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UA99150C2 - Производные тетрагидрохинолина для лечения посттравматических стрессовых расстройств - Google Patents

Производные тетрагидрохинолина для лечения посттравматических стрессовых расстройств

Info

Publication number
UA99150C2
UA99150C2 UAA201005122A UAA201005122A UA99150C2 UA 99150 C2 UA99150 C2 UA 99150C2 UA A201005122 A UAA201005122 A UA A201005122A UA A201005122 A UAA201005122 A UA A201005122A UA 99150 C2 UA99150 C2 UA 99150C2
Authority
UA
Ukraine
Prior art keywords
traumatic stress
stress disorders
treating post
tetrahydroquinoline derivatives
alkyl
Prior art date
Application number
UAA201005122A
Other languages
English (en)
Ukrainian (uk)
Inventor
Франсуа Жанк
Original Assignee
Актелион Фармасьютикалс Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40467356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99150(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Актелион Фармасьютикалс Лтд filed Critical Актелион Фармасьютикалс Лтд
Publication of UA99150C2 publication Critical patent/UA99150C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к применению производных тетрагидрохинолина формулы IIa,гдеRи Rкаждый независимо означает С-Салкоксигруппу,Rозначает арил(С-С)алкил или гетероарил(С-С)алкил, иRозначает С-Салкил,или фармацевтически приемлемым солям указанных соединений для получения лекарственного средства, предназначенного для профилактики или лечения посттравматических стрессовых расстройств.
UAA201005122A 2007-10-10 2008-10-09 Производные тетрагидрохинолина для лечения посттравматических стрессовых расстройств UA99150C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2007054130 2007-10-10

Publications (1)

Publication Number Publication Date
UA99150C2 true UA99150C2 (ru) 2012-07-25

Family

ID=40467356

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201005122A UA99150C2 (ru) 2007-10-10 2008-10-09 Производные тетрагидрохинолина для лечения посттравматических стрессовых расстройств

Country Status (28)

Country Link
US (1) US9532985B2 (ru)
EP (1) EP2207550B1 (ru)
JP (1) JP5883222B2 (ru)
KR (1) KR101733247B1 (ru)
CN (1) CN101820878B (ru)
AR (1) AR068768A1 (ru)
AU (1) AU2008309194B2 (ru)
BR (1) BRPI0818617A2 (ru)
CA (1) CA2699504C (ru)
CY (1) CY1114799T1 (ru)
DK (1) DK2207550T3 (ru)
EA (1) EA017443B1 (ru)
ES (1) ES2444418T3 (ru)
HK (1) HK1145440A1 (ru)
HR (1) HRP20140214T1 (ru)
IL (1) IL204838A (ru)
MA (1) MA31800B1 (ru)
MX (1) MX2010003711A (ru)
MY (1) MY153044A (ru)
NZ (1) NZ585086A (ru)
PE (1) PE20091010A1 (ru)
PL (1) PL2207550T3 (ru)
PT (1) PT2207550E (ru)
SI (1) SI2207550T1 (ru)
TW (1) TWI428129B (ru)
UA (1) UA99150C2 (ru)
WO (1) WO2009047723A2 (ru)
ZA (1) ZA201003251B (ru)

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WO2008078291A1 (en) 2006-12-22 2008-07-03 Actelion Pharmaceuticals Ltd 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives
CA2726834A1 (en) 2008-06-25 2009-12-30 Actelion Pharmaceuticals Ltd 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist
TW201209037A (en) 2010-08-24 2012-03-01 Actelion Pharmaceuticals Ltd Proline sulfonamide derivatives as orexin receptor antagonists
PT2626350E (pt) 2010-09-22 2015-08-03 Eisai R&D Man Co Ltd Composto de ciclopropano
WO2012063207A1 (en) 2010-11-10 2012-05-18 Actelion Pharmaceuticals Ltd Lactam derivatives useful as orexin receptor antagonists
WO2012085857A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-3-yl amides
KR101873083B1 (ko) 2011-02-18 2018-06-29 이도르시아 파마슈티컬스 리미티드 오렉신 길항제로서 유용한 신규 피라졸 및 이미다졸 유도체
WO2012114252A1 (en) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Novel indole and pyrrolopyridine amides
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
ES2572703T3 (es) 2011-11-08 2016-06-01 Actelion Pharmaceuticals Ltd. Derivados de 2-(1,2,3-triazol-2-il)benzamida y 3-(1,2,3-triazol-2-il)picolinamida como antagonistas del receptor de orexina
TWI510481B (zh) 2012-06-04 2015-12-01 Actelion Pharmaceuticals Ltd 苯并咪唑脯胺酸衍生物
CN104703980B (zh) 2012-10-10 2017-09-22 埃科特莱茵药品有限公司 属于[邻双(杂)芳基]‑[2‑(间双(杂)芳基)吡咯烷‑1‑基]甲酮衍生物的食欲素受体拮抗剂
JP2016510810A (ja) 2013-03-12 2016-04-11 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン受容体アンタゴニストとしてのアゼチジンアミド誘導体
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
KR102361418B1 (ko) 2013-12-03 2022-02-09 이도르시아 파마슈티컬스 리미티드 (S)-(2-(6-클로로-7-메틸-1H-벤조[d]이미다졸-2-일)-2-메틸피롤리딘-1- 일)(5-메톡시-2-(2H-1,2,3-트리아졸-2-일)페닐)메타논의 결정형 및 오렉신 수용체 길항제로서의 그 용도
JP6421185B2 (ja) 2013-12-04 2018-11-07 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ベンゾイミダゾール−プロリン誘導体の使用
EP3209298B1 (en) 2014-10-23 2020-12-02 Eisai R&D Management Co., Ltd. Compositions for treating insomnia
JP7179049B2 (ja) * 2017-08-01 2022-11-28 ベルゲン ファーマシューティカル、 エルエルシー オレキシン受容体拮抗薬の結晶形及びその製造方法並びに用途
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020007977A1 (en) 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd 7-trifluoromethyl-[1,4]diazepan derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
WO2023218023A1 (en) 2022-05-13 2023-11-16 Idorsia Pharmaceuticals Ltd Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100842698B1 (ko) * 2000-03-14 2008-07-01 액테리온 파마슈티칼 리미티드 1,2,3,4-테트라하이드로이소퀴놀린 유도체
BRPI0408681A (pt) * 2003-03-26 2006-03-28 Actelion Pharmaceuticals Ltd compostos, composições farmacêuticas, uso de um derivado da 1,2,3,4-tetraidroisoquinolina, método para tratar ou prevenir doenças, processo para a manufatura de composições farmacêuticas, e, uso de um ou mais compostos
SI1751111T1 (sl) * 2004-03-01 2015-04-30 Actelion Pharmaceuticals Ltd. Substituirani 1,2,3,4-tetrahidroizokinolinski derivati
US7501395B2 (en) * 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
KR101065239B1 (ko) * 2006-03-15 2011-09-16 액테리온 파마슈티칼 리미티드 기억 기능을 증진하는 테트라히드로이소퀴놀린 유도체
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist

Also Published As

Publication number Publication date
EP2207550A2 (en) 2010-07-21
PE20091010A1 (es) 2009-08-08
EP2207550B1 (en) 2013-12-11
EA017443B1 (ru) 2012-12-28
WO2009047723A3 (en) 2009-05-28
CA2699504A1 (en) 2009-04-16
HRP20140214T1 (hr) 2014-04-11
CN101820878A (zh) 2010-09-01
IL204838A0 (en) 2010-11-30
WO2009047723A2 (en) 2009-04-16
CN101820878B (zh) 2012-02-01
MA31800B1 (fr) 2010-10-01
JP2011500550A (ja) 2011-01-06
NZ585086A (en) 2012-03-30
ZA201003251B (en) 2011-07-27
JP5883222B2 (ja) 2016-03-09
CY1114799T1 (el) 2016-12-14
KR20100065203A (ko) 2010-06-15
MY153044A (en) 2014-12-31
US9532985B2 (en) 2017-01-03
TW200932231A (en) 2009-08-01
IL204838A (en) 2014-09-30
DK2207550T3 (da) 2014-01-27
AU2008309194A1 (en) 2009-04-16
TWI428129B (zh) 2014-03-01
ES2444418T3 (es) 2014-02-25
KR101733247B1 (ko) 2017-05-08
CA2699504C (en) 2015-11-24
PL2207550T3 (pl) 2014-05-30
PT2207550E (pt) 2014-02-07
US20100234420A1 (en) 2010-09-16
AU2008309194B2 (en) 2013-10-03
MX2010003711A (es) 2010-04-30
BRPI0818617A2 (pt) 2015-04-07
AR068768A1 (es) 2009-12-02
SI2207550T1 (sl) 2014-03-31
HK1145440A1 (en) 2011-04-21
EA201000557A1 (ru) 2010-10-29

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