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ID27035A - Indolinona tersubstitusi baru, pembuatannya dan penggunaannya sebagai komposisi farmasi - Google Patents

Indolinona tersubstitusi baru, pembuatannya dan penggunaannya sebagai komposisi farmasi

Info

Publication number
ID27035A
ID27035A IDW20002523A ID20002523A ID27035A ID 27035 A ID27035 A ID 27035A ID W20002523 A IDW20002523 A ID W20002523A ID 20002523 A ID20002523 A ID 20002523A ID 27035 A ID27035 A ID 27035A
Authority
ID
Indonesia
Prior art keywords
indolinona
production
new substituted
pharmacy composition
pharmacy
Prior art date
Application number
IDW20002523A
Other languages
English (en)
Inventor
Armin Dr Heckel
Rainer Dr Walter
Wolfgang Dr Grell
Jacobus C A Van Dr Meel
Norbert Dr Redemann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of ID27035A publication Critical patent/ID27035A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IDW20002523A 1998-06-04 1999-05-28 Indolinona tersubstitusi baru, pembuatannya dan penggunaannya sebagai komposisi farmasi ID27035A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (de) 1998-06-04 1998-06-04 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ID27035A true ID27035A (id) 2001-02-22

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20002523A ID27035A (id) 1998-06-04 1999-05-28 Indolinona tersubstitusi baru, pembuatannya dan penggunaannya sebagai komposisi farmasi

Country Status (23)

Country Link
EP (1) EP1100779A1 (id)
JP (1) JP2002516906A (id)
KR (1) KR20010043973A (id)
CN (1) CN1303374A (id)
AU (1) AU764782B2 (id)
BG (1) BG104938A (id)
BR (1) BR9910898A (id)
CA (1) CA2328291A1 (id)
CO (1) CO5050294A1 (id)
DE (1) DE19824922A1 (id)
EA (1) EA003514B1 (id)
EE (1) EE200000723A (id)
HR (1) HRP20000831A2 (id)
HU (1) HUP0102210A3 (id)
ID (1) ID27035A (id)
IL (1) IL138702A0 (id)
NO (1) NO20006138L (id)
PL (1) PL344467A1 (id)
SK (1) SK18222000A3 (id)
TR (1) TR200003515T2 (id)
WO (1) WO1999062882A1 (id)
YU (1) YU73900A (id)
ZA (1) ZA200005435B (id)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (de) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
UA75054C2 (uk) 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
AU8664701A (en) * 2000-09-01 2002-03-22 Glaxo Group Ltd Oxindole derivatives
AU2001288374A1 (en) 2000-09-01 2002-03-22 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
DE10117204A1 (de) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
JP2005500041A (ja) 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
ATE330608T1 (de) * 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
WO2003004007A2 (en) * 2001-06-29 2003-01-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (ibd)
DK1401413T3 (da) 2001-06-29 2007-03-26 Ab Science Anvendelse af tyrosinkinaseinhibitorer til behandling af allergiske sygdomme
DE60227709D1 (de) * 2001-06-29 2008-08-28 Ab Science Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen
WO2003027102A1 (en) * 2001-09-27 2003-04-03 Allergan, Inc. 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
CA2670285A1 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (zh) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 一种生产4-n,n-二甲胺基甲基苯胺的方法
CN103102352B (zh) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 酪氨酸激酶抑制剂吲哚满酮衍生物
CN103130775B (zh) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的吲哚满酮衍生物
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (zh) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物
PT3966207T (pt) 2019-05-10 2023-12-20 Deciphera Pharmaceuticals Llc Inibidores de autofagia de fenilaminopirimidina amida e métodos de utilização dos mesmos
WO2024050297A1 (en) * 2022-09-02 2024-03-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (fr) * 1976-02-16 1976-06-16 Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AU4155697A (en) * 1996-08-23 1998-03-06 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
BG104938A (en) 2001-06-29
CO5050294A1 (es) 2001-06-27
EA003514B1 (ru) 2003-06-26
BR9910898A (pt) 2001-02-13
DE19824922A1 (de) 1999-12-09
CA2328291A1 (en) 1999-12-09
JP2002516906A (ja) 2002-06-11
AU4370799A (en) 1999-12-20
SK18222000A3 (sk) 2001-08-06
EA200100001A1 (ru) 2001-08-27
WO1999062882A1 (de) 1999-12-09
KR20010043973A (ko) 2001-05-25
CN1303374A (zh) 2001-07-11
EE200000723A (et) 2002-04-15
TR200003515T2 (tr) 2001-06-21
NO20006138L (no) 2001-02-01
AU764782B2 (en) 2003-08-28
HUP0102210A2 (hu) 2001-11-28
EP1100779A1 (de) 2001-05-23
YU73900A (sh) 2003-04-30
PL344467A1 (en) 2001-11-05
IL138702A0 (en) 2001-10-31
NO20006138D0 (no) 2000-12-01
HRP20000831A2 (en) 2001-12-31
ZA200005435B (en) 2002-01-07
HUP0102210A3 (en) 2002-12-28

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