PT1468692E - Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma - Google Patents

Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma

Info

Publication number: PT1468692E
Authority: PT; Portugal
Prior art keywords: xantoma; silyphenols; dialquil; treatment; group
Prior art date: 1993-12-10

Application number

PT04016883T

Other languages

English (en)

Inventor

Mao Simon Jen Tan

Yates Mark Thirston

Roger Alan Parker

Original Assignee

Aventis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-10

Filing date

1994-11-03

Publication date

2006-09-29

1994-11-03 Application filed by Aventis Inc filed Critical Aventis Inc

2006-09-29 Publication of PT1468692E publication Critical patent/PT1468692E/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)

PT04016883T 1993-12-10 1994-11-03 Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma PT1468692E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16528193A	1993-12-10	1993-12-10

Publications (1)

Publication Number	Publication Date
PT1468692E true PT1468692E (pt)	2006-09-29

Family

ID=22598245

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT95901141T PT732928E (pt)	1993-12-10	1994-11-03	Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois
PT04016883T PT1468692E (pt)	1993-12-10	1994-11-03	Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT95901141T PT732928E (pt)	1993-12-10	1994-11-03	Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois

Country Status (16)

Country	Link
EP (3)	EP1468692B1 (pt)
JP (1)	JPH09511222A (pt)
CN (1)	CN1092517C (pt)
AT (2)	ATE285238T1 (pt)
AU (1)	AU681731B2 (pt)
CA (1)	CA2177968C (pt)
DE (2)	DE69434198T2 (pt)
DK (2)	DK1468692T3 (pt)
ES (2)	ES2263094T3 (pt)
HU (1)	HU220761B1 (pt)
IL (1)	IL111905A (pt)
NO (1)	NO311868B1 (pt)
NZ (1)	NZ276285A (pt)
PT (2)	PT732928E (pt)
WO (1)	WO1995015760A1 (pt)
ZA (1)	ZA949663B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA009370B1 (ru) *	1997-05-14	2007-12-28	Атеродженикс, Инк.	Соединение и фармацевтическая композиция для ингибирования экспрессии vcam-1
US6670398B2 (en)	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
CA2293461C (en) *	1997-06-24	2004-02-24	Hoechst Marion Roussel, Inc.	Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents
JP2002506443A (ja) *	1997-06-25	2002-02-26	アベンティス・ファーマスーティカルズ・インコーポレイテッド	２，６−ジ−ｔ−ブチル−４−［（ジメチル−４−メトキシフェニルシリル）メチルオキシ］フェノール及び２，６−ジ−ｔ−ブチル−４−［（ジメチル−２−メトキシフェニルシリル）メチルオキシ］フェノール
US6133467A (en) *	1997-06-25	2000-10-17	Hoechst Marion Roussel, Inc.	2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EA200000087A1 (ru)	1997-07-01	2000-08-28	Атеродженикс, Инк.	Повышение эффективности терапии гиперпролиферативных состояний с помощью антиоксиданта
ATE326014T1 (de) *	1998-11-09	2006-06-15	Atherogenics Inc	Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma
US6887712B1 (en)	1998-11-09	2005-05-03	Atherogenics, Inc.	Methods and compositions to lower plasma cholesterol levels
US6821738B2 (en)	1999-01-20	2004-11-23	The Board Of Regents For Oklahoma State University	Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
WO2002040021A2 (en)	2000-11-17	2002-05-23	Idenix (Cayman) Limited	Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
WO2003053368A2 (en)	2001-12-19	2003-07-03	Atherogenics, Inc.	Chalcone derivatives and their use to treat diseases
WO2004007423A1 (en)	2002-07-12	2004-01-22	Atherogenics, Inc.	Novel salt forms of poorly soluble probucol esters and ethers
WO2004108094A2 (en)	2003-06-06	2004-12-16	Atherogenics, Inc.	Sulfonamide-substituted chalcone derivatives and their use to treat diseases
JP2007509054A (ja) *	2003-10-17	2007-04-12	アミリン・ファーマシューティカルズ，インコーポレイテッド	血管健康を促進するシリルフェノール
US7271274B2 (en)	2004-04-20	2007-09-18	Ahterogenics, Inc.	Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
EP2139320A4 (en)	2007-03-26	2010-09-08	Salutria Pharmaceuticals Llc	METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE349046B (pt) *	1966-12-23	1972-09-18	C Guevne
FR2230376A1 (en) *	1973-05-24	1974-12-20	Gueyne Jean	Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) *	1975-04-21	1976-11-19	Cortial	Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) *	1982-07-12	1987-06-02	American Cyanamid Company	Antiatherosclerotic silanes
US4900757A (en) *	1988-12-08	1990-02-13	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
US5155250A (en) *	1990-07-05	1992-10-13	Merrell Dow Pharmaceuticals Inc.	2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
NZ238807A (en) *	1990-07-05	1994-03-25	Merrell Dow Pharma	Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions

1994
- 1994-11-03 JP JP7516186A patent/JPH09511222A/ja not_active Ceased
- 1994-11-03 CA CA002177968A patent/CA2177968C/en not_active Expired - Fee Related
- 1994-11-03 DE DE69434198T patent/DE69434198T2/de not_active Expired - Fee Related
- 1994-11-03 EP EP04016883A patent/EP1468692B1/en not_active Expired - Lifetime
- 1994-11-03 DK DK04016883T patent/DK1468692T3/da active
- 1994-11-03 WO PCT/US1994/012702 patent/WO1995015760A1/en active IP Right Grant
- 1994-11-03 AU AU10499/95A patent/AU681731B2/en not_active Ceased
- 1994-11-03 ES ES04016883T patent/ES2263094T3/es not_active Expired - Lifetime
- 1994-11-03 AT AT95901141T patent/ATE285238T1/de not_active IP Right Cessation
- 1994-11-03 CN CN94194438A patent/CN1092517C/zh not_active Expired - Fee Related
- 1994-11-03 NZ NZ276285A patent/NZ276285A/en not_active IP Right Cessation
- 1994-11-03 DE DE69434720T patent/DE69434720T2/de not_active Expired - Lifetime
- 1994-11-03 PT PT95901141T patent/PT732928E/pt unknown
- 1994-11-03 EP EP95901141A patent/EP0732928B1/en not_active Expired - Lifetime
- 1994-11-03 AT AT04016883T patent/ATE324113T1/de not_active IP Right Cessation
- 1994-11-03 HU HU9601590A patent/HU220761B1/hu not_active IP Right Cessation
- 1994-11-03 DK DK95901141T patent/DK0732928T3/da active
- 1994-11-03 EP EP04016884A patent/EP1468693A3/en not_active Withdrawn
- 1994-11-03 PT PT04016883T patent/PT1468692E/pt unknown
- 1994-11-03 ES ES95901141T patent/ES2233937T3/es not_active Expired - Lifetime
- 1994-12-05 ZA ZA949663A patent/ZA949663B/xx unknown
- 1994-12-07 IL IL11190594A patent/IL111905A/en not_active IP Right Cessation
1996
- 1996-06-07 NO NO19962415A patent/NO311868B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1468693A2 (en)	2004-10-20
WO1995015760A1 (en)	1995-06-15
DE69434720T2 (de)	2007-05-16
DK0732928T3 (da)	2005-04-18
CA2177968A1 (en)	1995-06-15
PT732928E (pt)	2005-03-31
EP0732928A1 (en)	1996-09-25
HU9601590D0 (en)	1996-08-28
IL111905A (en)	2001-04-30
HUT74015A (en)	1996-10-28
EP0732928B1 (en)	2004-12-22
CN1092517C (zh)	2002-10-16
DE69434720D1 (de)	2006-06-01
CN1140995A (zh)	1997-01-22
EP1468692A2 (en)	2004-10-20
AU681731B2 (en)	1997-09-04
NO962415D0 (no)	1996-06-07
ZA949663B (en)	1995-08-15
ES2233937T3 (es)	2005-06-16
EP1468693A3 (en)	2004-11-03
HU220761B1 (hu)	2002-05-28
AU1049995A (en)	1995-06-27
DE69434198D1 (de)	2005-01-27
DE69434198T2 (de)	2005-12-29
ATE285238T1 (de)	2005-01-15
NO311868B1 (no)	2002-02-11
ES2263094T3 (es)	2006-12-01
JPH09511222A (ja)	1997-11-11
NZ276285A (en)	2004-11-26
NO962415L (no)	1996-06-07
CA2177968C (en)	2000-03-28
IL111905A0 (en)	1995-03-15
DK1468692T3 (da)	2006-08-28
EP1468692B1 (en)	2006-04-26
ATE324113T1 (de)	2006-05-15
EP1468692A3 (en)	2004-11-03

Publication	Publication Date	Title
PT1468692E (pt)	2006-09-29	Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma
NO179142C (no)	1996-08-14	3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
DE3781716D1 (de)	1992-10-22	Mittel zur ortsspezifischen alkylierung.
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
EP0632031A4 (pt)	1995-02-08
FI894061A (fi)	1990-03-02	Menetelmä lääkeaineina käyttökelpoisten , -disubstituoitujen N-sykloalkyylialkyylibentsyyliamiinien valmistamiseksi ja niiden synteesivälituotteita
FI864618A (fi)	1987-05-14	Nya 3-oxadiazol- och 3-karboksylsyra- -karbolinderivat, deras framstaellning och deras anvaendning som laekemedel.
FI882477A (fi)	1988-11-30	Nya alkansulfonanilidderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
FI902632A0 (fi)	1990-05-25	Menetelmä terapeuttisesti käyttökelpoisten 5-substitoitujen 5,11-dihydrodibentso/b,e//1,4/tiatsepiinijohdannaisten valmistamiseksi sekä menetelmässä käyttökelpoisia välituotteita
SE8303913D0 (sv)	1983-07-08	Heterocykliska foreningar
DK0410305T3 (da)	1995-04-03	Anvendelse af bis(4-hydroxyphenylthio)methanderivater til behandling af diabetes mellitus
NO960308L (no)	1996-03-13	Terapeutisk aktive benzoksaziner og benzotioanoner
DK0532725T3 (da)	1997-06-02	Isoxazolderivater som lysfilterpræparater
ATE143591T1 (de)	1996-10-15	Verwendung von bis-(p- hydroxyphenylthio)methanderivaten zur hemmung der fortschreitenden entwicklung von insulinabhängingem diabetes mellitus
EA200200462A1 (ru)	2002-10-31	Производные 2-арилхинолина, их получение и терапевтическое применение
SE8000138L (sv)	1980-07-18	Nya 3-cyklopentan-1,2'(1'h)-naftalen-derivat, framstellning derav och lekemedel innehallande desamma
ATE44741T1 (de)	1989-08-15	2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.
AU8292787A (en)	1988-06-23	Fluorine-containing macrolide compounds and their use