[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

HRP20020518B1 - Substituted homopiperidinyl benzimidazole analogues as fundic relaxants - Google Patents

Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Info

Publication number
HRP20020518B1
HRP20020518B1 HR20020518A HRP20020518A HRP20020518B1 HR P20020518 B1 HRP20020518 B1 HR P20020518B1 HR 20020518 A HR20020518 A HR 20020518A HR P20020518 A HRP20020518 A HR P20020518A HR P20020518 B1 HRP20020518 B1 HR P20020518B1
Authority
HR
Croatia
Prior art keywords
alkyl
hydroxy
amino
substituted
alkyloxy
Prior art date
Application number
HR20020518A
Other languages
English (en)
Croatian (hr)
Inventor
Eduard Janssens Frans
Emile Jerome
Maria Sommen Francois
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HRP20020518A2 publication Critical patent/HRP20020518A2/hr
Publication of HRP20020518B1 publication Critical patent/HRP20020518B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
HR20020518A 1999-12-21 2002-06-13 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants HRP20020518B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204441 1999-12-21
PCT/EP2000/012858 WO2001046189A1 (en) 1999-12-21 2000-12-14 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Publications (2)

Publication Number Publication Date
HRP20020518A2 HRP20020518A2 (en) 2004-08-31
HRP20020518B1 true HRP20020518B1 (en) 2009-02-28

Family

ID=8241040

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020518A HRP20020518B1 (en) 1999-12-21 2002-06-13 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Country Status (33)

Country Link
US (1) US7304052B2 (xx)
EP (1) EP1250337B1 (xx)
JP (1) JP4852210B2 (xx)
KR (1) KR100715351B1 (xx)
CN (1) CN100343251C (xx)
AT (1) ATE416174T1 (xx)
AU (1) AU781144B2 (xx)
BG (1) BG65784B1 (xx)
BR (1) BRPI0016638B8 (xx)
CA (1) CA2393158C (xx)
CY (1) CY1108844T1 (xx)
CZ (1) CZ299803B6 (xx)
DE (1) DE60041001D1 (xx)
DK (1) DK1250337T3 (xx)
EA (1) EA005851B1 (xx)
EE (1) EE05182B1 (xx)
ES (1) ES2317856T3 (xx)
HK (1) HK1053109B (xx)
HR (1) HRP20020518B1 (xx)
HU (1) HU229929B1 (xx)
IL (2) IL150310A0 (xx)
MX (1) MXPA02006346A (xx)
MY (1) MY127758A (xx)
NO (1) NO322362B1 (xx)
NZ (1) NZ518816A (xx)
PL (1) PL199678B1 (xx)
PT (1) PT1250337E (xx)
SI (1) SI1250337T1 (xx)
SK (1) SK287113B6 (xx)
TW (1) TWI225488B (xx)
UA (1) UA73963C2 (xx)
WO (1) WO2001046189A1 (xx)
ZA (1) ZA200204983B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JP2005532991A (ja) 2002-01-10 2005-11-04 ニューロジェン・コーポレーション メラニン凝集ホルモン受容体リガンド：置換２−（４−ベンジル−ピペラジン−１−イルメチル）−及び２−（４−ベンジル−ジアゼパン−１−イルメチル）−１ｈ−ベンゾイミダゾールアナログ
JPWO2005080348A1 (ja) * 2004-02-19 2007-08-02 萬有製薬株式会社 新規スルホンアミド誘導体
WO2008090200A2 (en) * 2007-01-25 2008-07-31 Janssen Pharmaceutica Nv 2- piperazin-1-yl-3h-imidazo[4,5-b]pyridine derivatives
HUE029174T2 (hu) 2010-06-24 2017-02-28 Gilead Sciences Inc Pirazolo[1,5-A]pirimidinek és -triazinok mint antivirális szerek
WO2012070069A2 (en) * 2010-11-24 2012-05-31 Sequent Scientific Limited A process for preparation of albendazole
JP2014159375A (ja) * 2011-06-15 2014-09-04 Takeda Chem Ind Ltd アゼパン化合物
AU2012358805B2 (en) 2011-12-22 2017-07-20 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
CN104583211A (zh) 2012-04-17 2015-04-29 吉里德科学公司 用于抗病毒治疗的化合物和方法
WO2015091584A1 (en) * 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060197A1 (de) * 1970-12-08 1972-06-15 Bayer Ag Verfahren zur Herstellung von 2-Aminobenzthiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) * 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
EP0079545A1 (en) * 1981-11-06 1983-05-25 Kanebo, Ltd. Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EP0580541A1 (en) * 1992-07-20 1994-01-26 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New piperidine derivatives of benzimidazole as antihistanminic and antiallergic agents

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES482789A0 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
FR2528526A1 (fr) * 1982-06-09 1983-12-16 Sfr Sa Robinetterie Butee se fixant dans un alesage d'un dispositif
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
DE3634066A1 (de) * 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
JPH0260197A (ja) * 1988-08-26 1990-02-28 Nec Corp パッケージ構造
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
RU95105442A (ru) * 1992-07-08 1997-02-20 Монсанто Компани (US) Способ лечения язвы желудка у свиней, изделие для лечения язвы желудка у свиней
ES2172585T3 (es) * 1994-05-31 2002-10-01 Mitsui Chemicals Inc Derivado de benzoimidazol.
FR2766822B1 (fr) * 1997-07-30 2001-02-23 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060197A1 (de) * 1970-12-08 1972-06-15 Bayer Ag Verfahren zur Herstellung von 2-Aminobenzthiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) * 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
EP0079545A1 (en) * 1981-11-06 1983-05-25 Kanebo, Ltd. Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EP0580541A1 (en) * 1992-07-20 1994-01-26 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New piperidine derivatives of benzimidazole as antihistanminic and antiallergic agents

Also Published As

Publication number Publication date
DK1250337T3 (da) 2009-03-30
ES2317856T3 (es) 2009-05-01
NO20022977L (no) 2002-08-08
SK8542002A3 (en) 2003-07-01
CA2393158C (en) 2010-10-19
MXPA02006346A (es) 2002-12-13
EP1250337A1 (en) 2002-10-23
CA2393158A1 (en) 2001-06-28
SK287113B6 (sk) 2009-12-07
DE60041001D1 (de) 2009-01-15
BRPI0016638B8 (pt) 2017-04-25
EA005851B1 (ru) 2005-06-30
HK1053109B (zh) 2008-08-01
JP4852210B2 (ja) 2012-01-11
HRP20020518A2 (en) 2004-08-31
AU781144B2 (en) 2005-05-05
BG65784B1 (bg) 2009-11-30
HUP0203847A2 (hu) 2003-03-28
JP2003518118A (ja) 2003-06-03
PL355442A1 (en) 2004-04-19
HK1053109A1 (en) 2003-10-10
ZA200204983B (en) 2003-09-22
NZ518816A (en) 2003-01-31
CY1108844T1 (el) 2014-07-02
CZ299803B6 (cs) 2008-12-03
CN1411460A (zh) 2003-04-16
HU229929B1 (en) 2015-01-28
SI1250337T1 (sl) 2009-04-30
MY127758A (en) 2006-12-29
US7304052B2 (en) 2007-12-04
PT1250337E (pt) 2009-03-05
BR0016638B1 (pt) 2013-02-05
KR100715351B1 (ko) 2007-05-08
NO322362B1 (no) 2006-09-25
US20030139393A1 (en) 2003-07-24
KR20020062643A (ko) 2002-07-26
IL150310A0 (en) 2002-12-01
HUP0203847A3 (en) 2004-07-28
IL150310A (en) 2008-07-08
BR0016638A (pt) 2002-10-01
NO20022977D0 (no) 2002-06-20
WO2001046189A1 (en) 2001-06-28
EA200200700A1 (ru) 2003-06-26
EE05182B1 (et) 2009-06-15
EP1250337B1 (en) 2008-12-03
AU2167301A (en) 2001-07-03
ATE416174T1 (de) 2008-12-15
TWI225488B (en) 2004-12-21
BG106749A (en) 2003-01-31
CN100343251C (zh) 2007-10-17
PL199678B1 (pl) 2008-10-31
EE200200326A (et) 2003-10-15
UA73963C2 (uk) 2005-10-17
CZ20022055A3 (cs) 2003-06-18

Similar Documents

Publication Publication Date Title
HRP20020518B1 (en) Substituted homopiperidinyl benzimidazole analogues as fundic relaxants
MEP10709A (en) 2-ARYL-6-PHENYLIMIDAZO[1,2-alpha]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
YU48854B (sh) Derivati n-(4-piperidinil) (dihidrobenzofuran ili dihidro-2h-benzopiran)karboksamida i postupak za njihovo dobijanje
RS50164B (sr) Formulacije sa neprekidnim oslobađanjem
AR035991A1 (es) Derivados de benzimidazoles e imidazopiridinas, un procedimiento para su preparacion, composiciones farmaceuticas, un procedimiento para su preparacion, y un medicamento utiles como inhibidores de la replicacion del virus sincitial respiratorio
NO2015020I2 (no) Ceritinib eller et farmasøytisk akseptabelt salt derav
HRP20080064T3 (en) Prodrugs of piperazine and substituted piperidine antiviral agents
EA200300558A1 (ru) Агонисты альфа-рецепторов, активируемых пролифератором пероксисомы
HRP20120351T1 (hr) Macrociklički derivati kinazolina kao antiproliferativna sredstva
HRP20090162T1 (en) Quinolinone-carboxamide compounds as 5-ht4 receptor agonists
EA200100755A1 (ru) 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
AR056327A1 (es) Compuestos de nucleosidos para el tratamiento de infecciones virales
HRP20070510T3 (en) Benzimidazole derivative and its use as a ii receptor antagonist
MY119238A (en) 8-quinolinzanthine and 8-isoquinolinxanthine derivatives as pde 5 inhibitors
AR052458A1 (es) Amino-imidazolonas para la inhibicion de beta-secretasa
HRP20020175B1 (en) N-heterocyclikc derivatives as nos inhibitors
RS54533B1 (en) PHENYL AMINOPYRIMIDINE COMPOUNDS AND THEIR APPLICATIONS
RS51650B (en) KINUCLIDINE DERIVATIVES (HETERO) arylcycloheptanecarboxylic acids as antagonists of muscarinic receptor
MX2010003950A (es) Derivado de amina que tiene actividad antagonista del receptor y5 de neuropeptido y (npy) y uso del mismo.
HRP20070529T3 (en) Imidazole derivatives as glutmate receptor antagonists
AR060438A1 (es) 2-(piridin-2-il) - pirimidinas como fungicidas.
EA200100018A1 (ru) Гербицидная смесь, содержащая замещенное 3-гетероциклилом производное бензоила, азотосодержащее удобрение и вспомогательный агент
EA201070817A1 (ru) ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-α]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ
RS54112B1 (en) DERIVAT 1,2,4-TRIAZOLONA
RS51189B (sr) Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20171110

Year of fee payment: 18

PBON Lapse due to non-payment of renewal fee

Effective date: 20181214