ATE478888T1 - Verfahren zur herstellung von 16,17- ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy- pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation - Google Patents

Verfahren zur herstellung von 16,17- ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy- pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation

Info

Publication number: ATE478888T1
Authority: AT; Austria
Prior art keywords: cyclohexylmethylene; dione; diene; oxy; bis
Prior art date: 2000-11-10

Application number

AT01990391T

Other languages

English (en)

Inventor

Beate Schmidt

Original Assignee

Nycomed Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-10

Filing date

2001-11-06

Publication date

2010-09-15

2001-11-06 Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE478888T1 publication Critical patent/ATE478888T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Liquid Crystal Substances (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT01990391T 2000-11-10 2001-11-06 Verfahren zur herstellung von 16,17- ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy- pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation ATE478888T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00124626		2000-11-10
PCT/EP2001/012808 WO2002038584A1 (en)	2000-11-10	2001-11-06	Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation

Publications (1)

Publication Number	Publication Date
ATE478888T1 true ATE478888T1 (de)	2010-09-15

Family

ID=8170345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01990391T ATE478888T1 (de)	2000-11-10	2001-11-06	Verfahren zur herstellung von 16,17- ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy- pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation

Country Status (23)

Country	Link
US (1)	US7468433B2 (de)
EP (1)	EP1335929B1 (de)
JP (1)	JP4456811B2 (de)
KR (2)	KR100809510B1 (de)
CN (1)	CN1264855C (de)
AT (1)	ATE478888T1 (de)
AU (1)	AU2953602A (de)
BR (1)	BR0115220A (de)
CA (1)	CA2430196C (de)
CZ (1)	CZ303885B6 (de)
DE (1)	DE60142920D1 (de)
EA (1)	EA006231B1 (de)
ES (1)	ES2351184T3 (de)
HK (1)	HK1058043A1 (de)
HU (1)	HU228432B1 (de)
IL (1)	IL155274A0 (de)
MX (1)	MXPA03004123A (de)
NO (1)	NO325286B1 (de)
NZ (1)	NZ525707A (de)
PL (1)	PL205674B1 (de)
SK (1)	SK287545B6 (de)
WO (1)	WO2002038584A1 (de)
ZA (1)	ZA200303121B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100404545C (zh) *	2003-03-27	2008-07-23	尼科梅德有限责任公司	具有规定粒径的结晶环缩松的制备方法
MY143936A (en)	2003-03-27	2011-07-29	Nycomed Gmbh	Process for preparing crystalline ciclesonide with defined particle size
CN100338089C (zh) *	2004-08-12	2007-09-19	重庆医药工业研究院有限责任公司	一种哮喘病治疗药物环索奈德的新的制备方法
CN100345864C (zh) *	2004-10-29	2007-10-31	天津药业研究院有限公司	一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
WO2007054974A2 (en) *	2005-09-28	2007-05-18	Arch Pharmalab Limited	A green chemistry process for the preparation of pregnadiene esters
WO2008015696A2 (en) *	2006-05-23	2008-02-07	Cadila Healthcare Limited	Process for preparing ciclesonide
WO2008035066A2 (en) *	2006-09-19	2008-03-27	Cipla Limited	Processes for the preparation of ciclesonide and its crystal form
US9109005B2 (en)	2012-02-23	2015-08-18	Boehringer Ingelheim International Gmbh	Method for manufacturing of ciclesonide
US10233210B2 (en)	2015-01-30	2019-03-19	Coral Drugs Pvt. Ltd.	Process for preparation of glucocorticoid steroids
BR112018074922B1 (pt)	2016-06-02	2022-10-25	Abbvie Inc	Compostos agonistas de receptores de glucocorticoides, composição farmacêutica compreendendo ditos compostos e uso terapêutico dos mesmos
AU2018374634A1 (en)	2017-12-01	2020-05-28	Abbvie Inc.	Glucocorticoid receptor agonist and immunoconjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4880368A (en) *	1983-10-24	1989-11-14	Siegfried C. Hasl	In-mold label transfer apparatus
ES527509A0 (es)	1983-11-24	1985-08-01	Frumtost Zyma S A	Procedimiento para la obtencion de un corticoide de accion antipsoriatica
IT1196142B (it) *	1984-06-11	1988-11-10	Sicor Spa	Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) *	1986-09-25	1986-09-25	Astra Pharma Prod	A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) *	1990-09-07	1994-03-31	Elmuquimica Farm Sl	Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
FR2675146A1 (fr) *	1991-04-10	1992-10-16	Roussel Uclaf	Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
EP0701565B1 (de) *	1993-04-02	1998-10-28	Byk Gulden Lomberg Chemische Fabrik GmbH	Neue prednisolonderivate
DE19635498A1 (de)	1996-09-03	1998-03-26	Byk Gulden Lomberg Chem Fab	Verfahren zur Epimerenanreicherung

2001
- 2001-11-06 NZ NZ525707A patent/NZ525707A/en not_active IP Right Cessation
- 2001-11-06 AU AU2953602A patent/AU2953602A/xx active Pending
- 2001-11-06 PL PL361616A patent/PL205674B1/pl unknown
- 2001-11-06 SK SK555-2003A patent/SK287545B6/sk not_active IP Right Cessation
- 2001-11-06 BR BR0115220-3A patent/BR0115220A/pt not_active Application Discontinuation
- 2001-11-06 KR KR1020037006292A patent/KR100809510B1/ko active IP Right Grant
- 2001-11-06 MX MXPA03004123A patent/MXPA03004123A/es active IP Right Grant
- 2001-11-06 IL IL15527401A patent/IL155274A0/xx not_active IP Right Cessation
- 2001-11-06 CA CA2430196A patent/CA2430196C/en not_active Expired - Fee Related
- 2001-11-06 EA EA200300504A patent/EA006231B1/ru not_active IP Right Cessation
- 2001-11-06 US US10/399,689 patent/US7468433B2/en not_active Expired - Lifetime
- 2001-11-06 JP JP2002541116A patent/JP4456811B2/ja not_active Expired - Lifetime
- 2001-11-06 DE DE60142920T patent/DE60142920D1/de not_active Expired - Lifetime
- 2001-11-06 WO PCT/EP2001/012808 patent/WO2002038584A1/en active IP Right Grant
- 2001-11-06 ES ES01990391T patent/ES2351184T3/es not_active Expired - Lifetime
- 2001-11-06 CZ CZ20031272A patent/CZ303885B6/cs not_active IP Right Cessation
- 2001-11-06 KR KR1020077026436A patent/KR20070116185A/ko not_active Application Discontinuation
- 2001-11-06 EP EP01990391A patent/EP1335929B1/de not_active Expired - Lifetime
- 2001-11-06 HU HU0302220A patent/HU228432B1/hu unknown
- 2001-11-06 CN CNB018185517A patent/CN1264855C/zh not_active Expired - Lifetime
- 2001-11-06 AT AT01990391T patent/ATE478888T1/de active
2003
- 2003-04-23 ZA ZA200303121A patent/ZA200303121B/en unknown
- 2003-04-30 NO NO20031964A patent/NO325286B1/no not_active IP Right Cessation
2004
- 2004-02-09 HK HK04100855.0A patent/HK1058043A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
MXPA03004123A (es)	2004-09-10
CZ303885B6 (cs)	2013-06-12
EA006231B1 (ru)	2005-10-27
EA200300504A1 (ru)	2003-12-25
CN1264855C (zh)	2006-07-19
PL205674B1 (pl)	2010-05-31
HK1058043A1 (en)	2004-04-30
CA2430196A1 (en)	2002-05-16
KR100809510B1 (ko)	2008-03-04
JP4456811B2 (ja)	2010-04-28
NZ525707A (en)	2004-11-26
HU228432B1 (hu)	2013-03-28
JP2004513181A (ja)	2004-04-30
EP1335929A1 (de)	2003-08-20
PL361616A1 (en)	2004-10-04
ZA200303121B (en)	2004-04-23
ES2351184T3 (es)	2011-02-01
KR20030081329A (ko)	2003-10-17
CN1473164A (zh)	2004-02-04
HUP0302220A2 (hu)	2003-10-28
WO2002038584A1 (en)	2002-05-16
NO325286B1 (no)	2008-03-17
DE60142920D1 (de)	2010-10-07
US7468433B2 (en)	2008-12-23
NO20031964D0 (no)	2003-04-30
SK5552003A3 (en)	2003-08-05
SK287545B6 (sk)	2011-01-04
IL155274A0 (en)	2003-11-23
BR0115220A (pt)	2003-10-07
CA2430196C (en)	2010-01-26
NO20031964L (no)	2003-04-30
US20050080063A1 (en)	2005-04-14
AU2953602A (en)	2002-05-21
EP1335929B1 (de)	2010-08-25
KR20070116185A (ko)	2007-12-06
HUP0302220A3 (en)	2007-11-28

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