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SK286736B6 - Inhibítory kaspázy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie - Google Patents

Inhibítory kaspázy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie Download PDF

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Publication number
SK286736B6
SK286736B6 SK1382-2000A SK13822000A SK286736B6 SK 286736 B6 SK286736 B6 SK 286736B6 SK 13822000 A SK13822000 A SK 13822000A SK 286736 B6 SK286736 B6 SK 286736B6
Authority
SK
Slovakia
Prior art keywords
alkyl
mmol
aryl
group
ring system
Prior art date
Application number
SK1382-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK13822000A3 (sk
Inventor
Marion W. Wannamaker
Guy W. Bemis
Paul S. Charifson
David J. Lauffer
Michael D. Mullican
Mark A. Murcko
Keith P. Wilson
James W. Janetka
Robert J. Davies
Anne-Laure Grillot
Zhan Shi
Cornelia J. Forster
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of SK13822000A3 publication Critical patent/SK13822000A3/sk
Publication of SK286736B6 publication Critical patent/SK286736B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
SK1382-2000A 1998-03-19 1999-03-19 Inhibítory kaspázy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie SK286736B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7877098P 1998-03-19 1998-03-19
PCT/US1999/005919 WO1999047545A2 (en) 1998-03-19 1999-03-19 Inhibitors of caspases

Publications (2)

Publication Number Publication Date
SK13822000A3 SK13822000A3 (sk) 2001-04-09
SK286736B6 true SK286736B6 (sk) 2009-04-06

Family

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Family Applications (1)

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SK1382-2000A SK286736B6 (sk) 1998-03-19 1999-03-19 Inhibítory kaspázy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie

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Country Link
US (3) US6531474B1 (pt)
EP (6) EP2261233A3 (pt)
JP (3) JP4594520B2 (pt)
KR (2) KR100928878B1 (pt)
CN (1) CN1321129C (pt)
AP (1) AP2000001919A0 (pt)
AR (1) AR019011A1 (pt)
AT (1) ATE410439T1 (pt)
AU (1) AU769033B2 (pt)
BG (1) BG104863A (pt)
BR (2) BRPI9909660B8 (pt)
CA (1) CA2324226C (pt)
CZ (1) CZ302281B6 (pt)
DE (1) DE69939689D1 (pt)
DK (1) DK1064298T3 (pt)
ES (1) ES2315010T3 (pt)
GE (1) GEP20043163B (pt)
HK (1) HK1035733A1 (pt)
HU (1) HU227920B1 (pt)
ID (1) ID27002A (pt)
IL (3) IL138469A0 (pt)
IS (1) IS5622A (pt)
NO (1) NO331829B1 (pt)
NZ (2) NZ506963A (pt)
PL (1) PL204619B1 (pt)
PT (1) PT1064298E (pt)
RU (1) RU2274642C2 (pt)
SI (1) SI1064298T1 (pt)
SK (1) SK286736B6 (pt)
TR (1) TR200103406T2 (pt)
TW (1) TWI243828B (pt)
UA (2) UA74133C2 (pt)
WO (1) WO1999047545A2 (pt)
ZA (1) ZA200004652B (pt)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2261233A3 (en) * 1998-03-19 2011-04-20 Vertex Pharmaceuticals Incorporated Inhibitors of caspases
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
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EP2261232A3 (en) 2011-04-20
IL138469A0 (en) 2001-10-31
KR20010042038A (ko) 2001-05-25
CA2324226C (en) 2012-06-05
CN1323314A (zh) 2001-11-21
EP2011800A3 (en) 2009-06-24
IL138469A (en) 2010-11-30
NZ506963A (en) 2003-10-31
BR9909660A (pt) 2000-11-21
EP2261234A2 (en) 2010-12-15
IS5622A (is) 2000-09-08
IL206621A0 (en) 2010-12-30
TR200103406T2 (tr) 2002-06-21
KR100898094B1 (ko) 2009-05-18
SI1064298T1 (sl) 2009-02-28

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