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TR200003515T2 - İkame edilmiş indolinon, bunların imalatı ve ilaç olarak kullanımı - Google Patents

İkame edilmiş indolinon, bunların imalatı ve ilaç olarak kullanımı

Info

Publication number
TR200003515T2
TR200003515T2 TR2000/03515T TR200003515T TR200003515T2 TR 200003515 T2 TR200003515 T2 TR 200003515T2 TR 2000/03515 T TR2000/03515 T TR 2000/03515T TR 200003515 T TR200003515 T TR 200003515T TR 200003515 T2 TR200003515 T2 TR 200003515T2
Authority
TR
Turkey
Prior art keywords
medicines
manufacture
relates
substituted
substituted indolinone
Prior art date
Application number
TR2000/03515T
Other languages
English (en)
Inventor
Heckel Armin
Walter Rainer
Grell Wolfgang
C.A. Van Meel Jacobus
Redemann Norbert
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of TR200003515T2 publication Critical patent/TR200003515T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Isbu bulus R1 ila R5'in ve X'in 1 sayili istemde tanimlandigi gibi oldugu genel formül (I)'e ait ikame edilmis indolinler, bunlarin izomerleri ve bunlarin tuzlari, özellikle de degerli farmakolojik özellikler sergileyen, özellikle de farkli kinazlar ve siklin/CDK kompleksleri üzerinde ve farkli tümör hücrelerinin çogalmasi üzerinde baskilayici olan, fizyolojik olarak uygun olan tuzlari ile ilgilidir. Bulus ayni zamanda bu bilesikleri içeren ilaçlari, bunlarin kullanimi ve bunlarin üretimine yönelik bir yöntemle ilgilidir.
TR2000/03515T 1998-06-04 1999-05-28 İkame edilmiş indolinon, bunların imalatı ve ilaç olarak kullanımı TR200003515T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (de) 1998-06-04 1998-06-04 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
TR200003515T2 true TR200003515T2 (tr) 2001-06-21

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03515T TR200003515T2 (tr) 1998-06-04 1999-05-28 İkame edilmiş indolinon, bunların imalatı ve ilaç olarak kullanımı

Country Status (23)

Country Link
EP (1) EP1100779A1 (tr)
JP (1) JP2002516906A (tr)
KR (1) KR20010043973A (tr)
CN (1) CN1303374A (tr)
AU (1) AU764782B2 (tr)
BG (1) BG104938A (tr)
BR (1) BR9910898A (tr)
CA (1) CA2328291A1 (tr)
CO (1) CO5050294A1 (tr)
DE (1) DE19824922A1 (tr)
EA (1) EA003514B1 (tr)
EE (1) EE200000723A (tr)
HR (1) HRP20000831A2 (tr)
HU (1) HUP0102210A3 (tr)
ID (1) ID27035A (tr)
IL (1) IL138702A0 (tr)
NO (1) NO20006138L (tr)
PL (1) PL344467A1 (tr)
SK (1) SK18222000A3 (tr)
TR (1) TR200003515T2 (tr)
WO (1) WO1999062882A1 (tr)
YU (1) YU73900A (tr)
ZA (1) ZA200005435B (tr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (de) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
AU2001288374A1 (en) * 2000-09-01 2002-03-22 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
EP1317446A1 (en) * 2000-09-01 2003-06-11 Glaxo Group Limited Oxindole derivatives
DE10117204A1 (de) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1401416B1 (en) * 2001-06-29 2006-10-25 AB Science Use of c-kit inhibitors for treating inflammatory bowel diseases (ibd)
ES2266553T3 (es) * 2001-06-29 2007-03-01 Ab Science Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias.
JP2004536097A (ja) * 2001-06-29 2004-12-02 アブ サイエンス 自己免疫疾患を治療するためのチロシンキナーゼ阻害剤の使用法
DK1401413T3 (da) 2001-06-29 2007-03-26 Ab Science Anvendelse af tyrosinkinaseinhibitorer til behandling af allergiske sygdomme
JP2005500041A (ja) 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
JP2005508336A (ja) 2001-09-27 2005-03-31 アラーガン、インコーポレイテッド キナーゼ阻害物質としての３−（アリールアミノ）メチレン−１，３−ジヒドロ−２ｈ−インドール−２−オン類
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
CA2670285A1 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
GB0706072D0 (en) * 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (zh) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 一种生产4-n,n-二甲胺基甲基苯胺的方法
CN103102352B (zh) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 酪氨酸激酶抑制剂吲哚满酮衍生物
CN103130775B (zh) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的吲哚满酮衍生物
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (zh) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物
CA3139708A1 (en) 2019-05-10 2020-11-19 Deciphera Pharmaceuticals, Llc Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
US20240150368A1 (en) * 2022-09-02 2024-05-09 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (fr) * 1976-02-16 1976-06-16 Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
ES2251741T3 (es) * 1996-08-23 2006-05-01 Sugen, Inc. Bibliotecas combinatorias de indolinona y productos afines y metodos para el tratamiento de enfermedades.
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
YU73900A (sh) 2003-04-30
DE19824922A1 (de) 1999-12-09
HRP20000831A2 (en) 2001-12-31
HUP0102210A2 (hu) 2001-11-28
NO20006138D0 (no) 2000-12-01
CA2328291A1 (en) 1999-12-09
EA200100001A1 (ru) 2001-08-27
NO20006138L (no) 2001-02-01
BR9910898A (pt) 2001-02-13
CO5050294A1 (es) 2001-06-27
AU4370799A (en) 1999-12-20
ID27035A (id) 2001-02-22
SK18222000A3 (sk) 2001-08-06
WO1999062882A1 (de) 1999-12-09
KR20010043973A (ko) 2001-05-25
EE200000723A (et) 2002-04-15
EA003514B1 (ru) 2003-06-26
BG104938A (en) 2001-06-29
EP1100779A1 (de) 2001-05-23
AU764782B2 (en) 2003-08-28
JP2002516906A (ja) 2002-06-11
IL138702A0 (en) 2001-10-31
ZA200005435B (en) 2002-01-07
HUP0102210A3 (en) 2002-12-28
CN1303374A (zh) 2001-07-11
PL344467A1 (en) 2001-11-05

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