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DE69102176D1 - Stabile Zusammensetzungen zur parenteralen Anwendung und Verfahren zu ihrer Herstellung. - Google Patents

Stabile Zusammensetzungen zur parenteralen Anwendung und Verfahren zu ihrer Herstellung.

Info

Publication number
DE69102176D1
DE69102176D1 DE69102176T DE69102176T DE69102176D1 DE 69102176 D1 DE69102176 D1 DE 69102176D1 DE 69102176 T DE69102176 T DE 69102176T DE 69102176 T DE69102176 T DE 69102176T DE 69102176 D1 DE69102176 D1 DE 69102176D1
Authority
DE
Germany
Prior art keywords
preparation
parenteral use
stable compositions
compositions
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69102176T
Other languages
English (en)
Other versions
DE69102176T2 (de
Inventor
William Steber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DE69102176D1 publication Critical patent/DE69102176D1/de
Application granted granted Critical
Publication of DE69102176T2 publication Critical patent/DE69102176T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69102176T 1990-03-30 1991-01-21 Stabile Zusammensetzungen zur parenteralen Anwendung und Verfahren zu ihrer Herstellung. Expired - Fee Related DE69102176T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/502,382 US5213810A (en) 1990-03-30 1990-03-30 Stable compositions for parenteral administration and method of making same

Publications (2)

Publication Number Publication Date
DE69102176D1 true DE69102176D1 (de) 1994-07-07
DE69102176T2 DE69102176T2 (de) 1995-01-05

Family

ID=23997559

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69102176T Expired - Fee Related DE69102176T2 (de) 1990-03-30 1991-01-21 Stabile Zusammensetzungen zur parenteralen Anwendung und Verfahren zu ihrer Herstellung.

Country Status (29)

Country Link
US (1) US5213810A (de)
EP (1) EP0448930B1 (de)
JP (1) JP2966564B2 (de)
KR (1) KR0159778B1 (de)
CN (1) CN1063941C (de)
AR (1) AR248085A1 (de)
AT (1) ATE106240T1 (de)
AU (1) AU641994B2 (de)
BG (1) BG60850B1 (de)
CA (1) CA2039491C (de)
CZ (1) CZ283053B6 (de)
DE (1) DE69102176T2 (de)
DK (1) DK0448930T3 (de)
ES (1) ES2054380T3 (de)
FI (1) FI101676B1 (de)
HK (1) HK1000004A1 (de)
HU (1) HU219584B (de)
IE (1) IE65970B1 (de)
IL (1) IL97145A (de)
MX (1) MX172602B (de)
NO (1) NO300717B1 (de)
NZ (1) NZ237509A (de)
PL (1) PL167692B1 (de)
PT (1) PT97160B (de)
RO (1) RO106191B1 (de)
RU (1) RU2011377C1 (de)
SK (1) SK279461B6 (de)
YU (1) YU47650B (de)
ZA (1) ZA912398B (de)

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ES2086022T3 (es) * 1991-07-23 1996-06-16 American Cyanamid Co Composiciones estables para administracion parenteral y su uso.
US5599660A (en) * 1993-01-19 1997-02-04 Pharmacia Biotech Inc. Method and preparation for sequential delivery of wax-embedded, inactivated biological and chemical reagents
AU6029694A (en) * 1993-01-19 1994-08-15 Pharmacia P-L Biochemicals, Inc. Storage and delivery of purified protein reagents with carrier wax
US6083430A (en) * 1994-10-28 2000-07-04 Fuisz Technologies Ltd. Method of preparing a dosage unit by direct tableting and product therefrom
US5683720A (en) * 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
DE69828635T2 (de) * 1997-09-19 2005-06-16 Shire Laboratories, Inc. Feste lösungskügelchen
AU2002300572B2 (en) * 1997-09-19 2004-11-25 Shire Laboratories, Inc. Solid Solution Beadlet
US6117452A (en) * 1998-08-12 2000-09-12 Fuisz Technologies Ltd. Fatty ester combinations
US8663692B1 (en) * 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
AU4917900A (en) * 1999-05-07 2000-11-21 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
EE200100660A (et) * 1999-06-07 2003-04-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Ravimvorm happe suhtes labiilsete toimeainete jaoks, toimeaine üksus, selle valmistamismeetod ja mikrokerake
CA2407154A1 (en) 2000-04-27 2001-11-01 Verion, Inc Zero order release and temperature-controlled microcapsules and process for the preparation thereof
CA2413109C (en) * 2000-06-26 2007-11-27 Martek Biosciences Boulder Corporation Improved methods of incorporating polyunsaturated fatty acids in milk
CA2423484A1 (en) 2000-09-27 2002-04-04 Verion Inc. Instant water dissolvable encapsulate and process
DK1197207T3 (da) * 2000-10-10 2008-08-04 Wyeth Corp Stabile sammensætninger til parenteral indgivelse
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
EP1691786A1 (de) * 2003-12-04 2006-08-23 Pfizer Products Inc. Multiteilchenförmige zusammensetzungen mit verbesserter stabilität
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
EP1694304A2 (de) * 2003-12-04 2006-08-30 Pfizer Products Inc. Multiteilchenförmige dosierformen von azithromycin durch verfahren auf flüssigkeitsbasis
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
CN1889931A (zh) * 2003-12-04 2007-01-03 辉瑞产品公司 利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾－冻凝方法
ES2600577T3 (es) * 2003-12-04 2017-02-09 Bend Research, Inc. Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
PT2359808E (pt) 2006-08-09 2013-08-28 Intarcia Therapeutics Inc Sistemas de entrega osmótica e montagens de pistão
RU2440097C2 (ru) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
US8343140B2 (en) 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
WO2010028257A1 (en) * 2008-09-04 2010-03-11 Amylin Pharmaceuticals, Inc. Sustained release formulations using non-aqueous carriers
JP5494957B2 (ja) 2009-06-11 2014-05-21 株式会社リコー 静電荷像現像用トナー、現像剤、画像形成方法及び画像形成装置
EP3323423B1 (de) 2009-09-28 2020-06-17 Intarcia Therapeutics, Inc Schnelle initiierung und/oder beendigung der verabreichung substantiell stabiler arzneimittel
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9364549B2 (en) * 2011-11-30 2016-06-14 Andreas Voigt Hydrophobic drug-delivery material, method for manufacturing thereof and methods for delivery of a drug-delivery composition
US20160151286A1 (en) * 2013-05-29 2016-06-02 Therakine Biodelivery Gmbh Hydrophilic Microparticles, Drug-Delivery Material, Method For Manufacturing Thereof And Methods For Delivery of A Drug-Delivery Composition
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
JP6993235B2 (ja) 2015-06-03 2022-01-13 インターシア セラピューティクス，インコーポレイティド インプラントの設置及び撤去システム
BR112018073511A2 (pt) 2016-05-16 2019-03-26 Intarcia Therapeutics, Inc. polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
AU2020224158A1 (en) * 2019-02-21 2021-09-30 ChromaDex Inc. Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147187A (en) * 1962-09-10 1964-09-01 Don Hall Lab Sustained release pharmaceutical
CH637297A5 (fr) * 1978-12-05 1983-07-29 Nestle Sa Microbille comprenant un microorganisme et son procede de fabrication.
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3024416C2 (de) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
US4666839A (en) * 1982-12-01 1987-05-19 Amgen Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin
US4452775A (en) * 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4603044A (en) * 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4755387A (en) * 1985-03-21 1988-07-05 The Procter & Gamble Company Therapeutic particles
DE3527356A1 (de) * 1985-07-31 1987-02-05 Degussa Verfahren zur verbesserung der fruchtbarkeit von haustieren
SE462894B (sv) * 1985-10-28 1990-09-17 Biogram Ab Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning
US4837381A (en) * 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use
US4911928A (en) * 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles

Also Published As

Publication number Publication date
YU47650B (sh) 1995-12-04
NO911228D0 (no) 1991-03-26
ES2054380T3 (es) 1994-08-01
HK1000004A1 (en) 1997-10-03
MX172602B (es) 1993-01-03
PL167692B1 (en) 1995-10-31
PT97160B (pt) 1998-07-31
FI101676B (fi) 1998-08-14
EP0448930B1 (de) 1994-06-01
FI911531A (fi) 1991-10-01
HUT59834A (en) 1992-07-28
NO300717B1 (no) 1997-07-14
IE911041A1 (en) 1991-10-09
SK279461B6 (sk) 1998-11-04
EP0448930A1 (de) 1991-10-02
IL97145A0 (en) 1992-05-25
RU2011377C1 (ru) 1994-04-30
CN1055293A (zh) 1991-10-16
BG93923A (bg) 1993-12-24
AU7397291A (en) 1991-10-03
ATE106240T1 (de) 1994-06-15
HU219584B (hu) 2001-05-28
PL289657A1 (en) 1992-01-13
AU641994B2 (en) 1993-10-07
AR248085A1 (es) 1995-06-30
JPH04221319A (ja) 1992-08-11
JP2966564B2 (ja) 1999-10-25
RO106191B1 (ro) 1993-03-31
NO911228L (no) 1991-10-01
CN1063941C (zh) 2001-04-04
IL97145A (en) 1996-06-18
ZA912398B (en) 1992-01-29
CZ283053B6 (cs) 1997-12-17
YU57091A (sh) 1994-01-20
KR0159778B1 (ko) 1998-12-01
IE65970B1 (en) 1995-11-29
FI911531A0 (fi) 1991-03-28
FI101676B1 (fi) 1998-08-14
NZ237509A (en) 1993-04-28
KR910016322A (ko) 1991-11-05
CA2039491A1 (en) 1991-10-01
HU911054D0 (en) 1991-10-28
DK0448930T3 (da) 1994-06-20
PT97160A (pt) 1991-11-29
DE69102176T2 (de) 1995-01-05
US5213810A (en) 1993-05-25
CA2039491C (en) 2001-09-04
BG60850B1 (bg) 1996-05-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US

8339 Ceased/non-payment of the annual fee