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NI200900193A - Antagonistas piridil piperidina del receptor de orexina - Google Patents

Antagonistas piridil piperidina del receptor de orexina

Info

Publication number
NI200900193A
NI200900193A NI200900193A NI200900193A NI200900193A NI 200900193 A NI200900193 A NI 200900193A NI 200900193 A NI200900193 A NI 200900193A NI 200900193 A NI200900193 A NI 200900193A NI 200900193 A NI200900193 A NI 200900193A
Authority
NI
Nicaragua
Prior art keywords
orexin receptor
pyridyl piperidine
antagonists
piperidine antagonists
pyridyl
Prior art date
Application number
NI200900193A
Other languages
English (en)
Inventor
J Breslin Michael
J Coleman Paul
D Cox Christopher
D Schreier John
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NI200900193A publication Critical patent/NI200900193A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

La presente invención se refiere a compuestos de piridil piperidina que son antagonistas de los receptores de orexina y que son útiles en el tratamiento o prevención de trastornos y enfermedades neurológicas y psiquiátricas en las que están implicados los receptores de orexina. La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y al uso de estos compuestos y composiciones en la prevención o tratamiento de dichas enfermedades en las que están implicados los receptores de orexina.
NI200900193A 2007-05-23 2009-10-30 Antagonistas piridil piperidina del receptor de orexina NI200900193A (es)

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