[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

HK1053109B - 取代的高哌啶基苯並咪唑化合物和含其的藥物組合物以及其製法和製藥用途 - Google Patents

取代的高哌啶基苯並咪唑化合物和含其的藥物組合物以及其製法和製藥用途

Info

Publication number
HK1053109B
HK1053109B HK03105325.2A HK03105325A HK1053109B HK 1053109 B HK1053109 B HK 1053109B HK 03105325 A HK03105325 A HK 03105325A HK 1053109 B HK1053109 B HK 1053109B
Authority
HK
Hong Kong
Prior art keywords
medicament
preparing
preparation
methods
pharmaceutical compositions
Prior art date
Application number
HK03105325.2A
Other languages
English (en)
Other versions
HK1053109A1 (en
Inventor
Eduard Janssens Frans
Emile Georges Guillemont Jerome
Maria Sommen Francois
Original Assignee
詹森藥業有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 詹森藥業有限公司 filed Critical 詹森藥業有限公司
Publication of HK1053109A1 publication Critical patent/HK1053109A1/xx
Publication of HK1053109B publication Critical patent/HK1053109B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
HK03105325.2A 1999-12-21 2003-07-23 取代的高哌啶基苯並咪唑化合物和含其的藥物組合物以及其製法和製藥用途 HK1053109B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204441 1999-12-21
PCT/EP2000/012858 WO2001046189A1 (en) 1999-12-21 2000-12-14 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Publications (2)

Publication Number Publication Date
HK1053109A1 HK1053109A1 (en) 2003-10-10
HK1053109B true HK1053109B (zh) 2008-08-01

Family

ID=8241040

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03105325.2A HK1053109B (zh) 1999-12-21 2003-07-23 取代的高哌啶基苯並咪唑化合物和含其的藥物組合物以及其製法和製藥用途

Country Status (33)

Country Link
US (1) US7304052B2 (zh)
EP (1) EP1250337B1 (zh)
JP (1) JP4852210B2 (zh)
KR (1) KR100715351B1 (zh)
CN (1) CN100343251C (zh)
AT (1) ATE416174T1 (zh)
AU (1) AU781144B2 (zh)
BG (1) BG65784B1 (zh)
BR (1) BRPI0016638B8 (zh)
CA (1) CA2393158C (zh)
CY (1) CY1108844T1 (zh)
CZ (1) CZ299803B6 (zh)
DE (1) DE60041001D1 (zh)
DK (1) DK1250337T3 (zh)
EA (1) EA005851B1 (zh)
EE (1) EE05182B1 (zh)
ES (1) ES2317856T3 (zh)
HK (1) HK1053109B (zh)
HR (1) HRP20020518B1 (zh)
HU (1) HU229929B1 (zh)
IL (2) IL150310A0 (zh)
MX (1) MXPA02006346A (zh)
MY (1) MY127758A (zh)
NO (1) NO322362B1 (zh)
NZ (1) NZ518816A (zh)
PL (1) PL199678B1 (zh)
PT (1) PT1250337E (zh)
SI (1) SI1250337T1 (zh)
SK (1) SK287113B6 (zh)
TW (1) TWI225488B (zh)
UA (1) UA73963C2 (zh)
WO (1) WO2001046189A1 (zh)
ZA (1) ZA200204983B (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JP2005532991A (ja) 2002-01-10 2005-11-04 ニューロジェン・コーポレーション メラニン凝集ホルモン受容体リガンド:置換2−(4−ベンジル−ピペラジン−1−イルメチル)−及び2−(4−ベンジル−ジアゼパン−1−イルメチル)−1h−ベンゾイミダゾールアナログ
JPWO2005080348A1 (ja) * 2004-02-19 2007-08-02 萬有製薬株式会社 新規スルホンアミド誘導体
WO2008090200A2 (en) * 2007-01-25 2008-07-31 Janssen Pharmaceutica Nv 2- piperazin-1-yl-3h-imidazo[4,5-b]pyridine derivatives
HUE029174T2 (hu) 2010-06-24 2017-02-28 Gilead Sciences Inc Pirazolo[1,5-A]pirimidinek és -triazinok mint antivirális szerek
WO2012070069A2 (en) * 2010-11-24 2012-05-31 Sequent Scientific Limited A process for preparation of albendazole
JP2014159375A (ja) * 2011-06-15 2014-09-04 Takeda Chem Ind Ltd アゼパン化合物
AU2012358805B2 (en) 2011-12-22 2017-07-20 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
CN104583211A (zh) 2012-04-17 2015-04-29 吉里德科学公司 用于抗病毒治疗的化合物和方法
WO2015091584A1 (en) * 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060197C3 (de) 1970-12-08 1979-02-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von 2-Aminobenzothiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
ES482789A0 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
FR2528526A1 (fr) * 1982-06-09 1983-12-16 Sfr Sa Robinetterie Butee se fixant dans un alesage d'un dispositif
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
DE3634066A1 (de) * 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
JPH0260197A (ja) * 1988-08-26 1990-02-28 Nec Corp パッケージ構造
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
RU95105442A (ru) * 1992-07-08 1997-02-20 Монсанто Компани (US) Способ лечения язвы желудка у свиней, изделие для лечения язвы желудка у свиней
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
ES2172585T3 (es) * 1994-05-31 2002-10-01 Mitsui Chemicals Inc Derivado de benzoimidazol.
FR2766822B1 (fr) * 1997-07-30 2001-02-23 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues

Also Published As

Publication number Publication date
DK1250337T3 (da) 2009-03-30
ES2317856T3 (es) 2009-05-01
NO20022977L (no) 2002-08-08
SK8542002A3 (en) 2003-07-01
CA2393158C (en) 2010-10-19
MXPA02006346A (es) 2002-12-13
EP1250337A1 (en) 2002-10-23
CA2393158A1 (en) 2001-06-28
SK287113B6 (sk) 2009-12-07
DE60041001D1 (de) 2009-01-15
BRPI0016638B8 (pt) 2017-04-25
EA005851B1 (ru) 2005-06-30
JP4852210B2 (ja) 2012-01-11
HRP20020518A2 (en) 2004-08-31
AU781144B2 (en) 2005-05-05
BG65784B1 (bg) 2009-11-30
HUP0203847A2 (hu) 2003-03-28
JP2003518118A (ja) 2003-06-03
PL355442A1 (en) 2004-04-19
HK1053109A1 (en) 2003-10-10
ZA200204983B (en) 2003-09-22
NZ518816A (en) 2003-01-31
CY1108844T1 (el) 2014-07-02
CZ299803B6 (cs) 2008-12-03
CN1411460A (zh) 2003-04-16
HU229929B1 (en) 2015-01-28
SI1250337T1 (sl) 2009-04-30
MY127758A (en) 2006-12-29
US7304052B2 (en) 2007-12-04
PT1250337E (pt) 2009-03-05
BR0016638B1 (pt) 2013-02-05
KR100715351B1 (ko) 2007-05-08
NO322362B1 (no) 2006-09-25
US20030139393A1 (en) 2003-07-24
KR20020062643A (ko) 2002-07-26
IL150310A0 (en) 2002-12-01
HUP0203847A3 (en) 2004-07-28
HRP20020518B1 (en) 2009-02-28
IL150310A (en) 2008-07-08
BR0016638A (pt) 2002-10-01
NO20022977D0 (no) 2002-06-20
WO2001046189A1 (en) 2001-06-28
EA200200700A1 (ru) 2003-06-26
EE05182B1 (et) 2009-06-15
EP1250337B1 (en) 2008-12-03
AU2167301A (en) 2001-07-03
ATE416174T1 (de) 2008-12-15
TWI225488B (en) 2004-12-21
BG106749A (en) 2003-01-31
CN100343251C (zh) 2007-10-17
PL199678B1 (pl) 2008-10-31
EE200200326A (et) 2003-10-15
UA73963C2 (uk) 2005-10-17
CZ20022055A3 (cs) 2003-06-18

Similar Documents

Publication Publication Date Title
GB9914486D0 (en) Medicaments
SE9904505D0 (sv) Novel compounds
DE60112609D1 (en) Pyrazolopyridine
MY134892A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use
MY122392A (en) Adamantane derivatives of use of p2x7 receptor antagonists, a process for their preparation, pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions
YU57600A (sh) Derivarti biciklične hidroksaminske kiseline
JO2353B1 (en) New derivatives of mixed-ring fluoroglycosides and drugs containing these compounds and their use
NZ516347A (en) Indanyl-substituted benzenecarboxamides, process for their preparation, their use as a medicament and pharmaceutical formulations containing them
ATE316083T1 (de) Adamantanderivate
RS41104A (en) Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
AU2002239348A1 (en) Pyrazolopyridine derivatives
DE602004011966D1 (en) Heterocyclylverbindungen
GB0109122D0 (en) Novel compounds
UA86776C2 (ru) Производные бензимидазола, фармацевтическая композиция, которая их содержит, способ их получения и применение
ATE233754T1 (de) Diphenyl-piperidin derivate
BR0208205A (pt) Derivados de benzimidazol moduladores de receptores de quimocinas
TW200504029A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
MY133112A (en) 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use
HK1053109A1 (en) Substituted homopiperidinyl benzimidazole compounds, pharmaceutical compositions comprising the same, methods for preparing them and the use for the preparation of a medicament of them
MXPA05013050A (es) Derivados de bencimidazol, composiciones que los contienen preparacion de los mismos y usos de los mismos.
YU59400A (sh) Azabiciklični ligandi 5ht1 receptora
EP1019047A4 (en) ANTITHROMBOTIC AGENTS
MXPA04005484A (es) Procedimiento de preparacion de derivados de equinocandina.
AU2002248531A1 (en) Pyrazolopyriadine derivatives
AU6826700A (en) Ceramide analogs, process for their preparation and their use as antitumor agents

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20181208