CY1905A - Alpha-heterocycle substituted tolunitriles - Google Patents

Alpha-heterocycle substituted tolunitriles

Info

Publication number: CY1905A
Authority: CY; Cyprus
Prior art keywords: alkyl; substd; opt; alkylene; alkylthio
Prior art date: 1986-03-07

Application number

CY190587A

Other languages

English (en)

Inventor

Robert Mathews Bowman

Ronald Edward Steele

Leslie Johnston Browne

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-07

Filing date

1987-03-05

Publication date

1987-03-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1905(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-03-05 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1987-03-05 Publication of CY1905A publication Critical patent/CY1905A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Fats And Perfumes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Hydrogenated Pyridines (AREA)

CY190587A 1986-03-07 1987-03-05 Alpha-heterocycle substituted tolunitriles CY1905A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/837,489 US4749713A (en)	1986-03-07	1986-03-07	Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number	Publication Date
CY1905A true CY1905A (en)	1987-03-05

Family

ID=25274596

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY190587A CY1905A (en)	1986-03-07	1987-03-05	Alpha-heterocycle substituted tolunitriles

Country Status (36)

Country	Link
US (1)	US4749713A (ru)
EP (1)	EP0236940B3 (ru)
JP (1)	JPH0755930B2 (ru)
KR (1)	KR910000482B1 (ru)
AT (1)	ATE94873T1 (ru)
BG (4)	BG45700A3 (ru)
CA (1)	CA1316928C (ru)
CY (1)	CY1905A (ru)
CZ (3)	CZ279027B6 (ru)
DD (1)	DD264432A5 (ru)
DE (2)	DE19775016I2 (ru)
DK (1)	DK172190B1 (ru)
DZ (1)	DZ1055A1 (ru)
ES (1)	ES2059317T3 (ru)
FI (1)	FI91857C (ru)
HK (1)	HK50296A (ru)
HU (1)	HU202843B (ru)
IE (1)	IE61101B1 (ru)
IL (1)	IL81746A (ru)
LU (1)	LU90128I2 (ru)
LV (1)	LV5769B4 (ru)
MA (1)	MA20888A1 (ru)
MC (1)	MC1805A1 (ru)
MT (1)	MTP998B (ru)
MX (1)	MX5496A (ru)
MY (1)	MY102428A (ru)
NL (1)	NL970011I2 (ru)
NO (2)	NO170277C (ru)
PH (1)	PH24159A (ru)
PL (2)	PL152025B1 (ru)
PT (1)	PT84410B (ru)
RO (2)	RO101532B1 (ru)
SK (3)	SK279103B6 (ru)
SU (3)	SU1470184A3 (ru)
TN (1)	TNSN87033A1 (ru)
ZA (1)	ZA871637B (ru)

Families Citing this family (46)

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US5112845A (en) *	1986-03-07	1992-05-12	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US5352795A (en) *	1986-03-07	1994-10-04	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
GB8714013D0 (en) *	1987-06-16	1987-07-22	Ici Plc	(substituted-aralkyl)heterocyclic compounds
DE3811574A1 (de) *	1988-03-31	1989-10-19	Schering Ag	N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DK0408509T3 (da) *	1989-07-14	1996-04-01	Ciba Geigy Ag	Substituerede benzonitriler
DE3926365A1 (de) *	1989-08-04	1991-02-07	Schering Ag	Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) *	1990-04-12	1997-04-23	雪印乳業株式会社	子宮内膜症治療剤
EP0457716A1 (de) *	1990-04-20	1991-11-21	Ciba-Geigy Ag	Naphthalinderivate
DE4039559A1 (de) *	1990-12-07	1992-06-11	Schering Ag	Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
TW210334B (ru) *	1990-12-12	1993-08-01	Ciba Geigy Ag
CH683151A5 (de) *	1991-04-24	1994-01-31	Ciba Geigy Ag	Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4120107A1 (de) *	1991-06-14	1992-12-17	Schering Ag	Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
TW225526B (ru)	1991-09-02	1994-06-21	Yamanouchi Pharma Co Ltd
US5223539A (en) *	1991-11-22	1993-06-29	G. D. Searle & Co.	N,n-di-alkyl(phenoxy)benzamide derivatives
WO1994008973A1 (en) *	1992-10-21	1994-04-28	Sankyo Company, Limited	Azole compound
GB2273704B (en) *	1992-12-16	1997-01-22	Orion Yhtymae Oy	Triazolyl diaryl selective aromatase inhibiting compounds
US5426196A (en) *	1993-12-22	1995-06-20	Glaxo Inc.	Synthesis of diaryl methanes
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JP2000504014A (ja) *	1996-01-30	2000-04-04	メルクエンドカンパニーインコーポレーテッド	ファルネシル―タンパク質転移酵素の阻害剤
AU715603B2 (en) *	1996-04-03	2000-02-03	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US6063930A (en) *	1996-04-03	2000-05-16	Merck & Co., Inc.	Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
JP2000507955A (ja) *	1996-04-03	2000-06-27	メルクエンドカンパニーインコーポレーテッド	ファルネシル―タンパク質転移酵素の阻害剤
US6080870A (en) *	1996-04-03	2000-06-27	Merck & Co., Inc.	Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP2253319A1 (en)	2001-05-16	2010-11-24	Novartis AG	Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent.
AU2002366587A1 (en) *	2001-12-11	2003-06-23	Emory University	Bis(cyanophenyl)methyl-triazole for use in prevention of breast cancer
GB0217636D0 (en) *	2002-07-30	2002-09-11	Novartis Ag	Organic compounds
ES2276119T3 (es) *	2002-07-30	2007-06-16	Novartis Ag	Combinacion de un inhibidor de aromatasa con un bisfosfonato.
JP2004196795A (ja) *	2002-12-16	2004-07-15	Wyeth	外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
WO2005047269A1 (en) *	2003-11-14	2005-05-26	Natco Pharma Limited	A method for the separation of the letrozole precursor 4-‘1-(1,2,4-triazolyl) methyl!benzonitrile from its 1,3,4-triazolyl isomer
EP1694650A1 (en) *	2003-12-15	2006-08-30	Laboratoire Theramex	1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them
WO2007100346A1 (en) *	2005-07-06	2007-09-07	Sicor, Inc.	Improved process for the preparation of letrozole
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US20090082413A1 (en) *	2007-09-26	2009-03-26	Protia, Llc	Deuterium-enriched letrozole
WO2011128434A2 (en)	2010-04-16	2011-10-20	Novartis Ag	Treatment of endocrine resistant breast cancer
NZ607428A (en)	2010-08-27	2015-10-30	Generics Uk Ltd	Pure intermediate for preparing letrozole
EP2753313B1 (en)	2011-09-08	2016-12-14	Mereo BioPharma 2 Limited	Pharmaceutical compositions comprising an aromatase inhibitor
CN109939236A (zh)	2012-06-08	2019-06-28	豪夫迈·罗氏有限公司	用于治疗癌症的磷酸肌醇3激酶抑制剂化合物和化疗剂的突变选择性及组合
CN110368497B (zh)	2013-08-14	2022-05-13	诺华股份有限公司	用于治疗癌症的组合疗法
AR104068A1 (es)	2015-03-26	2017-06-21	Hoffmann La Roche	Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
GB201614179D0 (en)	2016-08-19	2016-10-05	Mereo Biopharma 2 Ltd	Dosage regimen for the treatment of endometriosis
AU2019310335A1 (en)	2018-07-23	2021-02-11	F. Hoffmann-La Roche Ag	Methods of treating cancer with PI3K inhibitor, GDC-0077
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AU2020396093A1 (en)	2019-12-03	2022-05-19	Genentech, Inc.	Combination therapies for treatment of breast cancer
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1986
- 1986-03-07 US US06/837,489 patent/US4749713A/en not_active Expired - Lifetime
1987
- 1987-03-02 FI FI870903A patent/FI91857C/fi not_active IP Right Cessation
- 1987-03-03 DD DD87300415A patent/DD264432A5/de not_active IP Right Cessation
- 1987-03-03 IL IL81746A patent/IL81746A/xx not_active IP Right Cessation
- 1987-03-04 DZ DZ870031A patent/DZ1055A1/fr active
- 1987-03-05 MA MA21124A patent/MA20888A1/fr unknown
- 1987-03-05 DE DE1997175016 patent/DE19775016I2/de active Active
- 1987-03-05 RO RO1987134373A patent/RO101532B1/ro unknown
- 1987-03-05 PT PT84410A patent/PT84410B/pt unknown
- 1987-03-05 ES ES87103099T patent/ES2059317T3/es not_active Expired - Lifetime
- 1987-03-05 EP EP87103099A patent/EP0236940B3/en not_active Expired - Lifetime
- 1987-03-05 DE DE87103099T patent/DE3787480T2/de not_active Expired - Lifetime
- 1987-03-05 HU HU87952A patent/HU202843B/hu unknown
- 1987-03-05 PL PL1987280247A patent/PL152025B1/pl unknown
- 1987-03-05 BG BG081514A patent/BG45700A3/xx unknown
- 1987-03-05 CY CY190587A patent/CY1905A/xx unknown
- 1987-03-05 BG BG081515A patent/BG45701A3/xx unknown
- 1987-03-05 MC MC871874A patent/MC1805A1/xx unknown
- 1987-03-05 PL PL1987264460A patent/PL151490B1/pl unknown
- 1987-03-05 BG BG078756A patent/BG46598A3/xx unknown
- 1987-03-05 AT AT87103099T patent/ATE94873T1/de active
- 1987-03-05 RO RO1987134372A patent/RO101533B1/ro unknown
- 1987-03-05 CA CA000531185A patent/CA1316928C/en not_active Expired - Lifetime
- 1987-03-06 SU SU874202145A patent/SU1470184A3/ru active
- 1987-03-06 ZA ZA871637A patent/ZA871637B/xx unknown
- 1987-03-06 SK SK7368-87A patent/SK279103B6/sk unknown
- 1987-03-06 CZ CS877367A patent/CZ279027B6/cs not_active IP Right Cessation
- 1987-03-06 SK SK7367-87A patent/SK279102B6/sk unknown
- 1987-03-06 TN TNTNSN87033A patent/TNSN87033A1/fr unknown
- 1987-03-06 CZ CS877368A patent/CZ279028B6/cs not_active IP Right Cessation
- 1987-03-06 JP JP62050446A patent/JPH0755930B2/ja not_active Expired - Lifetime
- 1987-03-06 CZ CS871512A patent/CZ279026B6/cs not_active IP Right Cessation
- 1987-03-06 MY MYPI87000247A patent/MY102428A/en unknown
- 1987-03-06 KR KR1019870002004A patent/KR910000482B1/ko not_active IP Right Cessation
- 1987-03-06 SK SK1512-87A patent/SK151287A3/sk unknown
- 1987-03-06 MX MX549687A patent/MX5496A/es unknown
- 1987-03-06 NO NO870937A patent/NO170277C/no not_active IP Right Cessation
- 1987-03-06 PH PH34986A patent/PH24159A/en unknown
- 1987-03-06 MT MT998A patent/MTP998B/xx unknown
- 1987-03-06 IE IE57587A patent/IE61101B1/en not_active IP Right Cessation
- 1987-03-06 DK DK117687A patent/DK172190B1/da not_active IP Right Cessation
1988
- 1988-01-18 SU SU884203990A patent/SU1549478A3/ru active
- 1988-01-18 SU SU884203999A patent/SU1577695A3/ru active
1993
- 1993-11-11 BG BG098212A patent/BG61204B2/bg unknown
1996
- 1996-03-21 HK HK50296A patent/HK50296A/xx not_active IP Right Cessation
- 1996-07-18 LV LV960274A patent/LV5769B4/xx unknown
1997
- 1997-03-03 NL NL970011C patent/NL970011I2/nl unknown
- 1997-08-20 LU LU90128C patent/LU90128I2/fr unknown
1998
- 1998-03-04 NO NO1998010C patent/NO1998010I1/no unknown

Also Published As

Publication number	Publication date
EP0236940B3 (en)	2011-03-23
MX5496A (es)	1993-12-01
FI870903A0 (fi)	1987-03-02
CS8707367A2 (en)	1991-02-12
DD264432A5 (de)	1989-02-01
TNSN87033A1 (fr)	1990-01-01
MTP998B (en)	1987-08-21
BG45701A3 (en)	1989-07-14
DK172190B1 (da)	1997-12-22
SK736887A3 (en)	1998-06-03
NO170277C (no)	1992-09-30
NO870937D0 (no)	1987-03-06
SU1470184A3 (ru)	1989-03-30
SK736787A3 (en)	1998-06-03
DK117687A (da)	1987-09-08
PH24159A (en)	1990-03-22
DE19775016I2 (de)	2002-02-21
PT84410B (pt)	1989-10-04
MY102428A (en)	1992-06-30
IE870575L (en)	1987-09-07
EP0236940A3 (en)	1989-10-18
PL152025B1 (en)	1990-10-31
NL970011I2 (nl)	1997-09-01
JPH0755930B2 (ja)	1995-06-14
NO870937L (no)	1987-09-08
LV5769A4 (lv)	1996-12-20
SK279101B6 (sk)	1998-06-03
FI870903A (fi)	1987-09-08
CZ279026B6 (en)	1994-11-16
SK279103B6 (sk)	1998-06-03
NL970011I1 (nl)	1997-05-01
LV5769B4 (lv)	1997-04-20
ZA871637B (en)	1987-10-28
DE3787480D1 (de)	1993-10-28
DK117687D0 (da)	1987-03-06
NO1998010I1 (no)	1998-03-04
AU6976887A (en)	1987-09-10
BG45700A3 (en)	1989-07-14
SK279102B6 (sk)	1998-06-03
PT84410A (en)	1987-04-01
DZ1055A1 (fr)	2004-09-13
SU1577695A3 (ru)	1990-07-07
FI91857C (fi)	1994-08-25
BG46598A3 (en)	1990-01-15
EP0236940A2 (en)	1987-09-16
SK151287A3 (en)	1998-06-03
FI91857B (fi)	1994-05-13
SU1549478A3 (ru)	1990-03-07
RO101533B1 (en)	1992-06-25
PL264460A1 (en)	1988-07-21
AU604011B2 (en)	1990-12-06
KR910000482B1 (ko)	1991-01-25
KR870008851A (ko)	1987-10-21
MA20888A1 (fr)	1987-10-01
BG61204B2 (bg)	1997-02-28
DE3787480T2 (de)	1994-02-24
RO101532B1 (en)	1992-11-03
LU90128I2 (fr)	1997-10-06
US4749713A (en)	1988-06-07
IL81746A0 (en)	1987-10-20
PL151490B1 (en)	1990-09-28
IL81746A (en)	1992-02-16
HK50296A (en)	1996-03-29
JPS62212369A (ja)	1987-09-18
NO170277B (no)	1992-06-22
CA1316928C (en)	1993-04-27
CS8701512A2 (en)	1991-02-12
ES2059317T3 (es)	1994-11-16
CS8707368A2 (en)	1991-02-12
ATE94873T1 (de)	1993-10-15
EP0236940B1 (en)	1993-09-22
CZ279028B6 (en)	1994-11-16
IE61101B1 (en)	1994-10-05
HU202843B (en)	1991-04-29
HUT43822A (en)	1987-12-28
CZ279027B6 (en)	1994-11-16
MC1805A1 (fr)	1987-12-22

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CY1905A (en)	1987-03-05	Alpha-heterocycle substituted tolunitriles
NZ336529A (en)	2001-03-30	3-Aryl substituted pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical use
RO96133A (ro)	1989-01-30	Procedeu pentru prepararea unor derivati ai tolunitrililor heterociclic substituiti
AU553859B2 (en)	1986-07-31	Tricyclic oxindole carboxamides
DURFEE et al.	1985	Making coherent communication decisions in a distributed problem solving network
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Curtis et al.	1987	The site selection process for a Chesapeake Bay National Estuarine Research Reserve System.
GB1460680A (en)	1977-01-06	1,4-benzodiazepines
IT1204495B (it)	1989-03-01	Procedimento di sintesi per l'ottenimento di molecole aventi attivita' farmacologica via uree mono e bisostiuite
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