WO2003002593A3 - Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv - Google Patents
Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv Download PDFInfo
- Publication number
- WO2003002593A3 WO2003002593A3 PCT/EP2002/007128 EP0207128W WO03002593A3 WO 2003002593 A3 WO2003002593 A3 WO 2003002593A3 EP 0207128 W EP0207128 W EP 0207128W WO 03002593 A3 WO03002593 A3 WO 03002593A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dipeptidyl peptidase
- catalysis
- peptide structures
- structures useful
- modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003508973A JP2004530729A (ja) | 2001-06-27 | 2002-06-27 | ジペプチジルペプチダーゼiv触媒作用の拮抗調節に有用なペプチド構造 |
EP02762308A EP1399469A2 (fr) | 2001-06-27 | 2002-06-27 | Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv |
CA002419888A CA2419888A1 (fr) | 2001-06-27 | 2002-06-27 | Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv |
NO20030900A NO20030900L (no) | 2001-06-27 | 2003-02-26 | Peptidstrukturer nyttige for kompetitiv modulering av dipeptidyl peptidaseIV-katalyse |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01114796.4 | 2001-06-27 | ||
EP01114796 | 2001-06-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003002593A2 WO2003002593A2 (fr) | 2003-01-09 |
WO2003002593A3 true WO2003002593A3 (fr) | 2003-09-04 |
Family
ID=8177756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/007128 WO2003002593A2 (fr) | 2001-06-27 | 2002-06-27 | Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1399469A2 (fr) |
JP (1) | JP2004530729A (fr) |
CN (2) | CN1688599A (fr) |
CA (1) | CA2419888A1 (fr) |
NO (1) | NO20030900L (fr) |
RU (2) | RU2299066C2 (fr) |
WO (1) | WO2003002593A2 (fr) |
ZA (3) | ZA200301312B (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7897633B2 (en) | 2004-02-05 | 2011-03-01 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
US8883714B2 (en) | 2008-04-07 | 2014-11-11 | Arena Pharmaceuticals, Inc. | Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues |
US9468598B2 (en) | 2002-02-20 | 2016-10-18 | Astrazeneca Ab | Oral dosage form containing a PDE 4 inhibitor as an active ingredient and polyvinylpyrrolidon as excipient |
Families Citing this family (108)
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DE10211555A1 (de) * | 2002-03-15 | 2003-10-02 | Imtm Inst Fuer Medizintechnolo | Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit sebozytärer Hyperproliferation und veränderten Differenzierungszuständen |
US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EP1608317B1 (fr) | 2003-03-25 | 2012-09-26 | Takeda Pharmaceutical Company Limited | Inhibiteurs de dipeptidyle peptidase |
EP1620082B9 (fr) | 2003-05-05 | 2010-08-25 | Probiodrug AG | Utilisation d'effecteurs de glutaminyl- et de glutamate-cyclases pour traiter la maladie d'alzheimer et le syndrome de down |
US7381537B2 (en) | 2003-05-05 | 2008-06-03 | Probiodrug Ag | Use of inhibitors of glutaminyl cyclases for treatment and prevention of disease |
US7371871B2 (en) | 2003-05-05 | 2008-05-13 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7579357B2 (en) | 2003-08-13 | 2009-08-25 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2005026148A1 (fr) | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Inhibiteurs de la dipeptidylpeptidase |
NZ546322A (en) | 2003-10-15 | 2008-11-28 | Probiodrug Ag | Use of effectors of glutaminyl and glutamate cyclases |
EP2338490A3 (fr) | 2003-11-03 | 2012-06-06 | Probiodrug AG | Combinaisons utiles pour le traitement de désordres neuronales |
KR20120126133A (ko) | 2003-11-17 | 2012-11-20 | 노파르티스 아게 | 디펩티딜 펩티다제 ⅳ 억제제의 용도 |
BR122018014389B1 (pt) | 2004-01-20 | 2023-04-25 | Novartis Ag | Processo para preparar comprimido farmacêutico por compressão direta |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
AU2004318013B8 (en) | 2004-03-15 | 2011-10-06 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN1938286A (zh) | 2004-03-29 | 2007-03-28 | 默克公司 | 作为11-β-羟甾类脱氢酶-1抑制剂的二芳基三唑 |
EP1734963A4 (fr) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | Methode destinee a traiter des hommes presentant des troubles metaboliques et anthropometriques |
US7687638B2 (en) | 2004-06-04 | 2010-03-30 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
WO2006019965A2 (fr) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Inhibiteurs de la dipeptidyl peptidase |
CA2574418A1 (fr) | 2004-07-23 | 2006-02-02 | Susan Marie Royalty | Inhibiteurs de peptidase |
EP1797034B1 (fr) | 2004-08-06 | 2010-06-30 | Merck Sharp & Dohme Corp. | Composes de sulfonyle comme inhibiteurs de la 11-beta-hydroxysteroide deshydrogenase-1 |
EP1828192B1 (fr) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Inhibiteurs de dipeptidyle peptidase |
JP5068174B2 (ja) | 2004-12-23 | 2012-11-07 | カンピナ ネーデルランド ホールディング ビー.ブイ. | Dpp−ivを阻害するペプチド中に濃縮されたタンパク質の加水分解物及びその使用 |
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RU2008116844A (ru) | 2005-09-29 | 2009-11-10 | Мерк энд Ко., Инк. (US) | Ацилированные производные спиропиперидина как модуляторы рецептора меланокортина-4 |
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WO2007064208A1 (fr) | 2005-11-30 | 2007-06-07 | Campina Nederland Holding B.V. | Utilisation d'un hydrolysat de proteine pour stimuler l'activite de peptide 1 similaire au glucagon |
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SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
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AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
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BR112015002080A2 (pt) | 2012-08-02 | 2017-07-04 | Merck Sharp & Dohme | composto, composição farmacêutica, uso de um composto, e, método de tratamento ou de prevenção de um transtorno, de uma condição ou de uma doença |
WO2014074668A1 (fr) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulateurs de gpr119 et traitement de troubles associés à ceux-ci |
CA2898482A1 (fr) | 2013-02-22 | 2014-08-28 | Linda L. Brockunier | Composes bicycliques antidiabetiques |
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KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
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PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
WO2020104456A1 (fr) | 2018-11-20 | 2020-05-28 | Tes Pharma S.R.L | Inhibiteurs de la semialdéhyde décarboxylase de l'acide alpha-amino-bêta-carboxymuconique |
EP3924058A1 (fr) | 2019-02-13 | 2021-12-22 | Merck Sharp & Dohme Corp. | Agonistes du récepteur de l'orexine 5-alkyl-pyrrolidine |
US20230018413A1 (en) | 2019-08-08 | 2023-01-19 | Merck Sharp & Dohme Corp. | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
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2002
- 2002-06-27 ZA ZA200301312A patent/ZA200301312B/en unknown
- 2002-06-27 JP JP2003508973A patent/JP2004530729A/ja active Pending
- 2002-06-27 WO PCT/EP2002/007128 patent/WO2003002593A2/fr active Application Filing
- 2002-06-27 CN CNA028022475A patent/CN1688599A/zh active Pending
- 2002-06-27 ZA ZA200300833A patent/ZA200300833B/en unknown
- 2002-06-27 CA CA002419888A patent/CA2419888A1/fr not_active Abandoned
- 2002-06-27 RU RU2003105464/15A patent/RU2299066C2/ru not_active IP Right Cessation
- 2002-06-27 EP EP02762308A patent/EP1399469A2/fr not_active Withdrawn
- 2002-06-27 RU RU2003105463/04A patent/RU2003105463A/ru not_active Application Discontinuation
- 2002-06-27 CN CNA028022467A patent/CN1471538A/zh active Pending
-
2003
- 2003-01-22 ZA ZA200300595A patent/ZA200300595B/en unknown
- 2003-02-26 NO NO20030900A patent/NO20030900L/no not_active Application Discontinuation
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Cited By (3)
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US9468598B2 (en) | 2002-02-20 | 2016-10-18 | Astrazeneca Ab | Oral dosage form containing a PDE 4 inhibitor as an active ingredient and polyvinylpyrrolidon as excipient |
US7897633B2 (en) | 2004-02-05 | 2011-03-01 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
US8883714B2 (en) | 2008-04-07 | 2014-11-11 | Arena Pharmaceuticals, Inc. | Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues |
Also Published As
Publication number | Publication date |
---|---|
ZA200301312B (en) | 2004-03-30 |
CN1688599A (zh) | 2005-10-26 |
NO20030900L (no) | 2003-04-24 |
JP2004530729A (ja) | 2004-10-07 |
RU2299066C2 (ru) | 2007-05-20 |
CA2419888A1 (fr) | 2003-01-09 |
EP1399469A2 (fr) | 2004-03-24 |
NO20030900D0 (no) | 2003-02-26 |
ZA200300595B (en) | 2004-02-13 |
CN1471538A (zh) | 2004-01-28 |
WO2003002593A2 (fr) | 2003-01-09 |
RU2003105463A (ru) | 2004-11-27 |
ZA200300833B (en) | 2004-02-10 |
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