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ES2051742T3 - Derivados cuaternarios de noroxi-morfina que mitigan las nauseas y la emesis. - Google Patents

Derivados cuaternarios de noroxi-morfina que mitigan las nauseas y la emesis.

Info

Publication number
ES2051742T3
ES2051742T3 ES87307999T ES87307999T ES2051742T3 ES 2051742 T3 ES2051742 T3 ES 2051742T3 ES 87307999 T ES87307999 T ES 87307999T ES 87307999 T ES87307999 T ES 87307999T ES 2051742 T3 ES2051742 T3 ES 2051742T3
Authority
ES
Spain
Prior art keywords
emesis
noroxi
morphine
nausea
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87307999T
Other languages
English (en)
Inventor
Leon I Goldberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Original Assignee
University of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Chicago filed Critical University of Chicago
Application granted granted Critical
Publication of ES2051742T3 publication Critical patent/ES2051742T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DERIVADOS CUATERNARIOS DE MOROXIMORFONE SON USADOS PARA PREVENIR O LIBERAR NAUSEAS Y EMESIS ASOCIADAS CON EL USO DE NARCOTICOS ANALGESICOS SIN QUE INTERFIERA CON LA ACTIVIDAD ANALGESICA DE LAS DROGAS. UN COMPONENTE PREFERIDO PARTICULARMENTE ES METILMALTREXONE. EL COMPONENTE ES ADMINISTRADO EN UNA CONCENTRACION ENTRE 0,05 MG/KG Y 1,0 MG/KG ANTERIOR A CONCURRENTEMENTE CON LA ADMINISTRACION DEL NARCOTICO ANALGESICO.
ES87307999T 1987-09-10 1987-09-10 Derivados cuaternarios de noroxi-morfina que mitigan las nauseas y la emesis. Expired - Lifetime ES2051742T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87307999A EP0306575B1 (en) 1987-09-10 1987-09-10 Quaternary derivatives of noroxymorphone which relieve nausea and emesis

Publications (1)

Publication Number Publication Date
ES2051742T3 true ES2051742T3 (es) 1994-07-01

Family

ID=8198027

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87307999T Expired - Lifetime ES2051742T3 (es) 1987-09-10 1987-09-10 Derivados cuaternarios de noroxi-morfina que mitigan las nauseas y la emesis.

Country Status (5)

Country Link
EP (1) EP0306575B1 (es)
AT (1) ATE78687T1 (es)
DE (1) DE3780819T2 (es)
ES (1) ES2051742T3 (es)
GR (1) GR3005834T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274591B1 (en) 1997-11-03 2001-08-14 Joseph F. Foss Use of methylnaltrexone and related compounds
NZ538726A (en) * 2002-09-25 2006-11-30 Euro Celtique S N-substituted hydromorphones and the use thereof
SI2368553T1 (sl) 2003-04-08 2015-05-29 Progenics Pharmaceuticals, Inc. Farmacevtske formulacije, vsebujoče metilnatrekson
CN104248763A (zh) 2005-03-07 2014-12-31 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
PL2139890T3 (pl) 2007-03-29 2014-11-28 Wyeth Llc Antagoniści obwodowych receptorów opioidowych i ich zastosowania
PE20130480A1 (es) 2007-03-29 2013-05-08 Progenics Pharm Inc Compuestos heterociclicos como antagonistas del receptor opioide periferico
AU2008233133B2 (en) 2007-03-29 2014-03-27 Progenics Pharmaceuticals, Inc. Crystal forms of (R) -N-methylnaltrexone bromide and uses thereof
WO2009099411A1 (en) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2719134C (en) 2008-03-21 2015-06-30 The University Of Chicago Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1202148A (en) * 1968-03-06 1970-08-12 Sankyo Co Pharmaceutical compositions
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
US4466968A (en) * 1980-11-24 1984-08-21 Dermall, Ltd. Method for prophylaxis or treatment of emesis and nausea
EP0103636B1 (en) * 1982-03-16 1990-09-12 Rockefeller University Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility

Also Published As

Publication number Publication date
GR3005834T3 (es) 1993-06-07
EP0306575A1 (en) 1989-03-15
DE3780819D1 (de) 1992-09-03
EP0306575B1 (en) 1992-07-29
ATE78687T1 (de) 1992-08-15
DE3780819T2 (de) 1993-01-14

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