2002-07-26
NO20022977D0 (no) 2002-06-20
HRP20020518A2 (en) 2004-08-31
SK287113B6 (sk) 2009-12-07
JP2003518118A (ja) 2003-06-03
HUP0203847A3 (en) 2004-07-28
AU781144B2 (en) 2005-05-05
US7304052B2 (en) 2007-12-04
CY1108844T1 (el) 2014-07-02
TWI225488B (en) 2004-12-21
IL150310A0 (en) 2002-12-01
EP1250337B1 (en) 2008-12-03
BG106749A (en) 2003-01-31
ZA200204983B (en) 2003-09-22
PL355442A1 (en) 2004-04-19
BRPI0016638B8 (pt) 2017-04-25
BR0016638A (pt) 2002-10-01
DE60041001D1 (de) 2009-01-15
EA200200700A1 (ru) 2003-06-26
CA2393158C (en) 2010-10-19
BG65784B1 (bg) 2009-11-30
HUP0203847A2 (hu) 2003-03-28
WO2001046189A1 (en) 2001-06-28
KR100715351B1 (ko) 2007-05-08
EE05182B1 (et) 2009-06-15

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20181214