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ZA949663B - Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols - Google Patents

Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols

Info

Publication number
ZA949663B
ZA949663B ZA949663A ZA949663A ZA949663B ZA 949663 B ZA949663 B ZA 949663B ZA 949663 A ZA949663 A ZA 949663A ZA 949663 A ZA949663 A ZA 949663A ZA 949663 B ZA949663 B ZA 949663B
Authority
ZA
South Africa
Prior art keywords
silyl
phenols
dialkyl
cholesterol levels
serum cholesterol
Prior art date
Application number
ZA949663A
Other languages
English (en)
Inventor
Simon J T Mao
Mark T Yates
Roger A Parker
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA949663B publication Critical patent/ZA949663B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
ZA949663A 1993-12-10 1994-12-05 Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols ZA949663B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16528193A 1993-12-10 1993-12-10

Publications (1)

Publication Number Publication Date
ZA949663B true ZA949663B (en) 1995-08-15

Family

ID=22598245

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA949663A ZA949663B (en) 1993-12-10 1994-12-05 Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols

Country Status (16)

Country Link
EP (3) EP1468693A3 (es)
JP (1) JPH09511222A (es)
CN (1) CN1092517C (es)
AT (2) ATE324113T1 (es)
AU (1) AU681731B2 (es)
CA (1) CA2177968C (es)
DE (2) DE69434720T2 (es)
DK (2) DK0732928T3 (es)
ES (2) ES2233937T3 (es)
HU (1) HU220761B1 (es)
IL (1) IL111905A (es)
NO (1) NO311868B1 (es)
NZ (1) NZ276285A (es)
PT (2) PT732928E (es)
WO (1) WO1995015760A1 (es)
ZA (1) ZA949663B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
JP3930056B2 (ja) 1997-05-14 2007-06-13 アセロジエニクス・インコーポレイテツド Ｖｃａｍ−１発現を阻害する化合物および方法
PT998477E (pt) * 1997-06-24 2003-07-31 Aventis Pharma Inc Fenois e tiofenois alquil-4-silil-heterociclicos como agentes antioxidantes
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
AU7588498A (en) * 1997-06-25 1999-01-04 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-{ (dimethyl-4-methoxyphenylsilyl) -methyloxy}phenol and 2,6-di-t-butyl-4-{ (dimethyl-2-methoxy-phenylsilyl) -methyloxy}phenol
CN1261803A (zh) 1997-07-01 2000-08-02 埃瑟若詹尼克斯公司 抗氧化剂增强对细胞过度增生性疾病的治疗
MXPA01004683A (es) * 1998-11-09 2002-09-18 Atherogenics Inc Metodos y composiciones para disminuir los niveles de colesterol en el plasma.
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6821738B2 (en) 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
US6545007B2 (en) 2000-11-17 2003-04-08 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrimidines
CN1596240A (zh) 2001-12-19 2005-03-16 阿特罗吉尼克斯公司 查耳酮衍生物及其治疗疾病的用途
WO2004007423A1 (en) 2002-07-12 2004-01-22 Atherogenics, Inc. Novel salt forms of poorly soluble probucol esters and ethers
US7173129B2 (en) 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
EP1677804A1 (en) * 2003-10-17 2006-07-12 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US8252840B2 (en) 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE349046B (es) * 1966-12-23 1972-09-18 C Guevne
FR2230376A1 (en) * 1973-05-24 1974-12-20 Gueyne Jean Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) * 1975-04-21 1976-11-19 Cortial Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) * 1982-07-12 1987-06-02 American Cyanamid Company Antiatherosclerotic silanes
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Also Published As

Publication number Publication date
DK0732928T3 (da) 2005-04-18
HUT74015A (en) 1996-10-28
HU9601590D0 (en) 1996-08-28
IL111905A (en) 2001-04-30
DE69434720T2 (de) 2007-05-16
CA2177968C (en) 2000-03-28
EP1468693A3 (en) 2004-11-03
ATE324113T1 (de) 2006-05-15
AU681731B2 (en) 1997-09-04
NO962415D0 (no) 1996-06-07
CN1140995A (zh) 1997-01-22
DK1468692T3 (da) 2006-08-28
ES2263094T3 (es) 2006-12-01
ES2233937T3 (es) 2005-06-16
EP0732928B1 (en) 2004-12-22
AU1049995A (en) 1995-06-27
EP1468693A2 (en) 2004-10-20
HU220761B1 (hu) 2002-05-28
EP0732928A1 (en) 1996-09-25
ATE285238T1 (de) 2005-01-15
EP1468692B1 (en) 2006-04-26
DE69434720D1 (de) 2006-06-01
NZ276285A (en) 2004-11-26
CN1092517C (zh) 2002-10-16
JPH09511222A (ja) 1997-11-11
EP1468692A2 (en) 2004-10-20
EP1468692A3 (en) 2004-11-03
NO311868B1 (no) 2002-02-11
WO1995015760A1 (en) 1995-06-15
IL111905A0 (en) 1995-03-15
DE69434198T2 (de) 2005-12-29
NO962415L (no) 1996-06-07
CA2177968A1 (en) 1995-06-15
DE69434198D1 (de) 2005-01-27
PT732928E (pt) 2005-03-31
PT1468692E (pt) 2006-09-29

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