UA73513C2 - 8-PHENYL-6,9 ûDIHYDRO- [1,2,4] TRIAZOLO [3,4-I] PURIN û5-ON DERIVATIVES, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON - Google Patents

8-PHENYL-6,9 ûDIHYDRO- [1,2,4] TRIAZOLO [3,4-I] PURIN û5-ON DERIVATIVES, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON Download PDF

Info

Publication number: UA73513C2
Authority: UA; Ukraine
Prior art keywords: dihydro; preparation; group; sulfonyl; propyl
Prior art date: 1999-07-27

Application number

UA2002010660A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Almirall Prodespharma S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-27

Filing date

2000-07-24

Publication date

2005-08-15

2000-07-24 Application filed by Almirall Prodespharma S A filed Critical Almirall Prodespharma S A

2005-08-15 Publication of UA73513C2 publication Critical patent/UA73513C2/uk

Links

238000000034 method Methods 0.000 title claims description 167
239000008194 pharmaceutical composition Substances 0.000 title claims description 6
238000002360 preparation method Methods 0.000 title description 217
150000003839 salts Chemical class 0.000 claims abstract description 17
150000001875 compounds Chemical class 0.000 claims description 211
-1 monoalkylamino Chemical group 0.000 claims description 126
239000000203 mixture Substances 0.000 claims description 51
125000000217 alkyl group Chemical group 0.000 claims description 41
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 27
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
238000006243 chemical reaction Methods 0.000 claims description 22
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239000001257 hydrogen Substances 0.000 claims description 19
125000000753 cycloalkyl group Chemical group 0.000 claims description 14
229910052757 nitrogen Inorganic materials 0.000 claims description 14
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
150000001412 amines Chemical class 0.000 claims description 12
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
208000035475 disorder Diseases 0.000 claims description 4
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150000002367 halogens Chemical class 0.000 claims description 4
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 4
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239000000546 pharmaceutical excipient Substances 0.000 claims description 4
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239000002253 acid Substances 0.000 claims description 3
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208000023819 chronic asthma Diseases 0.000 claims description 3
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125000004442 acylamino group Chemical group 0.000 claims description 2
230000015572 biosynthetic process Effects 0.000 claims description 2
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 2
125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 2
230000005764 inhibitory process Effects 0.000 claims description 2
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
125000005188 oxoalkyl group Chemical group 0.000 claims description 2
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims description 2
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230000003993 interaction Effects 0.000 claims 3
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208000009325 Variant Angina Pectoris Diseases 0.000 claims 2
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235000019359 magnesium stearate Nutrition 0.000 description 1
238000001819 mass spectrum Methods 0.000 description 1
STEPQTYSZVCJPV-UHFFFAOYSA-N metazachlor Chemical compound CC1=CC=CC(C)=C1N(C(=O)CCl)CN1N=CC=C1 STEPQTYSZVCJPV-UHFFFAOYSA-N 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
YCNHOXDFQLCQEU-UHFFFAOYSA-N n,1-dimethylazetidin-3-amine Chemical compound CNC1CN(C)C1 YCNHOXDFQLCQEU-UHFFFAOYSA-N 0.000 description 1
IRQWCOFOSMREBQ-UHFFFAOYSA-N n,n-dimethylazetidin-3-amine Chemical compound CN(C)C1CNC1 IRQWCOFOSMREBQ-UHFFFAOYSA-N 0.000 description 1
125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
NXJCBFBQEVOTOW-UHFFFAOYSA-L palladium(2+);dihydroxide Chemical compound O[Pd]O NXJCBFBQEVOTOW-UHFFFAOYSA-L 0.000 description 1
239000012071 phase Substances 0.000 description 1
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
RFIOZSIHFNEKFF-UHFFFAOYSA-N piperazine-1-carboxylic acid Chemical compound OC(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-N 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
JKANAVGODYYCQF-UHFFFAOYSA-N prop-2-yn-1-amine Chemical compound NCC#C JKANAVGODYYCQF-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
125000002098 pyridazinyl group Chemical group 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
150000003872 salicylic acid derivatives Chemical class 0.000 description 1
238000000926 separation method Methods 0.000 description 1
XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
229940055764 triaz Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

UA2002010660A 1999-07-27 2000-07-24 8-PHENYL-6,9 ûDIHYDRO- [1,2,4] TRIAZOLO [3,4-I] PURIN û5-ON DERIVATIVES, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON UA73513C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009901694A ES2166270B1 (es)	1999-07-27	1999-07-27	Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
PCT/EP2000/007062 WO2001007441A1 (fr)	1999-07-27	2000-07-24	DERIVES DE 8-PHENYL-6,9-DIHYDRO-[1,2,4]TRIAZOLO[3,4-i]PURINE-5-ONE

Publications (1)

Publication Number	Publication Date
UA73513C2 true UA73513C2 (en)	2005-08-15

Family

ID=8309393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2002010660A UA73513C2 (en)	1999-07-27	2000-07-24	8-PHENYL-6,9 ûDIHYDRO- [1,2,4] TRIAZOLO [3,4-I] PURIN û5-ON DERIVATIVES, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON

Country Status (34)

Country	Link
US (1)	US7034016B2 (fr)
EP (1)	EP1198464B1 (fr)
JP (1)	JP2003505461A (fr)
KR (1)	KR20020022786A (fr)
CN (1)	CN1198825C (fr)
AR (1)	AR024969A1 (fr)
AT (1)	ATE251625T1 (fr)
AU (1)	AU777571B2 (fr)
BG (1)	BG106346A (fr)
BR (1)	BR0012764A (fr)
CA (1)	CA2380181A1 (fr)
CO (1)	CO5190717A1 (fr)
CZ (1)	CZ2002311A3 (fr)
DE (1)	DE60005838T2 (fr)
DK (1)	DK1198464T3 (fr)
EE (1)	EE200200046A (fr)
ES (2)	ES2166270B1 (fr)
HK (1)	HK1044332B (fr)
HU (1)	HUP0202103A3 (fr)
IL (1)	IL147770A0 (fr)
MY (1)	MY129590A (fr)
NO (1)	NO20020391L (fr)
NZ (1)	NZ516780A (fr)
PE (1)	PE20010401A1 (fr)
PL (1)	PL353827A1 (fr)
PT (1)	PT1198464E (fr)
RU (1)	RU2258705C2 (fr)
SK (1)	SK1352002A3 (fr)
TR (1)	TR200200785T2 (fr)
TW (1)	TW568912B (fr)
UA (1)	UA73513C2 (fr)
UY (1)	UY26258A1 (fr)
WO (1)	WO2001007441A1 (fr)
ZA (1)	ZA200200561B (fr)

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SE0300917D0 (sv)	2003-03-31	2003-03-31	St Jude Medical	Multi-chamber pacing system
EP3342420A1 (fr) *	2003-06-13	2018-07-04	Ironwood Pharmaceuticals, Inc.	Procédé et compositions de traitement des troubles gastro-intestinaux
US7501426B2 (en)	2004-02-18	2009-03-10	Boehringer Ingelheim International Gmbh	8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
CN1946685A (zh) *	2004-04-29	2007-04-11	默克公司	氮杂环丁烷甘氨酸转运蛋白抑制剂
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
JP2008520679A (ja) *	2004-11-18	2008-06-19	シェーリングコーポレイション	うっ血性心不全の処置のためにｐｄｅｖインヒビターを使用する方法
DE102005035891A1 (de)	2005-07-30	2007-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (fr)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	Compositions d'inhibiteurs de la DPP IV
JP5323684B2 (ja)	2006-05-04	2013-10-23	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	多形体
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
PE20140960A1 (es)	2008-04-03	2014-08-15	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
KR20200118243A (ko)	2008-08-06	2020-10-14	베링거 인겔하임 인터내셔날 게엠베하	메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es)	2008-08-06	2010-03-26	Boehringer Ingelheim Int	"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
EP2344195A2 (fr)	2008-09-10	2011-07-20	Boehringer Ingelheim International GmbH	Polythérapie pour le traitement du diabète et des états pathologiques apparentés
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
NZ592924A (en)	2008-12-23	2014-05-30	Boehringer Ingelheim Int	Salt forms of a xanthine derivative
TW201036975A (en)	2009-01-07	2010-10-16	Boehringer Ingelheim Int	Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
NZ599298A (en)	2009-11-27	2014-11-28	Boehringer Ingelheim Int	Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
KR101819609B1 (ko)	2010-05-05	2018-01-17	베링거 인겔하임 인터내셔날 게엠베하	체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
KR102018038B1 (ko)	2010-06-24	2019-09-05	베링거 인겔하임 인터내셔날 게엠베하	당뇨병 요법
US9034883B2 (en)	2010-11-15	2015-05-19	Boehringer Ingelheim International Gmbh	Vasoprotective and cardioprotective antidiabetic therapy
HUE043540T2 (hu)	2011-07-15	2019-08-28	Boehringer Ingelheim Int	Szubsztituált dimer kinazolin-származék, elõállítása, valamint alkalmazása 1-es és 2-es típusú cukorbetegség kezelésére szolgáló gyógyászati készítményekben
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
US20130303462A1 (en)	2012-05-14	2013-11-14	Boehringer Ingelheim International Gmbh	Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (fr)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires
CN104583213B (zh)	2012-06-18	2018-10-26	达特神经科学(开曼)有限公司	取代的吡啶唑并嘧啶-5-(6h)-酮化合物
ES2950384T3 (es)	2014-02-28	2023-10-09	Boehringer Ingelheim Int	Uso médico de un inhibidor de DPP-4
CN109310697A (zh)	2016-06-10	2019-02-05	勃林格殷格翰国际有限公司	利格列汀和二甲双胍的组合
WO2019135259A1 (fr)	2018-01-04	2019-07-11	Impetis Biosciences Ltd.	Composés tricycliques, compositions et leurs applications médicinales
KR20210052478A (ko) *	2018-08-30	2021-05-10	테라 스톤 가부시키가이샤	크산틴옥시다아제를 저해하기 위한 하이드라지노퓨린 화합물 및 트리아졸로퓨린 화합물
CN112225761B (zh) *	2020-12-16	2021-03-12	南京颐媛生物医学研究院有限公司	一种嘧啶并三氮唑及其合成方法
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1999
- 1999-07-27 ES ES009901694A patent/ES2166270B1/es not_active Expired - Fee Related
2000
- 2000-07-24 WO PCT/EP2000/007062 patent/WO2001007441A1/fr active IP Right Grant
- 2000-07-24 PT PT00949400T patent/PT1198464E/pt unknown
- 2000-07-24 ES ES00949400T patent/ES2208378T3/es not_active Expired - Lifetime
- 2000-07-24 RU RU2002104935/04A patent/RU2258705C2/ru not_active IP Right Cessation
- 2000-07-24 PL PL00353827A patent/PL353827A1/xx not_active Application Discontinuation
- 2000-07-24 NZ NZ516780A patent/NZ516780A/en unknown
- 2000-07-24 BR BR0012764-7A patent/BR0012764A/pt not_active IP Right Cessation
- 2000-07-24 PE PE2000000742A patent/PE20010401A1/es not_active Application Discontinuation
- 2000-07-24 CZ CZ2002311A patent/CZ2002311A3/cs unknown
- 2000-07-24 AU AU62772/00A patent/AU777571B2/en not_active Ceased
- 2000-07-24 DK DK00949400T patent/DK1198464T3/da active
- 2000-07-24 EE EEP200200046A patent/EE200200046A/xx unknown
- 2000-07-24 DE DE60005838T patent/DE60005838T2/de not_active Expired - Lifetime
- 2000-07-24 HU HU0202103A patent/HUP0202103A3/hu unknown
- 2000-07-24 KR KR1020027001155A patent/KR20020022786A/ko not_active Application Discontinuation
- 2000-07-24 TR TR2002/00785T patent/TR200200785T2/xx unknown
- 2000-07-24 CA CA002380181A patent/CA2380181A1/fr not_active Abandoned
- 2000-07-24 UA UA2002010660A patent/UA73513C2/uk unknown
- 2000-07-24 CN CNB008130760A patent/CN1198825C/zh not_active Expired - Fee Related
- 2000-07-24 AT AT00949400T patent/ATE251625T1/de not_active IP Right Cessation
- 2000-07-24 IL IL14777000A patent/IL147770A0/xx unknown
- 2000-07-24 EP EP00949400A patent/EP1198464B1/fr not_active Expired - Lifetime
- 2000-07-24 JP JP2001512525A patent/JP2003505461A/ja not_active Withdrawn
- 2000-07-24 SK SK135-2002A patent/SK1352002A3/sk unknown
- 2000-07-26 MY MYPI20003424A patent/MY129590A/en unknown
- 2000-07-26 TW TW089114927A patent/TW568912B/zh active
- 2000-07-26 CO CO00056184A patent/CO5190717A1/es not_active Application Discontinuation
- 2000-07-27 AR ARP000103896A patent/AR024969A1/es not_active Application Discontinuation
- 2000-07-27 UY UY26258A patent/UY26258A1/es not_active Application Discontinuation
2002
- 2002-01-22 ZA ZA200200561A patent/ZA200200561B/en unknown
- 2002-01-24 BG BG06346A patent/BG106346A/xx unknown
- 2002-01-25 NO NO20020391A patent/NO20020391L/no unknown
- 2002-01-25 US US10/057,847 patent/US7034016B2/en not_active Expired - Fee Related
- 2002-05-15 HK HK02103667.4A patent/HK1044332B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
SK1352002A3 (en)	2003-04-01
CN1374962A (zh)	2002-10-16
ATE251625T1 (de)	2003-10-15
JP2003505461A (ja)	2003-02-12
BR0012764A (pt)	2002-07-02
HUP0202103A2 (en)	2002-10-28
ZA200200561B (en)	2003-06-25
ES2166270B1 (es)	2003-04-01
TW568912B (en)	2004-01-01
AU6277200A (en)	2001-02-13
UY26258A1 (es)	2000-12-29
HK1044332B (zh)	2004-10-15
CZ2002311A3 (cs)	2003-01-15
AR024969A1 (es)	2002-10-30
NZ516780A (en)	2004-01-30
ES2166270A1 (es)	2002-04-01
IL147770A0 (en)	2002-08-14
HK1044332A1 (en)	2002-10-18
EP1198464B1 (fr)	2003-10-08
US7034016B2 (en)	2006-04-25
NO20020391L (no)	2002-03-25
US20030060627A1 (en)	2003-03-27
CO5190717A1 (es)	2002-08-29
MY129590A (en)	2007-04-30
CA2380181A1 (fr)	2001-02-01
TR200200785T2 (tr)	2002-09-23
PL353827A1 (en)	2003-12-01
NO20020391D0 (no)	2002-01-25
RU2258705C2 (ru)	2005-08-20
KR20020022786A (ko)	2002-03-27
EP1198464A1 (fr)	2002-04-24
PT1198464E (pt)	2004-02-27
DK1198464T3 (da)	2004-02-16
WO2001007441A1 (fr)	2001-02-01
HUP0202103A3 (en)	2004-12-28
BG106346A (en)	2002-09-30
CN1198825C (zh)	2005-04-27
DE60005838D1 (de)	2003-11-13
DE60005838T2 (de)	2004-08-19
ES2208378T3 (es)	2004-06-16
AU777571B2 (en)	2004-10-21
PE20010401A1 (es)	2001-04-16
EE200200046A (et)	2003-04-15

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UA73513C2 (en)	2005-08-15	8-PHENYL-6,9 ûDIHYDRO- [1,2,4] TRIAZOLO [3,4-I] PURIN û5-ON DERIVATIVES, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON
JP4205168B2 (ja)	2009-01-07	ピリミジン誘導体およびその製造法
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BRPI0910690B1 (pt)	2020-10-20	derivados de 1-heterociclil-1,5-di-hidro-pirazolo[3,4-d]pirimidin-4-ona
EP1286997B1 (fr)	2004-08-18	Derives de 6-phenyl-pyrrolo-pyrimidinedione
EP1492793B1 (fr)	2008-01-16	Nouveaux derives de 4-(pyrrolopyrimidin-6-yl)benzenesulphonamide
EP1097153B1 (fr)	2003-10-01	Composes triazolo[4,5-d]pyrimidiniques
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