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NO20020391L - 8-Fenyl-6,9-dihydro-[1,2,4]-triazolo [3,4-i]-purin-5-on- derivater - Google Patents

8-Fenyl-6,9-dihydro-[1,2,4]-triazolo [3,4-i]-purin-5-on- derivater

Info

Publication number
NO20020391L
NO20020391L NO20020391A NO20020391A NO20020391L NO 20020391 L NO20020391 L NO 20020391L NO 20020391 A NO20020391 A NO 20020391A NO 20020391 A NO20020391 A NO 20020391A NO 20020391 L NO20020391 L NO 20020391L
Authority
NO
Norway
Prior art keywords
purin
triazolo
dihydro
phenyl
derivatives
Prior art date
Application number
NO20020391A
Other languages
English (en)
Norwegian (no)
Other versions
NO20020391D0 (no
Inventor
Jordi Gracia Ferrer
Joan Feixas Gras
Jose Manuel Prieto Soto
Armando Vega Noverola
Bernat Vidal Juan
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of NO20020391D0 publication Critical patent/NO20020391D0/no
Publication of NO20020391L publication Critical patent/NO20020391L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20020391A 1999-07-27 2002-01-25 8-Fenyl-6,9-dihydro-[1,2,4]-triazolo [3,4-i]-purin-5-on- derivater NO20020391L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009901694A ES2166270B1 (es) 1999-07-27 1999-07-27 Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
PCT/EP2000/007062 WO2001007441A1 (fr) 1999-07-27 2000-07-24 DERIVES DE 8-PHENYL-6,9-DIHYDRO-[1,2,4]TRIAZOLO[3,4-i]PURINE-5-ONE

Publications (2)

Publication Number Publication Date
NO20020391D0 NO20020391D0 (no) 2002-01-25
NO20020391L true NO20020391L (no) 2002-03-25

Family

ID=8309393

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020391A NO20020391L (no) 1999-07-27 2002-01-25 8-Fenyl-6,9-dihydro-[1,2,4]-triazolo [3,4-i]-purin-5-on- derivater

Country Status (34)

Country Link
US (1) US7034016B2 (fr)
EP (1) EP1198464B1 (fr)
JP (1) JP2003505461A (fr)
KR (1) KR20020022786A (fr)
CN (1) CN1198825C (fr)
AR (1) AR024969A1 (fr)
AT (1) ATE251625T1 (fr)
AU (1) AU777571B2 (fr)
BG (1) BG106346A (fr)
BR (1) BR0012764A (fr)
CA (1) CA2380181A1 (fr)
CO (1) CO5190717A1 (fr)
CZ (1) CZ2002311A3 (fr)
DE (1) DE60005838T2 (fr)
DK (1) DK1198464T3 (fr)
EE (1) EE200200046A (fr)
ES (2) ES2166270B1 (fr)
HK (1) HK1044332B (fr)
HU (1) HUP0202103A3 (fr)
IL (1) IL147770A0 (fr)
MY (1) MY129590A (fr)
NO (1) NO20020391L (fr)
NZ (1) NZ516780A (fr)
PE (1) PE20010401A1 (fr)
PL (1) PL353827A1 (fr)
PT (1) PT1198464E (fr)
RU (1) RU2258705C2 (fr)
SK (1) SK1352002A3 (fr)
TR (1) TR200200785T2 (fr)
TW (1) TW568912B (fr)
UA (1) UA73513C2 (fr)
UY (1) UY26258A1 (fr)
WO (1) WO2001007441A1 (fr)
ZA (1) ZA200200561B (fr)

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CN1127506C (zh) 2001-06-29 2003-11-12 刘宝顺 一种治疗阳痿的新化合物
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
SE0300917D0 (sv) 2003-03-31 2003-03-31 St Jude Medical Multi-chamber pacing system
EP3342420A1 (fr) * 2003-06-13 2018-07-04 Ironwood Pharmaceuticals, Inc. Procédé et compositions de traitement des troubles gastro-intestinaux
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
CN1946685A (zh) * 2004-04-29 2007-04-11 默克公司 氮杂环丁烷甘氨酸转运蛋白抑制剂
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
JP2008520679A (ja) * 2004-11-18 2008-06-19 シェーリング コーポレイション うっ血性心不全の処置のためにｐｄｅｖインヒビターを使用する方法
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (fr) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Compositions d'inhibiteurs de la DPP IV
JP5323684B2 (ja) 2006-05-04 2013-10-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 多形体
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
EP2344195A2 (fr) 2008-09-10 2011-07-20 Boehringer Ingelheim International GmbH Polythérapie pour le traitement du diabète et des états pathologiques apparentés
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
NZ592924A (en) 2008-12-23 2014-05-30 Boehringer Ingelheim Int Salt forms of a xanthine derivative
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
NZ599298A (en) 2009-11-27 2014-11-28 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
KR101819609B1 (ko) 2010-05-05 2018-01-17 베링거 인겔하임 인터내셔날 게엠베하 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
KR102018038B1 (ko) 2010-06-24 2019-09-05 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
HUE043540T2 (hu) 2011-07-15 2019-08-28 Boehringer Ingelheim Int Szubsztituált dimer kinazolin-származék, elõállítása, valamint alkalmazása 1-es és 2-es típusú cukorbetegség kezelésére szolgáló gyógyászati készítményekben
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (fr) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires
CN104583213B (zh) 2012-06-18 2018-10-26 达特神经科学(开曼)有限公司 取代的吡啶唑并嘧啶-5-(6h)-酮化合物
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合
WO2019135259A1 (fr) 2018-01-04 2019-07-11 Impetis Biosciences Ltd. Composés tricycliques, compositions et leurs applications médicinales
KR20210052478A (ko) * 2018-08-30 2021-05-10 테라 스톤 가부시키가이샤 크산틴옥시다아제를 저해하기 위한 하이드라지노퓨린 화합물 및 트리아졸로퓨린 화합물
CN112225761B (zh) * 2020-12-16 2021-03-12 南京颐媛生物医学研究院有限公司 一种嘧啶并三氮唑及其合成方法
WO2022189189A1 (fr) * 2021-03-09 2022-09-15 Basf Se Composés pesticides tricycliques

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US4593095A (en) * 1983-02-18 1986-06-03 The Johns Hopkins University Xanthine derivatives
DE3347290A1 (de) * 1983-12-28 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
EP0417790B1 (fr) * 1989-09-14 1996-12-04 Kyowa Hakko Kogyo Co., Ltd. Dérivés du S-triazolo[3,4-i]purine
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
CA2213420A1 (fr) * 1995-02-21 1996-08-29 Kazuki Endo Composes de purine et inhibiteurs de xanthine oxydase
CN1188415C (zh) * 1997-04-25 2005-02-09 美国辉瑞有限公司 抑制5型环鸟苷3',5'－单磷酸磷酸二酯酶(cG MP PDE5)并用于治疗性功能障碍的吡唑并嘧啶酮类化合物
AU4501199A (en) * 1998-06-03 1999-12-20 Almirall Prodesfarma S.A. 8-phenylxanthine derivatives and their use as phosphodiesterase inhibitors
JP2004505980A (ja) * 2000-08-09 2004-02-26 アルミラル　プロデスファルマ　ソシエダ　アノニマ ピロロトリアゾロピリミジノン誘導体

Also Published As

Publication number Publication date
SK1352002A3 (en) 2003-04-01
CN1374962A (zh) 2002-10-16
ATE251625T1 (de) 2003-10-15
JP2003505461A (ja) 2003-02-12
BR0012764A (pt) 2002-07-02
HUP0202103A2 (en) 2002-10-28
ZA200200561B (en) 2003-06-25
ES2166270B1 (es) 2003-04-01
TW568912B (en) 2004-01-01
AU6277200A (en) 2001-02-13
UY26258A1 (es) 2000-12-29
HK1044332B (zh) 2004-10-15
CZ2002311A3 (cs) 2003-01-15
AR024969A1 (es) 2002-10-30
NZ516780A (en) 2004-01-30
ES2166270A1 (es) 2002-04-01
IL147770A0 (en) 2002-08-14
HK1044332A1 (en) 2002-10-18
EP1198464B1 (fr) 2003-10-08
UA73513C2 (en) 2005-08-15
US7034016B2 (en) 2006-04-25
US20030060627A1 (en) 2003-03-27
CO5190717A1 (es) 2002-08-29
MY129590A (en) 2007-04-30
CA2380181A1 (fr) 2001-02-01
TR200200785T2 (tr) 2002-09-23
PL353827A1 (en) 2003-12-01
NO20020391D0 (no) 2002-01-25
RU2258705C2 (ru) 2005-08-20
KR20020022786A (ko) 2002-03-27
EP1198464A1 (fr) 2002-04-24
PT1198464E (pt) 2004-02-27
DK1198464T3 (da) 2004-02-16
WO2001007441A1 (fr) 2001-02-01
HUP0202103A3 (en) 2004-12-28
BG106346A (en) 2002-09-30
CN1198825C (zh) 2005-04-27
DE60005838D1 (de) 2003-11-13
DE60005838T2 (de) 2004-08-19
ES2208378T3 (es) 2004-06-16
AU777571B2 (en) 2004-10-21
PE20010401A1 (es) 2001-04-16
EE200200046A (et) 2003-04-15

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