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DE60142920D1 - Verfahren zur herstellung von 16,17-ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy-pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation - Google Patents

Verfahren zur herstellung von 16,17-ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy-pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation

Info

Publication number
DE60142920D1
DE60142920D1 DE60142920T DE60142920T DE60142920D1 DE 60142920 D1 DE60142920 D1 DE 60142920D1 DE 60142920 T DE60142920 T DE 60142920T DE 60142920 T DE60142920 T DE 60142920T DE 60142920 D1 DE60142920 D1 DE 60142920D1
Authority
DE
Germany
Prior art keywords
cyclohexylmethylene
oxy
preparation
transcetalization
pregna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142920T
Other languages
English (en)
Inventor
Beate Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Nycomed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed GmbH filed Critical Nycomed GmbH
Application granted granted Critical
Publication of DE60142920D1 publication Critical patent/DE60142920D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60142920T 2000-11-10 2001-11-06 Verfahren zur herstellung von 16,17-ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy-pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation Expired - Lifetime DE60142920D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124626 2000-11-10
PCT/EP2001/012808 WO2002038584A1 (en) 2000-11-10 2001-11-06 Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation

Publications (1)

Publication Number Publication Date
DE60142920D1 true DE60142920D1 (de) 2010-10-07

Family

ID=8170345

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60142920T Expired - Lifetime DE60142920D1 (de) 2000-11-10 2001-11-06 Verfahren zur herstellung von 16,17-ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy-pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation

Country Status (23)

Country Link
US (1) US7468433B2 (de)
EP (1) EP1335929B1 (de)
JP (1) JP4456811B2 (de)
KR (2) KR100809510B1 (de)
CN (1) CN1264855C (de)
AT (1) ATE478888T1 (de)
AU (1) AU2953602A (de)
BR (1) BR0115220A (de)
CA (1) CA2430196C (de)
CZ (1) CZ303885B6 (de)
DE (1) DE60142920D1 (de)
EA (1) EA006231B1 (de)
ES (1) ES2351184T3 (de)
HK (1) HK1058043A1 (de)
HU (1) HU228432B1 (de)
IL (1) IL155274A0 (de)
MX (1) MXPA03004123A (de)
NO (1) NO325286B1 (de)
NZ (1) NZ525707A (de)
PL (1) PL205674B1 (de)
SK (1) SK287545B6 (de)
WO (1) WO2002038584A1 (de)
ZA (1) ZA200303121B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100404545C (zh) * 2003-03-27 2008-07-23 尼科梅德有限责任公司 具有规定粒径的结晶环缩松的制备方法
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
CN100338089C (zh) * 2004-08-12 2007-09-19 重庆医药工业研究院有限责任公司 一种哮喘病治疗药物环索奈德的新的制备方法
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
WO2007054974A2 (en) * 2005-09-28 2007-05-18 Arch Pharmalab Limited A green chemistry process for the preparation of pregnadiene esters
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
EP2064227A2 (de) 2006-09-19 2009-06-03 Cipla Ltd. Verfahren zur herstellung von ciclesonid und dessen kristallform
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
US10233210B2 (en) 2015-01-30 2019-03-19 Coral Drugs Pvt. Ltd. Process for preparation of glucocorticoid steroids
UY37269A (es) 2016-06-02 2018-01-02 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados del mismo
LT3658192T (lt) 2017-12-01 2021-07-12 Abbvie Inc. Gliukokortikoidų receptorių agonistas ir jo imunokonjugatai

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880368A (en) * 1983-10-24 1989-11-14 Siegfried C. Hasl In-mold label transfer apparatus
ES527509A0 (es) 1983-11-24 1985-08-01 Frumtost Zyma S A Procedimiento para la obtencion de un corticoide de accion antipsoriatica
IT1196142B (it) 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
FR2675146A1 (fr) 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
RU2132854C1 (ru) * 1993-04-02 1999-07-10 Бик Гульден Ломберг Хемише Фабрик ГмбХ Производные преднизолона, способ их получения и лекарственное средство
DE19635498A1 (de) 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung

Also Published As

Publication number Publication date
CZ303885B6 (cs) 2013-06-12
JP2004513181A (ja) 2004-04-30
HK1058043A1 (en) 2004-04-30
IL155274A0 (en) 2003-11-23
US20050080063A1 (en) 2005-04-14
EA200300504A1 (ru) 2003-12-25
ES2351184T3 (es) 2011-02-01
NO20031964L (no) 2003-04-30
HUP0302220A3 (en) 2007-11-28
EP1335929A1 (de) 2003-08-20
EA006231B1 (ru) 2005-10-27
KR20070116185A (ko) 2007-12-06
EP1335929B1 (de) 2010-08-25
NZ525707A (en) 2004-11-26
PL361616A1 (en) 2004-10-04
SK5552003A3 (en) 2003-08-05
CN1473164A (zh) 2004-02-04
JP4456811B2 (ja) 2010-04-28
NO20031964D0 (no) 2003-04-30
ZA200303121B (en) 2004-04-23
CN1264855C (zh) 2006-07-19
HUP0302220A2 (hu) 2003-10-28
KR20030081329A (ko) 2003-10-17
NO325286B1 (no) 2008-03-17
PL205674B1 (pl) 2010-05-31
CA2430196A1 (en) 2002-05-16
AU2953602A (en) 2002-05-21
KR100809510B1 (ko) 2008-03-04
WO2002038584A1 (en) 2002-05-16
BR0115220A (pt) 2003-10-07
US7468433B2 (en) 2008-12-23
ATE478888T1 (de) 2010-09-15
MXPA03004123A (es) 2004-09-10
HU228432B1 (hu) 2013-03-28
CA2430196C (en) 2010-01-26
SK287545B6 (sk) 2011-01-04

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