ATE330958T1 - Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate - Google Patents

Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate

Info

Publication number: ATE330958T1
Authority: AT; Austria
Prior art keywords: böindol; 6öpyrido; pyrazino; derivatives; compounds
Prior art date: 2000-06-23

Application number

AT01935629T

Other languages

English (en)

Inventor

Mark W Orme

Jason Scott Sawyer

Lisa M Schultze

Alain Claude-Marie Daugan

Francoise Gellibert

Original Assignee

Lilly Icos Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-05-15

Publication date

2006-07-15

2001-05-15 Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc

2006-07-15 Application granted granted Critical

2006-07-15 Publication of ATE330958T1 publication Critical patent/ATE330958T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01935629T 2000-06-23 2001-05-15 Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate ATE330958T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US21364700P	2000-06-23	2000-06-23

Publications (1)

Publication Number	Publication Date
ATE330958T1 true ATE330958T1 (de)	2006-07-15

Family

ID=22795930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01935629T ATE330958T1 (de)	2000-06-23	2001-05-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate

Country Status (10)

Country	Link
US (1)	US6911542B2 (de)
EP (1)	EP1366049B1 (de)
JP (1)	JP4169149B2 (de)
AT (1)	ATE330958T1 (de)
AU (1)	AU2001261707A1 (de)
CA (1)	CA2412594C (de)
DE (1)	DE60121048T2 (de)
ES (1)	ES2269401T3 (de)
MX (1)	MXPA02012472A (de)
WO (1)	WO2002000656A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2004107323A (ja) *	2002-07-26	2004-04-08	Nippon Nohyaku Co Ltd	新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
AU2003252259A1 (en) *	2002-07-26	2004-02-16	Nihon Nohyaku Co., Ltd.	Novel haloalkylsulfonanilide derivatives, herbicides and usage thereof
CN101106997A (zh)	2004-08-17	2008-01-16	约翰·霍普金斯大学	Pde5抑制剂组合物及治疗心脏病征候的方法
DE06750162T1 (de) *	2005-04-12	2007-07-05	Teva Pharmaceutical Industries Ltd.	Herstellung von Tadalafil-Zwischenprodukten
WO2014100733A1 (en)	2012-12-21	2014-06-26	Mayo Foundation For Medical Education And Research	Methods and materials for treating calcific aortic valve stenosis
EP3054951A4 (de) *	2013-10-07	2017-05-10	Millennium Pharmaceuticals, Inc.	Inhibitor des brustkrebsresistenzproteins (bcrp)
AU2015399642B2 (en) *	2015-06-26	2020-04-09	Chongqing Dikang Erle Pharma Co. Ltd.	Novel phosphodiesterase type-5 inhibitor and application thereof
CN106279164B (zh) *	2015-06-26	2019-11-01	重庆迪康尔乐制药有限公司	5型磷酸二酯酶抑制剂及其应用
CN105384740A (zh) *	2015-12-18	2016-03-09	海南通用康力制药有限公司	一种制备他达拉非的中间体高纯度晶体及制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9401090D0 (en)	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514464D0 (en) *	1995-07-14	1995-09-13	Glaxo Lab Sa	Medicaments

2001
- 2001-05-15 ES ES01935629T patent/ES2269401T3/es not_active Expired - Lifetime
- 2001-05-15 CA CA002412594A patent/CA2412594C/en not_active Expired - Fee Related
- 2001-05-15 AT AT01935629T patent/ATE330958T1/de not_active IP Right Cessation
- 2001-05-15 DE DE60121048T patent/DE60121048T2/de not_active Expired - Lifetime
- 2001-05-15 US US10/297,682 patent/US6911542B2/en not_active Expired - Fee Related
- 2001-05-15 AU AU2001261707A patent/AU2001261707A1/en not_active Abandoned
- 2001-05-15 MX MXPA02012472A patent/MXPA02012472A/es active IP Right Grant
- 2001-05-15 WO PCT/US2001/015935 patent/WO2002000656A2/en active IP Right Grant
- 2001-05-15 JP JP2002505780A patent/JP4169149B2/ja not_active Expired - Fee Related
- 2001-05-15 EP EP01935629A patent/EP1366049B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20030225094A1 (en)	2003-12-04
MXPA02012472A (es)	2004-01-26
CA2412594A1 (en)	2002-01-03
EP1366049B1 (de)	2006-06-21
JP2004513072A (ja)	2004-04-30
WO2002000656A2 (en)	2002-01-03
WO2002000656A3 (en)	2003-10-02
JP4169149B2 (ja)	2008-10-22
CA2412594C (en)	2009-03-17
DE60121048D1 (de)	2006-08-03
EP1366049A2 (de)	2003-12-03
AU2001261707A1 (en)	2002-01-08
US6911542B2 (en)	2005-06-28
DE60121048T2 (de)	2007-01-25
ES2269401T3 (es)	2007-04-01

Publication	Publication Date	Title
DE60112974D1 (en)	2005-09-29	Carbolinderivate
DE69618231D1 (de)	2002-01-31	TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMER
DE60216233D1 (en)	2007-01-04	Carbolinderivate
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
MXPA02012659A (es)	2003-09-22	Derivados de pirazindiona condensados.
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
ATE259813T1 (de)	2004-03-15	Triazolopyrimidinderivate
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
MXPA03003971A (es)	2004-02-12	Derivados de indol como inhibidores de pde5.
DE60110124D1 (de)	2005-05-19	Kondensierte pyrazindionderivate als pde inhibitoren
MXPA03000887A (es)	2004-04-05	Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.
CA2445620A1 (en)	2002-12-12	Tetracyclic compounds as pde5-inhibitors
CY1105981T1 (el)	2011-04-06	Ενωσεις 5-πυριδυλ-1,3-αζολιου, μεθοδοι παρασκευης αυτων και χρηση αυτων

Legal Events

Date	Code	Title	Description
2006-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties