ZA200201709B - Quetiapine granules. - Google Patents

Quetiapine granules. Download PDF

Info

Publication number: ZA200201709B
Authority: ZA; South Africa
Prior art keywords: formulation; granules; water; granule; thiazepine
Prior art date: 1999-09-21

Application number

ZA200201709A

Other languages

English (en)

Inventor

Daniel Boyd Brown

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-21

Filing date

2002-02-28

Publication date

2003-05-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10861288&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200201709(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-02-28 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-05-28 Publication of ZA200201709B publication Critical patent/ZA200201709B/en

Links

239000008187 granular material Substances 0.000 title claims description 64
URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 title claims description 10
229960004431 quetiapine Drugs 0.000 title description 4
239000000203 mixture Substances 0.000 claims description 63
238000009472 formulation Methods 0.000 claims description 57
238000000034 method Methods 0.000 claims description 26
239000012530 fluid Substances 0.000 claims description 22
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
239000003232 water-soluble binding agent Substances 0.000 claims description 12
239000012736 aqueous medium Substances 0.000 claims description 10
239000005913 Maltodextrin Substances 0.000 claims description 8
229920002774 Maltodextrin Polymers 0.000 claims description 8
229940035034 maltodextrin Drugs 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 8
235000003599 food sweetener Nutrition 0.000 claims description 7
239000003765 sweetening agent Substances 0.000 claims description 7
208000028017 Psychotic disease Diseases 0.000 claims description 6
239000011230 binding agent Substances 0.000 claims description 6
238000001035 drying Methods 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 6
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
201000010099 disease Diseases 0.000 claims description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
201000000980 schizophrenia Diseases 0.000 claims description 4
NYERMPLPURRVGM-UHFFFAOYSA-N thiazepine Chemical compound S1C=CC=CC=N1 NYERMPLPURRVGM-UHFFFAOYSA-N 0.000 claims description 4
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
229930006000 Sucrose Natural products 0.000 claims description 3
210000003169 central nervous system Anatomy 0.000 claims description 3
239000003814 drug Substances 0.000 claims description 3
239000005720 sucrose Substances 0.000 claims description 3
230000001225 therapeutic effect Effects 0.000 claims description 3
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
229930195725 Mannitol Natural products 0.000 claims description 2
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
239000000594 mannitol Substances 0.000 claims description 2
235000010355 mannitol Nutrition 0.000 claims description 2
229960001855 mannitol Drugs 0.000 claims description 2
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
-1 poly[1-(2-oxo-1-pyrrolidinyl)ethylene] Polymers 0.000 claims description 2
239000000811 xylitol Substances 0.000 claims description 2
235000010447 xylitol Nutrition 0.000 claims description 2
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
229960002675 xylitol Drugs 0.000 claims description 2
229920000881 Modified starch Polymers 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 description 21
238000000889 atomisation Methods 0.000 description 8
239000007921 spray Substances 0.000 description 8
239000000725 suspension Substances 0.000 description 8
ABFPKTQEQNICFT-UHFFFAOYSA-M 2-chloro-1-methylpyridin-1-ium;iodide Chemical compound [I-].C[N+]1=CC=CC=C1Cl ABFPKTQEQNICFT-UHFFFAOYSA-M 0.000 description 7
239000000843 powder Substances 0.000 description 7
229960005197 quetiapine fumarate Drugs 0.000 description 7
239000000375 suspending agent Substances 0.000 description 7
ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
ZTHJULTYCAQOIJ-WXXKFALUSA-N quetiapine fumarate Chemical compound [H+].[H+].[O-]C(=O)\C=C\C([O-])=O.C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12.C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 ZTHJULTYCAQOIJ-WXXKFALUSA-N 0.000 description 4
229940035004 seroquel Drugs 0.000 description 4
108010011485 Aspartame Proteins 0.000 description 3
239000000605 aspartame Substances 0.000 description 3
235000010357 aspartame Nutrition 0.000 description 3
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 3
229960003438 aspartame Drugs 0.000 description 3
239000012458 free base Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
241001465754 Metazoa Species 0.000 description 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
230000037396 body weight Effects 0.000 description 2
238000009826 distribution Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
229940100688 oral solution Drugs 0.000 description 2
229940100692 oral suspension Drugs 0.000 description 2
230000002572 peristaltic effect Effects 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
229940069328 povidone Drugs 0.000 description 2
239000008213 purified water Substances 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
238000005029 sieve analysis Methods 0.000 description 2
239000008107 starch Substances 0.000 description 2
229940032147 starch Drugs 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 description 1
RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 description 1
101100172879 Caenorhabditis elegans sec-5 gene Proteins 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920002907 Guar gum Polymers 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
235000011850 desserts Nutrition 0.000 description 1
230000002542 deteriorative effect Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
238000011049 filling Methods 0.000 description 1
238000009477 fluid bed granulation Methods 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
235000010417 guar gum Nutrition 0.000 description 1
229960002154 guar gum Drugs 0.000 description 1
238000009533 lab test Methods 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000000463 material Substances 0.000 description 1
RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
235000015067 sauces Nutrition 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

ZA200201709A 1999-09-21 2002-02-28 Quetiapine granules. ZA200201709B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9922271.3A GB9922271D0 (en)	1999-09-21	1999-09-21	Formulation

Publications (1)

Publication Number	Publication Date
ZA200201709B true ZA200201709B (en)	2003-05-28

Family

ID=10861288

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200201709A ZA200201709B (en)	1999-09-21	2002-02-28	Quetiapine granules.

Country Status (37)

Country	Link
US (3)	US6599897B1 (hu)
EP (1)	EP1218009B1 (hu)
JP (1)	JP2003509461A (hu)
KR (1)	KR100748823B1 (hu)
CN (3)	CN1188130C (hu)
AR (1)	AR032596A1 (hu)
AT (1)	ATE288272T1 (hu)
AU (1)	AU776292B2 (hu)
BG (1)	BG65469B1 (hu)
BR (1)	BR0014107A (hu)
CA (1)	CA2383131A1 (hu)
CO (1)	CO5180585A1 (hu)
CZ (1)	CZ301585B6 (hu)
DE (1)	DE60017923T2 (hu)
DK (1)	DK1218009T3 (hu)
EE (1)	EE200200150A (hu)
EG (1)	EG24226A (hu)
ES (1)	ES2235941T3 (hu)
GB (2)	GB9922271D0 (hu)
HK (1)	HK1047706B (hu)
HU (1)	HUP0203531A3 (hu)
IL (2)	IL148440A0 (hu)
IS (1)	IS2139B (hu)
MX (1)	MXPA02002627A (hu)
MY (1)	MY130208A (hu)
NO (1)	NO320908B1 (hu)
NZ (1)	NZ517549A (hu)
PL (1)	PL198824B1 (hu)
PT (1)	PT1218009E (hu)
RU (1)	RU2256453C2 (hu)
SI (1)	SI1218009T1 (hu)
SK (1)	SK286884B6 (hu)
TR (1)	TR200200716T2 (hu)
TW (1)	TWI226832B (hu)
UA (1)	UA73529C2 (hu)
WO (1)	WO2001021179A1 (hu)
ZA (1)	ZA200201709B (hu)

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Publication number	Priority date	Publication date	Assignee	Title
GB9922271D0 (en) *	1999-09-21	1999-11-17	Zeneca Ltd	Formulation
SE0102855D0 (sv) *	2001-08-27	2001-08-27	Astrazeneca Ab	Method of treatment
WO2003039516A1 (en) *	2001-11-07	2003-05-15	Fujisawa Pharmaceuticla Co., Ltd.	Method for improving dissolution of poorly dispersible medicaments
JP4514473B2 (ja) *	2004-02-23	2010-07-28	富士通株式会社	コンピュータシステム、中央装置及びプログラム実行方法
UA88792C2 (ru) *	2004-11-10	2009-11-25	Таргасепт, Інк.	Гидроксибензоатные соли метаникотиновых соединений
US7459469B2 (en)	2004-11-10	2008-12-02	Targacept, Inc.	Hydroxybenzoate salts of metanicotine compounds
EP1879874A2 (en) *	2005-04-21	2008-01-23	Medichem, S.A.	Process for preparing quetiapine and quetiapine fumarate
US20100178333A1 (en)	2006-01-25	2010-07-15	Astron Research Limited	Sustained release dosage form of phenothiazine derivatives containing channelizer
EP2021325A2 (en) *	2006-05-09	2009-02-11	AstraZeneca AB	Salt forms of (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine
TWI389889B (zh) *	2006-05-09	2013-03-21	Targacept Inc	（２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
BRPI0714586A2 (pt) *	2006-07-28	2013-05-07	Farmaprojects S A	formulaÇço farmacÊutica de liberaÇço prolongada de metropolol e processo para a sua preparaÇço
WO2008034041A2 (en) *	2006-09-15	2008-03-20	Astrazeneca Ab	Therapeutic combinations
CN101610774B (zh) *	2006-11-03	2012-04-04	萨斯喀彻温大学	治疗脱髓鞘疾病的方法
EP2112923A1 (en) *	2007-01-22	2009-11-04	Targacept Inc.	Intranasal, buccal, and sublingual administration of metanicotine analogs
ES2352299T3 (es)	2007-02-14	2011-02-17	Laboratorios Lesvi, S.L.	Composiciones farmacéuticas que contienen fumarato de quetiapina.
AU2009219286B2 (en) *	2008-02-27	2012-02-09	Intercontinental Great Brands Llc	Multi-region confectionery
ES2402342T3 (es)	2008-08-01	2013-04-30	Krka, Tovarna Zdravil, D.D., Novo Mesto	Composición de quetiapina
DE102008046650A1 (de)	2008-09-10	2010-03-11	Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg	Quetiapin enthaltende Retardtablette
CA2927380C (en) *	2009-12-31	2017-07-04	Kempharm, Inc.	Amino acid conjugates of quetiapine, process for making and using the same
WO2011112657A1 (en)	2010-03-11	2011-09-15	Kempharm, Inc.	Fatty acid conjugates of quetiapine, process for making and using the same
US8703802B2 (en)	2010-05-20	2014-04-22	Targacept, Inc.	Process for the preparation of aryl substituted olefinic amines
DE102010033527A1 (de)	2010-08-05	2012-02-09	Acino Pharma Ag	Quetiapin-Tabletten
DE102011115690A1 (de)	2011-10-11	2013-04-11	Acino Pharma Ag	Quetiapin enthaltende Formulierungen
US9993486B1 (en)	2017-06-19	2018-06-12	Tlc Therapeutics, Llc	Oral quetiapine suspension formulations with extended shelf life and enhanced bioavailability

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Publication number	Priority date	Publication date	Assignee	Title
GB8607684D0 (en) *	1986-03-27	1986-04-30	Ici America Inc	Thiazepine compounds
GB8705574D0 (en) *	1987-03-10	1987-04-15	Ici Plc	Preparation of thiazepine compound
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1999
- 1999-09-21 GB GBGB9922271.3A patent/GB9922271D0/en not_active Ceased
2000
- 2000-09-01 GB GBGB0021406.4A patent/GB0021406D0/en not_active Ceased
- 2000-09-18 PL PL357369A patent/PL198824B1/pl unknown
- 2000-09-18 CN CNB00813166XA patent/CN1188130C/zh not_active Expired - Lifetime
- 2000-09-18 TR TR2002/00716T patent/TR200200716T2/xx unknown
- 2000-09-18 JP JP2001524605A patent/JP2003509461A/ja active Pending
- 2000-09-18 HU HU0203531A patent/HUP0203531A3/hu unknown
- 2000-09-18 IL IL14844000A patent/IL148440A0/xx active IP Right Grant
- 2000-09-18 SK SK372-2002A patent/SK286884B6/sk not_active IP Right Cessation
- 2000-09-18 CN CNA2006101007643A patent/CN1899288A/zh active Pending
- 2000-09-18 EE EEP200200150A patent/EE200200150A/xx unknown
- 2000-09-18 DK DK00960855T patent/DK1218009T3/da active
- 2000-09-18 WO PCT/GB2000/003598 patent/WO2001021179A1/en active IP Right Grant
- 2000-09-18 EP EP00960855A patent/EP1218009B1/en not_active Expired - Lifetime
- 2000-09-18 ES ES00960855T patent/ES2235941T3/es not_active Expired - Lifetime
- 2000-09-18 CA CA002383131A patent/CA2383131A1/en not_active Abandoned
- 2000-09-18 CZ CZ20020974A patent/CZ301585B6/cs not_active IP Right Cessation
- 2000-09-18 BR BR0014107-0A patent/BR0014107A/pt not_active Application Discontinuation
- 2000-09-18 SI SI200030640T patent/SI1218009T1/xx unknown
- 2000-09-18 CN CNB2004101011599A patent/CN1331472C/zh not_active Expired - Lifetime
- 2000-09-18 DE DE60017923T patent/DE60017923T2/de not_active Expired - Lifetime
- 2000-09-18 NZ NZ517549A patent/NZ517549A/en not_active IP Right Cessation
- 2000-09-18 AT AT00960855T patent/ATE288272T1/de active
- 2000-09-18 KR KR1020027003676A patent/KR100748823B1/ko not_active IP Right Cessation
- 2000-09-18 MX MXPA02002627A patent/MXPA02002627A/es active IP Right Grant
- 2000-09-18 RU RU2002110456/15A patent/RU2256453C2/ru not_active IP Right Cessation
- 2000-09-18 UA UA2002043283A patent/UA73529C2/uk unknown
- 2000-09-18 PT PT00960855T patent/PT1218009E/pt unknown
- 2000-09-18 US US10/088,804 patent/US6599897B1/en not_active Expired - Lifetime
- 2000-09-18 AU AU73023/00A patent/AU776292B2/en not_active Ceased
- 2000-09-19 CO CO00070974A patent/CO5180585A1/es not_active Application Discontinuation
- 2000-09-19 MY MYPI20004370A patent/MY130208A/en unknown
- 2000-09-20 EG EG20001205A patent/EG24226A/xx active
- 2000-09-20 TW TW089119338A patent/TWI226832B/zh not_active IP Right Cessation
- 2000-09-21 AR ARP000104954A patent/AR032596A1/es unknown
2002
- 2002-02-27 IL IL148440A patent/IL148440A/en not_active IP Right Cessation
- 2002-02-28 ZA ZA200201709A patent/ZA200201709B/en unknown
- 2002-03-11 BG BG106509A patent/BG65469B1/bg unknown
- 2002-03-19 IS IS6308A patent/IS2139B/xx unknown
- 2002-03-20 NO NO20021394A patent/NO320908B1/no not_active IP Right Cessation
- 2002-12-27 HK HK02109363.8A patent/HK1047706B/zh not_active IP Right Cessation
2003
- 2003-07-25 US US10/627,198 patent/US7022692B2/en not_active Expired - Fee Related
2006
- 2006-01-10 US US11/329,378 patent/US20060159768A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20040228914A1 (en)	2004-11-18
UA73529C2 (uk)	2005-08-15
SK286884B6 (sk)	2009-07-06
EG24226A (en)	2008-11-10
KR20020033186A (ko)	2002-05-04
KR100748823B1 (ko)	2007-08-13
CZ301585B6 (cs)	2010-04-21
IS6308A (is)	2002-03-19
HUP0203531A3 (en)	2004-12-28
EP1218009B1 (en)	2005-02-02
IS2139B (is)	2006-08-15
CN1331472C (zh)	2007-08-15
CN1899288A (zh)	2007-01-24
DE60017923D1 (de)	2005-03-10
CA2383131A1 (en)	2001-03-29
SI1218009T1 (en)	2005-06-30
NZ517549A (en)	2003-10-31
CN1188130C (zh)	2005-02-09
US6599897B1 (en)	2003-07-29
DK1218009T3 (da)	2005-05-09
AU7302300A (en)	2001-04-24
CN1626094A (zh)	2005-06-15
BG106509A (en)	2002-12-29
NO20021394D0 (no)	2002-03-20
IL148440A0 (en)	2002-09-12
HUP0203531A2 (hu)	2003-02-28
CN1374867A (zh)	2002-10-16
BR0014107A (pt)	2002-08-20
SK3722002A3 (en)	2002-07-02
BG65469B1 (bg)	2008-09-30
NO20021394L (no)	2002-03-20
JP2003509461A (ja)	2003-03-11
TR200200716T2 (tr)	2002-06-21
HK1047706B (zh)	2005-06-10
US7022692B2 (en)	2006-04-04
HK1047706A1 (en)	2003-03-07
PT1218009E (pt)	2005-05-31
TWI226832B (en)	2005-01-21
RU2256453C2 (ru)	2005-07-20
CZ2002974A3 (cs)	2002-06-12
NO320908B1 (no)	2006-02-13
EE200200150A (et)	2003-04-15
ES2235941T3 (es)	2005-07-16
CO5180585A1 (es)	2002-07-30
GB0021406D0 (en)	2000-10-18
GB9922271D0 (en)	1999-11-17
WO2001021179A1 (en)	2001-03-29
ATE288272T1 (de)	2005-02-15
EP1218009A1 (en)	2002-07-03
IL148440A (en)	2007-07-04
MXPA02002627A (es)	2002-07-30
MY130208A (en)	2007-06-29
AR032596A1 (es)	2003-11-19
PL198824B1 (pl)	2008-07-31
DE60017923T2 (de)	2006-01-12
PL357369A1 (en)	2004-07-26
AU776292B2 (en)	2004-09-02
US20060159768A1 (en)	2006-07-20

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