DK0732928T3 - Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler - Google Patents

Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler

Info

Publication number: DK0732928T3
Authority: DK; Denmark
Prior art keywords: alkyl; silyl; phenols; cholesterol levels; serum cholesterol
Prior art date: 1993-12-10

Application number

DK95901141T

Other languages

English (en)

Inventor

Simon J T Mao

Mark T Yates

Roger A Parker

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-10

Filing date

1994-11-03

Publication date

2005-04-18

1994-11-03 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

2005-04-18 Application granted granted Critical

2005-04-18 Publication of DK0732928T3 publication Critical patent/DK0732928T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)

DK95901141T 1993-12-10 1994-11-03 Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler DK0732928T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16528193A	1993-12-10	1993-12-10
EP95901141A EP0732928B1 (en)	1993-12-10	1994-11-03	Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols

Publications (1)

Publication Number	Publication Date
DK0732928T3 true DK0732928T3 (da)	2005-04-18

Family

ID=22598245

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK04016883T DK1468692T3 (da)	1993-12-10	1994-11-03	Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom
DK95901141T DK0732928T3 (da)	1993-12-10	1994-11-03	Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK04016883T DK1468692T3 (da)	1993-12-10	1994-11-03	Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom

Country Status (16)

Country	Link
EP (3)	EP1468692B1 (da)
JP (1)	JPH09511222A (da)
CN (1)	CN1092517C (da)
AT (2)	ATE285238T1 (da)
AU (1)	AU681731B2 (da)
CA (1)	CA2177968C (da)
DE (2)	DE69434198T2 (da)
DK (2)	DK1468692T3 (da)
ES (2)	ES2263094T3 (da)
HU (1)	HU220761B1 (da)
IL (1)	IL111905A (da)
NO (1)	NO311868B1 (da)
NZ (1)	NZ276285A (da)
PT (2)	PT732928E (da)
WO (1)	WO1995015760A1 (da)
ZA (1)	ZA949663B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA009370B1 (ru) *	1997-05-14	2007-12-28	Атеродженикс, Инк.	Соединение и фармацевтическая композиция для ингибирования экспрессии vcam-1
US6670398B2 (en)	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
CA2293461C (en) *	1997-06-24	2004-02-24	Hoechst Marion Roussel, Inc.	Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents
JP2002506443A (ja) *	1997-06-25	2002-02-26	アベンティス・ファーマスーティカルズ・インコーポレイテッド	２，６−ジ−ｔ−ブチル−４−［（ジメチル−４−メトキシフェニルシリル）メチルオキシ］フェノール及び２，６−ジ−ｔ−ブチル−４−［（ジメチル−２−メトキシフェニルシリル）メチルオキシ］フェノール
US6133467A (en) *	1997-06-25	2000-10-17	Hoechst Marion Roussel, Inc.	2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EA200000087A1 (ru)	1997-07-01	2000-08-28	Атеродженикс, Инк.	Повышение эффективности терапии гиперпролиферативных состояний с помощью антиоксиданта
ATE326014T1 (de) *	1998-11-09	2006-06-15	Atherogenics Inc	Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma
US6887712B1 (en)	1998-11-09	2005-05-03	Atherogenics, Inc.	Methods and compositions to lower plasma cholesterol levels
US6821738B2 (en)	1999-01-20	2004-11-23	The Board Of Regents For Oklahoma State University	Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
WO2002040021A2 (en)	2000-11-17	2002-05-23	Idenix (Cayman) Limited	Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
WO2003053368A2 (en)	2001-12-19	2003-07-03	Atherogenics, Inc.	Chalcone derivatives and their use to treat diseases
WO2004007423A1 (en)	2002-07-12	2004-01-22	Atherogenics, Inc.	Novel salt forms of poorly soluble probucol esters and ethers
WO2004108094A2 (en)	2003-06-06	2004-12-16	Atherogenics, Inc.	Sulfonamide-substituted chalcone derivatives and their use to treat diseases
JP2007509054A (ja) *	2003-10-17	2007-04-12	アミリン・ファーマシューティカルズ，インコーポレイテッド	血管健康を促進するシリルフェノール
US7271274B2 (en)	2004-04-20	2007-09-18	Ahterogenics, Inc.	Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
EP2139320A4 (en)	2007-03-26	2010-09-08	Salutria Pharmaceuticals Llc	METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE349046B (da) *	1966-12-23	1972-09-18	C Guevne
FR2230376A1 (en) *	1973-05-24	1974-12-20	Gueyne Jean	Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) *	1975-04-21	1976-11-19	Cortial	Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) *	1982-07-12	1987-06-02	American Cyanamid Company	Antiatherosclerotic silanes
US4900757A (en) *	1988-12-08	1990-02-13	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
US5155250A (en) *	1990-07-05	1992-10-13	Merrell Dow Pharmaceuticals Inc.	2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
NZ238807A (en) *	1990-07-05	1994-03-25	Merrell Dow Pharma	Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions

1994
- 1994-11-03 JP JP7516186A patent/JPH09511222A/ja not_active Ceased
- 1994-11-03 CA CA002177968A patent/CA2177968C/en not_active Expired - Fee Related
- 1994-11-03 DE DE69434198T patent/DE69434198T2/de not_active Expired - Fee Related
- 1994-11-03 EP EP04016883A patent/EP1468692B1/en not_active Expired - Lifetime
- 1994-11-03 DK DK04016883T patent/DK1468692T3/da active
- 1994-11-03 WO PCT/US1994/012702 patent/WO1995015760A1/en active IP Right Grant
- 1994-11-03 AU AU10499/95A patent/AU681731B2/en not_active Ceased
- 1994-11-03 ES ES04016883T patent/ES2263094T3/es not_active Expired - Lifetime
- 1994-11-03 AT AT95901141T patent/ATE285238T1/de not_active IP Right Cessation
- 1994-11-03 CN CN94194438A patent/CN1092517C/zh not_active Expired - Fee Related
- 1994-11-03 NZ NZ276285A patent/NZ276285A/en not_active IP Right Cessation
- 1994-11-03 DE DE69434720T patent/DE69434720T2/de not_active Expired - Lifetime
- 1994-11-03 PT PT95901141T patent/PT732928E/pt unknown
- 1994-11-03 EP EP95901141A patent/EP0732928B1/en not_active Expired - Lifetime
- 1994-11-03 AT AT04016883T patent/ATE324113T1/de not_active IP Right Cessation
- 1994-11-03 HU HU9601590A patent/HU220761B1/hu not_active IP Right Cessation
- 1994-11-03 DK DK95901141T patent/DK0732928T3/da active
- 1994-11-03 EP EP04016884A patent/EP1468693A3/en not_active Withdrawn
- 1994-11-03 PT PT04016883T patent/PT1468692E/pt unknown
- 1994-11-03 ES ES95901141T patent/ES2233937T3/es not_active Expired - Lifetime
- 1994-12-05 ZA ZA949663A patent/ZA949663B/xx unknown
- 1994-12-07 IL IL11190594A patent/IL111905A/en not_active IP Right Cessation
1996
- 1996-06-07 NO NO19962415A patent/NO311868B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1468693A2 (en)	2004-10-20
WO1995015760A1 (en)	1995-06-15
DE69434720T2 (de)	2007-05-16
CA2177968A1 (en)	1995-06-15
PT1468692E (pt)	2006-09-29
PT732928E (pt)	2005-03-31
EP0732928A1 (en)	1996-09-25
HU9601590D0 (en)	1996-08-28
IL111905A (en)	2001-04-30
HUT74015A (en)	1996-10-28
EP0732928B1 (en)	2004-12-22
CN1092517C (zh)	2002-10-16
DE69434720D1 (de)	2006-06-01
CN1140995A (zh)	1997-01-22
EP1468692A2 (en)	2004-10-20
AU681731B2 (en)	1997-09-04
NO962415D0 (no)	1996-06-07
ZA949663B (en)	1995-08-15
ES2233937T3 (es)	2005-06-16
EP1468693A3 (en)	2004-11-03
HU220761B1 (hu)	2002-05-28
AU1049995A (en)	1995-06-27
DE69434198D1 (de)	2005-01-27
DE69434198T2 (de)	2005-12-29
ATE285238T1 (de)	2005-01-15
NO311868B1 (no)	2002-02-11
ES2263094T3 (es)	2006-12-01
JPH09511222A (ja)	1997-11-11
NZ276285A (en)	2004-11-26
NO962415L (no)	1996-06-07
CA2177968C (en)	2000-03-28
IL111905A0 (en)	1995-03-15
DK1468692T3 (da)	2006-08-28
EP1468692B1 (en)	2006-04-26
ATE324113T1 (de)	2006-05-15
EP1468692A3 (en)	2004-11-03

Publication	Publication Date	Title
DK0732928T3 (da)	2005-04-18	Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
NO179142C (no)	1996-08-14	3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
BR1101017A (pt)	1999-12-07	Distamicina a análoga; processo para a apresentação de um composto; composição farmacêutica contendo um composto; e uso de um composto
CA2046051A1 (en)	1992-01-06	2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents
ATE181066T1 (de)	1999-06-15	Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten
FI864618A (fi)	1987-05-14	Nya 3-oxadiazol- och 3-karboksylsyra- -karbolinderivat, deras framstaellning och deras anvaendning som laekemedel.
FI882873A (fi)	1988-12-31	Tiofenderivat och foerfarande foer dess framstaellning.
IE880772L (en)	1988-09-18	Benzoxazines
AU598229B2 (en)	1990-06-21	Novel indenothiazole derivatives and process for their preparation
DK0410305T3 (da)	1995-04-03	Anvendelse af bis(4-hydroxyphenylthio)methanderivater til behandling af diabetes mellitus
NO960308L (no)	1996-03-13	Terapeutisk aktive benzoksaziner og benzotioanoner
ATE156487T1 (de)	1997-08-15	Mercapto-acetamid-derivate
DK0532725T3 (da)	1997-06-02	Isoxazolderivater som lysfilterpræparater
DE69214180D1 (de)	1996-11-07	Verwendung von Bis-(p-Hydroxyphenylthio)methanderivaten zur Hemmung der fortschreitenden Entwicklung von insulinabhängingem Diabetes mellitus
AU8292787A (en)	1988-06-23	Fluorine-containing macrolide compounds and their use