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YU57091A - Stabilna mikrosferna bioaktivna kompozicija i postupak njenog dobijanja - Google Patents

Stabilna mikrosferna bioaktivna kompozicija i postupak njenog dobijanja

Info

Publication number
YU57091A
YU57091A YU57091A YU57091A YU57091A YU 57091 A YU57091 A YU 57091A YU 57091 A YU57091 A YU 57091A YU 57091 A YU57091 A YU 57091A YU 57091 A YU57091 A YU 57091A
Authority
YU
Yugoslavia
Prior art keywords
oil
stable
microspheric
obtaining
mixtures
Prior art date
Application number
YU57091A
Other languages
English (en)
Other versions
YU47650B (sh
Inventor
W. Steber
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of YU57091A publication Critical patent/YU57091A/sh
Publication of YU47650B publication Critical patent/YU47650B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Opisana je stabilna mikrosferna kompozicija koja sadrži mast ili vosak ili njihove smese biološki aktivan protein, peptid ili polipeptid; i ulje, semi-tečnu mast, derivat masne kiseline ili njihove smese. Opisan je takodje i postupak za spravljanje te mikrosferne kompozicije. I on obuhvata mešanje oko 1 do 30 mas.% ulja, semi-tečne masti, derivata masne kiseline ili njihove smese, pre nego što ta smesa očvrsne. Takva smesa, pored ulja koje je glicerol ulje, sadrži 30 do 95 mas.% masti ili voska ili njihove smese i 2 do 70 mas.% biološki aktivnog proteina, kao što je hormon rasta, peptida ili polipeptida.
YU57091A 1990-03-30 1991-03-29 Stabilna mikrosferna kompozicija i postupak za njeno dobijanje YU47650B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/502,382 US5213810A (en) 1990-03-30 1990-03-30 Stable compositions for parenteral administration and method of making same

Publications (2)

Publication Number Publication Date
YU57091A true YU57091A (sh) 1994-01-20
YU47650B YU47650B (sh) 1995-12-04

Family

ID=23997559

Family Applications (1)

Application Number Title Priority Date Filing Date
YU57091A YU47650B (sh) 1990-03-30 1991-03-29 Stabilna mikrosferna kompozicija i postupak za njeno dobijanje

Country Status (29)

Country Link
US (1) US5213810A (sh)
EP (1) EP0448930B1 (sh)
JP (1) JP2966564B2 (sh)
KR (1) KR0159778B1 (sh)
CN (1) CN1063941C (sh)
AR (1) AR248085A1 (sh)
AT (1) ATE106240T1 (sh)
AU (1) AU641994B2 (sh)
BG (1) BG60850B1 (sh)
CA (1) CA2039491C (sh)
CZ (1) CZ283053B6 (sh)
DE (1) DE69102176T2 (sh)
DK (1) DK0448930T3 (sh)
ES (1) ES2054380T3 (sh)
FI (1) FI101676B1 (sh)
HK (1) HK1000004A1 (sh)
HU (1) HU219584B (sh)
IE (1) IE65970B1 (sh)
IL (1) IL97145A (sh)
MX (1) MX172602B (sh)
NO (1) NO300717B1 (sh)
NZ (1) NZ237509A (sh)
PL (1) PL167692B1 (sh)
PT (1) PT97160B (sh)
RO (1) RO106191B1 (sh)
RU (1) RU2011377C1 (sh)
SK (1) SK279461B6 (sh)
YU (1) YU47650B (sh)
ZA (1) ZA912398B (sh)

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DE69828635T2 (de) * 1997-09-19 2005-06-16 Shire Laboratories, Inc. Feste lösungskügelchen
AU2002300572B2 (en) * 1997-09-19 2004-11-25 Shire Laboratories, Inc. Solid Solution Beadlet
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US8663692B1 (en) * 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
AU4917900A (en) * 1999-05-07 2000-11-21 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
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CA2413109C (en) * 2000-06-26 2007-11-27 Martek Biosciences Boulder Corporation Improved methods of incorporating polyunsaturated fatty acids in milk
CA2423484A1 (en) 2000-09-27 2002-04-04 Verion Inc. Instant water dissolvable encapsulate and process
DK1197207T3 (da) * 2000-10-10 2008-08-04 Wyeth Corp Stabile sammensætninger til parenteral indgivelse
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
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WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
EP1694304A2 (en) * 2003-12-04 2006-08-30 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
CN1889931A (zh) * 2003-12-04 2007-01-03 辉瑞产品公司 利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾－冻凝方法
ES2600577T3 (es) * 2003-12-04 2017-02-09 Bend Research, Inc. Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
PT2359808E (pt) 2006-08-09 2013-08-28 Intarcia Therapeutics Inc Sistemas de entrega osmótica e montagens de pistão
RU2440097C2 (ru) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
US8343140B2 (en) 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
WO2010028257A1 (en) * 2008-09-04 2010-03-11 Amylin Pharmaceuticals, Inc. Sustained release formulations using non-aqueous carriers
JP5494957B2 (ja) 2009-06-11 2014-05-21 株式会社リコー 静電荷像現像用トナー、現像剤、画像形成方法及び画像形成装置
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US20160151286A1 (en) * 2013-05-29 2016-06-02 Therakine Biodelivery Gmbh Hydrophilic Microparticles, Drug-Delivery Material, Method For Manufacturing Thereof And Methods For Delivery of A Drug-Delivery Composition
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US4666839A (en) * 1982-12-01 1987-05-19 Amgen Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin
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Also Published As

Publication number Publication date
YU47650B (sh) 1995-12-04
NO911228D0 (no) 1991-03-26
DE69102176D1 (de) 1994-07-07
ES2054380T3 (es) 1994-08-01
HK1000004A1 (en) 1997-10-03
MX172602B (es) 1993-01-03
PL167692B1 (en) 1995-10-31
PT97160B (pt) 1998-07-31
FI101676B (fi) 1998-08-14
EP0448930B1 (en) 1994-06-01
FI911531A (fi) 1991-10-01
HUT59834A (en) 1992-07-28
NO300717B1 (no) 1997-07-14
IE911041A1 (en) 1991-10-09
SK279461B6 (sk) 1998-11-04
EP0448930A1 (en) 1991-10-02
IL97145A0 (en) 1992-05-25
RU2011377C1 (ru) 1994-04-30
CN1055293A (zh) 1991-10-16
BG93923A (bg) 1993-12-24
AU7397291A (en) 1991-10-03
ATE106240T1 (de) 1994-06-15
HU219584B (hu) 2001-05-28
PL289657A1 (en) 1992-01-13
AU641994B2 (en) 1993-10-07
AR248085A1 (es) 1995-06-30
JPH04221319A (ja) 1992-08-11
JP2966564B2 (ja) 1999-10-25
RO106191B1 (ro) 1993-03-31
NO911228L (no) 1991-10-01
CN1063941C (zh) 2001-04-04
IL97145A (en) 1996-06-18
ZA912398B (en) 1992-01-29
CZ283053B6 (cs) 1997-12-17
KR0159778B1 (ko) 1998-12-01
IE65970B1 (en) 1995-11-29
FI911531A0 (fi) 1991-03-28
FI101676B1 (fi) 1998-08-14
NZ237509A (en) 1993-04-28
KR910016322A (ko) 1991-11-05
CA2039491A1 (en) 1991-10-01
HU911054D0 (en) 1991-10-28
DK0448930T3 (da) 1994-06-20
PT97160A (pt) 1991-11-29
DE69102176T2 (de) 1995-01-05
US5213810A (en) 1993-05-25
CA2039491C (en) 2001-09-04
BG60850B1 (bg) 1996-05-31

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