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AU677297B2 - Peptide boronic acid derivatives having protease inhibiting activity - Google Patents

Peptide boronic acid derivatives having protease inhibiting activity Download PDF

Info

Publication number
AU677297B2
AU677297B2 AU62080/94A AU6208094A AU677297B2 AU 677297 B2 AU677297 B2 AU 677297B2 AU 62080/94 A AU62080/94 A AU 62080/94A AU 6208094 A AU6208094 A AU 6208094A AU 677297 B2 AU677297 B2 AU 677297B2
Authority
AU
Australia
Prior art keywords
compound
formula
document
mmol
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU62080/94A
Other languages
English (en)
Other versions
AU6208094A (en
Inventor
Nigel Scott Cook
Rainer Metternich
Carlo Tapparelli
Anette Wienand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304289A external-priority patent/GB9304289D0/en
Priority claimed from GB939306822A external-priority patent/GB9306822D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU6208094A publication Critical patent/AU6208094A/en
Application granted granted Critical
Publication of AU677297B2 publication Critical patent/AU677297B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: SANDOZ LTD.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU62080/94A 1993-03-03 1994-03-01 Peptide boronic acid derivatives having protease inhibiting activity Ceased AU677297B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB939304289A GB9304289D0 (en) 1993-03-03 1993-03-03 Organic compounds
GB9304289 1993-03-03
GB9306822 1993-04-01
GB939306822A GB9306822D0 (en) 1993-04-01 1993-04-01 Organic compounds
PCT/EP1994/000595 WO1994020526A1 (en) 1993-03-03 1994-03-01 Peptide boronic acid derivatives having protease inhibiting activity

Publications (2)

Publication Number Publication Date
AU6208094A AU6208094A (en) 1994-09-26
AU677297B2 true AU677297B2 (en) 1997-04-17

Family

ID=26302527

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62080/94A Ceased AU677297B2 (en) 1993-03-03 1994-03-01 Peptide boronic acid derivatives having protease inhibiting activity

Country Status (18)

Country Link
EP (1) EP0688336B1 (de)
JP (1) JPH08507501A (de)
KR (1) KR960701085A (de)
AT (1) ATE153670T1 (de)
AU (1) AU677297B2 (de)
CA (1) CA2153656A1 (de)
DE (1) DE69403459T2 (de)
DK (1) DK0688336T3 (de)
ES (1) ES2101516T3 (de)
GR (1) GR3023577T3 (de)
HU (1) HUT72735A (de)
IL (1) IL108797A0 (de)
MY (1) MY131622A (de)
NZ (1) NZ262415A (de)
PL (1) PL310940A1 (de)
SG (1) SG52766A1 (de)
TW (1) TW329428B (de)
WO (1) WO1994020526A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574014A (en) * 1988-04-28 1996-11-12 Thrombosis Research Institute Inhibitors of trypsin-like enzymes
US6313096B1 (en) 1988-04-28 2001-11-06 Trigen Limited Inhibitors of trypsin-like enzymes
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
GB9502985D0 (en) * 1995-02-16 1995-04-05 Thrombosis Res Inst Enzyme inhibitors
US5612378A (en) * 1995-06-06 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors
US5559150A (en) * 1995-06-06 1996-09-24 3-Dimensional Pharmaceuticals, Inc. N,N-disulfonylated aminobenzene carboxlic acids and the use thereof as thrombin inhibitors
US5741819A (en) * 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
US5612369A (en) * 1995-06-07 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Thrombin inhibitors
GB9515489D0 (en) * 1995-07-28 1995-09-27 Sandoz Ltd Organic compounds
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6100234A (en) * 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
IL135068A (en) 1997-09-29 2004-03-28 Point Therapeutics Inc Stimulation of hematopoietic cells in vitro
GB9724786D0 (en) * 1997-11-25 1998-01-21 Danbiosyst Uk Oral delivery system
AU770319C (en) 1998-05-04 2004-11-25 Point Therapeutics, Inc. Hematopoietic stimulation
DE69905038T2 (de) 1998-06-05 2003-06-05 Point Therapeutics, Inc. Cyclische boroprolinverbindungen
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
ATE376551T1 (de) 2002-09-09 2007-11-15 Trigen Ltd Peptidborsäuren und deren verwendung in der herstellung von salzen derselben
JP6265583B2 (ja) 2008-10-17 2018-01-24 ウィスコンシン アルムニ リサーチ ファンデイション 生理活性アルファベータペプチドを作製する方法
US10526315B2 (en) 2016-06-21 2020-01-07 Orion Ophthalmology LLC Carbocyclic prolinamide derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471651A2 (de) * 1990-08-13 1992-02-19 Sandoz Ltd. Peptidboronsäurederivate mit Protease-inhibierender Aktivität

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499082A (en) * 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471651A2 (de) * 1990-08-13 1992-02-19 Sandoz Ltd. Peptidboronsäurederivate mit Protease-inhibierender Aktivität

Also Published As

Publication number Publication date
EP0688336A1 (de) 1995-12-27
HUT72735A (en) 1996-05-28
TW329428B (en) 1998-04-11
ES2101516T3 (es) 1997-07-01
NZ262415A (en) 1996-10-28
DE69403459T2 (de) 1998-01-02
DK0688336T3 (da) 1997-10-20
ATE153670T1 (de) 1997-06-15
DE69403459D1 (de) 1997-07-03
AU6208094A (en) 1994-09-26
EP0688336B1 (de) 1997-05-28
GR3023577T3 (en) 1997-08-29
HU9501976D0 (en) 1995-09-28
PL310940A1 (en) 1996-01-08
WO1994020526A1 (en) 1994-09-15
SG52766A1 (en) 1998-09-28
CA2153656A1 (en) 1994-09-15
MY131622A (en) 2007-08-30
JPH08507501A (ja) 1996-08-13
KR960701085A (ko) 1996-02-24
IL108797A0 (en) 1994-06-24

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