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TNSN07071A1 - Composes aminohetero-aryliques a substituant pyrazole servant d'inhibiteurs de proteine-kinases - Google Patents

Composes aminohetero-aryliques a substituant pyrazole servant d'inhibiteurs de proteine-kinases

Info

Publication number
TNSN07071A1
TNSN07071A1 TNP2007000071A TNSN07071A TNSN07071A1 TN SN07071 A1 TNSN07071 A1 TN SN07071A1 TN P2007000071 A TNP2007000071 A TN P2007000071A TN SN07071 A TNSN07071 A TN SN07071A TN SN07071 A1 TNSN07071 A1 TN SN07071A1
Authority
TN
Tunisia
Prior art keywords
inhibitors
aminohetero
kinases
pyrazole
protein
Prior art date
Application number
TNP2007000071A
Other languages
English (en)
Inventor
Jingrong Jean Cui
Lee Andrew Funk
Lei Jia
Pei-Pei Kung
Jerry Jialun Meng
Mitchell David Nambu
Mason Alan Pairish
Hong Shen
Michelle Bich Tran-Dube
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35677463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN07071(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN07071A1 publication Critical patent/TNSN07071A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

Il est proposé des composés de formule (I), Ainsi que des procédés pour leur synthèse et leur utilisation. Les composés préférés sont de puissants inhibiteurs de la protéine-kinase c-Met et sont utiles dans le traitement de troubles comportant une croissance cellulaire anormale, tels que les cancers.
TNP2007000071A 2004-08-26 2007-02-23 Composes aminohetero-aryliques a substituant pyrazole servant d'inhibiteurs de proteine-kinases TNSN07071A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60524404P 2004-08-26 2004-08-26
US69080305P 2005-06-14 2005-06-14
PCT/IB2005/002695 WO2006021881A2 (fr) 2004-08-26 2005-08-15 Composes aminoheteroaryle a substitution pyrazole servant d'inhibiteurs de proteine kinase

Publications (1)

Publication Number Publication Date
TNSN07071A1 true TNSN07071A1 (fr) 2008-06-02

Family

ID=35677463

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2007000071A TNSN07071A1 (fr) 2004-08-26 2007-02-23 Composes aminohetero-aryliques a substituant pyrazole servant d'inhibiteurs de proteine-kinases

Country Status (44)

Country Link
US (1) US20060128724A1 (fr)
EP (1) EP1784396B8 (fr)
JP (1) JP4167295B2 (fr)
KR (1) KR100869393B1 (fr)
CN (1) CN101018780B (fr)
AP (1) AP2332A (fr)
AR (1) AR050529A1 (fr)
AT (1) ATE492544T1 (fr)
AU (1) AU2005276132B2 (fr)
BR (1) BRPI0514537B8 (fr)
CA (1) CA2577937C (fr)
CR (2) CR8938A (fr)
CY (1) CY1111138T1 (fr)
DE (1) DE602005025499D1 (fr)
DK (1) DK1784396T3 (fr)
EA (1) EA011725B1 (fr)
EC (1) ECSP077278A (fr)
ES (1) ES2355923T3 (fr)
GE (1) GEP20094845B (fr)
GT (1) GT200500226A (fr)
HK (1) HK1105415A1 (fr)
HN (1) HN2005000477A (fr)
HR (1) HRP20110116T1 (fr)
IL (1) IL181045A0 (fr)
MA (1) MA28827B1 (fr)
ME (1) ME01309B (fr)
MX (1) MX2007002310A (fr)
MY (1) MY139942A (fr)
NI (1) NI200700058A (fr)
NL (1) NL1029809C2 (fr)
NO (1) NO338656B1 (fr)
NZ (1) NZ552946A (fr)
PA (1) PA8643201A1 (fr)
PE (1) PE20060651A1 (fr)
PL (1) PL1784396T3 (fr)
PT (1) PT1784396E (fr)
RS (1) RS51601B (fr)
SI (1) SI1784396T1 (fr)
SV (1) SV2006002208A (fr)
TN (1) TNSN07071A1 (fr)
TW (1) TWI300411B (fr)
UY (1) UY29080A1 (fr)
WO (1) WO2006021881A2 (fr)
ZA (1) ZA200701281B (fr)

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