DE60227113D1 - Kondensierte camptothecine als antitumormittel - Google Patents

Kondensierte camptothecine als antitumormittel

Info

Publication number: DE60227113D1
Authority: DE; Germany
Prior art keywords: antitutside; camptothecines; condensate; agent; sup
Prior art date: 2001-11-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60227113T

Other languages

English (en)

Inventor

Takeshi Murata

Satoshi Niizuma

Nobuo Shimma

Hitomi Suda

Masao Tsukazaki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Chugai Pharmaceutical Co Ltd

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-30

Filing date

2002-11-25

Publication date

2008-07-24

2002-11-25 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

2008-07-24 Application granted granted Critical

2008-07-24 Publication of DE60227113D1 publication Critical patent/DE60227113D1/de

2022-11-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE60227113T 2001-11-30 2002-11-25 Kondensierte camptothecine als antitumormittel Expired - Lifetime DE60227113D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01128361		2001-11-30
PCT/EP2002/013216 WO2003045952A2 (en)	2001-11-30	2002-11-25	Condensed camptothecins as antitumor agents

Publications (1)

Publication Number	Publication Date
DE60227113D1 true DE60227113D1 (de)	2008-07-24

Family

ID=8179394

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60227113T Expired - Lifetime DE60227113D1 (de)	2001-11-30	2002-11-25	Kondensierte camptothecine als antitumormittel

Country Status (29)

Country	Link
US (2)	US6825194B2 (de)
EP (1)	EP1480984B9 (de)
JP (1)	JP4305909B2 (de)
KR (1)	KR100895746B1 (de)
CN (1)	CN100338066C (de)
AT (1)	ATE398131T1 (de)
AU (1)	AU2002356720B2 (de)
BR (1)	BR0214615A (de)
CA (1)	CA2468824C (de)
DE (1)	DE60227113D1 (de)
ES (1)	ES2307830T3 (de)
GT (1)	GT200200250A (de)
HK (2)	HK1072935A1 (de)
HU (1)	HUP0500062A3 (de)
IL (1)	IL162058A0 (de)
MX (1)	MXPA04005185A (de)
MY (1)	MY136138A (de)
NO (1)	NO329005B1 (de)
NZ (1)	NZ533568A (de)
PA (1)	PA8558901A1 (de)
PE (1)	PE20030725A1 (de)
PL (1)	PL207510B1 (de)
RS (1)	RS51051B (de)
RU (1)	RU2299212C2 (de)
TW (1)	TWI258481B (de)
UA (1)	UA80409C2 (de)
UY (1)	UY27560A1 (de)
WO (1)	WO2003045952A2 (de)
ZA (1)	ZA200404522B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7595400B2 (en)	2003-02-21	2009-09-29	Chugai Seiyaku Kabushiki Kaisha	Process for the preparation of hexacyclic compounds
WO2005097803A1 (ja)	2004-04-09	2005-10-20	Chugai Seiyaku Kabushiki Kaisha	新規水溶性プロドラッグ
TW200744603A (en)	2005-08-22	2007-12-16	Chugai Pharmaceutical Co Ltd	Novel anticancer concomitant drug
EP1938823A1 (de)	2005-10-19	2008-07-02	Chugai Seiyaku Kabushiki Kaisha	Mittel zur prävention oder behandlung von pankreaskarzinom, ovarialkarzinom oder leberkarzinom mit einem neuen wasserlöslichen prodrug
CN117263948A (zh)	2019-03-29	2023-12-22	免疫医疗有限公司	化合物及其缀合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4473692A (en)	1981-09-04	1984-09-25	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
US4939255A (en) *	1987-06-24	1990-07-03	Daiichi Pharmaceutical Co., Ltd.	Hexa-cyclic camptothecin derivatives
HU213136B (en) *	1990-08-14	1997-02-28	Kyorin Seiyaku Kk	Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP3008226B2 (ja) *	1991-01-16	2000-02-14	第一製薬株式会社	六環性化合物
JP3359955B2 (ja) *	1992-07-16	2002-12-24	第一製薬株式会社	抗腫瘍剤
GB9402934D0 (en) *	1994-02-16	1994-04-06	Erba Carlo Spa	Camptothecin derivatives and process for their preparation
US5663177A (en) *	1995-05-31	1997-09-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs
EP1017675B1 (de)	1997-02-14	2006-06-14	Bionumerik Pharmaceuticals, Inc.	Hochgradig lipophile camptothecin-derivate
GB9715821D0 (en) *	1997-07-25	1997-10-01	Pharmacia & Upjohn Spa	Amidino-camptothecin derivatives

2002
- 2002-11-25 WO PCT/EP2002/013216 patent/WO2003045952A2/en active IP Right Grant
- 2002-11-25 JP JP2003547402A patent/JP4305909B2/ja not_active Expired - Fee Related
- 2002-11-25 KR KR1020047008223A patent/KR100895746B1/ko not_active IP Right Cessation
- 2002-11-25 DE DE60227113T patent/DE60227113D1/de not_active Expired - Lifetime
- 2002-11-25 CA CA2468824A patent/CA2468824C/en not_active Expired - Fee Related
- 2002-11-25 AT AT02803790T patent/ATE398131T1/de not_active IP Right Cessation
- 2002-11-25 ES ES02803790T patent/ES2307830T3/es not_active Expired - Lifetime
- 2002-11-25 EP EP02803790A patent/EP1480984B9/de not_active Expired - Lifetime
- 2002-11-25 AU AU2002356720A patent/AU2002356720B2/en not_active Ceased
- 2002-11-25 BR BR0214615-0A patent/BR0214615A/pt not_active IP Right Cessation
- 2002-11-25 IL IL16205802A patent/IL162058A0/xx not_active IP Right Cessation
- 2002-11-25 HU HU0500062A patent/HUP0500062A3/hu unknown
- 2002-11-25 MX MXPA04005185A patent/MXPA04005185A/es active IP Right Grant
- 2002-11-25 CN CNB028277465A patent/CN100338066C/zh not_active Expired - Fee Related
- 2002-11-25 RS YUP-470/04A patent/RS51051B/sr unknown
- 2002-11-25 UA UA20040605013A patent/UA80409C2/uk unknown
- 2002-11-25 PL PL370479A patent/PL207510B1/pl not_active IP Right Cessation
- 2002-11-25 RU RU2004119841/04A patent/RU2299212C2/ru not_active IP Right Cessation
- 2002-11-25 NZ NZ533568A patent/NZ533568A/en not_active IP Right Cessation
- 2002-11-26 US US10/304,672 patent/US6825194B2/en not_active Expired - Fee Related
- 2002-11-27 TW TW091134463A patent/TWI258481B/zh not_active IP Right Cessation
- 2002-11-28 PA PA20028558901A patent/PA8558901A1/es unknown
- 2002-11-28 MY MYPI20024479A patent/MY136138A/en unknown
- 2002-11-28 PE PE2002001148A patent/PE20030725A1/es not_active Application Discontinuation
- 2002-11-29 UY UY27560A patent/UY27560A1/es not_active Application Discontinuation
- 2002-11-29 GT GT200200250A patent/GT200200250A/es unknown
2004
- 2004-06-08 ZA ZA200404522A patent/ZA200404522B/en unknown
- 2004-06-29 NO NO20042729A patent/NO329005B1/no not_active IP Right Cessation
- 2004-09-16 US US10/942,044 patent/US7109195B2/en not_active Expired - Fee Related
2005
- 2005-05-30 HK HK05104506A patent/HK1072935A1/xx not_active IP Right Cessation
- 2005-10-21 HK HK05109380A patent/HK1077303A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2299212C2 (ru)	2007-05-20
UY27560A1 (es)	2003-05-30
EP1480984B9 (de)	2009-03-11
ES2307830T3 (es)	2008-12-01
KR20040062976A (ko)	2004-07-09
CN1617874A (zh)	2005-05-18
WO2003045952A2 (en)	2003-06-05
RS47004A (en)	2007-02-05
RS51051B (sr)	2010-10-31
HK1077303A1 (en)	2006-02-10
CN100338066C (zh)	2007-09-19
NO20042729L (no)	2004-08-27
PL370479A1 (en)	2005-05-30
EP1480984B1 (de)	2008-06-11
RU2004119841A (ru)	2005-03-27
NZ533568A (en)	2006-01-27
CA2468824C (en)	2011-01-11
CA2468824A1 (en)	2003-06-05
ZA200404522B (en)	2005-01-04
US7109195B2 (en)	2006-09-19
TWI258481B (en)	2006-07-21
BR0214615A (pt)	2004-09-14
PL207510B1 (pl)	2010-12-31
UA80409C2 (en)	2007-09-25
TW200408642A (en)	2004-06-01
HUP0500062A2 (hu)	2005-04-28
PE20030725A1 (es)	2003-08-28
US20050059679A1 (en)	2005-03-17
GT200200250A (es)	2004-01-15
ATE398131T1 (de)	2008-07-15
EP1480984A2 (de)	2004-12-01
US6825194B2 (en)	2004-11-30
US20030144304A1 (en)	2003-07-31
MXPA04005185A (es)	2004-08-11
IL162058A0 (en)	2005-11-20
AU2002356720A1 (en)	2003-06-10
KR100895746B1 (ko)	2009-04-30
JP4305909B2 (ja)	2009-07-29
MY136138A (en)	2008-08-29
PA8558901A1 (es)	2003-06-30
NO329005B1 (no)	2010-07-19
HK1072935A1 (en)	2005-09-16
AU2002356720B2 (en)	2009-01-29
WO2003045952A3 (en)	2003-10-16
HUP0500062A3 (en)	2012-12-28
JP2005511643A (ja)	2005-04-28

Publication	Publication Date	Title
TR200102800T2 (tr)	2002-01-21	Yeni bileşikler.
TR200201874T2 (tr)	2002-10-21	Proteaz inhibitörleri olarak yeni bileşikler ve bileşimler.
SE9904508D0 (sv)	1999-12-09	New compounds
HK1089163A1 (en)	2006-11-24	Quinoxaline derivatives as neutrophil elastase inhibitors and their use
JO2311B1 (en)	2005-09-12	Alkyl inhibitors Ariel phosphodiesterase-4
NO20054404L (no)	2005-11-24	5,7-Diaminopyrazolo [4,3-D] Pyrimidiner Anvendelige ved behandling av of Hypertensjon
MXPA02012033A (es)	2003-04-25	Derivados de 2-aminocarbonil-9h-purina.
DE60324544D1 (de)	2008-12-18	Muskarin antagonisten
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
PE20030061A1 (es)	2003-02-08	1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4
PT992509E (pt)	2004-12-31	Novos derivados macrolidos
MXPA04006041A (es)	2004-09-27	Antivirales de piridoquinoxalina.
EA200301203A1 (ru)	2004-04-29	Новые соединения и композиции как ингибиторы катепсина
TR200201128T2 (tr)	2002-08-21	PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
ATE287886T1 (de)	2005-02-15	Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b) pyridinen als cyclin- abhängige kinase-hemmer
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
AP2001002188A0 (en)	2001-06-30	5HT1 antagonists for antidepressant therapy.
SE9803773D0 (sv)	1998-11-05	Compounds
CA2412596A1 (en)	2002-01-03	Cyclic gmp-specific phosphodiesterase inhibitors
DE60227113D1 (de)	2008-07-24	Kondensierte camptothecine als antitumormittel
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
ATE324368T1 (de)	2006-05-15	Heteroarylheteroalkylamin derivate und deren verwendung als inhibitoren der stickoxidsynthase
ATE265423T1 (de)	2004-05-15	Neue phenylheteroalkylamin-derivate
YU46302A (sh)	2005-06-10	Supstituisani piroli
SE9902596D0 (sv)	1999-07-06	Pharmaceutically active compounds

Legal Events

Date	Code	Title	Description
2009-07-02	8364	No opposition during term of opposition