BG62768B1 - Пиридазинонови производни и методи за получаването им - Google Patents
Пиридазинонови производни и методи за получаването им Download PDFInfo
- Publication number
- BG62768B1 BG62768B1 BG100684A BG10068496A BG62768B1 BG 62768 B1 BG62768 B1 BG 62768B1 BG 100684 A BG100684 A BG 100684A BG 10068496 A BG10068496 A BG 10068496A BG 62768 B1 BG62768 B1 BG 62768B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- group
- substituted
- atom
- pyridyl
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Optical Couplings Of Light Guides (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16062095 | 1995-06-27 | ||
| JP1985996 | 1996-02-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG100684A BG100684A (bg) | 1997-03-31 |
| BG62768B1 true BG62768B1 (bg) | 2000-07-31 |
Family
ID=26356726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG100684A BG62768B1 (bg) | 1995-06-27 | 1996-06-27 | Пиридазинонови производни и методи за получаването им |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5698554A (de) |
| EP (1) | EP0751132B1 (de) |
| KR (1) | KR970061873A (de) |
| CN (1) | CN1144802A (de) |
| AR (1) | AR002602A1 (de) |
| AT (1) | ATE195937T1 (de) |
| AU (1) | AU694955B2 (de) |
| BG (1) | BG62768B1 (de) |
| CA (1) | CA2179939A1 (de) |
| DE (1) | DE69610036T2 (de) |
| DK (1) | DK0751132T3 (de) |
| ES (1) | ES2151110T3 (de) |
| GR (1) | GR3034910T3 (de) |
| HU (1) | HUP9601766A3 (de) |
| IL (1) | IL118631A (de) |
| MY (1) | MY132263A (de) |
| NO (1) | NO311084B1 (de) |
| PT (1) | PT751132E (de) |
| RU (1) | RU2131419C1 (de) |
| SG (1) | SG46741A1 (de) |
| TW (1) | TW432052B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2235911C (en) * | 1997-05-27 | 2003-07-29 | Schneider (Usa) Inc. | Stent and stent-graft for treating branched vessels |
| KR20030061051A (ko) * | 2002-01-07 | 2003-07-18 | 대한민국 (경상대학교 총장) | 신규한 아렌(혹은 알케인)술폰일피리다진온 유도체, 이의제조방법 및 유기반응에서의 용도 |
| AR050552A1 (es) * | 2004-09-02 | 2006-11-01 | Osi Pharm Inc | Mercaptoamidas como inhibidores de histona desacetilasa |
| CN101443317B (zh) * | 2006-03-17 | 2011-07-06 | 住友化学株式会社 | 哒嗪酮化合物及其作为除草剂的用途 |
| DK2069312T3 (da) * | 2006-07-25 | 2013-02-04 | Cephalon Inc | Pyridazinonderivater |
| MX2010005070A (es) * | 2007-11-15 | 2010-05-24 | Angeletti P Ist Richerche Bio | Derivados de piridazinona como inhibidores de parp. |
| WO2011116287A1 (en) * | 2010-03-19 | 2011-09-22 | Purdue Research Foundation | Ccr5 modulators for treating hiv |
| RU2608109C2 (ru) | 2010-11-05 | 2017-01-13 | Синомикс, Инк. | Соединения, пригодные в качестве модуляторов trpm8 |
| US8778941B2 (en) | 2011-06-24 | 2014-07-15 | Amgen Inc. | TRPM8 antagonists and their use in treatments |
| CN103906733A (zh) | 2011-06-24 | 2014-07-02 | 安姆根有限公司 | Trpm8拮抗剂及其在治疗中的用途 |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| JP6865743B2 (ja) | 2015-10-01 | 2021-04-28 | フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｔｒｐｍ８の活性調節因子として有用な化合物 |
| MY190795A (en) | 2016-04-15 | 2022-05-12 | Abbvie Inc | Bromodomain inhibitors |
| US11192900B2 (en) * | 2018-10-30 | 2021-12-07 | Nuvation Bio Inc. | Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors |
| EP4248973A3 (de) | 2018-11-06 | 2023-12-06 | Edgewise Therapeutics, Inc. | Pyridazinonverbindungen und ihre verwendungen |
| KR102677015B1 (ko) | 2019-07-02 | 2024-06-19 | 누베이션 바이오 인크. | Bet 억제제로서의 헤테로시클릭 화합물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6053022B2 (ja) * | 1977-04-07 | 1985-11-22 | ウェルファイド株式会社 | ピリダジノン誘導体 |
| GB8323553D0 (en) * | 1983-09-02 | 1983-10-05 | Smith Kline French Lab | Pharmaceutical compositions |
| JPS6193169A (ja) * | 1984-10-12 | 1986-05-12 | Sankyo Co Ltd | ピリダジノン誘導体及びその製法 |
| KR860007219A (ko) * | 1985-03-12 | 1986-10-08 | 베쩰, 좀머 | 설포닐아미노에틸 화합물의 제조방법 |
| DE3508692A1 (de) | 1985-03-12 | 1986-09-18 | Dr. Karl Thomae Gmbh, 7950 Biberach | 3-(4-(2-benzolsulfonylamino-aethyl)-benzoyl)propionsaeure, diese verbindung enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0194548A3 (de) * | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE3623944A1 (de) * | 1986-07-16 | 1988-02-11 | Thomae Gmbh Dr K | Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JPS63145272A (ja) * | 1986-12-09 | 1988-06-17 | Morishita Seiyaku Kk | ４，５−ジヒドロ−６−（４−置換フエニル）−３（２ｈ）−ピリダジノン誘導体 |
| DE3728491A1 (de) * | 1987-08-26 | 1989-03-09 | Heumann Pharma Gmbh & Co | Dihydropyridazinon-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| CA2105067C (en) | 1991-03-01 | 2002-05-14 | Kiyoshi Yoshida | Indan derivative and thromboxane antagonist containing the same |
| JP2616584B2 (ja) * | 1992-07-02 | 1997-06-04 | 田辺製薬株式会社 | ピリダジノン誘導体及びその製法 |
| CA2099743A1 (en) * | 1992-07-02 | 1994-01-03 | Akihiko Ishida | Pyridazinone derivatives and processes for preparing the same |
| CA2139088A1 (en) * | 1993-12-28 | 1995-06-29 | Akihiko Ishida | Indane derivatives, processes for preparing the same and synthetic intermediate of the same |
| JP2757353B2 (ja) * | 1993-12-28 | 1998-05-25 | 田辺製薬株式会社 | インダン誘導体、その製法及びその合成中間体 |
| CA2138812A1 (en) * | 1993-12-28 | 1995-06-29 | Akihiko Ishida | Indane derivative and processes for preparing the same |
-
1996
- 1996-06-01 IL IL11863196A patent/IL118631A/en not_active IP Right Cessation
- 1996-06-21 NO NO19962643A patent/NO311084B1/no unknown
- 1996-06-26 AR AR10332096A patent/AR002602A1/es unknown
- 1996-06-26 TW TW085107678A patent/TW432052B/zh not_active IP Right Cessation
- 1996-06-26 CA CA002179939A patent/CA2179939A1/en not_active Abandoned
- 1996-06-26 RU RU96112778/04A patent/RU2131419C1/ru not_active IP Right Cessation
- 1996-06-26 HU HU9601766A patent/HUP9601766A3/hu unknown
- 1996-06-26 MY MYPI96002583A patent/MY132263A/en unknown
- 1996-06-26 SG SG1996010164A patent/SG46741A1/en unknown
- 1996-06-27 AT AT96110412T patent/ATE195937T1/de not_active IP Right Cessation
- 1996-06-27 CN CN96106873A patent/CN1144802A/zh active Pending
- 1996-06-27 BG BG100684A patent/BG62768B1/bg unknown
- 1996-06-27 DK DK96110412T patent/DK0751132T3/da active
- 1996-06-27 US US08/671,485 patent/US5698554A/en not_active Expired - Fee Related
- 1996-06-27 DE DE69610036T patent/DE69610036T2/de not_active Expired - Fee Related
- 1996-06-27 AU AU56221/96A patent/AU694955B2/en not_active Ceased
- 1996-06-27 EP EP96110412A patent/EP0751132B1/de not_active Expired - Lifetime
- 1996-06-27 KR KR1019960024718A patent/KR970061873A/ko not_active Application Discontinuation
- 1996-06-27 ES ES96110412T patent/ES2151110T3/es not_active Expired - Lifetime
- 1996-06-27 PT PT96110412T patent/PT751132E/pt unknown
-
1997
- 1997-08-25 US US08/917,113 patent/US5808065A/en not_active Expired - Fee Related
-
2000
- 2000-11-24 GR GR20000402616T patent/GR3034910T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69610036T2 (de) | 2001-04-12 |
| TW432052B (en) | 2001-05-01 |
| EP0751132A1 (de) | 1997-01-02 |
| KR970061873A (ko) | 1997-09-12 |
| NO962643D0 (no) | 1996-06-21 |
| GR3034910T3 (en) | 2001-02-28 |
| AU694955B2 (en) | 1998-08-06 |
| NO311084B1 (no) | 2001-10-08 |
| SG46741A1 (en) | 1998-02-20 |
| PT751132E (pt) | 2000-12-29 |
| AR002602A1 (es) | 1998-03-25 |
| IL118631A (en) | 2002-05-23 |
| HUP9601766A3 (en) | 1998-04-28 |
| NO962643L (no) | 1996-12-30 |
| ATE195937T1 (de) | 2000-09-15 |
| AU5622196A (en) | 1997-01-09 |
| HUP9601766A2 (en) | 1997-02-28 |
| CA2179939A1 (en) | 1996-12-28 |
| EP0751132B1 (de) | 2000-08-30 |
| BG100684A (bg) | 1997-03-31 |
| US5698554A (en) | 1997-12-16 |
| ES2151110T3 (es) | 2000-12-16 |
| CN1144802A (zh) | 1997-03-12 |
| HU9601766D0 (en) | 1996-08-28 |
| MY132263A (en) | 2007-09-28 |
| US5808065A (en) | 1998-09-15 |
| IL118631A0 (en) | 1996-10-16 |
| DE69610036D1 (de) | 2000-10-05 |
| RU2131419C1 (ru) | 1999-06-10 |
| DK0751132T3 (da) | 2000-11-13 |
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