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AU764782B2 - Substituted indolinones, the production thereof and their use as medicaments - Google Patents

Substituted indolinones, the production thereof and their use as medicaments Download PDF

Info

Publication number
AU764782B2
AU764782B2 AU43707/99A AU4370799A AU764782B2 AU 764782 B2 AU764782 B2 AU 764782B2 AU 43707/99 A AU43707/99 A AU 43707/99A AU 4370799 A AU4370799 A AU 4370799A AU 764782 B2 AU764782 B2 AU 764782B2
Authority
AU
Australia
Prior art keywords
group
methyl
substituted
alkyl
methylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU43707/99A
Other languages
English (en)
Other versions
AU4370799A (en
Inventor
Wolfgang Grell
Armin Heckel
Norbert Redemann
Jacobus C. A. Van Meel
Rainer Walter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU4370799A publication Critical patent/AU4370799A/en
Application granted granted Critical
Publication of AU764782B2 publication Critical patent/AU764782B2/en
Assigned to BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG reassignment BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Request to Amend Deed and Register Assignors: BOEHRINGER INGELHEIM PHARMA KG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU43707/99A 1998-06-04 1999-05-28 Substituted indolinones, the production thereof and their use as medicaments Ceased AU764782B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (de) 1998-06-04 1998-06-04 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19824922 1998-06-04
PCT/EP1999/003692 WO1999062882A1 (de) 1998-06-04 1999-05-28 Substituierte indolinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
AU4370799A AU4370799A (en) 1999-12-20
AU764782B2 true AU764782B2 (en) 2003-08-28

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43707/99A Ceased AU764782B2 (en) 1998-06-04 1999-05-28 Substituted indolinones, the production thereof and their use as medicaments

Country Status (23)

Country Link
EP (1) EP1100779A1 (tr)
JP (1) JP2002516906A (tr)
KR (1) KR20010043973A (tr)
CN (1) CN1303374A (tr)
AU (1) AU764782B2 (tr)
BG (1) BG104938A (tr)
BR (1) BR9910898A (tr)
CA (1) CA2328291A1 (tr)
CO (1) CO5050294A1 (tr)
DE (1) DE19824922A1 (tr)
EA (1) EA003514B1 (tr)
EE (1) EE200000723A (tr)
HR (1) HRP20000831A2 (tr)
HU (1) HUP0102210A3 (tr)
ID (1) ID27035A (tr)
IL (1) IL138702A0 (tr)
NO (1) NO20006138L (tr)
PL (1) PL344467A1 (tr)
SK (1) SK18222000A3 (tr)
TR (1) TR200003515T2 (tr)
WO (1) WO1999062882A1 (tr)
YU (1) YU73900A (tr)
ZA (1) ZA200005435B (tr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9951033B2 (en) 2012-05-18 2018-04-24 Universitetet I Oslo Tertiary amines for use in the treatment of cardiac disorders

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (de) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
JP2004517049A (ja) * 2000-09-01 2004-06-10 グラクソ　グループ　リミテッド チロシンキナーゼ阻害剤としての置換オキシインドール誘導体
US6964977B2 (en) 2000-09-01 2005-11-15 Smithkline Beecham Corporation Oxindole derivatives
DE10117204A1 (de) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
WO2003003006A2 (en) 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
ATE330608T1 (de) * 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
WO2003004007A2 (en) * 2001-06-29 2003-01-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (ibd)
WO2003002109A2 (en) * 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitors for treating autoimmune diseases
ATE345839T1 (de) 2001-06-29 2006-12-15 Ab Science Die verwendung von tyrosinkinasehemmer zur behandlung von allergischen erkrankungen
WO2003027102A1 (en) 2001-09-27 2003-04-03 Allergan, Inc. 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
CA2670285A1 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
GB0706072D0 (en) * 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (zh) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 一种生产4-n,n-二甲胺基甲基苯胺的方法
CN103102352B (zh) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 酪氨酸激酶抑制剂吲哚满酮衍生物
CN103130775B (zh) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的吲哚满酮衍生物
CN103848814B (zh) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物
JP2022531801A (ja) 2019-05-10 2022-07-11 デシフェラ・ファーマシューティカルズ，エルエルシー フェニルアミノピリミジンアミドオートファジー阻害剤およびその使用方法
WO2024050297A1 (en) * 2022-09-02 2024-03-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (fr) * 1976-02-16 1976-06-16 Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AU4155697A (en) * 1996-08-23 1998-03-06 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9951033B2 (en) 2012-05-18 2018-04-24 Universitetet I Oslo Tertiary amines for use in the treatment of cardiac disorders

Also Published As

Publication number Publication date
ID27035A (id) 2001-02-22
HUP0102210A3 (en) 2002-12-28
CN1303374A (zh) 2001-07-11
ZA200005435B (en) 2002-01-07
PL344467A1 (en) 2001-11-05
SK18222000A3 (sk) 2001-08-06
EE200000723A (et) 2002-04-15
NO20006138D0 (no) 2000-12-01
IL138702A0 (en) 2001-10-31
HRP20000831A2 (en) 2001-12-31
JP2002516906A (ja) 2002-06-11
CO5050294A1 (es) 2001-06-27
EA003514B1 (ru) 2003-06-26
CA2328291A1 (en) 1999-12-09
AU4370799A (en) 1999-12-20
YU73900A (sh) 2003-04-30
TR200003515T2 (tr) 2001-06-21
KR20010043973A (ko) 2001-05-25
BR9910898A (pt) 2001-02-13
EA200100001A1 (ru) 2001-08-27
DE19824922A1 (de) 1999-12-09
EP1100779A1 (de) 2001-05-23
WO1999062882A1 (de) 1999-12-09
NO20006138L (no) 2001-02-01
HUP0102210A2 (hu) 2001-11-28
BG104938A (en) 2001-06-29

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FGA Letters patent sealed or granted (standard patent)