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CR20180293A - HETEROCICLILAMINAS COMO INHIBIDORES DE PI3K (Divisional 2014-0111) - Google Patents

HETEROCICLILAMINAS COMO INHIBIDORES DE PI3K (Divisional 2014-0111)

Info

Publication number
CR20180293A
CR20180293A CR20180293A CR20180293A CR20180293A CR 20180293 A CR20180293 A CR 20180293A CR 20180293 A CR20180293 A CR 20180293A CR 20180293 A CR20180293 A CR 20180293A CR 20180293 A CR20180293 A CR 20180293A
Authority
CR
Costa Rica
Prior art keywords
heterociclilaminas
pi3k
divisional
inhibitors
pi3ks
Prior art date
Application number
CR20180293A
Other languages
English (en)
Inventor
Joseph Glenn
Andrew P Combs
Wenyu Zhu
Brent Douty
Eddy W Yue
Richard B Sparks
Song Mei
Chunhong He
Yun-Long Li
Thomas P Maduskuie Jr
Wenqing Yao
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of CR20180293A publication Critical patent/CR20180293A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona derivados de heterociclilamina de la fórmula I en donde las variables se definen en la presente, que modulan la actividad de las fosfoinositida 3¿quinasas (PI3Ks) y son de utilidad en el tratamiento de enfermedades relacionadas con la actividad de PI3Ks que incluyen, por ejemplo, trastornos inflamatorios, trastornos con base inmune, cáncer y otras enfermedades
CR20180293A 2011-09-02 2012-08-31 HETEROCICLILAMINAS COMO INHIBIDORES DE PI3K (Divisional 2014-0111) CR20180293A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161530866P 2011-09-02 2011-09-02
US201261594882P 2012-02-03 2012-02-03
US201261677445P 2012-07-30 2012-07-30
PCT/US2012/053398 WO2013033569A1 (en) 2011-09-02 2012-08-31 Heterocyclylamines as pi3k inhibitors

Publications (1)

Publication Number Publication Date
CR20180293A true CR20180293A (es) 2018-09-19

Family

ID=47071429

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20180293A CR20180293A (es) 2011-09-02 2012-08-31 HETEROCICLILAMINAS COMO INHIBIDORES DE PI3K (Divisional 2014-0111)
CR20140111A CR20140111A (es) 2011-09-02 2014-03-04 Heterociclilaminas como inhibidores de pi3k

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20140111A CR20140111A (es) 2011-09-02 2014-03-04 Heterociclilaminas como inhibidores de pi3k

Country Status (38)

Country Link
US (9) US9199982B2 (es)
EP (4) EP3196202B1 (es)
JP (8) JP6067709B2 (es)
KR (7) KR102249236B1 (es)
CN (1) CN106986867B (es)
AR (1) AR087760A1 (es)
AU (5) AU2012301721B2 (es)
BR (2) BR112014004971B1 (es)
CA (1) CA2846652C (es)
CL (1) CL2014000517A1 (es)
CO (1) CO6910199A2 (es)
CR (2) CR20180293A (es)
CY (3) CY1118679T1 (es)
DK (3) DK2751109T3 (es)
EA (2) EA033646B1 (es)
EC (1) ECSP14013274A (es)
ES (3) ES2722524T3 (es)
HK (1) HK1199644A1 (es)
HR (3) HRP20170285T1 (es)
HU (3) HUE043703T2 (es)
IL (7) IL314671A (es)
LT (3) LT2751109T (es)
ME (2) ME02595B (es)
MX (2) MX360262B (es)
MY (1) MY179332A (es)
NZ (1) NZ769326A (es)
PE (2) PE20181272A1 (es)
PH (3) PH12021552978A1 (es)
PL (3) PL2751109T3 (es)
PT (3) PT3196202T (es)
RS (3) RS55737B1 (es)
SG (3) SG10201912484RA (es)
SI (3) SI3196202T1 (es)
SM (4) SMT201900243T1 (es)
TW (6) TWI765515B (es)
UA (1) UA121539C2 (es)
WO (1) WO2013033569A1 (es)
ZA (1) ZA201904877B (es)

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