[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ZA977474B - 6-O-substituted ketolides having antibacterial activity. - Google Patents

6-O-substituted ketolides having antibacterial activity.

Info

Publication number
ZA977474B
ZA977474B ZA9707474A ZA977474A ZA977474B ZA 977474 B ZA977474 B ZA 977474B ZA 9707474 A ZA9707474 A ZA 9707474A ZA 977474 A ZA977474 A ZA 977474A ZA 977474 B ZA977474 B ZA 977474B
Authority
ZA
South Africa
Prior art keywords
antibacterial activity
substituted ketolides
ketolides
substituted
antibacterial
Prior art date
Application number
ZA9707474A
Other languages
English (en)
Inventor
Yat Sun Or
Zhenkun Ma
Richard F Clark
Daniel T Chu
Jacob J Plattner
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ZA977474B publication Critical patent/ZA977474B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9707474A 1996-09-04 1997-08-20 6-O-substituted ketolides having antibacterial activity. ZA977474B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04

Publications (1)

Publication Number Publication Date
ZA977474B true ZA977474B (en) 1998-03-23

Family

ID=24843126

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9707474A ZA977474B (en) 1996-09-04 1997-08-20 6-O-substituted ketolides having antibacterial activity.

Country Status (12)

Country Link
US (1) US5866549A (xx)
JP (8) JP2009084282A (xx)
AR (1) AR008164A1 (xx)
CO (1) CO4910135A1 (xx)
CZ (4) CZ303581B6 (xx)
GT (1) GT199700099A (xx)
IL (4) IL199746A (xx)
RO (4) RO123371B1 (xx)
TW (1) TW458980B (xx)
UA (1) UA51730C2 (xx)
YU (1) YU11699A (xx)
ZA (1) ZA977474B (xx)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230166B1 (hu) * 1996-09-04 2015-09-28 Abbvie Inc. Baktériumellenes hatékonyságú, 6-O-szubsztituált ketolid származékok
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
TR200200435T2 (tr) * 1998-11-03 2002-07-22 Pfizer Products Inc. Yeni makrolit antibiyotikler.
ES2212655T3 (es) 1999-01-27 2004-07-16 Pfizer Products Inc. Antibioticos de cetolidos.
ES2222189T3 (es) * 1999-03-15 2005-02-01 Abbott Laboratories Macrolidos sustituidos en 6-o con una actividad antibacteriana.
AU4354900A (en) * 1999-04-16 2000-11-02 Kosan Biosciences, Inc. Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
WO2000063225A2 (en) 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
US6417366B2 (en) 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6569836B2 (en) 1999-12-02 2003-05-27 Abbott Laboratories 6-O-alkyl-2-nor-2-substituted ketolide derivatives
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6605707B1 (en) 2000-03-23 2003-08-12 Abbott Laboratories Process for the preparation of 6-O-propargyl erythromycin derivatives
US6947844B2 (en) * 2000-08-09 2005-09-20 Yale University Modulators of ribosomal function and identification thereof
US6638908B1 (en) * 2000-08-09 2003-10-28 Yale University Crystals of the large ribosomal subunit
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
US6455680B1 (en) 2000-12-21 2002-09-24 Abbott Laboratories Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
EP1390081A2 (en) * 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
TWI246515B (en) 2001-05-30 2006-01-01 Abbott Lab An arylation method for the functionalization of O-allyl erythromycin derivatives
JP4509553B2 (ja) * 2001-07-03 2010-07-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド
IL151012A0 (en) 2001-08-03 2003-02-12 Ribosomes Structure And Protei Ribosomes structure and protein synthesis inhibitors
US6952650B2 (en) 2001-08-03 2005-10-04 Yale University Modulators of ribosomal function and identification thereof
US6713455B2 (en) 2001-09-17 2004-03-30 Ortho-Mcneil Pharmaceutical, Inc. 6-O-carbamate-11,12-lacto-ketolide antimicrobials
US6670331B2 (en) * 2001-12-04 2003-12-30 Enanta Pharmaceuticals, Inc. 11-O-substituted ketolide derivatives
HUP0500018A3 (en) 2001-12-05 2009-09-28 Ortho Mcneil Pharm Inc 6-o-acyl ketolide derivatives of erythromycine processes for preparing them and using them as antibacterials
US7045116B2 (en) 2001-12-13 2006-05-16 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
JPWO2003068792A1 (ja) * 2002-02-13 2005-06-02 大正製薬株式会社 エリスロマイシンａ誘導体の製造方法
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
US6992069B2 (en) * 2002-04-30 2006-01-31 Yu-Gui Gu Tricyclic macrolide antibacterial compounds
EP1501845A1 (en) * 2002-04-30 2005-02-02 Abbott Laboratories Antibacterial compounds with improved pharmacokinetic profiles
DE60326710D1 (de) * 2002-04-30 2009-04-30 Abbott Lab Trizyklische antibakterielle makrolidderivate
US20050267054A1 (en) * 2002-04-30 2005-12-01 Clark Richard F Antibacterial compounds with improved pharmacokinetic profiles
US20040033970A1 (en) * 2002-04-30 2004-02-19 Clark Richard F. Antibacterial compounds with improved pharmacokinetic profiles
US7129221B2 (en) * 2002-05-13 2006-10-31 Enanta Pharmaceuticals, Inc. 6,11-bicyclic erythromycin derivatives
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US7064110B2 (en) * 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
AU2003239403B2 (en) * 2002-05-13 2007-01-11 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6753318B1 (en) * 2002-07-25 2004-06-22 Enanta Pharmaceuticals, Inc. 6,11-4-carbon bridged erythromycin derivatives
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
WO2005070918A1 (en) * 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Process for the preparation of t-11 bicyclic erythromycin derivatives
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
EP1513856A1 (en) 2002-05-31 2005-03-16 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
TW200420573A (en) * 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
BRPI0408117A (pt) * 2003-03-05 2006-03-01 Rib X Pharmaceuticals Inc compostos heterocìclicos bifuncionais e métodos de produção e uso dos mesmos
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives
JP2006524702A (ja) * 2003-04-25 2006-11-02 カイロン コーポレイション ピリジル置換ケトライド抗体
US6790835B1 (en) 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US6716820B1 (en) * 2003-06-05 2004-04-06 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic macrolides
US6765016B1 (en) 2003-06-05 2004-07-20 Enanta Pharmaceuticals, Inc. Bicyclic ketolide derivatives
US6774115B1 (en) 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
JP2007509980A (ja) * 2003-10-30 2007-04-19 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法
EP1699808A1 (en) * 2003-11-18 2006-09-13 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
WO2005067564A2 (en) * 2004-01-07 2005-07-28 Enanta Pharmaceuticals, Inc. 6-11 bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
WO2006080954A1 (en) * 2004-07-28 2006-08-03 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
US20090170790A1 (en) * 2004-10-25 2009-07-02 Biswajit Das Ketolide derivatives as antibacterial agents
KR100924610B1 (ko) * 2004-12-07 2009-11-02 이난타 파마슈티칼스, 인코포레이티드 3,6-비시클롤리드
US7229972B2 (en) * 2004-12-07 2007-06-12 Enanta Pharmaceuticals, Inc. 3,6-Bicyclolides
US7312201B2 (en) * 2004-12-13 2007-12-25 Enanta Pharmaceuticals, Inc. Tetracyclic bicyclolides
US7291602B2 (en) * 2004-12-13 2007-11-06 Enanta Pharmaceuticals, Inc. 11,12-lactone bicyclolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
EP1957508A2 (en) * 2005-11-23 2008-08-20 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
US20090130225A1 (en) * 2005-11-23 2009-05-21 Anjan Chakrabarti Macrolides derivatives as antibacterial agents
US7595300B2 (en) * 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
WO2007091393A1 (ja) * 2006-02-07 2007-08-16 Taisho Pharmaceutical Co., Ltd. １０ａ－アザライド化合物
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
CN101855219B (zh) * 2007-09-17 2014-06-25 英安塔制药有限公司 6，11-桥联的联芳大环内酯类
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
WO2021113357A1 (en) * 2019-12-02 2021-06-10 AliquantumRx, Inc. Salts and polymorphs of cethromycin for the treatment of disease salts and polymorphs of cethromycin

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2526951B2 (ja) * 1986-12-17 1996-08-21 大正製薬株式会社 エリスロマイシンａ誘導体およびその製造方法
KR930702369A (ko) * 1990-10-15 1993-09-08 우에노 아키라 에리쓰로마이신 또는 그의 유도체의 2'위치 수식 화합물
FR2669337B1 (fr) * 1990-11-21 1995-03-24 Roussel Uclaf Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
WO1992009614A1 (fr) * 1990-11-28 1992-06-11 Taisho Pharmaceutical Co., Ltd. Derive de 6-o-methylerythromycine a
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
DE69301916T2 (de) * 1992-04-22 1996-08-08 Taisho Pharmaceutical Co., Ltd., Tokio/Tokyo 5-0-desosaminylerythronolid a derivate
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
EP0876388B1 (en) * 1995-11-08 2004-02-18 Abbott Laboratories Tricyclic erythromycin derivatives
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
HU230166B1 (hu) * 1996-09-04 2015-09-28 Abbvie Inc. Baktériumellenes hatékonyságú, 6-O-szubsztituált ketolid származékok

Also Published As

Publication number Publication date
GT199700099A (es) 1999-02-24
TW458980B (en) 2001-10-11
JP2009073840A (ja) 2009-04-09
JP2013047243A (ja) 2013-03-07
UA51730C2 (uk) 2002-12-16
JP2009221214A (ja) 2009-10-01
JP2009062378A (ja) 2009-03-26
JP5107201B2 (ja) 2012-12-26
IL199743A (en) 2010-11-30
JP2009263370A (ja) 2009-11-12
JP2015038095A (ja) 2015-02-26
US5866549A (en) 1999-02-02
JP2009084282A (ja) 2009-04-23
RO123371B1 (ro) 2011-11-30
CO4910135A1 (es) 2000-04-24
YU11699A (sh) 2001-07-10
IL199746A (en) 2010-11-30
IL199745A (en) 2010-11-30
RO123529B1 (ro) 2013-04-30
CZ303474B6 (cs) 2012-10-03
JP4981776B2 (ja) 2012-07-25
JP5222913B2 (ja) 2013-06-26
CZ303382B6 (cs) 2012-08-22
JP4981846B2 (ja) 2012-07-25
JP5107303B2 (ja) 2012-12-26
RO123591B1 (ro) 2014-03-28
JP2011016808A (ja) 2011-01-27
AR008164A1 (es) 1999-12-09
IL199744A (en) 2010-11-30
RO123573B1 (ro) 2013-11-29
CZ303581B6 (cs) 2012-12-19
CZ303573B6 (cs) 2012-12-12

Similar Documents

Publication Publication Date Title
ZA977474B (en) 6-O-substituted ketolides having antibacterial activity.
HUP9902869A3 (en) 6-o-substituted ketolides having antibacterial activity and process for preparing them
HK1004136A1 (en) Cyclic hexapeptides having antibiotic activity.
HK1031058A1 (en) Networking systems.
ZA99919B (en) Catalyst system.
GR950100048A (en) Improved remote gaming system.
EP0684584A3 (en) Objective-based color selection system.
ZA985018B (en) 9-oxime erythromycin derivatives.
AU3046499A (en) 15-membered lactams ketolides with antibacterial activity
ZA200103289B (en) Novel macrolide antibiotics.
IL134608A0 (en) 3'-n- modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity
ZA976034B (en) Nonwoven barrier.
ZA963758B (en) Antibacterial compounds.
ZA975742B (en) Modified oligonucleotides.
MXPA99001777A (es) Dihidropirones con actividad antiviral mejorada.
ZA975114B (en) Pesticidal barrier.
ZA964512B (en) Triphenylalkyl antimicrobial agents.
GB9716038D0 (en) Macrolides having immunosuppressive activity
EP0668679A3 (en) MDFO system.
ZA977083B (en) Dihaloformaldoxime carbamates as antimicrobial agents.
SG46775A1 (en) Selective wsix deposition
AU2215097A (en) Selected oligonucleotides with anti-cytomegalovirus activity
ZA200007397B (en) Tetrahydronaphthydridinyl-carboxamides having anti-convulsant activity.
AU2801497A (en) Oligonucleotides with anti-epstein-barr virus activity
BR1100639B1 (pt) cetolÍdeos 6-o-substituÍdos possuindo atividade antibacteriana.