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BRPI0409133B8 - preparações farmacêuticas estavéis compreendendo metilnaltrexona - Google Patents

preparações farmacêuticas estavéis compreendendo metilnaltrexona

Info

Publication number
BRPI0409133B8
BRPI0409133B8 BRPI0409133A BRPI0409133A BRPI0409133B8 BR PI0409133 B8 BRPI0409133 B8 BR PI0409133B8 BR PI0409133 A BRPI0409133 A BR PI0409133A BR PI0409133 A BRPI0409133 A BR PI0409133A BR PI0409133 B8 BRPI0409133 B8 BR PI0409133B8
Authority
BR
Brazil
Prior art keywords
methylnaltrexone
pharmaceutical preparations
stable pharmaceutical
pharmaceutical compositions
stable
Prior art date
Application number
BRPI0409133A
Other languages
English (en)
Inventor
P Sanghvi Suketu
A Boyd Thomas
Original Assignee
Progenics Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33299842&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0409133(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Progenics Pharm Inc filed Critical Progenics Pharm Inc
Publication of BRPI0409133A publication Critical patent/BRPI0409133A/pt
Publication of BRPI0409133B1 publication Critical patent/BRPI0409133B1/pt
Publication of BRPI0409133B8 publication Critical patent/BRPI0409133B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A—HUMAN NECESSITIES
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

formulações farmacêuticas contendo metilnaltrexona. as composições farmacêuticas estáveis úteis para administrar metilnaltrexona são descritas, assim como são os métodos para a preparação das mesmas. os kits, incluindo essas composições farmacêuticas, também são fornecidos.
BRPI0409133A 2003-04-08 2004-04-08 preparações farmacêuticas estavéis compreendendo metilnaltrexona BRPI0409133B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46161103P 2003-04-08 2003-04-08
PCT/US2004/010997 WO2004091623A1 (en) 2003-04-08 2004-04-08 Pharmaceutical formulations containing methylnaltrexone

Publications (3)

Publication Number Publication Date
BRPI0409133A BRPI0409133A (pt) 2006-05-02
BRPI0409133B1 BRPI0409133B1 (pt) 2019-09-03
BRPI0409133B8 true BRPI0409133B8 (pt) 2021-05-25

Family

ID=33299842

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409133A BRPI0409133B8 (pt) 2003-04-08 2004-04-08 preparações farmacêuticas estavéis compreendendo metilnaltrexona

Country Status (19)

Country Link
US (8) US20040266806A1 (pt)
EP (3) EP2368554B1 (pt)
JP (3) JP2006522818A (pt)
CN (2) CN1767831B (pt)
AU (2) AU2004229463B2 (pt)
BR (1) BRPI0409133B8 (pt)
CA (2) CA2811272C (pt)
CY (3) CY1116272T1 (pt)
DK (3) DK2368554T3 (pt)
ES (3) ES2527870T5 (pt)
HK (1) HK1207965A1 (pt)
HR (3) HRP20150037T4 (pt)
IL (1) IL171228A (pt)
MX (1) MXPA05010817A (pt)
PL (3) PL2368554T3 (pt)
PT (3) PT2368554E (pt)
RU (1) RU2362560C2 (pt)
SI (3) SI1615646T2 (pt)
WO (1) WO2004091623A1 (pt)

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US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
PL193273B1 (pl) 1997-12-22 2007-01-31 Euro Celtique Sa Postać dawkowania doustnego
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
AU2002305559B2 (en) 2001-05-11 2008-04-03 Mundipharma Pty Limited Abuse-resistant controlled-release opioid dosage form
EP2319496A1 (en) 2002-04-05 2011-05-11 Euro-Celtique S.A. Pharmaceutical preparation containing oxycodone and naloxone
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
DK2368554T3 (en) † 2003-04-08 2015-01-26 Progenics Pharm Inc A pharmaceutical composition comprising methylnaltrexone
CA2521369A1 (en) * 2003-04-08 2004-10-28 Progenics Pharmaceuticals, Inc. The use of peripheral opiois antagonists, especially methylnaltrexone to treat irritable bowel syndrome
WO2004091665A1 (en) * 2003-04-08 2004-10-28 Progenics Pharmaceuticals, Inc. Combination therapy for constipation comprising a laxative and a peripheral opioid antagonist
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1845989A1 (en) * 2005-01-20 2007-10-24 Progenics Pharmaceuticals, Inc. Use of methylnaltrexone and related compounds to treat post-operative gastrointestinal dysfunction
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AU2006220682B2 (en) 2005-03-07 2012-05-31 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
CA2609999C (en) * 2005-06-07 2017-05-30 Esbatech Ag Stable and soluble antibodies inhibiting tnf.alpha.
JP5324223B2 (ja) 2005-12-08 2013-10-23 トランセイブ， インク． 肺感染症を治療する抗感染薬の脂質ベースの組成物及びその使用法
DK2010220T3 (da) * 2006-04-03 2022-05-23 Ceva Animal Health Pty Ltd Stabiliserede pentosanpolysulfat-(pps)-formuleringer
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
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EP1615646A1 (en) 2006-01-18
PL2368554T3 (pl) 2015-05-29
PL1615646T5 (pl) 2022-12-19
HRP20150038T1 (hr) 2015-06-05
ES2527870T5 (es) 2022-10-14
EP2368553A1 (en) 2011-09-28
US20100261745A1 (en) 2010-10-14
SI2368554T1 (sl) 2015-05-29
EP1615646B2 (en) 2022-07-27
JP6262169B2 (ja) 2018-01-17
AU2010202824B2 (en) 2013-05-02
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US20100261744A1 (en) 2010-10-14
ES2528631T3 (es) 2015-02-11
ES2527870T3 (es) 2015-02-02
HRP20150039T1 (hr) 2015-06-05
PT2368553E (pt) 2015-03-03
CY1116272T1 (el) 2017-02-08
US9669096B2 (en) 2017-06-06
JP2006522818A (ja) 2006-10-05
HRP20150037T1 (hr) 2015-06-05
CN104383542A (zh) 2015-03-04
US20100261746A1 (en) 2010-10-14
EP1615646B1 (en) 2014-12-24
WO2004091623A1 (en) 2004-10-28
CN1767831B (zh) 2014-12-10
CA2521379C (en) 2013-07-02
CY1116373T1 (el) 2017-02-08
DK1615646T4 (da) 2022-10-10
US20100267758A1 (en) 2010-10-21
DK2368553T3 (en) 2015-02-09
HK1082181A1 (en) 2006-06-02
CN1767831A (zh) 2006-05-03
CA2811272A1 (en) 2004-10-28
AU2004229463A1 (en) 2004-10-28
SI2368553T1 (sl) 2015-05-29
PL1615646T3 (pl) 2015-05-29
PL2368553T3 (pl) 2015-05-29
HRP20150037T4 (hr) 2022-09-02
BRPI0409133B1 (pt) 2019-09-03
SI1615646T2 (sl) 2022-11-30
JP2012184240A (ja) 2012-09-27
DK1615646T3 (en) 2015-02-02
US8552025B2 (en) 2013-10-08
CA2811272C (en) 2016-12-20
BRPI0409133A (pt) 2006-05-02
RU2362560C2 (ru) 2009-07-27
PT1615646E (pt) 2015-02-12
US20040266806A1 (en) 2004-12-30
CY1116372T1 (el) 2017-02-08
US10376584B2 (en) 2019-08-13

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